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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Person Details: Xinhua Liu

Superfund Research Program

Xinhua Liu

Columbia University
MSPH/BIO
Mailman School of Public Health
722 W 168 St, 6 Flr
New York, New York 10032
Phone: 212-342-1262
Email: xl26@cumc.columbia.edu

Projects

Publications

2023

  • Abuawad A, Bozack AK, Navas-Acien A, Goldsmith J, Liu X, Hall MN, Ilievski V, Lomax-Luu A, Parvez F, Shahriar H, Uddin MN, Islam T, Graziano JH, Gamble MV. 2023. The folic acid and creatine trial: treatment effects of supplementation on arsenic methylation indices and metabolite concentrations in blood in a Bangladeshi population. Environ Health Perspect 131(3):37015. doi:10.1289/EHP11270 PMID:36976258 PMCID:PMC1004504

2022

  • Liu X, Jin Z. 2022. On detecting the effect of exposure mixture. Journal of Applied Statistics 12:doi:10.1080/02664763.2022.2061430
  • Saxena R, Gamble MV, Wasserman GA, Liu X, Parvez F, Navas-Acien A, Islam T, Factor-Litvak P, Uddin MN, Kioumourtzoglou M, Gibson EA, Shahriar H, Slavkovich VN, Ilievski V, Lolacono NJ, Balac O, Graziano JH. 2022. Mixed metals exposure and cognitive function in Bangladeshi adolescents. Ecotoxicol Environ Saf 232:113229. doi:10.1016/j.ecoenv.2022.113229 PMID:35131582

2021

  • Saxena R, Liu X, Navas-Acien A, Parvez F, Lolacono NJ, Islam T, Uddin MN, Ilievski V, Slavkovich VN, Balac O, Graziano JH, Gamble MV. 2021. Nutrition, one-carbon metabolism and arsenic methylation in Bangladeshi adolescents. Environ Res 195:110750. doi:10.1016/j.envres.2021.110750 PMID:33476663 PMCID:PMC7987757

2020

  • Bozack AK, Howe CG, Hall MN, Liu X, Slavkovich VN, Ilievski V, Lomax-Luu A, Parvez F, Siddique A, Shahriar H, Uddin MN, Islam T, Graziano JH, Gamble MV. 2020. Betaine and choline status modify the effects of folic acid and creatine supplementation on arsenic methylation in a randomized controlled trial of Bangladeshi adults. Eur J Nutr doi:10.1007/s00394-020-02377-z PMID:32918135 PMCID:PMC7947037
  • Burchiel SW, Lauer FT, Factor-Litvak P, Liu X, Islam T, Eunus M, Abu Horayara M, Islam M, Rahman M, Ahmed A, Cremers S, Nandakumar R, Ahsan H, Olopade C, Graziano JH, Parvez F. 2020. Arsenic exposure associated T cell proliferation, smoking, and vitamin D in Bangladeshi men and women. PLoS One 15:13. doi:10.1371/journal.pone.0234965 PMID:32574193 PMCID:PMC7310686

2019

  • Burchiel SW, Lauer FT, Factor-Litvak P, Liu X, Santella RM, Islam T, Eunus M, Alam N, Islam T, Rahman M, Ahmed A, Ahsan H, Graziano JH, Parvez F. 2019. An increase in circulating B cells and B cell activation markers in peripheral blood is associated with cigarette smoking in a male cohort in Bangladesh. Toxicol Appl Pharmacol 384:114783. doi:10.1016/j.taap.2019.114783 PMID:31669812 PMCID:PMC6886671
  • Lauer FT, Parvez F, Factor-Litvak P, Liu X, Santella RM, Islam M, Eunus M, Alam N, Hasan R, Rahman M, Ahsan H, Graziano JH, Burchiel SW. 2019. Changes in human peripheral blood mononuclear cell (HPBMC) populations and T-cell subsets associated with arsenic and polycyclic aromatic hydrocarbon exposures in a Bangladesh cohort. PLoS One 14(7):e0220451. doi:10.1371/journal.pone.0220451 PMID:31365547 PMCID:PMC6668812
  • Parvez F, Lauer FT, Factor-Litvak P, Liu X, Santella RM, Islam T, Eunus M, Alam N, Sarwar G, Rahman M, Ahsan H, Graziano JH, Burchiel SW. 2019. Assessment of arsenic and polycyclic aromatic hydrocarbon (PAH) exposures on immune function among males in Bangladesh. PLoS One 14:doi:10.1371/journal.pone.0216662 PMID:31095595 PMCID:PMC6522035

