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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Person Details: Joel N. Meyer

Superfund Research Program

Joel N. Meyer

Duke University
Nicholas School of the Environment
Box 90328
Durham, North Carolina 27708-0328
Phone: 919-613-8109
Email: joel.meyer@duke.edu

Projects

Hazardous Waste Sites

Atlantic Wood Site, Elizabeth River

  • Duke University: Persistent Mitochondrial and Epigenetic Effects of Early Life Toxicant Exposure

Publications

2024

2023

  • Clark AS, Kalmanson Z, Morton KS, Hartman JH, Meyer JN, San-Miguel A. 2023. An unbiased, automated platform for scoring dopaminergic neurodegeneration in C. elegans. PLoS One doi:10.1371/journal.pone.0281797 PMID:37418455 PMCID:PMC10328331
  • Kozal JS, Jayasundara N, Massarsky A, Lindberg C, Oliveri A, Cooper EM, Levin ED, Meyer JN, Di Giulio RT. 2023. Mitochondrial dysfunction and oxidative stress contribute to cross-generational toxicity of benzo(a)pyrene in Danio rerio. Aquat Toxicol 263:106658. doi:10.1016/j.aquatox.2023.106658 PMID:37722151 PMCID:PMC10591944
  • Lalwani P, King DE, Morton KS, Rivera NA, Huayta J, Hsu-Kim H, Meyer JN. 2023. Increased cytotoxicity of Pb2+ with co-exposures to a mitochondrial uncoupler and mitochondrial calcium uniporter inhibitor. Environ Sci Process Impacts doi:10.1039/d3em00188a PMID:37503664
  • Morton KS, Hartman JH, Heffernan N, Ryde IT, Kenny-Ganzert IW, Meng L, Sherwood DR, Meyer JN. 2023. Chronic high-sugar diet in adulthood protects Caenorhabditis elegans from 6-OHDA-induced dopaminergic neurodegeneration. BMC Biol 21(1):252. doi:10.1186/s12915-023-01733-9 PMID:37950228 PMCID:PMC10636816
  • Sparling A, King DE, Meyer JN. 2023. rol-6 and dpy-10 C. elegans mutants have normal mitochondrial function after normalizing to delayed development. J Hazard Mater Lett doi:10.17912/MICROPUB.BIOLOGY.000798

2022

  • King DE, Sparling A, Lloyd D, Satusky MJ, Martinez M, Grenier C, Bergemann CM, Maguire R, Hoyo C, Meyer JN, Murphy SK. 2022. Sex-specific DNA methylation and associations with in utero tobacco smoke exposure at nuclear-encoded mitochondrial genes. Epigenetics doi:10.1080/15592294.2022.2043591 PMID:35238269
  • Leuthner T, Benzing L, Kohrn BF, Bergemann CM, Hipp MJ, Hershberger KA, Mello DF, Sokolskyi T, Stevenson K, Merutka IR, Seay SA, Gregory SG, Kennedy SR, Meyer JN. 2022. Resistance of mitochondrial DNA to cadmium and Aflatoxin B1 damage-induced germline mutation accumulation in C. elegans. Nucleic Acids Res 50(15):8696-8642. doi:10.1093/nar/gkac666 PMID:35947695 PMCID:PMC9410910
  • Maglioni S, Schiavi A, Melcher M, Brinkmann V, Luo Z, Laromaine A, Raimundo N, Meyer JN, Distelmaier F, Ventura N. 2022. Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans. Nat Commun doi:10.1038/s41467-022-29972-4 PMID:35551180 PMCID:PMC9098500
  • Markovich Z, Hartman JH, Ryde IT, Hershberger KA, Joyce A, Ferguson PL, Meyer JN. 2022. Mild pentachlorophenol-mediated uncoupling of mitochondria depletes ATP but does not cause an oxidized redox state or dopaminergic neurodegeneration in Caenorhabditis elegans. Curr Res Toxicol 3:doi:10.1016/j.crtox.2022.100084 PMID:35957653 PMCID:PMC9361317
  • Mello DF, Bergemann CM, Fisher K, Chitrakar R, Bijwadia SR, Wang Y, Caldwell A, Baugh LR, Meyer JN. 2022. Rotenone modulates Caenorhabditis elegans immunometabolism and pathogen susceptibility. Front Immunol 13:840272. doi:10.3389/fimmu.2022.840272 PMID:35273616 PMCID:PMC8902048
  • Mello DF, Maurer LL, Ryde IT, Songr D, Marinakos SM, Jiang C, Wiesner MR, Hsu-Kim H, Meyer JN. 2022. In vivo effects of silver nanoparticles on development, behavior, and mitochondrial function are altered by genetic defects in mitochondrial dynamics. Environ Sci Technol 56:1113-1124. doi:10.1021/acs.est.1c05915 PMID:35038872 PMCID:PMC8802983

