Superfund Research Program

Roger W. Giese

Northeastern University
Bouve College of Health Sciences
360 Huntington Avenue, 206 TF
Boston, Massachusetts 02115
Phone: 617-373-3227
Email: r.giese@northeastern.edu

Projects

• Northeastern University: Discovery of Xenobiotics Associated with Preterm Birth (2010-2020)

Research Briefs

• 264 - The Porous Extraction Paddle: A Non-Targeted Sampling Device to Detect Contaminants in Urine

Patents

• Active Tea Bag with Magnetic Stirrer
• Cationic Tags for Attomole Level Detection of Analytes by Mass Spectrometry
• On-Surface Mass Tagging
• Porous Extraction Paddle
• Satellite MALDI for Nucleic Acid Modifications
• Sorptive Tab Device for Breath Collection and Analysis
• Tower Flow Device for Liquid Extraction

Hazardous Waste Sites

Corozal Well

• Northeastern University: Discovery of Xenobiotics Associated with Preterm Birth

Naval Security Group

• Northeastern University: Discovery of Xenobiotics Associated with Preterm Birth

Pesticide Warehouse I

• Northeastern University: Discovery of Xenobiotics Associated with Preterm Birth

Pesticide Warehouse III

• Northeastern University: Discovery of Xenobiotics Associated with Preterm Birth

RCA del Caribe

• Northeastern University: Discovery of Xenobiotics Associated with Preterm Birth

Scorpio Recycling

• Northeastern University: Discovery of Xenobiotics Associated with Preterm Birth

Upjohn

• Northeastern University: Discovery of Xenobiotics Associated with Preterm Birth

V&M Albaladejo

• Northeastern University: Discovery of Xenobiotics Associated with Preterm Birth

Vega Alta Public Supply Wells

• Northeastern University: Discovery of Xenobiotics Associated with Preterm Birth

Vega Baja SWD

• Northeastern University: Discovery of Xenobiotics Associated with Preterm Birth

Publications

• Cordero JF, Meeker JD, Loch-Caruso R, Giese RW, Padilla IY, Vesper D, Kaeli D, Sheahan TC, Brown P, Velez Vega CM, Alshawabkeh AN. Team science applied to environmental health research: karst hydrogeology and preterm birth in Puerto Rico. In: Karst Groundwater Contamination and Public Health. Advances in Karst Science. Springer International Publishing,
• Cordero JF, Meeker JD, Sheahan TC, Padilla IY, Giese RW, Silevitch M, Loch-Caruso R, Kaeli D, Alshawabkeh AN. Case study: Puerto Rico test site for exploring contamination threats. In: GeoCongress 2012: State of the Art and Practice in Geotechnical Engineering. American Society of Civil Engineers, Reston, VA.

2022

• Mungalachetty P, Kulkarni P, Wang P, Giese RW. 2022. A high specificity aniline-based mass tag for aldehyde detection. Rapid Commun Mass Spectrom 36(15):e9322. doi:10.1002/rcm.9322 PMID:35506207

2021

• Wang P, Roider E, Coulter ME, Walsh CA, Kramer C, Beuning PJ, Giese RW. 2021. DNA adductomics by mass tag prelabeling. Rapid Commun Mass Spectrom 35:e9095. doi:10.1002/rcm.9095 PMID:33821547

2020

• Lin Y, Sevillano M, Jiang T, Li G, Cotto I, Vosloo S, Carpenter CM, Larese-Casanova P, Giese RW, Helbling DE, Padilla IY, Rosario-Pabon Z, Velez-Vega C, Cordero JF, Alshawabkeh AN, Pinto A, Gu AZ. 2020. Impact of Hurricane Maria on drinking water quality in Puerto Rico. Environ Sci Technol 54(15):9495-9509. doi:10.1021/acs.est.0c01655 PMID:32640159

2019

• Muenter MM, Aiken A, Akanji JO, Baig S, Bellou S, Carlson A, Conway C, Cowell CM, DeLateur NA, Hester A, Joshi C, Kramer C, Leifer BS, Nash E, Qi MH, Travers M, Wong KC, Hu M, Gou N, Giese RW, Gu AZ, Beuning PJ. 2019. The response of Escherichia coli to the alkylating agents chloroacetaldehyde and styrene oxide. Mutat Res 840:1-10. doi:10.1016/j.mrgentox.2019.02.001 PMID:30857727 PMCID:PMC6525637