2018

  • Bozack AK, Hall MN, Liu X, Ilievski V, Lomax-Luu A, Parvez F, Siddique A, Shahriar H, Uddin MN, Islam T, Graziano JH, Gamble MV. 2018. Folic acid supplementation enhances arsenic methylation: results from a folic acid and creatine supplementation randomized controlled trial in Bangladesh. Am J Clin Nutr 109(2):380-391. doi:10.1093/ajcn/nqy148 PMID:30590411 PMCID:PMC6367980
  • Niedzwiecki M, Liu X, Zhu H, Hall MN, Slavkovich VN, Ilievski V, Levy D, Siddique AB, Kibriya MG, Parvez F, Islam T, Ahmed A, Navas-Acien A, Graziano JH, Finnell RH, Ahsan H, Gamble MV. 2018. Serum homocysteine, arsenic methylation, and arsenic-induced skin lesion incidence in Bangladesh: A one-carbon metabolism candidate gene study. Environ Int 113:133-142. doi:10.1016/j.envint.2018.01.015 PMID:29421402 PMCID:PMC5873983
  • Wasserman GA, Liu X, Parvez F, Chen Y, Factor-Litvak P, Lolacono NJ, Levy D, Shahriar H, Uddin MN, Islam T, Lomax A, Saxena R, Gibson EA, Kioumourtzoglou M, Balac O, Sanchez TR, Kline JK, Santiago D, Ellis T, Graziano JH, van Geen AF. 2018. A cross-sectional study of water arsenic exposure and intellectual function in adolescence in Araihazar, Bangladesh. Environ Int 118:304-313. doi:10.1016/j.envint.2018.05.037 PMID:29933234

2017

  • Howe CG, Liu X, Hall MN, Ilievski V, Caudill MA, Malysheva O, Lomax-Luu A, Parvez F, Siddique A, Shahriar H, Uddin MN, Islam T, Graziano JH, Costa M, Gamble MV. 2017. Sex-specific associations between one-carbon metabolism indices and posttranslational histone modifications in arsenic-exposed Bangladeshi adults. Cancer Epidemiol Biomarkers Prev 26(2):261-269. doi:10.1158/1055-9965.EPI-16-0202 PMID:27765800 PMCID:PMC5296278

2016

  • Hall MN, Howe CG, Liu X, Caudill MA, Malysheva O, Ilievski V, Lomax-Luu A, Parvez F, Siddique A, Shahriar H, Uddin MN, Islam T, Graziano JH, Gamble MV. 2016. Supplementation with folic acid, but not creatine, increases plasma betaine, decreases plasma dimethylglycine, and prevents a decrease in plasma choline in arsenic-exposed Bangladeshi adults. J Nutr 146(5):1062-1067. doi:10.3945/jn.115.227132 PMID:27052531 PMCID:PMC4841924
  • Howe CG, Liu X, Hall MN, Slavkovich VN, Ilievski V, Parvez F, Siddique A, Shahriar H, Uddin MN, Islam T, Graziano JH, Costa M, Gamble MV. 2016. Associations between blood and urine arsenic concentrations and global levels of post-translational histone modifications in Bangladeshi men and women. Environ Health Perspect 124(8):1234-1240. doi:10.1289/ehp.1510412 PMID:26967670 PMCID:PMC4977054
  • Liu X, Jin Z, Graziano JH. 2016. Comparing paired biomarkers in predicting quantitative health outcome subject to random censoring. Stat Methods Med Res 25(1):447-457. doi:10.1177/0962280212460434 PMID:23070589 PMCID:PMC4390496
  • Wasserman GA, Liu X, Parvez F, Factor-Litvak P, Kline JK, Siddique A, Shahriar H, Uddin MN, van Geen AF, Mey JL, Balac O, Graziano JH. 2016. Child intelligence and reductions in water arsenic and manganese: a two-year follow-up study in Bangladesh. Environ Health Perspect 124(7):1114-1120. doi:10.1289/ehp.1509974 PMID:26713676 PMCID:PMC4937860

