Superfund Research Program
Early Life Exposure to Tetrachloroethylene (PCE)-Contaminated Drinking Water and Social Stressors may Interact to Increase the Risk of Substance Use Later in Life
This retrospective cohort study is testing the hypothesis that perchloroethylene found in public drinking water supplies in Cape Cod, Massachusetts is associated with reproductive and developmental disorders. The study population is comprised of families who were exposed to contaminated drinking water during 1969-1983 and a comparable group of unexposed families. As described below, progress has occurred in the areas of questionnaire development, subject identification and tracing, data collection, and dose model development.
- Finalized self-administered questionnaire
- Obtained paper copies and computerized data from 13,400 birth certificates
- Identified 1,275 exposed children and randomly selected 1,239 unexposed children born in 1969-1980 for the study population
- Traced 89% of selected mothers
- Sent questionnaires to 507 mothers. To date, received responses from 67%
- Developed and fine-tuned dose model that incorporates the physical properties of perchloroethylene as well as behavioral information on bathing and water consumption.