2018

• Wang P, Giese RW. 2018. Interpretation of mass spectral data for the cisplatin 1,2 intrastrand guanine-guanine adduct. Chem Res Toxicol 31:1106-1107. doi:10.1021/acs.chemrestox.8b00134 PMID:30280575

2017

• Cordero JF, Meeker JD, Loch-Caruso R, Giese RW, Padilla IY, Vesper D, Kaeli D, Sheahan TC, Brown P, Velez Vega CM, Alshawabkeh AN. 2017. Team science applied to environmental health research: karst hydrogeology and preterm birth in Puerto Rico. In: Karst Groundwater Contamination and Public Health: Beyond Case Studies. Springer, New York, NY. pp.17-25.
• Pleil JD, Giese RW. 2017. Integrating exhaled breath diagnostics by disease-sniffing dogs with instrumental laboratory analysis. J Breath Res 11(3):032001. doi:10.1088/1752-7163/aa79bc PMID:28879861 PMCID:PMC5751435
• Shao G, Agar J, Giese RW. 2017. Cold-induced aqueous acetonitrile phase separation: A salt-free way to begin quick, easy, cheap, effective, rugged, safe. J Chromatogr A 1506:128-133. doi:10.1016/j.chroma.2017.05.045 PMID:28558907 PMCID:PMC5534357
• Wang P, Giese RW. 2017. Recommendations for quantitative analysis of small molecules by matrix-assisted laser desorption ionization mass spectrometry. J Chromatogr A 1486:35-41. doi:10.1016/j.chroma.2017.01.040 PMID:28118972 PMCID:PMC5323262

2016

• Li X, Yu L, Kaeli D, Yao Y, Wang P, Giese RW, Yusa V, Alshawabkeh AN. 2016. A framework for big metabolomic data management and analysis. IJAS 9(1-2):50-61.
• Shao G, MacNeil M, Yao Y, Giese RW. 2016. Porous extraction paddle: a solid phase extraction technique for studying the urine metabolome. Rapid Commun Mass Spectrom 30(23):2462-2470. doi:10.1002/rcm.7739 PMID:27624170
• Yao Y, Wang P, Shao G, Anzalota del Toro LV, Codero J, Giese RW. 2016. Nontargeted analysis of the urine nonpolar sulfateome: a pathway to the nonpolar xenobiotic exposome. Rapid Commun Mass Spectrom 30(21):2341-2350. doi:10.1002/rcm.7726 PMID:27557133 PMCID:PMC5070653

2015

• Wang P, Zhang Q, Yao Y, Giese RW. 2015. Cationic xylene tag for increasing sensitivity in mass spectrometry. J Am Soc Mass Spectrom 26(10):1713-1721. doi:10.1007/s13361-015-1200-4 PMID:26115969 PMCID:PMC4567951

2014

• Peluso M, Munnia A, Bollati V, Srivatanakul P, Jedpiyawongse A, Sangrajrang S, Ceppi M, Giese RW, Boffetta P, Baccarelli A. 2014. Aberrant methylation of hypermethylated-in-cancer-1 and exocyclic DNA adducts in tobacco smokers. Toxicol Sci 137(1):47-54. doi:10.1093/toxsci/kft241 PMID:24154486 PMCID:PMC3871933
• Peluso M, Munnia A, Tarocchi M, Arciello M, Balsano C, Giese RW, Galli A. 2014. Exocycilic DNA adducts in a murine model of non-alcoholic steatohepatitis. J Carcinog Mutagen S3:003. doi:10.4172/2157-2518.S3-003
• Yao Y, Wang P, Giese RW. 2014. Evaporative derivatization of phenols with 2-sulfobenzoic anhydride for detection by matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun Mass Spectrom 28(6):653-661. doi:10.1002/rcm.6816 PMID:24519828 PMCID:PMC4041620