2015

  • Khan K, Ahmed EB, Factor-Litvak P, Liu X, Siddique A, Wasserman GA, Slavkovich VN, Levy D, Mey JL, van Geen AF, Graziano JH. 2015. Evaluation of an elementary school-based educational intervention for reducing arsenic exposure in Bangladesh. Environ Health Perspect 123(12):1331-1336. doi:10.1289/ehp.1409462 PMID:25956010 PMCID:PMC4671245
  • Niedzwiecki M, Liu X, Hall MN, Thomas T, Slavkovich VN, Ilievski V, Levy D, Alam S, Siddique A, Parvez F, Graziano JH, Gamble MV. 2015. Sex-specific associations of arsenic exposure with global DNA methylation and hydroxymethylation in leukocytes: results from two studies in Bangladesh. Cancer Epidemiol Biomarkers Prev 24(11):1748-1757. doi:10.1158/1055-9965.EPI-15-0432 PMID:26364164 PMCID:PMC4633312
  • Peters BA, Hall MN, Liu X, Parvez F, Sanchez TR, van Geen AF, Mey JL, Siddique A, Shahriar H, Uddin MN, Islam T, Balac O, Ilievski V, Factor-Litvak P, Graziano JH, Gamble MV. 2015. Folic acid and creatine as therapeutic approaches to lower blood arsenic: a randomized controlled trial. Environ Health Perspect 123(12):1294-1301. doi:10.1289/ehp.1409396 PMID:25978852 PMCID:PMC4671237
  • Peters BA, Hall MN, Liu X, Parvez F, Siddique A, Shahriar H, Uddin MN, Islam T, Ilievski V, Graziano JH, Gamble MV. 2015. Low-dose creatine supplementation lowers plasma guanidinoacetate, but not plasma homocysteine, in a double-blind, randomized, placebo-controlled trial. J Nutr 145(10):2245-2252. doi:10.3945/jn.115.216739 PMID:26311810 PMCID:PMC4580963
  • Peters BA, Hall MN, Liu X, Slavkovich VN, Ilievski V, Alam S, Siddique A, Islam T, Graziano JH, Gamble MV. 2015. Renal function is associated with indicators of arsenic methylation capacity in Bangladeshi adults. Environ Res 143(PtA):123-130. doi:10.1016/j.envres.2015.10.001 PMID:26476787 PMCID:PMC4740972
  • Peters BA, Liu X, Hall MN, Ilievski V, Slavkovich VN, Siddique A, Alam S, Islam T, Graziano JH, Gamble MV. 2015. Arsenic exposure, inflammation, and renal function in Bangladeshi adults: effect modification by plasma glutathione redox potential. Free Radic Biol Med 85:174-182. doi:10.1016/j.freeradbiomed.2015.04.020 PMID:25916185 PMCID:PMC4679178

