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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Person Details: Hans-Joachim Lehmler

Superfund Research Program

Hans-Joachim Lehmler

University of Iowa
UI Research Park, #124 IREH
Iowa City, Iowa 52242-5000
Phone: 319-335-4414
Fax: 319-335-4290
Email: hans-joachim-lehmler@uiowa.edu

Projects

Research Briefs

Publications

2024

2023

  • Behan-Bush RM, Liszewski JN, Schrodt MV, Vats B, Li X, Lehmler H, Klingelhutz AJ, Ankrum J. 2023. Toxicity impacts on human adipose mesenchymal stem/stronal cells acutely exposed to aroclor and non-aroclor mixtures of polychorinated biphenyl. Environ Sci Technol 57(4):1731-1742. doi:10.1021/acs.est.2c07281 PMID:36651682 PMCID:PMC9893815
  • Bullert AJ, Li X, Chunyun Z, Lee K, Pulliam CF, Cagle B, Doorn JA, Klingelhutz AJ, Robertson LW, Lehmler H. 2023. Disposition and metabolomic effects of 2,2',5,5'-tetrachlorobiphenyl in female rats following intraperitoneal exposure. Environ Toxicol Pharmacol 102:104245. doi:10.1016/j.etap.2023.104245 PMID:37572994
  • Gourronc FA, Chimenti MS, Lehmler H, Ankrum J, Klingelhutz AJ. 2023. Hydroxylation markedly alters how the polychlorinated biphenyl (PCB) congener, PCB52, affects gene expression in human preadipocytes. Toxicol Vitro 89:105568. doi:10.1016/j.tiv.2023.105568 PMID:36804509 PMCID:PMC10081964
  • Gourronc FA, Chimenti MS, Lehmler H, Ankrum J, Klingelhutz AJ. 2023. Updating Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB126) with additional data on exposure to 2,2',5,5'-tetrachlorobiphenyl (PCB52) or its 4-hydroxy metabolite (4-OH-PCB52). Data Brief 49:109415. doi:10.1016/j.dib.2023.109415 PMID:37520642 PMCID:PMC10375549
  • Li X, Bullert AJ, Han W, Yang W, Zhang Q, Ding X, Lehmler H. 2023. Enantiomeric fractions reveal differences in the atroposelective disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) in wildtype, cyp2abfgs-null, and CYP2A6-humanized mice. Chem Res Toxicol doi:10.1021/acs.chemrestox.3c00128 PMID:37467352
  • Mouat JS, Li X, Neier K, Zhu Y, Mordaunt CE, La Merrill MA, Lehmler H, Jones MP, Lein PJ, Schmidt RJ, LaSalle J. 2023. Networks of placental DNA methylation correlate with maternal serum PCB concentrations and child neurodevelopment. Environ Res 220:115227. doi:10.1016/j.envres.2023.115227 PMID:36608759
  • Paranjape N, Dean LE, Martinez A, Tjalkens RB, Lehmler H, Doorn JA. 2023. Structure-activity relationship of lower chlorinated biphenyls and their human-relevant metabolites for astrocyte toxicity. Chem Res Toxicol 36(6):971-981. doi:10.1021/acs.chemrestox.3c00095 PMID:37279407 PMCID:PMC10283044
  • Wang H, Bullert AJ, Li X, Stevens HE, Klingelhutz AJ, Ankrum J, Adamcakova-Dodd A, Thorne PS, Lehmler H. 2023. Use of a polymeric implant system to assess the neurotoxicity of subacute exposure to 2,2',5,5'-tetrachlorobiphenyl-4-ol, a human metabolite of PCB 52, in male adolescent rats. Toxicology 500:153677. doi:10.1016/j.tox.2023.153677 PMID:37995827 PMCID:PMC10757425
  • Zhang C, Li X, Stietz KP, Sethi S, Yang W, Marek RF, Ding X, Lein PJ, Hornbuckle KC, Lehmler H. 2023. Rebuttal to correspondence on "machine learning-assisted identification and quantification of hydroxylated metabolites of polychlorinated biphenyls in animal samples". Environ Sci Technol 57(15):6251-6252. doi:10.1021/acs.est.3c01659 PMID:37017328

2022

  • Gourronc FA, Helm BK, Robertson LW, Chimenti MS, Lehmler H, Ankrum J, Klingelhutz AJ. 2022. Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB126). Data Brief 45:108571. doi:10.1016/j.dib.2022.108571 PMID:36131953 PMCID:PMC9483567
  • Lehmler H, Uwimana E, Dean LE, Kovalchuk N, Zhang Q, Ding X. 2022. Probing the role of CYP2 enzymes in the atroposelective metabolism of polychlorinated biphenyls using liver microsomes from transgenic mouse models. Chem Res Toxicol 35(12):2310-2323. doi:10.1021/acs.chemrestox.2c00276 PMID:36473170
  • Li X, Hefti MM, Marek RF, Hornbuckle KC, Wang K, Lehmler H. 2022. Assessment of polychlorinated biphenyls and their hydroxylated metabolites in postmortem human brain samples: Age and brain region differences. Environ Sci Technol 56(13):9515-9526. doi:10.1021/acs.est.2c00581 PMID:35658127 PMCID:PMC9260965
  • Li X, Lim JJ, Wang K, Prasad B, Bhatt D, Cui JY, Lehmler H. 2022. The disposition of polychlorinated biphenyls (PCBs) differs between germ-free and conventional mice. Environ Toxicol Pharmacol 92:103854. doi:10.1016/j.etap.2022.103854 PMID:35331926 PMCID:PMC9090986
  • Saktrakulkla P, Li X, Martinez A, Lehmler H, Hornbuckle KC. 2022. Hydroxylated polychlorinated biphenyls are emerging legacy pollutants in contaminated sediments. Environ Sci Technol 56:2269-2278. doi:10.1021/acs.est.1c04780 PMID:35107261 PMCID:PMC8851693
  • Wang H, Adamcakova-Dodd A, Lehmler H, Hornbuckle KC, Thorne PS. 2022. Toxicity assessment of 91-day repeated inhalation exposure to an indoor school air mixture of PCBs. Environ Sci Technol doi:10.1021/acs.est.1c05084 PMID:34994547
  • Yaghoobi B, Miller GW, Holland EB, Li X, Harvey D, Li S, Lehmler H, Pessah IN, Lein PJ. 2022. Ryanodine receptor-active non-dioxin-like polychlorinated biphenyls cause neurobehavioral deficits in larval zebrafish. Front Toxicol 4:947795. doi:10.3389/ftox.2022.947795 PMID:36278027 PMCID:PMC9582434
  • Zhang C, Li X, Flor S, Ruiz P, Kruve A, Ludewig G, Lehmler H. 2022. Metabolism of 3-chlorobiphenyl (PCB 2) in a human-relevant cell line: evidence of dechlorinated metabolites. Environ Sci Technol 56(17):12460-12472. doi:10.1021/acs.est.2c03687 PMID:35994059 PMCID:PMC9573771
  • Zhang D, Saktrakulkla P, Marek RF, Lehmler H, Wang K, Thorne PS, Hornbuckle KC, Duffel MW. 2022. PCB sulfates in serum from mothers and children in urban and rural US communities. Environ Sci Technol doi:10.1021/acs.est.2c00223 PMID:35500099 PMCID:PMC9118556