2013

• Kautz R, Wang P, Giese RW. 2013. Nuclear magnetic resonance at the picomole level of a DNA adduct. Chem Res Toxicol 26(10):1424-1429. doi:10.1021/tx400051j PMID:24028148 PMCID:PMC3925674
• Peluso M, Munnia A, Ceppi M, Giese RW, Catelan D, Rusconi F, Godschalk RW, Biggeri A. 2013. Malondialdehyde-deoxyguanosine and bulky DNA adducts in schoolchildren resident in the proximity of the Sarroch industrial estate on Sardinia Island, Italy. Mutagenesis 28(3):315-321. doi:10.1093/mutage/get005 PMID:23446175 PMCID:PMC3630521
• Tetz LM, Cheng AA, Korte C, Giese RW, Wang P, Harris C, Meeker JD, Loch-Caruso R. 2013. Mono-2-ethylhexyl phthalate induces oxidative stress responses in human placental cells in vitro. Toxicol Appl Pharmacol 268(1):47-54. doi:10.1016/j.taap.2013.01.020 PMID:23360888 PMCID:PMC3657603

2012

• Cordero JF, Meeker JD, Sheahan TC, Padilla IY, Giese RW, Silevitch M, Loch-Caruso R, Kaeli D, Alshawabkeh AN. 2012. Case Study - Puerto Rico Test Site for Exploring Contamination Threats. In: GeoCongress 2012: State of the Art and Practice in Geotechnical Engineering. American Society of Civil Engineers, Reston, VA.
• Peluso M, Munnia A, Piro S, Jedpiyawongse A, Sangrajrang S, Giese RW, Ceppi M, Boffetta P, Srivatanakul P. 2012. Fruit and vegetable and fried food consumption and 3-(2-deoxy-beta-D-erythro-pentafuranosyl)pyrimido 1,2-alpha purin-10(3H)-one deoxyguanosine adduct formation. Free Radic Res 46(1):85-92. doi:10.3109/10715762.2011.640676 PMID:22081860 PMCID:PMC3293701
• Tetz LM, Loch-Caruso R, Giese RW, Wang P. 2012. Mono-2-ethylhexyl phthalate induced oxidative stress in human placental cells. The Toxicologist - Supplement to Toxicol. Sci., Abstract #2383, 2012.
• Wang P, Fisher D, Rao A, Giese RW. 2012. Nontargeted nucleotide analysis based on benzoylhistamine labeling-MALDI-TOF/TOF-MS: Discovery of putative 6-oxo-thymine in DNA. Anal Chem 84(8):3811-3819. doi:10.1021/ac300532z PMID:22409256 PMCID:PMC3341171
• Wang P, Gao J, Li G, Shimelis O, Giese RW. 2012. Nontargeted analysis of DNA adducts by mass-tag MS: Reaction of p-Benzoquinone with DNA. Chem Res Toxicol 25:2737-2743. doi:10.1021/tx300363a PMID:23113579 PMCID:PMC3527073

2011

• Peluso M, Munnia A, Risso GG, Catarzi S, Piro S, Ceppi M, Giese RW, Brancato B. 2011. Breast fine-needle aspiration malondialdehyde deoxyguanosine adduct in breast cancer. Free Radic Res 45(4):477-482. doi:10.3109/10715762.2010.549485 PMID:21250785 PMCID:PMC3315697

2010

• Bono R, Romanazzi V, Munnia A, Piro S, Allione A, Ricceri F, Guarrera S, Pignata C, Matullo G, Wang P, Giese RW, Peluso M. 2010. Malondialdehyde-deoxyguanosine adduct formation in workers of pathology wards: the role of air formaldehyde exposure. Chem Res Toxicol 23(8):1342-1348. doi:10.1021/tx100083x PMID:20707408 PMCID:PMC2924748
• Silevitch M, Giese RW, Kaeli D, Sheahan TC, Nobrega MC, Alshawabkeh AN, Cordero JF, Padilla IY, Loch-Caruso R, Meeker JD. 2010. Interdisciplinary Three-Level Approach to Study Impact of Contamination on Public Health in Puerto Rico. In: Proceedings of Sixth International Congress on Environmental Geotechnics. New Delhi, India.

1999

• Wu K, Scheller NA, Ranasinghe A, Yen T, Sangaiah R, Giese RW, Swenberg JA. 1999. A gas chromatography/electron capture/negative chemical ionization-high resolution mass spectrometry method for analysis of endogenous and exogenous N7-(2-hydroxyethyl)guanine in rodents and its potential for human biological monitoring. Chem Res Toxicol 12(8):722-729. PMID:10458706