Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Internet Explorer is no longer a supported browser.

This website may not display properly with Internet Explorer. For the best experience, please use a more recent browser such as the latest versions of Google Chrome, Microsoft Edge, and/or Mozilla Firefox. Thank you.

Your Environment. Your Health.

Progress Reports: Boston University: Mechanisms and Impacts of PCB Resistant Fish

Superfund Research Program

Mechanisms and Impacts of PCB Resistant Fish

Project Leader: Mark E. Hahn (Woods Hole Oceanographic Institution)
Co-Investigators: Sibel I. Karchner (Woods Hole Oceanographic Institution), Neelakanteswar Aluru (Woods Hole Oceanographic Institution)
Grant Number: P42ES007381
Funding Period: 1995-2020
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

Learn More About the Grantee

Visit the grantee's eNewsletter page Visit the grantee's eNewsletter page Visit the grantee's Twitter page View the grantee's Factsheet(377KB)

Progress Reports

Year:   2019  2018  2017  2016  2015  2014  2013  2012  2010  2009  2008  2007  2006  2005  2004  2003  2002  2001  2000  1999  1998  1997  1996  1995 

This year, the team of Mark Hahn, Ph.D., Sibel Karchner, Ph.D., Neelakanteswar Aluru, Ph.D., and colleagues continued their research into understanding how fish in the New Bedford Harbor developed the ability to survive historically high levels of toxic polychlorinated biphenyls (PCBs) and related chemicals. By sequencing the entire genome of the sentinel killifish genome, the research team, together with colleagues around the country, were able to shed light on the changes in the genetic makeup of this model species. This genome sequence contributed to studies on factors responsible for responses to low oxygen levels and ryanodine receptors, both of which were shown to be altered in PCB-resistant killifish. The team published a review paper exploring the mechanisms and significance of rapid adaptation in fish populations exposed to Superfund chemicals and continued efforts, using cutting edge genome-editing technology, attempt to recapitulate the genomic changes driven by high level PCB exposures. These studies pinpointed changes in a gene (AIP) critical to PCB responses in the fish. An important milestone was reached when fish with mutations in AIP and two other genes linked to AIP were genetically engineered. Overall, this research has helped them to understand how natural populations of animals are affected by long-term exposure to toxic chemicals in the environment. Furthermore, the research applies innovative molecular approaches in an ecological context to understand generational, early-life exposure to Superfund chemicals. In other words, environmental chemicals can change the gene pool of exposed populations.

Back
to Top