2021

2020

  • Dhakal RC, Li X, Parkin S, Lehmler H. 2020. Synthesis of mono- and dimethoxylated polychlorinated biphenyl derivatives starting from fluoroarene derivatives. Environ Sci Pollut Res Int 27:8905-8925. doi:10.1007/s11356-019-07133-3
  • Egusquiza RJ, Ambrosio ME, Wang SG, Kay KM, Zhang C, Lehmler H, Blumberg B. 2020. Evaluating the role of the steroid and xenobiotic receptor (SXR/PXR) in PCB-153 metabolism and protection against associated adverse effects during perinatal and chronic exposure in mice. Environ Health Perspect 128:16. doi:10.1289/EHP6262 PMID:32352317 PMCID:PMC7228131
  • Grimm FA, Klaren WD, Li X, Lehmler H, Karmakar M, Robertson LW, Chiu WA, Rusyn I. 2020. Cardiovascular effects of polychlorinated biphenyls and their major metabolites. Environ Health Perspect 128:77008. doi:10.1289/EHP7030 PMID:32701041 PMCID:PMC7377239
  • Li X, Zhang C, Wang K, Lehmler H. 2020. Fatty liver and impaired hepatic metabolism alter the congener-specific distribution of polychlorinated biphenyls (PCBs) in mice with a liver-specific deletion of cytochrome P450 reductase. Environ Pollut 266:115233. doi:10.1016/j.envpol.2020.115233 PMID:32712482 PMCID:PMC7492420
  • Lim JJ, Li X, Lehmler H, Wang D, Gu H, Cui JY. 2020. Gut microbiome critically impacts PCB-induced changes in metabolic fingerprints and the hepatic transcriptome in mice. Toxicol Sci 177:168-187. doi:10.1093/toxsci/kfaa090 PMID:32544245 PMCID:PMC7553702
  • Wang H, Adamcakova-Dodd A, Flor S, Gosse L, Klenov V, Stolwijk J, Lehmler H, Hornbuckle KC, Ludewig G, Thorne PS. 2020. Comprehensive subchronic inhalation toxicity assessment of an indoor school air mixture of PCBs. Environ Sci Technol 54:15976-15985. doi:10.1021/acs.est.0c04470 PMID:33256405 PMCID:PMC7879961
  • Wu X, Zhai G, Schnoor JL, Lehmler H. 2020. Atropselective disposition of 2,2 ,3,4 ,6-Pentachlorobiphenyl (PCB 91) and identification of its metabolites in mice with liver-specific deletion of Cytochrome P450 Reductase. Chem Res Toxicol 33:1328-1338. doi:10.1021/acs.chemrestox.9b00255 PMID:31403789 PMCID:PMC7042073
  • Zhang C, Flor S, Ludewig G, Lehmler H. 2020. Atropselective partitioning of polychlorinated biphenyls in a HepG2 cell culture system: Experimental and modeling results. Environ Sci Technol 54:13817-13827. doi:10.1021/acs.est.0c02508 PMID:33059451 PMCID:PMC7642102
  • Zhang C, Flor S, Ruiz P, Dhakal RC, Hu X, Teesch LM, Ludewig G, Lehmler H. 2020. 3,3'-dichlorobiphenyl is metabolized to a complex mixture of oxidative metabolites, including novel methoxylated metabolites, by HepG2 cells. Environ Sci Technol 54:12345-12357. doi:10.1021/acs.est.0c03476 PMID:32910851 PMCID:PMC7544623

2019

  • Dhakal RC, Parkin S, Lehmler H. 2019. 3,5-Dichloro-3 ,4 -dimethoxybiphenyl. IUCrData 4:doi:10.1107/S2414314619005182
  • Li X, Wu X, Kelly KM, Veng-Pedersen P, Lehmler H. 2019. Toxicokinetics of chiral PCB 136 and its hydroxylated metabolites in mice with a liver-specific deletion of cytochrome P450 reductase. Chem Res Toxicol 32:727-736. doi:10.1021/acs.chemrestox.8b00389 PMID:30729780 PMCID:PMC6465157
  • Saktrakulkla P, Dhakal RC, Lehmler H, Hornbuckle KC. 2019. A semi-target analytical method for quantification of OH-PCBs in environmental samples. Environ Sci Pollut Res Int 1-13. doi:10.1007/s11356-019-05775-x PMID:31359319 PMCID:PMC6986979
  • Sethi S, Morgan RK, Feng W, Lin Y, Li X, Luna C, Koch M, Bansal R, Duffel MW, Puschner B, Zoeller RT, Lehmler H, Pessah IN, Lein PJ. 2019. Comparative analyses of the 12 most abundant PCB congeners detected in human maternal serum for activity at the thyroid hormone receptor and ryanodine receptor. Environ Sci Technol 53:3948-3958. doi:10.1021/acs.est.9b00535 PMID:30821444 PMCID:PMC6457253
  • Uwimana E, Cagle B, Yeung C, Li X, Patterson EV, Doorn JA, Lehmler H. 2019. Atropselective oxidation of 2,2 ,3,3 ,4,6 -hexachlorobiphenyl (PCB 132) to hydroxylated metabolites by human liver microsomes and its implications for pcb 132 neurotoxicity. Toxicology 171:406-420. doi:10.1093/toxsci/kfz150 PMID:31268529 PMCID:PMC6760323
  • Uwimana E, Ruiz P, Li X, Lehmler H. 2019. Human CYP2A6, CYP2B6, and CYP2E1 atropselectively metabolize polychlorinated biphenyls to hydroxylated metabolites. Environ Sci Technol 53(4):2114-2123. doi:10.1021/acs.est.8b05250 PMID:30576102 PMCID:PMC6380921

