Superfund Research Program

Robert H. Rice

University of California-Davis
Department of Environmental Toxicology
4243 Meyer Hall
One Shields Avenue
Davis, California 95616
Phone: 530-752-5176
Fax: 530-752-3394
Email: rhrice@ucdavis.edu

Projects

• University of California-Davis: Integrated Response to Toxic Perturbation (2000-2010)
• University of California-Davis: Training Core (1995-2023)

Publications

2021

• Lin L, Denison MS, Rice RH. 2021. Woodsmoke extracts cross-link proteins and induce cornified envelope formation without stimulating keratinocyte terminal differentiation. Toxicol Sci 183(1):PMID:34086961

2020

• Chan LK, Nguyen KQ, Karim N, Yang Y, Rice RH, He G, Denison MS, Nguyen TB. 2020. Relationship between the molecular composition, visible light absorption, and health-related properties of smoldering woodsmoke aerosols. Atmos Chem Phys 20:539-559. doi:10.5194/acp-20-539-2020

2018

• Hill T, Rice RH. 2018. DUOX expression in human keratinocytes and bronchial epithelial cells: Influence of vanadate. Toxicol In Vitro 46:257-264. doi:10.1016/j.tiv.2017.10.010 PMID:29031483 PMCID:PMC5683910

2016

• Parker GJ, Leppert T, Anex DS, Hilmer JK, Matsunami N, Baird L, Stevens J, Parsawar K, Durbin-Johnson BP, Rocke DM, Nelson C, Fairbanks DJ, Wilson A, Rice RH, Woodward SR, Bothner B, Hart B, Leppert M. 2016. Demonstration of protein-based human identification using the hair shaft proteome. PLoS One 11(9):e0160653. doi:10.1371/journal.pone.0160653 PMID:27603779 PMCID:PMC5014411
• Phillips MA, Canovas A, Wu P, Islas-Trejo A, Medrano JF, Rice RH. 2016. Parallel responses of human epidermal keratinocytes to inorganic Sb-III and As-III. Environ Chem 13:963-970. doi:10.1071/en16019
• Rice RH, Durbin-Johnson BP, Ishitsuka Y, Salemi MR, Phinney BS, Rocke DM, Roop DR. 2016. Proteomic analysis of loricrin knockout mouse epidermis. J Proteome Res 15(8):2560-2566. doi:10.1021/acs.jproteome.6b00108 PMID:27418529

2015

• Cao Y, Hickerson RP, Seegmiller BL, Grapov D, Gross MM, Bessette MR, Phinney BS, Flores MA, Speaker TJ, Vermeulen A, Bravo AA, Bruckner AL, Milstone LM, Schwartz ME, Rice RH, Kaspar RL. 2015. Gene expression profiling in pachyonychia congenita skin. J Dermatol Sci 77(3):156-165. doi:10.1016/j.jdermsci.2015.01.001 PMID:25656049 PMCID:PMC4374015
• Kumar V, Bouameur J, Bar J, Rice RH, Hornig-Do H, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Vijayaraj P, Brazel CB, Heller S, Binder H, Loffler-Wirth H, Seibel P, Magin TM. 2015. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity. J Cell Biol 211(5):1057-1075. doi:10.1083/jcb.201404147 PMID:26644517 PMCID:PMC4674273

2014

• Gardell AM, Qin Q, Rice RH, Li J, Kültz D. 2014. Derivation and osmotolerance characterization of three immortalized tilapia (Oreochromis mossambicus) cell lines. PLoS One 9(5):e95919. doi:10.1371/journal.pone.0095919 PMID:24797371 PMCID:PMC4010420
• Laatsch CN, Durbin-Johnson BP, Rocke DM, Mukwana S, Newland AB, Flagler MJ, Davis MG, Eigenheer RA, Phinney BS, Rice RH. 2014. Human hair shaft proteomic profiling: individual differences, site specificity and cuticle analysis. PeerJ 2:e506. doi:10.7717/peerj.506 PMID:25165623 PMCID:PMC4137660
• Schebb N, Muvvala JB, Morin D, Buckpitt AR, Hammock BD, Rice RH. 2014. Metabolic activation of the antibacterial agent triclocarban by cytochrome P450 1A1 yielding glutathione adducts. Drug Metab Dispos 42(7):1098-1102. doi:10.1124/dmd.114.058206 PMID:24733789 PMCID:PMC4170114
• Sundberg JP, Awgulewitsch A, Pruett ND, Potter CS, Silva KA, Stearns TM, Sundberg BA, Munoz MW, Cuasnicu PS, King LE, Rice RH. 2014. Crisp1 and alopecia areata in C3H/HeJ mice. Exp Mol Pathol 97(3):525-528. doi:10.1016/j.yexmp.2014.10.010 PMID:25446841 PMCID:PMC4262666

