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Your Environment. Your Health.

Person Details: Kathleen T. Shiverick

Superfund Research Program

Kathleen T. Shiverick

University of Florida
P.O. Box 100267
Gainesville, Florida 32610
Phone: 352-392-3545
Fax: 352-392-9696
Email: Kshiveri@pharmacology.ufl.edu

Projects

Research Briefs

Publications

2007

  • Rice L, Handayani R, Cui Y, Medrano TA, Samedi VG, Baker HV, Szabo N, Rosser CJ, Goodison S, Shiverick KT. 2007. Soy isoflavones exert differential effects on androgen responsive genes in LNCaP human prostate cancer cells. J Nutr 137(4):964-972. PMID:17374662 PMCID:PMC1975677

2005

  • Drukteinis JS, Medrano TA, Ablordeppy EA, Kitzman JM, Shiverick KT. 2005. Benzo[a]pyrene, but not 2,3,7,8-TCDD, induces G2/M cell cycle arrest, p21CIP1 and p53 phosphorylation in human choriocarcinoma JEG-3 cells: a distinct signaling pathway. Placenta 26(Supp.A):S87-95. doi:10.1016/j.placenta.2005.01.013 PMID:15837074

2004

  • Handayani R, Rice L, Benedict R, Iragavarapu V, Medrano TA, Shiverick KT. 2004. Antiproliferative Effects of Soy Isoflavone Concentrate and Vitamin E Succinate are Additive and Involve Induction of p21CIP1 in Human Prostate Cancer Cells. In: Proceedings of the Ninety Fifth Annual Meeting of the (AACR) American Association for Cancer Research, March 27-31, 2004, Orlando. Orlando, FL.
  • Kitzman JM, Medrano TA, Shiverick KT. 2004. Benzo(a)pyrene induces ATM-dependent p53 phosphorylation and cell cycle arrest in human placental and endometrial cell lines. In: Proceedings of the 43rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.

2003

  • Gude N, Shiverick KT, Myatt L. 2003. Clinical complications of pregnancy. Placenta 24Suppl.A:
  • Medrano TA, Chegini N, Shiverick KT. 2003. Th1 cytokine expression is up-regulated by aryl hydrocarbon receptor agonists in human endometral RL95-2 cells. International Federation of Placenta Associations Meeting, Mainz, Germany, September 2003. Placenta 24:A17.
  • Shiverick KT, Handayani R, Rice L, Medrano TA. 2003. Antiprolifetative effects of vitamin E involve induction of p21cip1 and CCCAAT/enhancer-binding protein beta in PC-3 human prostate cancer cells. In: Proceedings of the American Association for Cancer Research Annual Meeting, 2003.
  • Shiverick KT, Medrano TA. 2003. Maternal-fetal programming in utero: adult metabolic disease and diabetes. Toxicol Sci 72(1):273Suppl.S.
  • Shiverick KT, Slikker W, Rogerson SJ, Miller RK. 2003. Drugs and the placenta--a workshop report. Placenta 24SupplA:S55-S59. PMID:12842414

2002

  • Ablordeppy EA, Medrano TA, Shiverick KT. 2002. Effects of polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin on proliferation and cell regulation in human placental trophoblastic JEG-3 cells. Toxicol Sci Suppl66(1-S):349.
  • McGarry MA, Charles GD, Medrano TA, Bubb M, Grant MB, Campbell-Thompson M, Shiverick KT. 2002. Benzo(a)pyrene, but not 2,3,7,8-tetrachlorodiobenzo-p-dioxin, alters attachment and adhesion proteins in human uterine RL95-2 cells. Biochem Biophys Res Commun 294(1):101-107.
  • Medrano TA, Chegini N, Shiverick KT. 2002. Benzo(a)pyrene induces a shift to a Th1 cytokine expression profile in human endometrial RL95-2 cells. Placenta 23:A32.
  • Medrano TA, Schwanke JL, Ablordeppy EA, Shiverick KT. 2002. Identification of differential effects of benzo(a)pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin on gene expression in human placental JEG-3 cells using cell cycle and DNA microarray analysis. Toxicol Sci Suppl66(1-S):298.
  • Rice L, Samedi VG, Medrano TA, Sweeney CA, Baker HV, Stenstrom A, Furman J, Shiverick KT. 2002. Mechanisms of the growth inhibitory effects of the isoflavonoid biochanin A on LNCaP cells and xenografts. Prostate 52(3):201-212. PMID:12111696
  • Samedi VG, Rice L, Handayani R, Sweeney CA, Medrano TA, Shiverick KT. 2002. Differential Effects of the Tyrosine Kinase Inhibitors Genistein and Tyrophostin A25 on Proliferation and Cell Cycle Regulation in PC-3 Prostate Cancer Cells. In: Proceedings of the 93rd Annual Meeting of the American Association for Cancer Research, April 6-10, 2002. San Francisco, CA. pp.193.
  • Shiverick KT. 2002. Differential effects of AhR ligands on cell cycle regulation in human utero-placental cells. J Mol Biol 43(Suppl1):13.
  • Shiverick KT, Cetin I, Marconi AM, Sibley CP. 2002. The placenta and fetal growth. Placenta 23Suppl.A:
  • Shiverick KT, Medrano TA. 2002. Maternal-Fetal Programming of adult metabolic diseases and diabetes. In: Proceedings of the 41st Annual Meeting of the Society of Toxicology (SOT), March 17-21, 2002. Nashville, TN.
  • St. Pierre MV, Ugele B, Gambling L, Shiverick KT. 2002. Mechanisms of drug transfer across the human placenta. Placenta 23SupplA:S159-164. PMID:9762726