2018

  • Alam S, Carter GS, Krager KJ, Li X, Lehmler H, Aykin-Burns N. 2018. PCB11 metabolite, 3,3-dichlorobiphenyl-4-ol, exposure alters the expression of genes governing fatty acid metabolism in the absence of functional sirtuin 3: examining the contribution of MnSOD. Antioxidants (Basel) 7(9):121. doi:10.3390/antiox7090121 PMID:30223548
  • Cheng SL, Li X, Lehmler H, Phillips B, Shen D, Cui JY. 2018. Gut microbiota modulates interactions between polychlorinated biphenyls and bile acid homeostasis. Toxicol Sci 166:269-287. doi:10.1093/toxsci/kfy208 PMID:30496569 PMCID:PMC6260149
  • Das S, Oldham E, Lehmler H, Knutson BL, Rankin S. 2018. Tuning the position of head groups by surfactant design in mixed micelles of cationic and carbohydrate surfactants. Journal of Colloid and Interface Science 517:428-438. doi:10.1016/j.jcis.2017.10.066 PMID:29096103
  • Dhakal K, Gadupudi GS, Lehmler H, Ludewig G, Duffel MW, Robertson LW. 2018. Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs). Environ Sci Pollut Res Int 25:16277-16290. doi:10.1007/s11356-017-9694-x PMID:28744683 PMCID:PMC5785587
  • Li X, Holland EB, Feng W, Zheng J, Dong Y, Pessah IN, Duffel MW, Robertson LW, Lehmler H. 2018. Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example. Environ Sci Pollut Res Int 25(17):1-14. doi:10.1007/s11356-017-1162-0 PMID:29322390 PMCID:PMC6015536
  • Li X, Parkin S, Lehmler H. 2018. Absolute configuration of 2,2',3,3',6-pentachlorinatedbiphenyl (PCB 84) atropisomers. Environ Sci Pollut Res Int 25:16402-16410. doi:10.1007/s11356-017-9259-z PMID:28537024 PMCID:PMC5823790
  • Liu Y, Richardson ES, Derocher AE, Lunn NJ, Lehmler H, Li X, Zhang Y, Cui JY, Cheng L, Martin JW. 2018. Hundreds of unrecognized halogenated contaminants discovered in polar bear serum. Angew Chem Int Ed Engl 57:16401-16406. doi:10.1002/anie.201809906 PMID:30376612
  • Parker VS, Squirewell EJ, Lehmler H, Robertson LW, Duffel MW. 2018. Hydroxylated and sulfated metabolites of commonly occurring airborne polychlorinated biphenyls inhibit human steroid sulfotransferases SULT1E1 and SULT2A1. Environ Toxicol Pharmacol 58:196-201. doi:10.1016/j.etap.2018.01.010 PMID:29408762 PMCID:PMC6078096
  • Pencikova K, Svrzkova L, Strapacova S, Neca J, Bartonkova I, Dvorak Z, Hyzdalova M, Pivnicka J, Palkova L, Lehmler H, Li X, Vondracek J, Machala M. 2018. In vitro profiling of toxic effects of prominent environmental lower-chlorinated PCB congeners linked with endocrine disruption and tumor promotion. Environ Pollut 237:473-486. doi:10.1016/j.envpol.2018.02.067 PMID:29518658 PMCID:PMC5908724
  • Rodriguez EA, Vanle BC, Doorn JA, Lehmler H, Robertson LW, Duffel MW. 2018. Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells. Environ Toxicol Pharmacol 62:69-78. doi:10.1016/j.etap.2018.06.010 PMID:29986280 PMCID:PMC609219
  • Uwimana E, Li X, Lehmler H. 2018. Human liver microsomes atropselectively metabolize 2,2 ',3,4 ',6-pentachlorobiphenyl (PCB 91) to a 1,2-shift product as the major metabolite. Environ Sci Technol 52:6000-6008. doi:10.1021/acs.est.8b00612 PMID:29659268 PMCID:PMC5966832

2017

  • Das S, Xu W, Lehmler H, Miller A, Knutson BL, Rankin S. 2017. Inverted micelle-in-micelle configuration in cationic/carbohydrate surfactant mixtures. Chemphyschem 18(1):79-86. doi:10.1002/cphc.201600908 PMID:27788284
  • Grimm FA, Lehmler H, Koh W, DeWall J, Teesch LM, Hornbuckle KC, Thorne PS, Robertson LW, Duffel MW. 2017. Identification of a sulfate metabolite of PCB 11 in human serum. Environ Int 98:120-128. doi:10.1016/j.envint.2016.10.023 PMID:27816204 PMCID:PMC5127762
  • Holland EB, Feng W, Zheng J, Dong Y, Li X, Lehmler H, Pessah IN. 2017. An extended structure-activity relationship of nondioxin-like PCBs evaluates and supports modeling predictions and identifies picomolar potency of PCB 202 towards ryanodine receptors. Toxicol Sci 155(1):170-181. doi:10.1093/toxsci/kfw189 PMID:27655348 PMCID:PMC5216651
  • Joshi S, Lehmler H, Knutson BL, Rankin S. 2017. Imprinting of Stöber particles for chirally-resolved adsorption of target monosaccharides and disaccharides. New J Chem 20(41):11525-11532. doi:10.1039/C7NJ01938F
  • Kania-Korwel I, Lukasiewicz T, Barnhart CD, Stamou M, Chung H, Kelly KM, Bandiera SM, Lein PJ, Lehmler H. 2017. Congener-specific disposition of chiral polychlorinated biphenyls in lactating mice and their offspring: Implications for PCB developmental neurotoxicity. Toxicol Sci 158(1):101-115. doi:10.1093/toxsci/kfx071 PMID:28431184 PMCID:PMC6070089
  • Kania-Korwel I, Wu X, Wang K, Lehmler H. 2017. Identification of lipidomic markers of chronic 3,3 ,4,4 ,5-pentachlorobiphenyl (PCB 126) exposure in the male rat liver. Toxicology 390:124-134. doi:10.1016/j.tox.2017.09.005 PMID:28890136 PMCID:PMC5633524
  • Klinefelter K, Hoover MK, Bates C, Colter BT, Dailey A, Infante SK, Kania-Korwel I, Lehmler H, Lopez-Juarez A, Ludwig CP, Curran CP. 2017. Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders. Mamm Genome 1-16. doi:10.1007/s00335-017-9728-1 PMID:29197979
  • Liu B, Lehmler H, Sun Y, Xu G, Sun Q, Hu F, Wallace RB, Boa W, Hu FB, Zhong G, Liu Y. 2017. Bisphenol A substitutes and obesity in US adults: analysis of a population-based, cross-sectional study. Lancet Planet Health 1(3):e114-e122. doi:10.1016/S2542-5196(17)30049-9 PMID:29308453 PMCID:PMC5751959
  • Schroer HW, Langenfeld KL, Li X, Lehmler H, Just CL. 2017. Biotransformation of 2,4-dinitroanisole by a fungal Penicillium sp. Biodegradation 28(1):95-109. doi:10.1007/s10532-016-9780-7 PMID:27913891
  • Schroer HW, Li X, Lehmler H, Just CL. 2017. Metabolism and photolysis of 2,4-Dinitroanisole in Arabidopsis. Environ Sci Technol 51:13714-13722. doi:10.1021/acs.est.7b04220 PMID:29131608
  • Sethi S, Keil KP, Chen H, Hayakawa K, Li X, Lin Y, Lehmler H, Puschner B, Lein PJ. 2017. Detection of 3,3 '-dichlorobiphenyl in human maternal plasma and its effects on axonal and dendritic growth in primary rat neurons. Toxicol Sci 158(2):401-411. doi:10.1093/toxsci/kfx100 PMID:28510766 PMCID:PMC5837364
  • Uwimana E, Maiers A, Li X, Lehmler H. 2017. Microsomal metabolism of prochiral polychlorinated biphenyls results in the enantioselective formation of chiral metabolites. Environ Sci Technol 51(3):1820-1829. doi:10.1021/acs.est.6b05387 PMID:28038482 PMCID:PMC5300040
  • Zhao H, Lehmler H, Chen J, Liu S, Cai X. 2017. Antibiotic pollution in marine food webs in laizhou bay, north China: trophodynamics and human exposure implication. Environ Sci Technol 51(4):doi:10.1021/acs.est.6b04556 PMID:28106989 PMCID:PMC5618103