2021

  • Bijwadia SR, Morton KS, Meyer JN. 2021. Quantifying levels of dopaminergic neuron morphological alteration and degeneration in Caenorhabditis elegans. J Vis Exp 177:doi:10.3791/62894 PMID:34866619
  • Hartman JH, Widmayer SJ, Bergemann CM, King DE, Morton KS, Romersi RF, Jameson LE, Leung MC, Andersen EC, Taubert S, Meyer JN. 2021. Xenobiotic metabolism and transport in Caenorhabditis elegans. J Toxicol Environ Health B Crit Rev 24(2):51-94. doi:10.1080/10937404.2021.1884921 PMID:33616007 PMCID:PMC7958427
  • Hershberger KA, Rooney JP, Turner EA, Donoghue LJ, Bodhicharla R, Maurer LL, Ryde IT, Kim JJ, Joglekar R, Hibshman JD, Smith LL, Bhatt DP, Ilkayeva OR, Hirschey MD, Meyer JN. 2021. Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans. Redox Biol 43:102000. doi:10.1016/j.redox.2021.102000 PMID:33993056 PMCID:PMC8134077
  • King DE, Sparling A, Joglekar R, Meyer JN, Murphy SK. 2021. Direct comparisons of bisulfite pyrosequencing versus targeted bisulfite sequencing. micropub bio doi:10.17912/micropub.biology.000444 PMID:34423283 PMCID:PMC8377520
  • Leuthner T, Hartman JH, Ryde IT, Meyer JN. 2021. PCR-based determination of mitochondrial DNA copy number in multiple species. Methods Mol Biol 2310:91-111. doi:10.1007/978-1-0716-1433-4_8 PMID:34096001
  • Leuthner T, Meyer JN. 2021. Mitochondrial DNA mutagenesis: Feature of and biomarker for environmental exposures and aging. Curr Environ Health Rep 8(4):doi:10.1007/s40572-021-00329-1 PMID:34761353 (ahead of print)
  • Wang L, Mello DF, Zucker RM, Rivera NA, Rogers NM, Geitner NK, Boyes W, Wiesner MR, Hsu-Kim H, Meyer JN. 2021. Lack of detectable direct effects of silver and silver nanoparticles on mitochondria in mouse hepatocytes. Environ Sci Technol 11166-11175. doi:10.1021/acs.est.1c02295 PMID:34346225 (ahead of print)

2020

  • Gonzalez-Hunt CP, Luz AL, Ryde IT, Turner EA, Ilkayeva OR, Bhatt DP, Hirschey MD, Meyer JN. 2020. Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone. Toxicology 447(10):152630. doi:10.1016/j.tox.2020.152630 PMID:33188857 PMCID:PMC7750303
  • Harris JB, Hartman JH, Luz AL, Wilson JY, Dinyari A, Meyer JN. 2020. Zebrafish CYP1A expression in transgenic Caenorhabditis elegans protects from exposures to benzo[a]pyrene and a complex polycyclic aromatic hydrocarbon mixture. Toxicology 440(11):doi:10.1016/j.tox.2020.152473 PMID:32360973 PMCID:PMC7313633
  • Zhang J, Hartman JH, Chen C, Yang S, Li Q, Tian Z, Huang P, Wang L, Meyer JN, Huang TJ. 2020. Fluorescence-based Sorting of Caenorhabditis Elegans via Acoustofluidics. Chem Sci 20:1729-1739. doi:10.1039/d0lc00051e PMID:32292982 PMCID:PMC723976

