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Your Environment. Your Health.

Person Details: Joel N. Meyer

Superfund Research Program

Joel N. Meyer

Duke University
Nicholas School of the Environment
Box 90328
Durham, North Carolina 27708-0328
Phone: 919-613-8109
Email: joel.meyer@duke.edu

Projects

Publications

2019

  • Berky AJ, Ryde IT, Feingold BJ, Ortiz EJ, Wyatt LH, Weinhouse C, Hsu-Kim H, Meyer JN, Pan WK. 2019. Predictors of mitochondrial DNA copy number and damage in a mercury-exposed rural Peruvian population near artisanal and small-scale gold mining: An exploratory study. Environ Mol Mutagen 60(2):197-210. doi:10.1002/em.22244 PMID:30289587
  • Dreier DA, Mello DF, Meyer JN, Martyniuk CJ. 2019. Linking mitochondrial dysfunction to organismal and population health in context of environmental pollutants: progress and considerations for mitochondrial adverse outcome pathways. Environ Toxicol Chem doi:10.1002/etc.4453 PMID:31034624
  • Zhang J, Yang S, Chen C, Hartman JH, Huang P, Wang L, Tian Z, Zhang P, Faulkenberry D, Meyer JN, Huang TJ. 2019. Surface acoustic waves enable rotational manipulation of Caenorhabditis elegans. Lab Chip 19(6):984-992. doi:10.1039/c8lc01012a PMID:30768117

2018

  • Cothren SD, Meyer JN, Hartman JH. 2018. Blinded visual scoring of images using the freely-available software Blinder. Bio Protoc 8(23):e3103. doi:10.21769/BioProtoc.3103 PMID:30761327 PMCID:PMC6370323
  • Hartman JH, Smith LL, Gordon KL, Laranjeiro R, Drsicoll M, Sherwood DR, Meyer JN. 2018. Swimming exercise and transient food deprivation in Caenorhabditis elegans promote mitochondrial maintenance and protect against chemical-induced mitotoxicity. Sci Rep 8:8359. doi:10.1038/s41598-018-26552-9 PMID:29844465 PMCID:PMC597439
  • Hibshman JD, Leuthner T, Shoben C, Mello DF, Sherwood DR, Meyer JN, Baugh LR. 2018. Non-selective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans. Am J Physiol Cell Physiol 315:C781-C792. doi:10.1152/ajpcell.00109.2018 PMID:30133321 PMCID:PMC6336938
  • Luz AL, Kassotis CD, Stapleton HM, Meyer JN. 2018. The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPARgamma activation, in 3T3-L1 cells. Toxicology 393:150-159. doi:10.1016/j.tox.2017.11.010 PMID:29127035 PMCID:PMC5726929
  • Maurer LL, Luz AL, Meyer JN. 2018. Detection of Mitochondrial Toxicity of Environmental Pollutants Using Caenorhabditis elegans. Chapter 43 in: Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants. John Wiley & Sons, Inc., pp.655-689.
  • Meyer JN, Hartman JH, Mello DF. 2018. Mitochondrial toxicity. Toxicol Sci 162(1):15-23. doi:10.1093/toxsci/kfy008 PMID:29340618 PMCID:PMC5837373 (in press)
  • Sanders LH, Rouanet JP, Howlett EH, Leuthner T, Rooney JP, Greenamyre JT, Meyer JN. 2018. Newly revised quantitative PCR-based assay for mitochondrial and nuclear DNA damage. Curr Protoc Toxicol 76(1):e50. doi:10.1002/cptx.50 PMID:30040241 PMCID:PMC6060631
  • Weinhouse C, Truong L, Meyer JN, Allard P. 2018. Caenorhabditis elegans as an emerging model system in environmental epigenetics. Environ Mol Mutagen 59:560-575. doi:10.1002/em.22203 PMID:30091255 PMCID:PMC6113102

2017

2016

  • Gonzalez-Hunt CP, Rooney JP, Ryde IT, Anbalagan C, Joglekar R, Meyer JN. 2016. PCR-based analysis of mitochondrial DNA copy number, mitochondrial DNA damage, and nuclear DNA damage. Curr Protoc Toxicol 67:20.11.1-20.11.25. doi:10.1002/0471140856.tx2011s67 PMID:26828332 PMCID:PMC4928199
  • Luz AL, Godebo TR, Bhatt DP, Ilkayeva OR, Maurer LL, Hirschey MD, Meyer JN. 2016. From the cover: arsenite uncouples mitochondrial respiration and induces a Warburg-like effect in Caenorhabditis elegans. Toxicol Sci 152(2):349-362. doi:10.1093/toxsci/kfw093 PMID:27208080 PMCID:PMC4960910
  • Luz AL, Lagido C, Hirschey MD, Meyer JN. 2016. In vivo determination of mitochondrial function using luciferase-expressing Caenorhabditis elegans: contribution of oxidative phosphorylation, glycolysis, and fatty acid oxidation to toxicant-induced dysfunction. Curr Protoc Toxicol 69:25.8.1-25.8.22. doi:10.1002/cptx.10 PMID:27479364 PMCID:PMC5002950
  • Santa-Gonzalez GA, Gomez-Molina A, Arcos-Burgos M, Meyer JN, Camargo M. 2016. Distinctive adaptive response to repeated exposure to hydrogen peroxide associated with upregulation of DNA repair genes and cell cycle arrest. Redox Biol 9:124-133. doi:10.1016/j.redox.2016.07.004 PMID:27479053 PMCID:PMC4971155
  • Van Houten B, Hunter SE, Meyer JN. 2016. Mitochondrial DNA damage induced autophagy, cell death, and disease. Front Biosci (Landmark Ed) 21:42-54. PMID:26709760 PMCID:PMC4750375
  • Wyatt LH, Diringer SE, Rogers LA, Hsu-Kim H, Pan WK, Meyer JN. 2016. Antagonistic growth effects of mercury and selenium in Caenorhabditis elegans are chemical-species-dependent and do not depend on internal Hg/Se ratios. Environ Sci Technol 50(6):3256-3264. doi:10.1021/acs.est.5b06044 PMID:26938845 PMCID:PMC4964607

