Superfund Research Program

Heather M. Stapleton

Duke University
Nicholas School of the Environment
LSRC Rm. A207B
Box 90328
Durham, North Carolina 27708-0328
Phone: 919-613-8717
Email: heather.stapleton@duke.edu

Projects

• Duke University: Administrative and Research Translation Core (ARTC) (2022-2027)
• Duke University: Altering the Balance of Adipogenic and Osteogenic Regulatory Pathways from Early Life Exposure to HPCs and AOPEs (2017-2022)
• Duke University: Analytical Chemistry Core (2011-2022)
• Duke University: Prenatal Exposures to PAHs and Metals in an Impacted Community: Assessing Neurodevelopment Impacts and Tracing Metal Sources (2022-2027)
• Duke University: Thyroid Metabolism Disruption Key in Toxicant-Induced Developmental Impairment (2011-2017)

Publications

• Stapleton HM, Olshan A. Cancer Research Advisory Panel Recommendations. In: Cancer Research Advisory Panel.

2023

• Hall SM, Zhang S, Tait GH, Hoffman K, Collier D, Hoppin JA, Stapleton HM. 2023. PFAS levels in paired drinking water and serum samples collected from an exposed community in Central North Carolina. Sci Total Environ 895:165091. doi:10.1016/j.scitotenv.2023.165091 PMID:37355130
• Samon S, Herkert N, Ghassabian A, Liu H, Hammel SC, Trasande L, Stapleton HM, Hoffman K. 2023. Measuring semi-volatile organic compound exposures during pregnancy using silicone wristbands. Chemosphere 339:139778. doi:10.1016/j.chemosphere.2023.139778 PMID:37567263

2022

• Habre R, Dorman DC, Abbat J, Bahnfleth WP, Carter E, Farmer D, Gawne-Mittelstaedt G, Grassian VH, Morrison G, Peccia JL, Poppendieck D, Prather KA, Shiraiwa M, Stapleton HM, Willilams H, Harries ME. 2022. Why indoor chemistry matters: A national academies consensus report. Environ Sci Technol doi:10.1021/acs.est.2c04163 PMID:35833728
• Samon S, Hammel SC, Stapleton HM, Anderson KA. 2022. Silicone wristbands as personal passive sampling devices: Current knowledge, recommendations for use, and future directions. Environ Int doi:10.1016/j.envint.2022.107339

2021

• Patisaul HB, Behl M, Birnbaum LS, Blum A, Diamond ML, Fernandez SR, Hogberg HT, Kwiatkowski C, Page JD, Soehl A, Stapleton HM. 2021. Beyond cholinesterase inhibition: Developmental neurotoxicity of organophosphate ester flame retardants and plasticizers. Environ Health Perspect 129(10):105001. doi:10.1289/EHP9285 PMID:34612677 PMCID:PMC8493874

2020

• Cooper EM, Rushing R, Hoffman K, Phillips AL, Hammel SC, Zylka MJ, Stapleton HM. 2020. Strobilurin fungicides in house dust: Is wallboard a source?. J Expo Sci Environ Epidemiol 30:247-252. doi:10.1038/s41370-019-0180-z PMID:31636368 PMCID:PMC7044059
• Kassotis CD, Herkert N, Hammel SC, Hoffman K, Xia Q, Kullman SW, Sosa JA, Stapleton HM. 2020. Thyroid receptor antagonism of chemicals extracted from personal silicone wristbands within a papillary thyroid cancer pilot study. Environ Sci Technol 54:15296-15312. doi:10.1021/acs.est.0c05972 PMID:33185092 PMCID:PMC7819617
• Phillips AL, Herkert N, Ulrich JC, Hartman JH, Ruis MT, Cooper EM, Ferguson PL, Stapleton HM. 2020. In vitro metabolism of isopropylated and tert-butylated triarylphosphate esters using human liver subcellular fractions. Chem Res Toxicol 33:1428-1441. doi:10.1021/acs.chemrestox.0c00002 PMID:32129605 PMCID:PMC7508416