2016

2015

2014

  • Aqil F, Shen H, Jeyabalan J, Xin X, Lehmler H, Ludewig G, Robertson LW, Gupta RC. 2014. Sustained expression of CYPs and DNA adduct accumulation with continuous exposure to PCB126 and PCB153 through a new delivery method: Polymeric implants. Toxicol Rep 1:820-833. doi:10.1016/j.toxrep.2014.09.010 PMID:25530946 PMCID:PMC4266188
  • Dhakal K, Uwimana E, Adamcakova-Dodd A, Thorne PS, Lehmler H, Robertson LW. 2014. Disposition of phenolic and sulfated metabolites after inhalation exposure to 4-chlorobiphenyl (PCB3) in female rats. Chem Res Toxicol 27(8):1411-1420. doi:10.1021/tx500150h PMID:24988477 PMCID:PMC4137987
  • Ekuase EJ, Lehmler H, Robertson LW, Duffel MW. 2014. Binding interactions of hydroxylated polychlorinated biphenyls (OHPCBs) with human hydroxysteroid sulfotransferase hSULT2A1. Chem Biol Interact 212:56-64. doi:10.1016/j.cbi.2014.01.018 PMID:24508592 PMCID:PMC3994546
  • Li X, Parkin S, Lehmler H. 2014. 2,4-Di-chloro-1-iodo-6-nitro-benzene. Acta Crystallogr B 70(Pt5):o607. doi:10.1107/S1600536814008733 PMID:24860400 PMCID:PMC4011245
  • Stamou M, Wu X, Kania-Korwel I, Lehmler H, Lein PJ. 2014. Cytochrome p450 mRNA expression in the rodent brain: species-, sex-, and region-dependent differences. Drug Metab Dispos 42(2):239-244. doi:10.1124/dmd.113.054239 PMID:24255117 PMCID:PMC3912540
  • Staudt S, Kundu S, Lehmler H, He X, Cui T, Lin Y, Kristensen K, Glasius M, Zhang X, Weber R, Surratt JD, Stone EA. 2014. Aromatic organosulfates in atmospheric aerosols: synthesis, characterization, and abundance. Atmos Environ (1994) 94:366-373. doi:10.1016/j.atmosenv.2014.05.049 PMID:24976783 PMCID:PMC4071301
  • Sueyoshi T, Li L, Wang H, Moore R, Kodavanti PS, Lehmler H, Negishi M, Birnbaum LS. 2014. Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes. Toxicol Sci 137(2):292-302. doi:10.1093/toxsci/kft243 PMID:24218150 PMCID:PMC3908718
  • Wu X, Kammerer A, Lehmler H. 2014. Microsomal oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) results in species-dependent chiral signatures of the hydroxylated metabolites. Environ Sci Technol 48(4):2436-2444. doi:10.1021/es405433t PMID:24467194 PMCID:PMC3983324
  • Yang DR, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler H, Lein PJ. 2014. PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms. Toxicol Sci 138(2):379-392. doi:10.1093/toxsci/kft334 PMID:24385416 PMCID:PMC4007107
  • Zhai G, Lehmler H, Schnoor JL, Gutowski SM. 2014. Enantioselective transport and biotransformation of chiral hydroxylated metabolites of polychlorinated biphenyls in whole poplar plants. Environ Sci Technol 48(20):12213-12220. doi:10.1021/es503443e PMID:25238141 PMCID:PMC4207536

2013

2012

  • Ambati J, Song Y, Rankin S, Lehmler H. 2012. Density functional theory study of semiquinone radical anions of polychlorinated biphenyls in the syn- and anti-like conformation. J Phys Chem A 116:1586-1595. doi:10.1021/jp2077193 PMID:22257259 PMCID:PMC3417754
  • Dhakal K, He X, Lehmler H, Teesch LM, Duffel MW, Robertson LW. 2012. Identification of sulfated metabolites of 4-chlorobiphenyl (PCB3) in the serum and urine of male rats. Chem Res Toxicol 25(12):2796-2804. doi:10.1021/tx300416v PMID:23137097 PMCID:PMC3524396
  • Hu X, Adamcakova-Dodd A, Lehmler H, Hu D, Hornbuckle KC, Thorne PS. 2012. Subchronic inhalation exposure study of an airborne polychlorinated biphenyl mixture resembling the Chicago ambient air congener profile. Environ Sci Technol 46(17):9653-9662. doi:10.1021/es301129h PMID:22846166 PMCID:PMC3573703
  • Kania-Korwel I, Barnhart CD, Stamou M, Truong KM, El-Komy MH, Lein PJ, Veng-Pedersen P, Lehmler H. 2012. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. Environ Sci Technol 46(20):11393-11401. doi:10.1021/es302810t PMID:22974126 PMCID:PMC3475189
  • Oldham E, Xie W, Farnoud AM, Fiegel J, Lehmler H. 2012. Disruption of phosphatidylcholine mono layers and bilayers by perfluorobutane sulfonate. Journal of Physical Chemistry B 116:9999-10007. doi:10.1021/jp304412p PMID:22834732 PMCID:PMC3464004