2013

• He G, Zhao J, Brennan JC, Affatato AA, Zhao B, Rice RH, Denison MS. 2013. Cell-based assays for identification of aryl hydrocarbon (Ah) receptor activators. In: Optimization of Drug Discovery: In Vitro Methods (2E). Humana Press, New York, NY. pp.221-235.
• He G, Zhao J, Brennan JC, Affatato AA, Zhao B, Rice RH, Denison MS. 2013. Cell-based assays for identification of aryl hydrocarbon (AhR) receptor activators. Chapter 13 in: Optimization of Drug Discovery: In Vitro Methods (2E). Humana Press, New York, NY. pp.221-235.
• Hu Q, Rice RH, Qin Q, Phinney BS, Eigenheer RA, Bao W, Zhao B. 2013. Proteomic analysis of human keratinocyte response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure. J Proteome Res 12(11):5340-5347. doi:10.1021/pr4006266 PMID:23991859 PMCID:PMC4026210
• Phillips MA, Qin Q, Hu Q, Zhao B, Rice RH. 2013. Arsenite suppression of BMP signaling in human keratinocytes. Toxicol Appl Pharmacol 269(3):290-296. doi:10.1016/j.taap.2013.02.017 PMID:23566955 PMCID:PMC3759367
• Rice RH, Bradshaw KM, Durbin-Johnson BP, Rocke DM, Eigenheer RA, Phinney BS, Schmuth M, Gruber R. 2013. Distinguishing ichthyoses by protein profiling. PLoS One 8(10):e75355. doi:10.1371/journal.pone.0075355 PMID:24130705 PMCID:PMC3793978
• Rice RH, Winters BR, Durbin-Johnson BP, Rocke DM. 2013. Chicken corneocyte cross-linked proteome. J Proteome Res 12(2):771-776. doi:10.1021/pr301036k PMID:23256538 PMCID:PMC3569041
• Zhao B, Bohonowych JE, Timme-Laragy AR, Jung D, Affatato AA, Rice RH, Di Giulio RT, Denison MS. 2013. Common commercial and consumer products contain activators of the aryl hydrocarbon (dioxin) receptor. PLoS One 8(2):e56860. doi:10.1371/journal.pone.0056860 PMID:23441220 PMCID:PMC3575475

2012

• Aufenvenne K, Rice RH, Hausser I, Oji V, Hennies H, Del Rio M, Traupe H, Larcher F. 2012. Long-term faithful recapitulation of transglutaminase 1-deficient lamellar ichthyosis in a skin-humanized mouse model, and insights from proteomic studies. Journal of Investigative Dermatology 132:1918-1921. doi:10.1038/jid.2012.65 PMID:22437313 PMCID:PMC3375344
• Rice RH, Bradshaw KM, Durbin-Johnson BP, Rocke DM, Eigenheer RA, Phinney BS, Sundberg JP. 2012. Differentiating inbred mouse strains from each other and those with single gene mutations using hair proteomics. PLoS One 7(12):e51956. doi:10.1371/journal.pone.0051956 PMID:23251662 PMCID:PMC3522583
• Schebb N, Buchholz BA, Hammock BD, Rice RH. 2012. Metabolism of the antibacterial triclocarban by human epidermal keratinocytes to yield protein adducts. J Biochem Mol Toxicol 26(6):230-234. doi:10.1002/jbt.21411 PMID:22711420 PMCID:PMC3522462

2011

• Rice RH. 2011. Proteomic analysis of hair shaft and nail plate. Biol Res 62:222-236. PMID:21635850 PMCID:PMC3227502
• Rice RH, Phillips MA, Sundberg JP. 2011. Localization of hair shaft protein VSIG8 in the hair follicle, nail unit, and oral cavity. Journal of Investigative Dermatology 131:1936-1938. doi:10.1038/jid.2011.133 PMID:21614015 PMCID:PMC3156960