2019

• Craig J, Ceballos DM, Fruh V, Petropoulos ZE, Allen JG, Calafat AM, Ospina M, Stapleton HM, Hammel SC, Gray R, Webster TF. 2019. Exposure of nail salon workers to phthalates, di(2-ethylhexyl) terephthalate, and organophosphate esters: A pilot study. Environ Sci Technol 53:14630-14637. doi:10.1021/acs.est.9b02474 PMID:31736299
• Kassotis CD, Kollitz EM, Hoffman K, Sosa JA, Stapleton HM. 2019. Thyroid receptor antagonism as a contributory mechanism for adipogenesis induced by environmental mixtures in 3T3-L1 cells. Sci Total Environ 666:431-444. doi:10.1016/j.scitotenv.2019.02.273 PMID:30802659 PMCID:PMC6456385
• Lefevre E, Redfern L, Cooper EM, Stapleton HM, Gunsch C. 2019. Acetate promotes microbial reductive debromination of tetrabromobisphenol A during the startup phase of anaerobic wastewater sludge bioreactors. Sci Total Environ 656:959-968. doi:10.1016/j.scitotenv.2018.11.403 PMID:30625682 PMCID:PMC6481660
• Tuttle AH, Salazar G, Cooper EM, Stapleton HM, Zylka MJ. 2019. Choice of vehicle affects pyraclostrobin toxicity in mice. Chemosphere 218:501-506. doi:10.1016/j.chemosphere.2018.11.126 PMID:30497033 PMCID:PMC6338344

2018

• Hammel SC, Phillips AL, Hoffman K, Stapleton HM. 2018. Evaluating the use of silicone wristbands to measure personal exposure to brominated flame retardants. Environ Sci Technol 52:11875-11885. doi:10.1021/acs.est.8b03755 PMID:30216050 PMCID:PMC6445795
• Kassotis CD, Kollitz EM, Ferguson PL, Stapleton HM. 2018. Nonionic ethoxylated surfactants induce adipogenesis in 3T3-L1 cells. Toxicol Sci 162(1):124-136. doi:10.1093/toxsci/kfx234 PMID:29106673 PMCID:PMC625695
• Kollitz EM, De Carbonnel L, Stapleton HM, Ferguson PL. 2018. The affinity of brominated phenolic compounds for human and zebrafish thyroid receptor beta: Influence of chemical structure. Toxicol Sci doi:10.1093/toxsci/kfy028 PMID:29409039
• Kollitz EM, Kassotis CD, Hoffman K, Ferguson PL, Sosa JA, Stapleton HM. 2018. Chemical mixtures isolated from house dust disrupt thyroid receptor beta signaling. Environ Sci Technol 52:11857-11864. doi:10.1021/acs.est.8b03283 PMID:30212187
• Lefevre E, Bossa N, Gardner CM, Gehrke GE, Cooper EM, Stapleton HM, Hsu-Kim H, Gunsch C. 2018. Biochar and activated carbon act as promising amendments for promoting the microbial debromination of tetrabromobisphenol A. Water Res 128:102-110. doi:10.1016/j.watres.2017.09.047 PMID:29091801 PMCID:PMC5796758
• Luz AL, Kassotis CD, Stapleton HM, Meyer JN. 2018. The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPARgamma activation, in 3T3-L1 cells. Toxicology 393:150-159. doi:10.1016/j.tox.2017.11.010 PMID:29127035 PMCID:PMC5726929

2017

• Ferguson PL, Stapleton HM. 2017. Comment on: Mutagenic azo dyes, rather than flame retardants, are the predominant brominated compounds in house dust. Environ Sci Technol 51(6):3588-3590. doi:10.1021/acs.est.7b00372 PMID:28282131
• Hammel SC, Hoffman K, Lorenzo AM, Chen A, Phillips AL, Butt CM, Sosa JA, Webster TF, Stapleton HM. 2017. Associations between flame retardant applications in furniture foam, house dust levels, and residents' serum levels. Environ Int 107:181-189. doi:10.1016/j.envint.2017.07.015 PMID:28750223 PMCID:PMC5572835
• Kassotis CD, Masse L, Kim S, Schlezinger JJ, Webster TF, Stapleton HM. 2017. Characterization of adipogenic chemicals in three different cell culture systems: Implications for reproducibility based on cell source and handling. Sci Rep 7(42104):doi:10.1038/srep42104 PMID:28176856 PMCID:PMC5296734
• Macaulay LJ, Chernick M, Chen A, Hinton DE, Bailey JM, Kullman SW, Levin ED, Stapleton HM. 2017. Exposure to a PBDE/OH-BDE mixture alters juvenile zebrafish (Danio rerio) development. Environ Toxicol Chem 36(1):36-48. doi:10.1002/etc.3535 PMID:27329031
• Siebenaler R, Cameron R, Butt CM, Hoffman K, Higgins CP, Stapleton HM. 2017. Serum perfluoroalkyl acids (PFAAs) and associations with behavioral attributes. Chemosphere 184:687-693. doi:10.1016/j.chemosphere.2017.06.023 PMID:28633063 PMCID:PMC5535816
• Slotkin TA, Skavicus S, Stapleton HM, Seidler FJ. 2017. Brominated and organophosphate flame retardants target different neurodevelopmental stages, characterized with embryonic neural stem cells and neuronotypic PC12 cells. Toxicology 390:32-42. doi:10.1016/j.tox.2017.08.009 PMID:28851516 PMCID:PMC5633518