2001

  • Medrano TA, Schwanke JL, Shiverick KT. 2001. Identification of differential effects of benzo(a)pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin on gene expression in human trophoblast JEG-3 cells using DNA microarray analysis. In: Proceedings of the American Institute for Cancer Research 11th Annual Research Conference on Diet, Nutrition and Cancer. Washington, DC.
  • Medrano TA, Shiverick KT. 2001. Effects of Organochlorine compounds on proliferation, apoptosis and cell cycle in JEG-3 human choriocarcinoma cells. In: Proceedings of the 9th Conference of The European Placenta Group. Sorrento, Italy.
  • Shiverick KT, King A, Frank HG, Whitley GS, Cartwright JE, Schneider H. 2001. Cell culture models of human trophoblast II: trophoblast cell lines--a workshop report. Placenta 22SupplA:S104-S106. doi:10.1053/plac.2001.0647 PMID:11312640

2000

  • McGarry MA, Bubb M, Campbell-Thompson M, Medrano TA, Shiverick KT. 2000. Differential effects of benzo(a)pyrene and 2,3,7,8-tetrachlorodibenzo(a)pyrene on cell adherens junction and actin cytoskeletal proteins in human uterine RL95-2 cells. Toxicol Sci 54:348.
  • Medrano TA, Schwanke JL, Zhang L, Shiverick KT. 2000. The anti-proliferative effect of benzo(a)pyrene in JEG-3 choriocarcinoma cells does not involve apoptosis. Placenta 21:A32.
  • Samedi VG, Rice L, Medrano TA, Shiverick KT. 2000. Identification of genes differentially regulated by genistein in human prostate cancer LNCaP cells using cDNA microarray screening. In: Proceedings of the 91st Annual Meeting of American Association for Cancer Research Annual Meeting, 2000. San Diego, CA. pp.310.
  • Shiverick KT, Medrano TA, McGarry MA, Campbell-Thompson M, Schwanke JL, Gant M, Bubb M. 2000. Uterine and placental effects of organochlorine compounds. In: Proceedings of the University of Florida Superfund Symposium on Endocrine Active Agents in the Environment. Gainesville, FL.

1999

  • Campbell-Thompson M, Lauwers GY, Reyher KK, Cromwell J, Shiverick KT. 1999. 17B-Estradiol modulates gastroduodenal preneoplastic alterations in rat exposed to the carcinogen N-methyl-N'-nitroso-guanidine. Endocrinology 140(10):4886-4894.
  • Charles GD, Grant MB, Medrano TA, Saunders P, Edery M, Kelly PA, Shiverick KT. 1999. Endothelial cell chemotoxic activity expressed in rat placenta is not associated with prolactin-like proteins B and C. Life Sciences 65(8):798-804. PMID:10466745
  • McGarry MA, Charles GD, Medrano TA, Campbell-Thompson M, Shiverick KT. 1999. 2,3,7,8-Tetra-chlorodibenzo-p-dioxin and benzo(a)pyrene differentially regulate cell attachment and expression of epi-dermal growth factor expression, e-cadherin and prostaglandin H synthase in human uterine endometrial cells. Environ Health Perspect 48:13.
  • Medrano TA, Conliffe PR, Novack DA, Millard WJ, Shiverick KT. 1999. Differential effects of protein malnutrition on the epxression of placental prolactin-like proteins. Chapter Vol. 13 in: Trophoblast Research. University of Rochester Press, New York, NY. pp.427-442.
  • Salafia C, Shiverick KT. 1999. Cigarette smoking and pregnancy II: vascular effects. Placenta 20(4):273-279. PMID:10329347
  • Samedi VG, Medrano TA, Devereaux S, Rice L, Narayan P, Shiverick KT. 1999. Human prostate cancer LNCaP cells derived from low and high passage numbers display divergent expression of CYP1A1 in response to benzo(a)pyrene. Environ Health Perspect 48:14.
  • Samedi VG, Medrano TA, Rice L, Narayan P, Shiverick KT. 1999. Differential effects of genistein biochanin A and coumestrol on cell cycle, proliferation and apoptosis in human prostate cancer LNCaP cells. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999.
  • Shiverick KT, Charles GD, McGarry MA. 1999. Benzo(a)pyrene mediated inhibition of utero-placental cell invasion and expression of cell adhesion molecules. Environ Health Perspect 48:365.
  • Shiverick KT, Medrano TA, Rice L, Narayan P. 1999. Inhibitory effects of dietary isoflavones on cell proliferation and c-myc expression in LNCaP human prostate cancer cells. In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.288.
  • Shiverick KT, Salafia C. 1999. Cigarette smoking and pregnancy I: ovarian, uterine and placental effects. Placenta 20(4):265-272. doi:10.1053/plac.1998.0377 PMID:10329346
  • Shiverick KT, Shah S, Medrano TA, Rosario-Ortiz A. 1999. Cytokine expression in human uterine endometrial RL95-2 cells is altered by polychlorinated biphenyls, 2,3,7,8-tetrachlorodibenzo-p-dioxin and benzo(a)pyrene. Placenta 20:A61.