2019

  • Bachman H, Fu H, Huang P, Tian Z, Embry-Seckler J, Rufo J, Xie Z, Hartman JH, Zhao S, Yang S, Meyer JN, Huang TJ. 2019. Open source acoustofluidics. Lab Chip 19(14):2404-2414. doi:10.1039/c9lc00340a PMID:31240285 PMCID:PMC6934416
  • Berky AJ, Ryde IT, Feingold BJ, Ortiz EJ, Wyatt LH, Weinhouse C, Hsu-Kim H, Meyer JN, Pan WK. 2019. Predictors of mitochondrial DNA copy number and damage in a mercury-exposed rural Peruvian population near artisanal and small-scale gold mining: An exploratory study. Environ Mol Mutagen 60(2):197-210. doi:10.1002/em.22244 PMID:30289587 PMCID:PMC6452630
  • Dreier DA, Mello DF, Meyer JN, Martyniuk CJ. 2019. Linking mitochondrial dysfunction to organismal and population health in context of environmental pollutants: progress and considerations for mitochondrial adverse outcome pathways. Environ Toxicol Chem 38:1625-1634. doi:10.1002/etc.4453 PMID:31034624 PMCID:PMC6961808
  • Hartman JH, Gonzalez-Hunt CP, Hall SM, Ryde IT, Caldwell KA, Caldwell GA, Meyer JN. 2019. Genetic defects in mitochondrial dynamics in Caenorhabditis elegans impact ultraviolet C radiation- and 6-hydroxydopamine-induced neurodegeneration. Int J Mol Sci 20(13):E3202. doi:10.3390/ijms20133202 PMID:31261893 PMCID:PMC6651461
  • Hershberger KA, Leuthner T, Waters TA, Meyer JN. 2019. Caenorhabditis elegans strain sensitivity to sodium arsenite exposure is varied based on age and outcome measured. micropub bio doi:10.17912/micropub.biology.000186 PMID:32550437 PMCID:PMC7252313
  • Leung MC, Meyer JN. 2019. Mitochondria as a target of organophosphate and carbamate pesticides: Revisiting common mechanisms of action with new approach methodologies. Reprod Toxicol 89:83-92. doi:10.1016/j.reprotox.2019.07.007 PMID:31315019 PMCID:PMC6766410
  • Maglioni S, Mello DF, Schiavi A, Meyer JN, Ventura N. 2019. Mitochondrial bioenergetic changes during development as an indicator of C. elegans health-span. Aging-US 11:6535-6554. doi:10.18632/aging.102208 PMID:31454791 PMCID:PMC6738431
  • Smith LL, Ryde IT, Hartman JH, Romersi RF, Markovich Z, Meyer JN. 2019. Strengths and limitations of morphological and behavioral analyses in detecting dopaminergic deficiency in Caenorhabditis elegans. Neurotoxicology 74:209-220. doi:10.1016/j.neuro.2019.07.002 PMID:31323240 PMCID:PMC6751008
  • Zhang J, Yang S, Chen C, Hartman JH, Huang P, Wang L, Tian Z, Zhang P, Faulkenberry D, Meyer JN, Huang TJ. 2019. Surface acoustic waves enable rotational manipulation of Caenorhabditis elegans. Lab Chip 19(6):984-992. doi:10.1039/c8lc01012a PMID:30768117 PMCID:PMC6659422

2018

  • Cothren SD, Meyer JN, Hartman JH. 2018. Blinded visual scoring of images using the freely-available software Blinder. Bio Protoc 8(23):e3103. doi:10.21769/BioProtoc.3103 PMID:30761327 PMCID:PMC6370323
  • Hartman JH, Smith LL, Gordon KL, Laranjeiro R, Drsicoll M, Sherwood DR, Meyer JN. 2018. Swimming exercise and transient food deprivation in Caenorhabditis elegans promote mitochondrial maintenance and protect against chemical-induced mitotoxicity. Sci Rep 8:8359. doi:10.1038/s41598-018-26552-9 PMID:29844465 PMCID:PMC597439
  • Hibshman JD, Leuthner T, Shoben C, Mello DF, Sherwood DR, Meyer JN, Baugh LR. 2018. Non-selective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans. Am J Physiol Cell Physiol 315:C781-C792. doi:10.1152/ajpcell.00109.2018 PMID:30133321 PMCID:PMC6336938
  • Luz AL, Kassotis CD, Stapleton HM, Meyer JN. 2018. The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPARgamma activation, in 3T3-L1 cells. Toxicology 393:150-159. doi:10.1016/j.tox.2017.11.010 PMID:29127035 PMCID:PMC5726929
  • Maurer LL, Luz AL, Meyer JN. 2018. Detection of Mitochondrial Toxicity of Environmental Pollutants Using Caenorhabditis elegans. Chapter 43 in: Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants. John Wiley & Sons, Inc., pp.655-689.
  • Meyer JN, Hartman JH, Mello DF. 2018. Mitochondrial toxicity. Toxicol Sci 162(1):15-23. doi:10.1093/toxsci/kfy008 PMID:29340618 PMCID:PMC5837373 (in press)
  • Sanders LH, Rouanet JP, Howlett EH, Leuthner T, Rooney JP, Greenamyre JT, Meyer JN. 2018. Newly revised quantitative PCR-based assay for mitochondrial and nuclear DNA damage. Curr Protoc Toxicol 76(1):e50. doi:10.1002/cptx.50 PMID:30040241 PMCID:PMC6060631
  • Weinhouse C, Truong L, Meyer JN, Allard P. 2018. Caenorhabditis elegans as an emerging model system in environmental epigenetics. Environ Mol Mutagen 59:560-575. doi:10.1002/em.22203 PMID:30091255 PMCID:PMC6113102