2014

  • Harper KN, Liu X, Hall MN, Ilievski V, Oka J, Calancie L, Slavkovich VN, Levy D, Siddique A, Alam S, Mey JL, van Geen AF, Graziano JH, Gamble MV. 2014. A dose-response study of arsenic exposure and markers of oxidative damage in Bangladesh. J Occup Environ Med 56(6):652-658. doi:10.1097/JOM.0000000000000166 PMID:24854259 PMCID:PMC4050339
  • Howe CG, Niedzwiecki M, Hall MN, Liu X, Ilievski V, Slavkovich VN, Alam S, Siddique A, Graziano JH, Gamble MV. 2014. Folate and cobalamin modify associations between s-adenosylmethionine and methylated arsenic metabolites in arsenic-exposed Bangladeshi adults. J Nutr 144:690-697. doi:10.3945/jn.113.188789 PMID:24598884 PMCID:PMC3985826
  • Niedzwiecki M, Hall MN, Liu X, Slavkovich VN, Ilievski V, Levy D, Alam S, Siddique A, Parvez F, Graziano JH, Gamble MV. 2014. Interaction of plasma glutathione redox and folate deficiency on arsenic methylation capacity in Bangladeshi adults. Free Radic Biol Med 73:67-74. doi:10.1016/j.freeradbiomed.2014.03.042 PMID:24726863 PMCID:PMC4111991
  • Peters BA, Hall MN, Liu X, Neugut Y, Pilsner JR, Levy D, Ilievski V, Slavkovich VN, Islam T, Factor-Litvak P, Graziano JH, Gamble MV. 2014. Creatinine, arsenic metabolism, and renal function in an arsenic-exposed population in Bangladesh. PLoS One 9(12):e113760. doi:10.1371/journal.pone.0113760 PMID:25438247 PMCID:PMC4249915
  • Wasserman GA, Liu X, LoIacono NJ, Kline JK, Factor-Litvak P, van Geen AF, Mey JL, Levy D, Abramson R, Schwartz A, Graziano JH. 2014. A cross-sectional study of well water arsenic and child IQ in Maine schoolchildren. Environ Health 13:23. doi:10.1186/1476-069x-13-23 PMID:24684736 PMCID:PMC4104994

2013

  • Hall MN, Niedzwiecki M, Liu X, Harper KN, Alam S, Slavkovich VN, Ilievski V, Levy D, Siddique A, Parvez F, Mey JL, van Geen AF, Graziano JH, Gamble MV. 2013. Chronic arsenic exposure and blood glutathione and glutathione disulfide concentrations in Bangladeshi adults. Environ Health Perspect 121(9):1068-1074. doi:10.1289/ehp.1205727 PMID:23792557 PMCID:PMC3764071
  • Niedzwiecki M, Hall MN, Liu X, Oka J, Harper KN, Slavkovich VN, Ilievski V, Levy D, van Geen AF, Mey JL, Alam S, Siddique A, Parvez F, Graziano JH, Gamble MV. 2013. A dose-response study of arsenic exposure and global methylation of peripheral blood mononuclear cell DNA in Bangladeshi adults. Environ Health Perspect 121:1306-1312. doi:10.1289/ehp.1206421 PMID:24013868 PMCID:PMC3855504
  • Niedzwiecki M, Hall MN, Liu X, Oka J, Harper KN, Slavkovich VN, Ilievski V, Levy D, van Geen AF, Mey JL, Alam S, Siddique A, Parvez F, Graziano JH, Gamble MV. 2013. Blood glutathione redox status and global methylation of peripheral blood mononuclear cell DNA in Bangladeshi adults. Epigenetics 8(7):730-738. doi:10.4161/epi.25012 PMID:23803688 PMCID:PMC3781192

2012

  • Chervona Y, Hall MN, Arita A, Wu F, Sun H, Tseng H, Ali E, Uddin MN, Liu X, Zoroddu MA, Gamble MV, Costa M. 2012. Association between arsenic exposure and global posttranslational histone modifications among adults in Bangladesh. Cancer Epidemiol Biomarkers Prev 21:2252-2260. doi:10.1158/1055-9965.epi-12-0833 PMID:23064002 PMCID:PMC3518638
  • George CM, van Geen AF, Slavkovich VN, Singha A, Levy D, Islam T, Ahmed KM, Moon-Howard J, Tarozzi A, Liu X, Factor-Litvak P, Graziano JH. 2012. A cluster-based randomized controlled trial promoting community participation in arsenic mitigation efforts in Bangladesh. Environ Health 11:41. doi:10.1186/1476-069x-11-41 PMID:22713347 PMCID:PMC3506475
  • Khan K, Wasserman GA, Liu X, Ahmed EB, Parvez F, Slavkovich VN, Levy D, Mey JL, van Geen AF, Graziano JH, Factor-Litvak P. 2012. Manganese exposure from drinking water and children's academic achievement. Neurotoxicology 33(1):91-97. doi:10.1016/j.neuro.2011.12.002 PMID:22182530 PMCID:PMC3282923
  • Liu X. 2012. Classification accuracy and cut point selection. Stat Med 31:2676-2686. doi:10.1002/sim.4509 PMID:22307964
  • Pilsner JR, Hall MN, Liu X, Ilievski V, Slavkovich VN, Levy D, Factor-Litvak P, Yunus M, Rahman M, Graziano JH, Gamble MV. 2012. Influence of prenatal arsenic exposure and newborn sex on global methylation of cord blood DNA. PLoS One 7:doi:10.1371/journal.pone.0037147 PMID:22662134 PMCID:PMC3360698