2011

  • Bunaciu RP, Tharappel JC, Lehmler H, Lee EY, Robertson LW, Bruckner GG, Spear BT, Glauert HP. 2011. Role of oil vehicle on hepatic cell proliferation in PCB-treated rats. J Environ Pathol Toxicol Oncol 30(4):273-282. PMID:22181977 PMCID:PMC3522147
  • Ekuase EJ, Liu Y, Lehmler H, Robertson LW, Duffel MW. 2011. Structure-activity relationships for hydroxylated polychlorinated biphenyls as inhibitors of the sulfation of dehydroepiandrosterone catalyzed by human hydroxysteroid sulfotransferase SULT2A1. Chem Res Toxicol 24:1720-1728. doi:10.1021/tx200260h PMID:21913674 PMCID:PMC3196794
  • Joshi SN, Vyas SM, Duffel MW, Parkin S, Lehmler H. 2011. Synthesis of sterically hindered polychlorinated biphenyl derivatives. Synthesis 7:1045-1054. doi:10.1055/s-0030-1258454 PMID:21516177 PMCID:PMC3080045
  • Joshi SN, Vyas SM, Wu H, Duffel MW, Parkin S, Lehmler H. 2011. Regioselective iodination of chlorinated aromatic compounds using silver salts. Tetrahedron 67(39):7461-7469. doi:10.1016/j.tet.2011.07.064 PMID:21918585 PMCID:PMC3170769
  • Kania-Korwel I, Duffel MW, Lehmler H. 2011. Gas chromatographic analysis with chiral cyclodextrin phases reveals the enantioselective formation of hydroxylated polychlorinated biphenyls by rat liver microsomes. Environ Sci Technol 45:9590-9596. doi:10.1021/es2014727 PMID:21966948 PMCID:PMC3216237
  • Liu Y, Lehmler H, Robertson LW, Duffel MW. 2011. Physicochemical properties of hydroxylated polychlorinated biphenyls aid in predicting their interactions with rat sulfotransferase 1A1 (rSULT1A1). Chem Biol Interact 189:153-160. doi:10.1016/j.cbi.2010.11.009 PMID:21130751 PMCID:PMC3032042
  • Senthilkumar PK, Klingelhutz AJ, Jacobus JA, Lehmler H, Robertson LW, Ludewig G. 2011. Airborne polychlorinated biphenyls (PCBs) reduce telomerase activity and shorten telomere length in immortal human skin keratinocytes (HaCat). Toxicol Lett 204:64-70. doi:10.1016/j.toxlet.2011.04.012 PMID:21530622 PMCID:PMC3109099
  • Song Y, Ambati J, Parkin S, Rankin S, Robertson LW, Lehmler H. 2011. Crystal structure and density functional theory studies of toxic quinone metabolites of polychlorinated biphenyls. Chemosphere 85:386-392. doi:10.1016/j.chemosphere.2011.07.004 PMID:21824639 PMCID:PMC3206982
  • Wu X, Pramanik A, Duffel MW, Hrycay EG, Bandiera SM, Lehmler H, Kania-Korwel I. 2011. 2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) is enantioselectively oxidized to hydroxylated metabolites by rat liver microsomes. Chem Res Toxicol 24(12):2249-2257. doi:10.1021/tx200360m PMID:22026639 PMCID:PMC3243785
  • Zhai G, Lehmler H, Schnoor JL. 2011. New hydroxylated metabolites of 4-monochlorobiphenyl in whole poplar plants. Chem Cent J 5:87. doi:10.1186/1752-153X-5-87 PMID:22185578 PMCID:PMC3260099
  • Zhai G, Lehmler H, Schnoor JL, Hu D. 2011. Enantioselective biotransformation of chiral PCBs in whole poplar plants. Environ Sci Technol 45(6):2308-2316. doi:10.1021/es1033662 PMID:21329345 PMCID:PMC3066656