2017

2016

  • Gonzalez-Hunt CP, Rooney JP, Ryde IT, Anbalagan C, Joglekar R, Meyer JN. 2016. PCR-based analysis of mitochondrial DNA copy number, mitochondrial DNA damage, and nuclear DNA damage. Curr Protoc Toxicol 67:20.11.1-20.11.25. doi:10.1002/0471140856.tx2011s67 PMID:26828332 PMCID:PMC4928199
  • Luz AL, Godebo TR, Bhatt DP, Ilkayeva OR, Maurer LL, Hirschey MD, Meyer JN. 2016. From the cover: arsenite uncouples mitochondrial respiration and induces a Warburg-like effect in Caenorhabditis elegans. Toxicol Sci 152(2):349-362. doi:10.1093/toxsci/kfw093 PMID:27208080 PMCID:PMC4960910
  • Luz AL, Lagido C, Hirschey MD, Meyer JN. 2016. In vivo determination of mitochondrial function using luciferase-expressing Caenorhabditis elegans: contribution of oxidative phosphorylation, glycolysis, and fatty acid oxidation to toxicant-induced dysfunction. Curr Protoc Toxicol 69:25.8.1-25.8.22. doi:10.1002/cptx.10 PMID:27479364 PMCID:PMC5002950
  • Santa-Gonzalez GA, Gomez-Molina A, Arcos-Burgos M, Meyer JN, Camargo M. 2016. Distinctive adaptive response to repeated exposure to hydrogen peroxide associated with upregulation of DNA repair genes and cell cycle arrest. Redox Biol 9:124-133. doi:10.1016/j.redox.2016.07.004 PMID:27479053 PMCID:PMC4971155
  • Van Houten B, Hunter SE, Meyer JN. 2016. Mitochondrial DNA damage induced autophagy, cell death, and disease. Front Biosci (Landmark Ed) 21:42-54. PMID:26709760 PMCID:PMC4750375
  • Wyatt LH, Diringer SE, Rogers LA, Hsu-Kim H, Pan WK, Meyer JN. 2016. Antagonistic growth effects of mercury and selenium in Caenorhabditis elegans are chemical-species-dependent and do not depend on internal Hg/Se ratios. Environ Sci Technol 50(6):3256-3264. doi:10.1021/acs.est.5b06044 PMID:26938845 PMCID:PMC4964607

2015

  • Jayasundara N, Garner LV, Meyer JN, Erwin K, Di Giulio RT. 2015. AHR2-Mediated transcriptomic responses underlying the synergistic cardiac developmental toxicity of PAHs. Toxicol Sci 143(2):469-481. doi:10.1093/toxsci/kfu245 PMID:25412620 PMCID:PMC4306723
  • Luz AL, Rooney JP, Kubik L, Gonzalez C, Song DH, Meyer JN. 2015. Mitochondrial morphology and fundamental parameters of the mitochondrial respiratory chain are altered in Caenorhabditis elegans strains deficient in mitochondrial dynamics and homeostasis processes. PLoS One 10(6):e0130940. doi:10.1371/journal.pone.0130940 PMID:26106885 PMCID:PMC4480853
  • Luz AL, Smith LL, Meyer JN, Rooney JP. 2015. Seahorse Xfe 24 extracellular flux analyzer-based analysis of cellular respiration in Caenorhabditis elegans. Curr Protoc Toxicol 66:25.7.1-15. doi:10.1002/0471140856.tx2507s66 PMID:26523474 PMCID:PMC4632645
  • Robey R, Weisz J, Kuemmerle NB, Salzberg AC, Berg A, Brown DG, Kubik L, Palorini R, Al-Mulla F, Al-Temaimi R, Colacci A, Mondello C, Raju J, Woodrick J, Scovassi A, Singh N, Vaccari M, Roy R, Forte S, Memeo L, Salem HK, Amedei A, Hamid RA, Williams GP, Lowe L, Meyer JN, Martin FL, Bisson WH, Chiaradonna F, Ryan EP. 2015. Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?. Carcinogenesis 36Suppl1:S203-S231. doi:10.1093/carcin/bgv037 PMID:26106140 PMCID:PMC4565609
  • Rooney JP, Ryde IT, Saunders LH, Howlett EH, Colton MD, Germ KE, Mayer GD, Greenamyre JT, Meyer JN. 2015. PCR based determination of mitochondrial DNA copy number in multiple species. Methods Mol Biol 1241:23-38. doi:10.1007/978-1-4939-1875-1_3 PMID:25308485 PMCID:PMC4312664