2011

  • Khan K, Factor-Litvak P, Wasserman GA, Liu X, Ahmed EB, Parvez F, Slavkovich VN, Levy D, van Geen AF, Mey JL, Graziano JH. 2011. Manganese exposure from drinking water and children's classroom behavior in Bangladesh. Environ Health Perspect 119:1501-1506. doi:10.1289/ehp.1003397 PMID:21493178 PMCID:PMC3230445
  • Louis ED, Hafeman D, Parvez F, Liu X, Alcalay RN, Islam T, Ahmed A, Siddique A, Patwary T, Melkonian S, Argos M, Levy D, Ahsan H. 2011. Tremor severity and age: a cross-sectional, population-based study of 2,524 young and midlife normal adults. Movement Disorders 26:1515-1520. doi:10.1002/mds.23674 PMID:21442657
  • Parvez F, Wasserman GA, Factor-Litvak P, Liu X, Slavkovich VN, Siddique A, Sultana R, Islam T, Levy D, Mey JL, van Geen AF, Khan K, Kline JK, Ahsan H, Graziano JH. 2011. Arsenic exposure and motor function among children in Bangladesh. Environ Health Perspect 119:1665-1670. doi:10.1289/ehp.1103548 PMID:21742576 PMCID:PMC3226503
  • Pilsner JR, Hall MN, Liu X, Ahsan H, Ilievski V, Slavkovich VN, Levy D, Factor-Litvak P, Graziano JH, Gamble MV. 2011. Associations of plasma selenium with arsenic and genomic methylation of leukocyte DNA in Bangladesh. Environ Health Perspect 119(1):113-118. doi:10.1289/ehp.1001937 PMID:21205583 PMCID:PMC3018489
  • Wasserman GA, Liu X, Parvez F, Factor-Litvak P, Ahsan H, Levy D, Kline JK, van Geen AF, Mey JL, Slavkovich VN, Siddique A, Islam T, Graziano JH. 2011. Arsenic and manganese exposure and children's intellectual function. Neurotoxicology 32(4):450-457. doi:10.1016/j.neuro.2011.03.009 PMID:21453724 PMCID:PMC4062913

2010

  • Chen Y, Ahsan H, Slavkovich VN, Peltier GL, Gluskin RT, Parvez F, Liu X, Graziano JH. 2010. No association between arsenic exposure from drinking water and diabetes mellitus: a cross-sectional study in Bangladesh. Environ Health Perspect 118(9):1299-1305. doi:10.1289/ehp.0901559 PMID:20813654 PMCID:PMC2944093

2009

  • Hall M, Liu X, Slavkovich VN, Ilievski V, Pilsner JR, Alam S, Factor-Litvak P, Graziano JH, Gamble MV. 2009. Folate, cobalamin, cysteine, homocysteine, and arsenic metabolism among children in Bangladesh. Environ Health Perspect 117(5):825-831. doi:10.1289/ehp.0800164 PMID:19479028 PMCID:PMC2685848
  • Liu X, Slavkovich VN, Ilievski V, Mi Z, Alam S, Factor-Litvak P, Ahsan H, Graziano JH, Gamble MV, Hall MN. 2009. Influence of cobalamin on arsenic metabolism in Bangladesh. Environ Health Perspect 117(11):1724-1729. doi:10.1289/ehp.0900734 PMID:20049124 PMCID:PMC2801198
  • Pilsner JR, Liu X, Ahsan H, Ilievski V, Slavkovich VN, Levy D, Factor-Litvak P, Graziano JH, Gamble MV. 2009. Folate deficiency, hyperhomocysteinemia, low urinary creatinine, and hypomethylation of leukocyte DNA are risk factors for arsenic-induced skin lesions. Environ Health Perspect 117(2):254-260. doi:10.1289/ehp.11872 PMID:19270796 PMCID:PMC2649228

