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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Person Details: Angela L. Slitt

Superfund Research Program

Angela L. Slitt

University of Rhode Island
Avedisian Hall
7 Greenhouse Road
Kingston, Rhode Island 02881
Phone: 401-874-5020
Email: aslitt@uri.edu

Projects

Research Briefs

Publications

2024

  • Hmila I, Hill J, Shalaby K, Ouararhni K, Abedsselem H, Modaresi SM, Bihaqi SW, Marques E, Sondhi A, Slitt AL, Zawia N. 2024. Perinatal exposure to PFOS and sustained high-fat diet promote neurodevelopmental disorders via genomic reprogramming of pathways associated with neuromotor development. Ecotoxicol Environ Saf 272:doi:10.1016/j.ecoenv.2024.116070

2023

  • Zhang Y, Mustieles V, Wang Y, Sun Q, Coull BA, Sun Y, Slitt AL, Messerlian C. 2023. Red blood cell folate modifies the association between serum per- and polyfluoroalkyl substances and antibody concentrations in U.S. adolescents. Environ Sci Technol 57(6):2445-2456. doi:10.1021/acs.est.2c07152 PMID:36715557

2022

  • Marques E, Pfohl M, Wei W, Tarantola G, Ford L, Amaeze O, Alesio J, Ryu S, Jia X, Zhu H, Bothun GD, Slitt AL. 2022. Replacement per- and polyfluoroalkyl substances (PFAS) are potent modulators of lipogenic and drug metabolizing gene expression signatures in primary human hepatocytes. Toxicol Appl Pharmacol 442:115991. doi:10.1016/j.taap.2022.115991 PMID:35337807 PMCID:PMC9036616
  • Modaresi SM, Wei W, Marques E, DaSilva NA, Slitt AL. 2022. Per- and polyfluoroalkyl substances (PFAS) augment adipogenesis and shift the proteome in murine 3T3-L1 adipocytes. Toxicology 465:doi:10.1016/j.tox.2021.153044 PMID:34800597 PMCID:PMC8756374

2021

  • Alesio J, Slitt AL, Bothun GD. 2021. Critical new insights into the binding of poly- and perfluoroalkyl substances (PFAS) to albumin protein. Chemosphere 287(Pt1):131979. doi:10.1016/j.chemosphere.2021.131979 PMID:34450368 (ahead of print)
  • Amaeze O, Eng H, Horlbogen L, Varma MV, Slitt AL. 2021. Cytochrome P450 enzyme inhibition and herb-drug interaction potential of medicinal plant extracts used for management of diabetes in Nigeria. Eur J Drug Metab Pharmacokinet 46(3):437-450. doi:10.1007/s13318-021-00685-1 PMID:33844145
  • Amaeze O, Marques E, Wei W, Lazzaro S, Johnson N, Varma MV, Slitt AL. 2021. Evaluation of Nigerian medicinal plants extract on human P-glycoprotein and Cytochrome P450 enzyme induction: Implications for herb-drug interaction. Curr Drug Metab 22(14):PMID:34915831
  • Basaly V, Hill J, Bihaqi SW, Marques E, Slitt AL, Zawia NH. 2021. Developmental perfluorooctanesulfonic acid (PFOS) exposure as a potential risk factor for late-onset Alzheimer's disease in CD-1 mice and SH-SY5Y cells. Neurotoxicology 86:26-36. doi:10.1016/j.neuro.2021.06.008 PMID:34224775 (ahead of print)
  • Fedorenko M, Alesio J, Fedorenko A, Slitt AL, Bothun GD. 2021. Dominant entropic binding of perfluoroalkyl substances (PFASs) to albumin protein revealed by 19 F NMR. Chemosphere 263(9):doi:10.1016/j.chemosphere.2020.128083 PMID:33297081
  • Hamilton MC, Heintz MM, Pfohl M, Marques E, Ford L, Slitt AL, Baldwin WS. 2021. Increased toxicity and retention of perflourooctane sulfonate (PFOS) in humanized CYP2B6-Transgenic mice compared to Cyp2b-null mice is relieved by a high-fat diet (HFD). Food Chem Toxicol 152:112175. doi:10.1016/j.fct.2021.112175 PMID:33838175 PMCID:PMC8154739
  • Marques E, Agudelo J, Kaye EM, Modaresi SM, Pfohl M, Becanova J, Wei W, Polunas M, Goedken M, Slitt AL. 2021. The role of maternal high fat diet on mouse pup metabolic endpoints following perinatal PFAS and PFAS mixture exposure. Toxicology 462(15):152921. doi:10.1016/j.tox.2021.152921 PMID:34464680 PMCID:PMC8554779
  • Pfohl M, DaSilva NA, Marques E, Agudelo J, Liu C, Goedken M, Slitt AL, Seeram NP, Ma H. 2021. Hepatoprotective and anti-inflammatory effects of a standardized pomegranate (Punica granatum) fruit extract in high fat diet-induced obese C57BL/6 mice. Int J Food Sci Nutr 72(4):499-510. doi:10.1080/09637486.2020.1849041 PMID:33203257
  • Pfohl M, Marques E, Auclair A, Barlock BJ, Jamwal R, Goedken M, Akhlaghi F, Slitt AL. 2021. An 'omics approach to unraveling the paradoxical effect of diet on perfluorooctanesulfonic acid (PFOS) and perfluorononanoic acid (PFNA)-induced hepatic steatosis. Toxicol Sci 180:277-294. doi:10.1093/toxsci/kfaa172 PMID:33483757 PMCID:PMC8041463
  • Salter DM, Wei W, Nahar PP, Marques E, Slitt AL. 2021. Perfluorooctanesulfonic acid (PFOS) thwarts the beneficial effects of calorie restriction and Metformin. Toxicol Sci 182(1):doi:10.1093/toxsci/kfab043 PMID:33844015 (ahead of print)

2020

  • Marques E, Pfohl M, Auclair A, Jamwal R, Barlock BJ, Sammoura FM, Goedken M, Akhlaghi F, Slitt AL. 2020. Perfluorooctanesulfonic acid (PFOS) administration shifts the hepatic proteome and augments dietary outcomes related to hepatic steatosis in mice. Toxicol Appl Pharmacol 408:doi:10.1016/j.taap.2020.115250 PMID:32979393
  • Pfohl M, Ingram L, Marques E, Auclair A, Barlock BJ, Jamwal R, Anderson D, Cummings BS, Slitt AL. 2020. Perfluorooctanesulfonic acid and perfluorohexanesulfonic acid alter the blood lipidome and the hepatic proteome in a murine model of diet-induced obesity. Toxicol Sci 178:311-324. doi:10.1093/toxsci/kfaa148 PMID:32991729 PMCID:PMC7751193

2019

  • Dassuncao C, Pickard HM, Pfohl M, Tokranov AK, Li M, Mikkelsen B, Slitt AL, Sunderland EM. 2019. Phospholipid levels predict the tissue distribution of poly- and perfluoroalkyl substances in a marine mammal. Environ Sci Technol Lett 6(3):119-125. doi:10.1021/acs.estlett.9b00031
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