1998

  • Campbell-Thompson M, Reyher KK, Lauwers GY, Shiverick KT. 1998. Estrogens modulate gastro-duodenal hyerplasia and dysplasia induced by N-methyl-N'-nitrosoguanidine in rats. Gastroenterology 114(4):G2347.
  • Charles GD, Grant MB, Shiverick KT. 1998. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and benzo(a)pyrene on growth and cellular invasiveness in a human endometrial cell line. Environ Health Perspect 42:30.
  • Medrano TA, Zhang L, Shiverick KT. 1998. Differential effects of benzo(a)pyrene and polychlorinated biphenyls on proliferation, EGF receptor and cytochrome P-450 1A1 in human placental choriocarcinoma cells. Environ Health Perspect 42:133.
  • Shiverick KT. 1998. Dysregulation of trophoblast and endometrial gene expression by environmental endocrine disrupting chemicals. Placenta 19:A-7.
  • Shiverick KT, Medrano TA, Rice L, Narayan P. 1998. Benzo(a)pyrene, but not 2,3,7,8-tetrachlorodibenzo-p-dioxin, significantly alters human prostate cancer cell proliferation and growth factor suppression. Environ Health Perspect 42:67.
  • Zhang L, Shiverick KT. 1998. Differential effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and benzo(a)pyrene on proliferation and growth factor gene expression in human choriocarcinoma BeWo cells. Trophoblast Research 19:177-191.

1997

  • Charles GD, Shiverick KT. 1997. 2,3,7,8-Tetrachlorodibenzo-p-dioxin increases mRNA levels for interleukin-1B, urokinase plasminogen activator and tumor necrosis factor-a in human uterine endometrial adenocarcinoma RL95-2 cells. Biochem Biophys Res Commun 238:338-342. doi:10.1006/bbrc.1997.7291 PMID:9299508
  • Zhang L, Shiverick KT. 1997. Benzo(a)pyrene, but not 2,3,7,8-Tetrachlorodibenzo-p-dioxin, alters, cell proliferation, c-myc and growth factor expression in human placental choriocarcinoma JEG-3 cells. Biochem Biophys Res Commun 231:117-120. PMID:9070231

1996

  • Charles GD, Shiverick KT. 1996. Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on EGF Receptor Binding and CYP1A1 Expression in a Human Endometrial Cell Line. Environ Health Perspect 15:66.
  • Masten S, Shiverick KT. 1996. Characterization of the aryl hydrocarbon receptor complex in human B lymphocytes: evidence for a distinct nuclear DNA-binding form. Arch Biochem Biophys 336(2):297-308. PMID:8954578
  • Zhang L, Shiverick KT. 1996. Differential effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo(a)pyrene (BAP) on gene expression in human placental trophoblast cells. Fundam Appl Toxicol 30:323.

1995

  • Zhang L, Connor EE, Chegini N, Shiverick KT. 1995. Modulation by benzo(a)pyrene of epidermal growth factor receptors, cell proliferation, and secretion of human chorionic gonadotrophin in human placental cell lines. Biochem Pharmacol 50:1171-1180. PMID:7488231
  • Zhang L, Shiverick KT. 1995. Regulation of gene expression and cell proliferation in human placental choriocarcinoma cells by 2,3,7,8-tetachlorodibenzo-p-dioxin. Environ Health Perspect 15:67.
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