2016

• Carignan C, Fang M, Stapleton HM, Heiger-Bernays WJ, McClean MD, Webster TF. 2016. Urinary biomarkers of flame retardant exposure among collegiate US gymnasts. Environ Int 94:362-368. doi:10.1016/j.envint.2016.06.030 PMID:27395335 PMCID:PMC4980234
• Cooper EM, Kroeger G, Davis K, Clark C, Ferguson PL, Stapleton HM. 2016. Results from screening polyurethane foam based consumer products for flame retardant chemicals: assessing impacts on the change in the furniture flammability standards. Environ Sci Technol 50(19):10653-10660. doi:10.1021/acs.est.6b01602 PMID:27552529 PMCID:PMC5052662
• Czaplicki LN, Cooper EM, Ferguson PL, Stapleton HM, Vilgalys R, Gunsch C. 2016. A new perspective on sustainable soil remediation-case study suggests novel fungal genera could facilitate in situ biodegradation of hazardous contaminants. Remediation (N Y) 26(2):59-72. doi:10.1002/rem.21458 PMID:27917031 PMCID:PMC5130160
• Hammel SC, Hoffman K, Webster TF, Anderson KA, Stapleton HM. 2016. Measuring personal exposure to organophosphate flame retardants using silicone wristbands and hand wipes. Environ Sci Technol 50(8):4483-4491. doi:10.1021/acs.est.6b00030 PMID:26975559 PMCID:PMC4872512
• Lefevre E, Cooper EM, Stapleton HM, Gunsch C. 2016. Characterization and adaptation of anaerobic sludge microbial communities exposed to tetrabromobisphenol A. PLoS One 11(7):e0157622. doi:10.1371/journal.pone.0157622 PMID:27463972 PMCID:PMC4963083

2015

• Fang M, Webster T, Stapleton HM. 2015. Effect-directed analysis of human peroxisome proliferator-activated nuclear receptors (PPARγ1) ligands in indoor dust. Environ Sci Technol 49(16):10065-10073. doi:10.1021/acs.est.5b01524 PMID:26172369 PMCID:PMC4786017
• Fang M, Webster TF, Ferguson PL, Stapleton HM. 2015. Characterizing the peroxisome proliferator-activated receptor (PPARγ) ligand binding potential of several major flame retardants, their metabolites, and chemical mixtures in house dust. Environ Health Perspect 123(2):166-172. doi:10.1289/ehp.1408522 PMID:25314719 PMCID:PMC4314249
• Fang M, Webster TF, Stapleton HM. 2015. Activation of human peroxisome proliferator-activated nuclear receptors (PPARγ1) by semi-volatile compounds (SVOCs) and chemical mixtures in indoor dust. Environ Sci Technol 49(16):10057-10064. doi:10.1021/acs.est.5b01523 PMID:26172262 PMCID:PMC4786016
• Macaulay LJ, Bailey JM, Levin ED, Stapleton HM. 2015. Persisting effects of a PBDE metabolite, 6-OH-BDE-47, on larval and juvenile zebrafish swimming behavior. Neurotoxicol Teratol 52(PtB):119-126. doi:10.1016/j.ntt.2015.05.002 PMID:25979796 PMCID:PMC4644107
• Macaulay LJ, Chen A, Rock KD, Dishaw L, Dong W, Hinton DE, Stapleton HM. 2015. Developmental toxicity of the PBDE metabolite 6-OH-BDE-47 in zebrafish and the potential role of thyroid receptor β. Aquat Toxicol 168:38-47. doi:10.1016/j.aquatox.2015.09.007 PMID:26433919 PMCID:PMC4618599