2014

  • Colton MD, Kwok KW, Brandon JA, Warren IH, Ryde IT, Cooper EM, Hinton DE, Rittschof D, Meyer JN. 2014. Developmental toxicity and DNA damage from exposure to parking lot runoff retention pond samples in the Japanese medaka (Oryzias latipes). Mar Environ Res 99:117-124. doi:10.1016/j.marenvres.2014.04.007 PMID:24816191 PMCID:PMC4309550
  • Shaughnessy DT, McAllister KA, Worth L, Haugen AC, Meyer JN, Domann FE, Van Houten B, Mostoslavsky R, Bultman SJ, Baccarelli A, Begley T, Sobol RW, Hirschey MD, Ideker T, Santos JH, Copeland WC, Tice RR, Balshaw DM, Tyson FL. 2014. Mitochondria, energetics, epigenetics, and cellular responses to stress. Environ Health Perspect 122(12):1271-1278. doi:10.1289/ehp.1408418 PMID:25127496 PMCID:PMC4256704

2013

2010

2008

2007

  • Burnett KG, Bain LJ, Baldwin WS, Callard GV, Cohen S, Di Giulio RT, Evans DH, Gomez-Chiarri M, Hahn ME, Hoover CA, Karchner SI, Katoh F, MacLatchy DL, Marshall WS, Meyer JN, Nacci DE, Rees BB, Singer TD, Stegeman JJ, Towle DW, van Veld PA, Vogelbein WK, Whitehead A, Winn RN, Crawford DL, Oleksiak MF. 2007. Fundulus as the premier teleost model in environmental biology: opportunities for new insights using genomics. Comp Biochem Physiol Part D Genomics Proteomics 2(4):257-286. doi:10.1016/j.cbd.2007.09.001 PMID:18071578 PMCID:PMC2128618

2005

  • Meyer JN, Volz DC, Freedman JH, Di Giulio RT. 2005. Differential display of hepatic mRNA from killifish (Fundulus heteroclitus) inhabiting a Superfund estuary. Aquat Toxicol 73(4):327-341. PMID:15916819
  • Timme-Laragy AR, Meyer JN, Waterland RA, Di Giulio RT. 2005. Analysis of CpG methylation in the killifish CYP1A promoter. Comp Biochem Physiol C Toxicol Pharmacol 141(4):406-411. PMID:16257583

2003

  • Meyer JN, Di Giulio RT. 2003. Heritable adaptation and fitness costs in killifish (Fundulus heteroclitus) inhabiting a polluted estuary. Ecol Appl 13(2):490-503.
  • Meyer JN, Smith JD, Winston GW, Di Giulio RT. 2003. Antioxidant defenses in killifish (Fundulus heteroclitus) exposed to contaminated sediments and model prooxidants: short-term and heritable responses. Aquat Toxicol 65(4):377-395. doi:10.1016/j.aquatox.2003.06.001 PMID:14568353
  • Meyer JN, Wassenberg DM, Karchner SI, Hahn ME, Di Giulio RT. 2003. Expression and inducibility of aryl hydrocarbon receptor pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure histories. Environ Toxicol Chem 22(10):2337-2343. PMID:14551997

2002

  • Maurer LL, Luz AL, Meyer JN. 2002. Detection of mitochondrial toxicity of environmental pollutants using Caenorhabditis elegans. In: Wiley Encyclopedia of Molecular Medicine. Medicine John Wiley & Sons Inc., New York, NY.
  • Meyer JN, Di Giulio RT. 2002. Patterns of heritability of decreased EROD activity and resistance to PCB 126-induced teratogenesis in laboratory-reared offspring of killifish (Fundulus heteroclitus) from a creosote-contaminated site in the Elizabeth River, VA, USA. Mar Environ Res 54(3-5):621-626. PMID:12408627
  • Meyer JN, Nacci DE, Di Giulio RT. 2002. Cytochrome P4501A (CYP1A) in killifish (Fundulus heteroclitus): heritability of altered expression and relationship to survival in contaminated sediments. Toxicol Sci 68(1):69-81. PMID:12075112
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