2010

• Reznikova TV, Phillips MA, Patterson TP, Rice RH. 2010. Opposing actions of insulin and arsenite converge on PKCS to alter keratinocyte proliferative potential and differentiation. Mol Carcinog 49:398-409.
• Rice RH, Xia Y, Alvarado RJ, Phinney BS. 2010. Proteomic analysis of human nail plate. J Proteome Res 9(12):67526758. doi:10.1021/pr1009349 PMID:20939611 PMCID:PMC3007598
• Sinitsyna NN, Reznikova TV, Qin Q, Song H, Phillips MA, Rice RH. 2010. Arsenite suppression of involucrin transcription through AP1 promoter sites in cultured human keratinocytes. Toxicol Appl Pharmacol 243(3):275-282. doi:10.1016/j.taap.2009.12.006 PMID:20006635 PMCID:PMC2830317

2009

• Berglund SR, Santana A, Rice RH, Rocke DM, Goldberg Z, Li D. 2009. Proteomic analysis of low dose arsenic and ionizing radiation exposure on keratinocytes. Proteomics 9(7):1925-1938. doi:10.1002/pmic.200800118 PMID:19294697 PMCID:PMC2666104
• Nishi K, Inoue H, Schnier JB, Rice RH. 2009. Cyclin D1 downregulation is important for permanent cell cycle exit and initiation of differentiation induced by anchorage-deprivation in human keratinocytes. J Cell Biochem 106(1):63-72. doi:10.1002/jcb.21978 PMID:19021145 PMCID:PMC2987797
• Rice RH, Vidrio E, Kumfer BM, Qin Q, Willits NH, Kennedy IM, Anastasio C. 2009. Generation of oxidant response to copper and iron nanoparticles and salts: Stimulation by ascorbate. Chem Biol Interact 181(3):359-365. doi:10.1016/j.cbi.2009.08.007 PMID:19683516 PMCID:PMC2763550

2008

• Lu R, Lee G, Shultz MA, Dardick C, Jung K, Rice RH, Phetsom J, Jia Y, Goldberg Z, Schnable PS, Ronald P, Rocke DM. 2008. Assessing probe-specific dye and slide biases in two-color microarray data. BMC Bioinformatics 9:314. doi:10.1186/1471-2105-9-314 PMID:18638416 PMCID:PMC2496918

2007

• Ngo MA, Sinitsyna NN, Qin Q, Rice RH. 2007. Oxygen-dependent differentiation of human keratinocytes. Journal of Investigative Dermatology 127(2):354-61. PMID:16977326
• Patterson TP, Rice RH. 2007. Arsenite and insulin exhibit opposing effects on epidermal growth factor receptor and keratinocyte proliferative potential. Toxicol Appl Pharmacol 221(1):119-28. PMID:17400267

2006

• Lee YJ, Rice RH, Lee YM. 2006. Proteome analysis of human hair shaft: from protein identification to posttranslational modification. Mol Cell Proteomics 5(5):789-800. doi:10.1074/mcp.M500278-MCP200 PMID:16446289
• Rea MA, Zhou L, Qin Q, Barrandon Y, Easley KW, Gungner SF, Phillips MA, Holland WS, Gumerlock PH, Rocke DM, Rice RH. 2006. Spontaneous immortalization of human epidermal cells with naturally elevated telomerase. Journal of Investigative Dermatology 126(11):2507-15. PMID:16778798

2005

• Lee C, Lee YM, Rice RH. 2005. Human epidermal cell protein responses to arsenite treatment in culture. Chem Biol Interact 155(1-2):43-54. PMID:15899475
• Patterson TP, Reznikova TV, Phillips MA, Rice RH. 2005. Arsenite maintains germinative state in cultured human epidermal cells. Toxicol Appl Pharmacol 207(1):69-77. PMID:16054901
• Rice RH, Crumrine D, Uchida Y, Gruber R, Elias PM. 2005. Structural changes in epidermal scale and appendages as indicators of defective TGM1 activity. Arch Dermatol Res 297(3):127-133. PMID:16133457

2004

• Phillips MA, Jessen BA, Lu Y, Qin Q, Stevens ME, Rice RH. 2004. A distal region of the human TGM1 promoter is required for expression in transgenic mice and cultured keratinocytes. BMC Dermatol 4:2. doi:10.1186/1471-5945-4-2 PMID:15061870 PMCID:PMC416661

2003

• Monk SA, Denison MS, Rice RH. 2003. Reversible stepwise negative regulation of CYP1A1 in cultured rat epidermal cells. Arch Biochem Biophys 419(12):158-169. PMID:14592459
• Rea MA, Gregg JP, Qin Q, Phillips MA, Rice RH. 2003. Global alteration of gene expression inhuman keratinocytes by inorganic arsenic. Carcinogenesis 24(4):747-756. PMID:12727804

2002

• Krig SR, Chandraratna RA, Chang MM, Wu R, Rice RH. 2002. Gene-specific TCDD suppression of RAR- and RXR-mediated induction of tissue transglutaminase. Toxicol Sci 68(1):102-108. PMID:12075115
• Rea MA, Gregg JP, Rice RH. 2002. Expression profiling of TCDD-treated human epidermal cells in culture. Organohalogen Compounds 55:469-472.