2014

• Dong W, Macaulay LJ, Kwok KW, Hinton DE, Ferguson PL, Stapleton HM. 2014. The PBDE metabolite 6-OH-BDE 47 affects melanin pigmentation and THRβ MRNA expression in the eye of zebrafish embryos. Endocr Disruptors (Austin) 2(1):doi:10.4161/23273739.2014.969072 PMID:25767823 PMCID:PMC4354867
• Fang M, Getzinger GJ, Cooper EM, Clark BW, Garner LV, Di Giulio RT, Ferguson PL, Stapleton HM. 2014. Effect-directed analysis of Elizabeth River porewater: developmental toxicity in zebrafish (Danio rerio). Environ Toxicol Chem 33(12):2767-2774. doi:10.1002/etc.2738 PMID:25196082 PMCID:PMC4393830
• Levin ED, Cauley M, Johnson JE, Cooper EM, Stapleton HM, Ferguson PL, Seidler FJ, Slotkin TA. 2014. Prenatal dexamethasone augments the neurobehavioral teratology of chlorpyrifos: significance for maternal stress and preterm labor. Neurotoxicol Teratol 41:35-42. doi:10.1016/j.ntt.2013.10.004 PMID:24177596 PMCID:PMC3943881
• Pillai HK, Fang M, Beglov D, Kozakov D, Vajda S, Stapleton HM, Webster TF, Schlezinger JJ. 2014. Ligand binding and activation of PPARγ by Firemaster® 550: effects on adipogenesis and osteogenesis in vitro. Environ Health Perspect 122(11):1225-1232. doi:10.1289/ehp.1408111 PMID:25062436 PMCID:PMC4216168

2013

• Clark BW, Cooper EM, Stapleton HM, Di Giulio RT. 2013. Compound- and mixture-specific differences in resistance to polycyclic aromatic hydrocarbons and PCB-126 among Fundulus heteroclitus subpopulations throughout the Elizabeth River Estuary (Virginia, USA). Environ Sci Technol 47(18):10556-10566. doi:10.1021/es401604b PMID:24003986 PMCID:PMC4079253
• Dong W, Macaulay LJ, Kwok KW, Hinton DE, Stapleton HM. 2013. Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: a tool for examining OH-BDE toxicity to early life stages. Aquat Toxicol 132-133:190-199. doi:10.1016/j.aquatox.2013.02.008 PMID:23531416 PMCID:PMC3642849
• Slotkin TA, Cooper EM, Stapleton HM, Seidler FJ. 2013. Does thyroid disruption contribute to the developmental neurotoxicity of chlorpyrifos?. Environ Toxicol Pharmacol 36(2):284-287. doi:10.1016/j.etap.2013.04.003 PMID:23686008 PMCID:PMC3745805

2012

• McClain V, Stapleton HM, Tilton F, Gallagher EP. 2012. BDE 49 and developmental toxicity in zebrafish. Comp Biochem Physiol C Toxicol Pharmacol 155:253-258. doi:10.1016/j.cbpc.2011.09.004 PMID:21951712 PMCID:PMC3246048
• Springer C, Dere E, Hall SJ, McDonnell EV, Roberts SC, Butt CM, Stapleton HM, Watkins DJ, McClean MD, Webster TF, Schlezinger JJ, Boekelheide K. 2012. Rodent thyroid, liver, and fatal testis toxicity of the monoester metabolite of Bis-(2-ethylhexyl) Tetrabromophthalate (TBPH), a novel brominated flame retardant present in indoor dust. Environ Health Perspect 120:1711-1719. doi:10.1289/ehp.1204932 PMID:23014847 PMCID:PMC3548273

2011

• Jung D, Matson CW, Collins LB, Laban G, Stapleton HM, Bickham JW, Swenberg JA, Di Giulio RT. 2011. Genotoxicity in Atlantic killifish (Fundulus heteroclitus) from a PAH-contaminated Superfund site on the Elizabeth River, Virginia. Ecotoxicology 20:1890-1899. doi:10.1007/s10646-011-0727-9 PMID:21706406 PMCID:PMC3203518