2010

2009

2008

  • Glauert HP, Tharappel JC, Banerjee S, Chan NL, Kania-Korwel I, Lehmler H, Lee EY, Robertson LW, Spear BT. 2008. Inhibition of the promotion of hepatocarcinogenesis by 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) by the deletion of the p50 subunit of NF-kappa B in mice. Toxicol Appl Pharmacol 232(2):302-308. doi:10.1016/j.taap.2008.06.013 PMID:18644402 PMCID:PMC2583134
  • Glauert HP, Tharappel JC, Lu Z, Stemm DN, Banerjee S, Chan L, Lee EY, Lehmler H, Robertson LW, Spear BT. 2008. Role of oxidative stress in the promoting activities of pcbs. Environ Toxicol Pharmacol 25(2):247-250. doi:10.1016/j.etap.2007.10.025 PMID:19122744 PMCID:PMC2836878
  • Kania-Korwel I, Hornbuckle KC, Robertson LW, Lehmler H. 2008. Dose-dependent enantiomeric enrichment of 2,2',3,3',6,6'-hexachlorobiphenyl in female mice. Environ Toxicol Chem 27(2):299-305. doi:10.1897/07-359R.1 PMID:18348647
  • Kania-Korwel I, Hornbuckle KC, Robertson LW, Lehmler H. 2008. Influence of dietary fat on the enantioselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in female mice. Food Chem Toxicol 46(2):637-644. doi:10.1016/j.fct.2007.09.072 PMID:17950514 PMCID:PMC2289907
  • Kania-Korwel I, Hrycay EG, Bandiera SM, Lehmler H. 2008. 2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) atropisomers interact enantioselectively with hepatic microsomal cytochrome P450 enzymes. Chem Res Toxicol 21(6):1295-1303. doi:10.1021/tx800059j PMID:18494506 PMCID:PMC2574739
  • Kania-Korwel I, Vyas SM, Song Y, Lehmler H. 2008. Gas chromatographic separation of methoxylated polychlorinated biphenyl atropisomers. J Chromatogr A 1207:146-154. PMID:18760792
  • Kania-Korwel I, Xie W, Hornbuckle KC, Robertson LW, Lehmler H. 2008. Enantiomeric enrichment of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in mice after induction of CYP enzymes. Arch Environ Contam Toxicol 55(3):510-517. doi:10.1007/s00244-007-9111-4 PMID:18437444
  • Kania-Korwel I, Zhao H, Norstrom K, Li X, Hornbuckle KC, Lehmler H. 2008. Simultaneous extraction and clean-up of polychlorinated biphenyls and their metabolites from small tissue samples using pressurized liquid extraction. J Chromatogr A 1214(1-2):37-46. doi:10.1016/j.chroma.2008.10.089 PMID:19019378 PMCID:PMC2648864
  • Sacco JC, Lehmler H, Robertson LW, Li W, James MO. 2008. Glucuronidation of polychlorinated biphenylols and UDP-glucuronic acid concentrations in channel catfish liver and intestine. Drug Metab Dispos 36(4):623-630. doi:10.1124/dmd.107.019596 PMID:18180271
  • Song Y, Buettner GR, Parkin S, Wagner BA, Robertson LW, Lehmler H. 2008. Chlorination increases the persistence of semiquinone free radicals derived from polychlorinated biphenyl hydroquinones and quinones. J Org Chem 73(21):8296-8304. doi:10.1021/jo801397g PMID:18839991 PMCID:PMC2629131
  • Stemm DN, Tharappel JC, Lehmler H, Srinivasan C, Morris J, Spate VL, Robertson LW, Spear BT, Glauert HP. 2008. Effect of dietary selenium on the promotion of hepatocarcinogenesis by 3,3', 4,4'-tetrachlorobiphenyl and 2,2', 4,4', 5,5'-hexachlorobiphenyl. Exp Biol Med (Maywood) 233(3):366-376. doi:10.3181/0708-RM-211 PMID:18296742
  • Tharappel JC, Lehmler H, Srinivasan C, Robertson LW, Spear BT, Glauert HP. 2008. Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3',4,4'-tetrachlorobiphenyl (PCB-77). Food Chem Toxicol 46(11):3467-3474. doi:10.1016/j.fct.2008.08.023 PMID:18796325 PMCID:PMC2597727
  • Venkatesha VA, Venkataraman S, Sarsour EH, Kalen AL, Buettner GR, Robertson LW, Lehmler H, Goswami PC. 2008. Catalase ameliorates polychlorinated biphenyl-induced cytotoxicity in nonmalignant human breast epithelial cells. Free Radic Biol Med 45(8):1094-1102. doi:10.1016/j.freeradbiomed.2008.07.007 PMID:18691649 PMCID:PMC2614346

2007

  • Bunaciu RP, Tharappel JC, Lehmler H, Kania-Korwel I, Robertson LW, Srinivasan C, Spear BT, Glauert HP. 2007. The effect of dietary glycine on the hepatic tumor promoting activity of polychlorinated biphenyls (PCBs) in rats. Toxicology 239(3):147-55. PMID:17703865
  • Kania-Korwel I, Shaikh NS, Hornbuckle KC, Robertson LW, Lehmler H. 2007. Enantioselective disposition of PCB 136 (2,2',3,3',6,6'-hexachlorobiphenyl) in C57BL/6 mice after oral and intraperitoneal administration. Chirality 19(1):56-66. doi:10.1002/chir.20342 PMID:17089340
  • Sadeghi-aliabadi H, Chan K, Lehmler H, Robertson LW, O-Brian PJ. 2007. Molecular cytotoxic mechanisms of catecholic polychlorinated biphenyl metabolites in isolated rat hepatocytes. Chem Biol Interact 167:184-192. PMID:17408604
  • Song Y, Parkin S, Lehmler H. 2007. 4-Bromo-2-chloro-1-methoxybenzene. Acta Crystallogr B 63:2091-2092.

2006

  • Bender RP, Lehmler H, Robertson LW, Ludewig G, Osheroff N. 2006. Polychlorinated biphenyl quinone mtabolites Poison human topoisomerase II: Altering enzyme function by blocking the N-terminal protein gate. Biochemistry 45(33):10140-10152. PMID:16906772
  • Feliciano JS, Xu S, Guan X, Lehmler H, Bachas LG, Daunert S. 2006. ClcR-based biosensing system in the detection of cis-dihydroxylated (chloro-)biphenyls. Anal Bioanal Chem 385(5):807-813. PMID:16791559
  • Kania-Korwel I, Garrison AW, Avants JK, Hornbuckle KC, Robertson LW, Sulkowski WW, Lehmler H. 2006. Distribution of chiral PCBs in selected tissues in the laboratory rat. Environ Sci Technol 40(12):3704-3710. PMID:16830530
  • Kunz S, Schwarz M, Schilling B, Papke O, Lehmler H, Robertson LW, Schrenk D, Schmitz H. 2006. Tumor promoting potency of PCBs 28 and 101 in rat liver. Toxicol Lett 164(2):133-143. PMID:16426774
  • Liu Y, Apak TI, Lehmler H, Robertson LW, Duffel MW. 2006. Hydroxylated polychlorinated biphenyls are substrates and inhibitors of human hydroxysteroid sulfotransferase SULT2A1. Chem Res Toxicol 19(11):1420-1425. PMID:17112228
  • Ptak A, Ludewig G, Kapiszewska M, Magnowska Z, Lehmler H, Robertson LW, Gregoraszczuk EL. 2006. Induction of cytochromes P450, caspase-3 and DNA damage by PCB3 and its hydroxylated metabolites in porcine ovary. Toxicol Lett 166(3):200-211. PMID:16949219
  • Ptak A, Ludewig G, Robertson LW, Lehmler H, Gregoraszczuk EL. 2006. In vitro exposure of porcine prepubertal follicles to 4-chlorobiphenyl (PCB3) and its hydroxylated metabolites: Effects on sex hormone levels and aromatase activity. Toxicol Lett 164(2):113-122. PMID:16412591
  • Shaikh NS, Swenson DC, Lehmler H. 2006. 2,3,6-Trichloroiodobenzene. Acta Crystallogr B E62,Part10:o4672-o4673.
  • Vyas SM, Parkin S, Robertson LW, Lehmler H. 2006. 2,5-Dichloro-4'-methoxybiphenyl. Acta Crystallogr B E62,Part9:o4162-o4163.
  • Vyas SM, Parkin S, Robertson LW, Lehmler H. 2006. 4-Chloro-2',3'-dimethoxybiphenyl. Acta Crystallogr B E62,Part9:o3639-o3640.
  • Wang L, Lehmler H, Robertson LW, James MO. 2006. Polychlorobiphenylols are selective inhibitors of human phenol sulfotransferase 1A1 with 4-nitrophenol as a substrate. Chem Biol Interact 159(3):235-246. PMID:16413005

