Title: Steatohepatitis progresses to cancer via immunosuppression of HCC directed CD8+ T cells

Accession Number: GSE90497

Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE90497

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Array expression profiling by high throughput sequencing

Organism(s): Mus musculus

Summary: We show that chronic inflammation and fibrosis in mice with non-alcoholic fatty liver disease (NASH) is accompanied by accumulation of immunoglobulin A (IgA) positive plasmocytes. These cells suppress activation of cytotoxic T cells (CTL) derived from liver infiltrating CD8+ cells. CD8+ T cell ablation greatly accelerates HCC appearance, genetic or pharmacological targeting of IgA and PD-L1 expressing plasmocytes attenuates hepatic carcinogenesis and induces CTL-dependent regression of established HCC.

Publication(s) associated with this dataset:

• Shalapour S, Lin X, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner CW, Anstee QM, Karin M. 2017. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature 551(7680):340-345. doi:10.1038/nature24302 PMID:29144460 PMCID:PMC5884449

Project(s) associated with this dataset:

• University of California-San Diego: Nuclear Receptor Mediated Epigenetic and Immune Cell Changes in Liver Fibrosis Resulting From Toxicant Exposure
• University of California-San Diego: The Role of Reactive Oxygen Species and the Microbiome in Toxicant Induced Liver Fibrosis
• University of California-San Diego: Genetics and Metabolomics Core
• University of California-San Diego: Control of Toxin and Obesity Induced Liver Fibrosis by B Cells
• University of California-San Diego: Effects of Superfund Toxicants on Liver Cancer Progenitor Cells