Superfund Research Program

February 2026

Paper of the Month

Scientists at the University of Louisville Superfund Research Program Center discovered potential connections between volatile organic compounds (VOCs), carbon-based chemicals that easily evaporate, and stress responses tied to heart disease. VOCs are emitted from vehicles, industrial processes, household products, and more.

Compared to particulate air pollution, less is known about the health effects of VOCs in air pollution. To explore the effects, researchers measured VOC metabolites in urine, indicators of VOC exposure, and levels of neurotransmitters associated with stress responses, like epinephrine and dopamine.

The results revealed that higher concentrations of VOC metabolites were associated with higher levels of the neurotransmitters associated with chronic stress responses linked to heart disease.

To learn more, see the NIEHS Environmental Factor Newsletter.