2005

  • Glauert HP, Lu Z, Kumar A, Bunaciu RP, Patel S, Tharappel JC, Stemm DN, Lehmler H, Lee EY, Robertson LW, Spear BT. 2005. Dietary vitamin E does not inhibit the promotion of liver carcinogenesis by polychlorinated biphenyls in rats. J Nutr 135(2):283-286. PMID:15671227
  • Wang L, Lehmler H, Robertson LW, James MO. 2005. In vitro inhibition of human hepatic and cDNA-expressed sulfotransferase activity with 3-hydroxybenzo[a]pyrene by polychlorobiphenylols. Environ Health Perspect 113(6):680-687. PMID:15929889 PMCID:PMC1257591

2004

  • Espandiari P, Glauert HP, Lehmler H, Lee EY, Srinivasan C, Robertson LW. 2004. Initiating activity of 4-chlorobiphenyl metabolites in the resistant hepatocyte model. Toxicol Sci 79(1):41-46. PMID:14976334
  • Gauger KJ, Kato Y, Haraguchi K, Lehmler H, Robertson LW, Bansal R, Zoeller RT. 2004. Polychlorinated biphenyls (PCBs) exert thyroid hormone-like effects in the fetal rat brain but do not bind to thyroid hormone receptors. Environ Health Perspect 112(5):516-523. PMID:15064154
  • Machala M, Blaha L, Lehmler H, Pliskova M, Majkova Z, Kapplova P, Sovadinova I, Vondracek J, Malmberg T, Robertson LW. 2004. Toxicity of hydroxylated and quinoid PCB metabolites: inhibition of gap junctional intercellular communication and activation of aryl hydrocarbon and estrogen receptors in hepatic and mammary cells. Chem Res Toxicol 17(3):340-347. doi:10.1021/tx030034v PMID:15025504

2003

  • Arif JM, Lehmler H, Robertson LW, Gupta RC. 2003. Interaction of benzoquinone- and hydroquinone-derivatives of lower chlorinated biphenyls with DNA and nucleotides in vitro. Chem Biol Interact 142(3):307-316. PMID:12453668
  • Espandiari P, Glauert HP, Lehmler H, Lee EY, Srinivasan C, Robertson LW. 2003. Polychlorinated biphenyls (PCBs) as initiators in liver carcinogensis: resistant hepatocyte model. Toxicol Appl Pharmacol 186(1):55-62. PMID:12583993
  • Espandiari P, Lehmler H, Stemm DN, Glauert HP, Robertson LW. 2003. PCB metabolites as initiating agents in hepatocarcinogenesis. In: Proceedings of the 42nd Annual Meeting of the Society of Toxicology (SOT), March 9-13, 2003. Salt Lake City, UT.
  • Espandiari P, Lehmler H, Stemm DN, Glauert HP, Robertson LW. 2003. PCB metabolites as initiating agents in hepatocarcinogenesis. Toxicol Sci 72(S-1):1145.
  • Kania-Korwel I, Lehmler H, Robertson LW, Parkin S. 2003. 2,4,5-trichloro-1-iodobenzene. Acta Crystallogr B E59(Part7):o1048-o1049.
  • Kania-Korwel I, Robertson LW, Lehmler H, Parkin S. 2003. 2,4,6-Trichloroiodobenzene. Acta Crystallogr B E59(Part1):o1770-o1771.
  • Lehmler H, Price DJ, Garrison AW, Birge WJ, Robertson LW. 2003. Distribution of PCB 84 atropisomers in female C57BL/6 mice. Presented at the 42nd Annual Meeting of the Society of Toxicology in Salt Lake City, Utah, March 9-13, 2003. In: Proceedings of the 42nd Annual Meeting of the Society of Toxicology (SOT), March 9-13, 2003. Salt Lake City, UT.
  • Lehmler H, Price DJ, Garrison AW, Birge WJ, Robertson LW. 2003. Distribution of PCB 84 Enantiomers in C57BL/6 Mice. Fresenius Environmental Bulletin 12(2):254-260.

2002

  • James MO, van den Hurk P, Kubiczak GA, Robertson LW, Lehmler H. 2002. Hydroxylated PCBs that are poor substrates but good inhibitors of UDP-glucuronosyltransferase in the channel catfish. FASEB J 16:A573.
  • James MO, Wang L, Faux LR, Lehmler H, Robertson LW. 2002. Hydroxylated PCB as inhibitors of the glucuronidation and sulfonation of hydroxylated benzo(a)pyrene metabolites. In: Proceedings of the 2nd International PCB (Polychlorinated Biphenyls) workshop. Brno, Czech Republic.
  • Lehmler H, Parkin S, Robertson LW. 2002. The three-dimensional structure of 3,3 ',5 '-trichloro-4-methoxybiphenyl, a "coplanar" polychlorinated biphenyl (PCB) derivative. Chemosphere 46(3):485-488. PMID:11829405
  • Lehmler H, Robertson LW, Parkin S. 2002. 2-(3,5-Dichlorophenyl)-1,4-benzoquinone. Acta Crystallogr B E58:o366-o367.
  • Lehmler H, Robertson LW, Parkin S, Brock CP. 2002. Z'=4 structure without obvious pseudosymmetry: implications for the formation of solid-state compounds. Acta Crystallogr B 58(Pt1):140-147. PMID:11818662
  • Machala M, Blaha L, Pliskova M, Vondracek J, Lehmler H, Malmberg T, Robertson LW. 2002. Comparison of relative toxic potencies of hydroxylated PCBs and quinones in hepatic and mammary cell lines. Organohalogen Compounds 56:25-28.
  • Tampal N, Lehmler H, Espandiari P, Malmberg T, Robertson LW. 2002. Glucuronidation of hydroxylated polychlorinated biphenyls (PCBs). Chem Res Toxicol 15(10):1259-1266. doi:10.1021/tx0200212 PMID:12387623
  • van den Hurk P, Kubiczak GA, Lehmler H, James MO. 2002. Hydroxylated polychlorinated biphenyls as inhibitors of the sulfation and glucuronidation of 3-hydroxy-benzo[a]pyrene. Environ Health Perspect 110(4):343-348. PMID:11940451 PMCID:PMC1240796
  • Wang L, Lehmler H, Robertson LW, James MO. 2002. In vitro inhibition of sulfotransferase activity of 3-hydroxy-benzo(a)pyrene by hydroxylated PCBs. In: Proceedings of the 11th North American ISSX (International Study of Xenobiotics) Meeting, October 27-31. Orlando, FL.
  • Wang L, Lehmler H, Robertson LW, James MO. 2002. In vitro inhibition of sulfotransferase activity of 3-hydroxy-benzo(a)pyrene by hydroxylated PCBs. J Mol Biol Suppl34:195.

