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Your Environment. Your Health.

Michigan State University: Dataset Details, ID=GSE119780

Superfund Research Program

Environmental, Microbial, and Mammalian Biomolecular Responses to AhR Ligands

Center Director: Norbert E. Kaminski
Grant Number: P42ES004911
Funding Period: 1989-2021
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Title: RNA-Seq Analysis of TCDD-Elicited Changes in Circadian Hepatic Gene Expression in Male Mice

Accession Number: GSE119780

Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE119780

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Expression profiling by high throughput sequencing

Organism(s): Mus musculus

Summary: Hepatic gene expression was examined every 3 hours for 24 hours following repeated exposure (every 4 days for 28 days) to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). These data were used to examine the effect of repeated TCDD exposure on the circadian rhythmicity of hepatic gene expression in C57BL/6 male mice.

Publication(s) associated with this dataset:
  • Fader KA, Nault R, Doskey CM, Fling RR, Zacharewski TR. 2019. 2,3,7,8-Tetrachlorodibenzo-p-dioxin abolishes circadian regulation of hepatic metabolic activity in mice. Sci Rep 9:6514. doi:10.1038/s41598-019-42760-3 PMID:31015483
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