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Your Environment. Your Health.

Progress Reports: Dartmouth College: Arsenic and Innate Immunity in Human Lung

Superfund Research Program

Arsenic and Innate Immunity in Human Lung

Project Leader: Bruce A. Stanton
Grant Number: P42ES007373
Funding Period: 2005-2020
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Progress Reports

Year:   2019  2018  2017  2016  2015  2014  2013  2012  2011  2010  2009  2008  2007  2006  2005 

The goal of Bruce A. Stanton, Ph.D., and his research team's project is to test the hypothesis that arsenic exposure in water and food, relevant to the U.S. population, causes disease by disrupting the innate immune response of the lungs to infection by Pseudomonas aeruginosa. Their project has been focused on a major theme of Dartmouth College's SRP program—the effects of arsenic on human disease. In the last year, the Project has:

  1. Developed a novel toxicogenomic approach to identify biologically relevant, adverse interactions between arsenic and other environmental stressors;
  2. Demonstrated that environmentally relevant levels of arsenic suppress the expression of genes involved in host defense and thereby reduce the ability to clear bacterial lung infections;
  3. Identified a table top water filter that is a cost effective and short-term solution to remove arsenic from drinking water and reduces plastic waste associated with bottled water; and
  4. Developed several novel computational and bioinformatics approaches to interrogate big data sets, including ScanGEO, an approach for parallel data mining of high-throughput gene expression data and an automated sample group detection approach of GEO microarray data and functional annotation of hypothetical genes using machine learning.

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