2001

  • Arif JM, Lehmler H, Robertson LW, Gupta RC. 2001. Covalent interaction of synthetic benzoquinones and hydroquinones of polychlorinated biphenyls with DMA. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY. pp.403-404.
  • Lehmler H, Brock CP, Patrick B, Robertson LW. 2001. Synthesis of polychlorinated biphenyls (PCBs) and their metabolites using the Suzuki-Coupling. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY.
  • Lehmler H, Parkin S, Robertson LW. 2001. 2,3,4-Trichlorobiphenyl. Acta Crystallogr B E57Part2:o111-o112.
  • Lehmler H, Robertson LW. 2001. Atropisomers of PBCs. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY. pp.61-66.
  • Lehmler H, Robertson LW. 2001. Synthesis of hydroxylated PCB metabolites with the Suzuki-coupling. Chemosphere 45(8):1119-1127. PMID:11695625
  • Lehmler H, Robertson LW. 2001. Synthesis of polychlorinated biphenyls (PCBs) using the Suzuki-Coupling. Chemosphere 45(2):137-143. PMID:11572605
  • Lehmler H, Robertson LW, Parkin S. 2001. 4-Chloro-3',4'-dihydroxybiphenyl. Acta Crystallogr B E57Part7:o590-o591.
  • Oakley GG, Roe AL, Blouin RA, Twaroski TP, Ganguly TC, Vore M, Lehmler H, Robertson LW. 2001. 2,4,4'-trichlorobiphenyl increases STAT5 transcriptional activity. Mol Carcinog 30(4):199-208. PMID:11346882
  • Slim RM, Toborek M, Robertson LW, Lehmler H, Hennig B. 2001. Cellular glutathione status modulates PCB-induced stress response and apoptosis in vascular endothelial cells. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY. pp.313-315.
  • Srinivasan A, Lehmler H, Robertson LW, Ludewig G. 2001. Production of DNA strand breaks in vitro and Reactive Oxygen Species in vitro and in HL-60 cells by PCB Metabolites. Toxicol Sci 60(1):92-102. PMID:11222876
  • Tampal N, Robertson LW, Lehmler H, Srinivasan C, Ludewig G. 2001. PCBs as Substrates for the MDR Transporter. In: Proceedings of the 40th Annual Meeting of the Society of Toxicology (SOT), March 25-29, 2001. San Franciso, CA.
  • Tampal N, Robertson LW, Lehmler H, Srinivasan C, Ludewig G. 2001. PCBs as Substrates for the MDR Transporter. Environ Health Perspect 60(1):1118.

2000

  • Ludewig G, Espandiari P, Festag M, Lehmler H, Pereg D, Srinivasan A, Tampal N, Twaroski TP, Arif JM, Gupta RC, Robertson LW. 2000. Mechanisms of cancer induction by polychlorinated biphenyls (PCBs). In: Proceedings of the 2nd Department of Defense Breast Cancer Research Program, 2000. Alanta, GA. pp.325.
  • Ludewig G, Espandiari P, Festag M, Lehmler H, Pereg D, Srinivasan A, Tampal N, Twaroski TP, Arif JM, Gupta RC, Robertson LW. 2000. Mechanisms of cancer induction by polychlorinated biphenyls (PCBs). In: Proceedings of the "Era of Hope" Department of Defense Breast Cancer Research Program Meeting, June 8-11, 2000. Atlanta, GA.
  • Ludewig G, Lehmler H, Boivin R, Srinivasan A, Robertson LW. 2000. Reactivity of halogenated and non-halogenated dihydroxy-biphenyls in vitro and in cells in culture. In: Proceedings of the 39th Annual Meeting of the Society of Toxicology (SOT), March 19-23, 2000. Philadelphia, PA.
  • Ludewig G, Lehmler H, Boivin R, Srinivasan A, Robertson LW. 2000. Reactivity of halogenated and non-halogenated dihydroxy-biphenyls in vitro and in cells in culture. Toxicol Sci 54(1):76.
  • Robertson LW, Espandiari P, Lehmler H, Pereg D, Srinivasan A, Tampal N, Twaroski TP, Ludewig G, Glauert HP, Arif JM, Gupta RC. 2000. Metabolism and activation of polychlorinated biphenyls (PCBs). Cent Eur J Public Health 8Suppl:14-15. PMID:10943437
  • Slim RM, Toborek M, Robertson LW, Lehmler H, Hennig B. 2000. Cellular glutathione status modulates PCB-induced stress response and apoptosis in porcine endothelial cells. In: Proceedings of the 39th Annual Meeting of the Society of Toxicology (SOT), March 19-23, 2000. Philadelphia, PA.
  • Slim RM, Toborek M, Robertson LW, Lehmler H, Hennig B. 2000. Cellular glutathione status modulates Polychlorinated Biphenyl-induced stress response and apoptosis in vascular endothelial cells. Toxicol Appl Pharmacol 166(1):36-42. PMID:10873716
  • Slim RM, Toborek M, Robertson LW, Lehmler H, Hennig B. 2000. PCB-induced stress response and apoptosis in vascular endothelial cells. In: Proceedings of the 1st PCB Workshop: Recent Advances in the Environmental Toxicology and Health Effects of PCBs (polychlorinated biphenyls), 2000. Lexington, KY.

1999

  • Srinivasan A, Lehmler H, Shaw JR, Robertson LW, Ludewig G. 1999. Superoxide production and glutathione binding by hydroquinone and p-quinone metabolites of Polychlorinated Biphenyls (PCBs). In: Proceedings of the Ninetieth Annual Meeting of the (AACR) American Association of Cancer Research, 1999. pp.4261.

1998

  • Robertson LW, Amaro AR, Bauer U, Lehmler H, Shaw JR, McLean MR, Twaroski TP, Oakley GG, Arif JM, Gupta RC. 1998. A new mechanism of toxicity for Polychlorinated Biphenyls (PCBs). Pol J Pharmacol 50(84):
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