Superfund Research Program

Douglas R. Spitz

University of Iowa
Department of Radiation Oncology-Free Radical & Radiation
Iowa City, Iowa 52242
Phone: 319-335-8001
Email: douglas-spitz@uiowa.edu

Projects

• University of Iowa: Oxidative Stress and PCB Exposure in Mammalian Cells (2006 - 2015)

Publications

2021

• Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO, Guo D, Weiss R, Bradberry K, Taylor EB, Rauckhorst AJ, Dick DW, Akurathi V, Falls-Hubert KC, Wagner BA, Carter WA, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC. 2021. Response to: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes. Am J Physiol Endocrinol Metab doi:10.1152/ajpendo.00119.2021 PMID:33843283

2020

• Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO, Guo D, Weiss R, Bradberry K, Taylor EB, Rauckhorst AJ, Dick DW, Akurathi V, Falls-Hubert KC, Wagner BA, Carter WA, Wang K, Norris AW, Rahmouni K, Buettner GR, Hansen JM, Spitz DR, Abel ED, Sheffield VC. 2020. Exposure to static magnetic and electric fields treats type 2 diabetes. Cell Metab 32:561-574. doi:10.1016/j.cmet.2020.09.012 PMID:33027675

2016

• Klaren WD, Gibson-Corley KN, Wels B, Simmons DL, McCormick ML, Spitz DR, Robertson LW. 2016. Assessment of the mitigative capacity of dietary zinc on PCB126 hepatotoxicity and the contribution of zinc to toxicity. Chem Res Toxicol 29(5):851-859. doi:10.1021/acs.chemrestox.6b00022 PMID:26967026 PMCID:PMC5100827

2013

• Xiao W, Zhu Y, Sarsour EH, Kalen AL, Aykin-Burns N, Spitz DR, Goswami PC. 2013. Selenoprotein P regulates 1-(4-Chlorophenyl)-benzo-2, 5-quinone-induced oxidative stress and toxicity in human keratinocytes. Free Radic Biol Med 65:70-77. doi:10.1016/j.freeradbiomed.2013.06.010 PMID:23770201 PMCID:PMC3830697
• Zhu Y, Mapuskar KA, Marek RF, Xu W, Lehmler H, Robertson LW, Hornbuckle KC, Spitz DR, Aykin-Burns N. 2013. A new player in environmentally induced oxidative stress: polychlorinated biphenyl congener, 3,3'-dichlorobiphenyl (PCB11). Toxicol Sci 136(1):39-50. doi:10.1093/toxsci/kft186 PMID:23997111 PMCID:PMC3829572

2010

• Chaudhuri L, Sarsour EH, Kalen AL, Aykin-Burns N, Spitz DR, Goswami PC. 2010. Polychlorinated biphenyl induced ROS signaling delays the entry of quiescent human breast epithelial cells into the proliferative cycle. Free Radic Biol Med 49(1):40-49. doi:10.1016/j.freeradbiomed.2010.03.012 PMID:20307652 PMCID:PMC2875331
• Hadzic T, Aykin-Burns N, Zhu Y, Coleman MC, Leick K, Jacobson GM, Spitz DR. 2010. Paclitaxel combined with inhibitors of glucose and hydroperoxide metabolism enhances breast cancer cell killing via H2O2-mediated oxidative stress. Free Radic Biol Med 48(8):1024-1033. doi:10.1016/j.freeradbiomed.2010.01.018 PMID:20083194 PMCID:PMC2843822
• Lai IK, Chai Y, Simmons DL, Luthe G, Coleman MC, Spitz DR, Haschek-Hock WM, Ludewig G, Robertson LW. 2010. Acute toxicity of 3,3,4,4,5-pentachlorobiphenyl (PCB 126) in male Sprague-Dawley rats: effects on hepatic oxidative stress, glutathione and metals status. Environ Int 36(8):918-923. doi:10.1016/j.envint.2009.11.002 PMID:19969354 PMCID:PMC2891598