2001

• Jessen BA, Qin Q, Phillips MA, Phillips DL, Rice RH. 2001. Keratinocyte differentiation marker suppression by arsenic: mediation by AP1 response elements and antagonism by tetradecanoylphorbol acetate. Toxicol Appl Pharmacol 174(3):302-311. PMID:11485391
• Mazina OM, Phillips MA, Williams T, Vines CA, Cherr GN, Rice RH. 2001. Redistribution of transcription factor AP-2a in differentiating cultured human epidermal cells. Journal of Investigative Dermatology 117(4):864-870. PMID:11676824
• Monk SA, Denison MS, Rice RH. 2001. Transient expression of CYP1A1 in rat epithelial cells cultured in suspension. Arch Biochem Biophys 393(1):154-162. PMID:11516172
• Rea MA, Rice RH. 2001. Telomerase deregulation in immortalized human epidermal cells: Modulation by cellular microenvironment. Int J Cancer 94(5):669-673. PMID:11745461

2000

• Chun H, Kuzmicky A, Rucoba L, Kado NY, Rice RH. 2000. Cytotoxicity and keratinocyte microsome mediated mutagenic activation of carcinogens in cultured epidermal cells. Toxicol Lett 115(2):165-172. PMID:10802392
• Chun H, Kuzmicky PA, Kado NY, Rice RH. 2000. Toxicity of Trp-P-2 to cultured human and rat keratinocytes. Chem Biol Interact 127(3):237-253. PMID:10967320
• Jessen BA, Phillips MA, Hovnanian A, Rice RH. 2000. Role of Sp1 response element in transcription of the human transglutaminase 1 gene. Journal of Investigative Dermatology 115(1):113-117. PMID:10886517
• Jessen BA, Qin Q, Rice RH. 2000. Functional AP1 and CRE response elements in the human keratinocyte transglutaminase promoter mediating Whn suppression. Gene 254(1-2):77-85. PMID:10974538
• Krig SR, Rice RH. 2000. TCDD suppression of tissue transglutaminase stimulation by retinoids in malignant human keratinocytes. Toxicol Sci 56(2):357-364. PMID:10910994
• Phillips MA, Qin Q, Rice RH. 2000. Identification of an involucrin promoter transcriptional response element with activity restricted to keratinocytes. Biochem J 348(Pt.1):45-53. PMID:10794712

1998

• Rea MA, Phillips MA, Degraffenried LA, Qin Q, Rice RH. 1998. Modulation of human epidermal cell response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by epidermal growth factor. Carcinogenesis 19(3):479-483. PMID:9525283

1997

• Kachinskas DJ, Qin Q, Phillips MA, Rice RH. 1997. Arsenate suppression of human keratinocyte programming. Mutat Res Rev Mutat Res 386(3):253-261. PMID:9219563

1996

• Rice RH, Mehrpouyan M, Qin Q, Phillips MA, Lee YM. 1996. Identification of phosphorylation sites in keratinocyte transglutaminase. Biochemistry 320(Pt.2):547-550. PMID:8973564
• Rice RH, Wong VJ, Price VH, Hohl D, Pinkerton KE. 1996. Cuticle cell defects in lamellar ichthyosis hair and anomalous hair shaft syndromes visualized after detergent extraction. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 246(4):433-440. PMID:8955782
• Walsh AA, Tullis K, Rice RH, Denison MS. 1996. Identification of a novel cis-acting negative regulatory element affecting expression of the CYP1A1 gene in rate epidermal cells. J Biol Chem 271(37):22746-22753.

1995

• Mariniello L, Qin Q, Jessen BA, Rice RH. 1995. Keratinocyte transglutaminase promoter analysis. Identification of a functional response element. J Biol Chem 270(52):31358-31363. PMID:8537408
• Stewart BE, Rice RH. 1995. Differentiation-associated expression of the proto-oncogene pim-1 in cultured human keratinocytes. Journal of Investigative Dermatology 105(5):699-703. PMID:7594647
• Walsh AA, Degraffenried LA, Rice RH. 1995. 2,3,7,8-Tetrachlorodibenzo-p dioxin sensitization of cultured human epidermal cells to toxicity from a carcinogenic heterocyclic amine. Carcinogenesis 16(9):2187-2191. PMID:7554073