2007

  • Hall M, Gamble MV, Slavkovich VN, Liu X, Levy D, Cheng Z, van Geen AF, Yunus M, Rahman M, Pilsner JR, Graziano JH. 2007. Determinants of arsenic metabolism: Blood arsenic metabolites, plasma folate, cobalamin, and homocysteine concentrations in maternal-newborn pairs. Environ Health Perspect 115(10):1503-1509. PMID:17938743
  • Pilsner JR, Liu X, Ahsan H, Ilievski V, Slavkovich VN, Levy D, Factor-Litvak P, Graziano JH, Gamble MV. 2007. Genomic methylation of peripheral blood leukocyte DMA: influences of arsenic and folate in Bangladeshi adults. Am J Clin Nutr 86(4):1179-1186. PMID:17921400
  • Wasserman GA, Liu X, Parvez F, Ahsan H, Factor-Litvak P, Kline JK, van Geen AF, Slavkovich VN, Lolacono NJ, Levy D, Cheng Z, Graziano JH. 2007. Water arsenic exposure and ntellectual function in six-year-old children in Araihazar, Bangladesh. Environ Health Perspect 115(2):285-289.

2006

  • Gamble MV, Liu X, Ahsan H, Pilsner JR, Ilievski V, Slavkovich VN, Parvez F, Chen Y, Levy D, Factor-Litvak P, Graziano JH. 2006. Folate and arsenic metabolism: a double-blind, placebo-controlled folic acid-supplementation trial in Bangladesh. Am J Clin Nutr 84(5):1093-1101. PMID:17093162 PMCID:PMC2046214
  • Gamble MV, Pilsner JR, Liu X, Ahsan H, Ilievski V, Slavkovich VN, Parvez F, Factor-Litvak P, Graziano JH. 2006. Methylation of arsenic and DNA: A double-blind, placebo controlled trial of folic acid supplementation in Gangladesh. In: Proceedings of the FASEB (Federation of American Societies) Summer Conferenence Folic Acid, B12 and One Carbon Metabolism, August 5-10. Indian Wells, CA.
  • Wasserman GA, Liu X, Parvez F, Ahsan H, Levy D, Factor-Litvak P, Kline JK, van Geen AF, Slavkovich VN, Lolacono NJ, Cheng Z, Zheng Y, Graziano JH. 2006. Water manganese exposure and children's intellectual function in Araihazar, Bangladesh. Environ Health Perspect 114(1):124-129. PMID:16393669

2005

  • Gamble MV, Liu X. 2005. Urinary creatinine and arsenic metabolism. Environ Health Perspect 113(7):A442. PMID:16002357
  • Gamble MV, Liu X, Ahsan H, Pilsner JR, Ilievski V, Slavkovich VN, Parvez F, Levy D, Factor-Litvak P, Graziano JH. 2005. Folate, homocysteine, and arsenic metabolism in arsenic-exposed individuals in Bangladesh. Environ Health Perspect 113(12):1683-1688. PMID:16330347

2004

  • Wasserman GA, Liu X, Parvez F, Ahsan H, Factor-Litvak P, van Geen AF, Slavkovich VN, Lolacono NJ, Cheng Z, Hussain A, Momotaj H, Graziano JH. 2004. Water arsenic exposure and children's intellectual function in Araihazar, Bangladesh. Environ Health Perspect 112(13):1329-1333. PMID:15345348 PMCID:PMC1247525

2003

  • Wasserman GA, Factor-Litvak P, Liu X, Todd AC, Kline JK, Slavkovich VN, Popovac D, Graziano JH. 2003. The relationship between blood lead, bone lead and child intelligence. Child Neuropsychology (Neuropsychology, Development and Cognition: Section C) 9(1):22-34. PMID:12815520
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