2015

  • Jayasundara N, Garner LV, Meyer JN, Erwin K, Di Giulio RT. 2015. AHR2-Mediated transcriptomic responses underlying the synergistic cardiac developmental toxicity of PAHs. Toxicol Sci 143(2):469-481. doi:10.1093/toxsci/kfu245 PMID:25412620 PMCID:PMC4306723
  • Luz AL, Rooney JP, Kubik L, Gonzalez C, Song DH, Meyer JN. 2015. Mitochondrial morphology and fundamental parameters of the mitochondrial respiratory chain are altered in Caenorhabditis elegans strains deficient in mitochondrial dynamics and homeostasis processes. PLoS One 10(6):e0130940. doi:10.1371/journal.pone.0130940 PMID:26106885 PMCID:PMC4480853
  • Luz AL, Smith LL, Meyer JN, Rooney JP. 2015. Seahorse Xfe 24 extracellular flux analyzer-based analysis of cellular respiration in Caenorhabditis elegans. Curr Protoc Toxicol 66:25.7.1-15. doi:10.1002/0471140856.tx2507s66 PMID:26523474 PMCID:PMC4632645
  • Robey R, Weisz J, Kuemmerle NB, Salzberg AC, Berg A, Brown DG, Kubik L, Palorini R, Al-Mulla F, Al-Temaimi R, Colacci A, Mondello C, Raju J, Woodrick J, Scovassi A, Singh N, Vaccari M, Roy R, Forte S, Memeo L, Salem HK, Amedei A, Hamid RA, Williams GP, Lowe L, Meyer JN, Martin FL, Bisson WH, Chiaradonna F, Ryan EP. 2015. Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?. Carcinogenesis 36Suppl1:S203-S231. doi:10.1093/carcin/bgv037 PMID:26106140 PMCID:PMC4565609
  • Rooney JP, Ryde IT, Saunders LH, Howlett EH, Colton MD, Germ KE, Mayer GD, Greenamyre JT, Meyer JN. 2015. PCR based determination of mitochondrial DNA copy number in multiple species. Methods Mol Biol 1241:23-38. doi:10.1007/978-1-4939-1875-1_3 PMID:25308485 PMCID:PMC4312664

2014

  • Colton MD, Kwok KW, Brandon JA, Warren IH, Ryde IT, Cooper EM, Hinton DE, Rittschof D, Meyer JN. 2014. Developmental toxicity and DNA damage from exposure to parking lot runoff retention pond samples in the Japanese medaka (Oryzias latipes). Mar Environ Res 99:117-124. doi:10.1016/j.marenvres.2014.04.007 PMID:24816191 PMCID:PMC4309550
  • Shaughnessy DT, McAllister KA, Worth L, Haugen AC, Meyer JN, Domann FE, Van Houten B, Mostoslavsky R, Bultman SJ, Baccarelli A, Begley T, Sobol RW, Hirschey MD, Ideker T, Santos JH, Copeland WC, Tice RR, Balshaw DM, Tyson FL. 2014. Mitochondria, energetics, epigenetics, and cellular responses to stress. Environ Health Perspect 122(12):1271-1278. doi:10.1289/ehp.1408418 PMID:25127496 PMCID:PMC4256704

2013

2010

2008

2007

  • Burnett KG, Bain LJ, Baldwin WS, Callard GV, Cohen S, Di Giulio RT, Evans DH, Gomez-Chiarri M, Hahn ME, Hoover CA, Karchner SI, Katoh F, MacLatchy DL, Marshall WS, Meyer JN, Nacci DE, Rees BB, Singer TD, Stegeman JJ, Towle DW, van Veld PA, Vogelbein WK, Whitehead A, Winn RN, Crawford DL, Oleksiak MF. 2007. Fundulus as the premier teleost model in environmental biology: opportunities for new insights using genomics. Comp Biochem Physiol Part D Genomics Proteomics 2(4):257-286. doi:10.1016/j.cbd.2007.09.001 PMID:18071578 PMCID:PMC2128618

2005

  • Meyer JN, Volz DC, Freedman JH, Di Giulio RT. 2005. Differential display of hepatic mRNA from killifish (Fundulus heteroclitus) inhabiting a Superfund estuary. Aquat Toxicol 73(4):327-341. PMID:15916819
  • Timme-Laragy AR, Meyer JN, Waterland RA, Di Giulio RT. 2005. Analysis of CpG methylation in the killifish CYP1A promoter. Comp Biochem Physiol C Toxicol Pharmacol 141(4):406-411. PMID:16257583

2003

  • Meyer JN, Di Giulio RT. 2003. Heritable adaptation and fitness costs in killifish (Fundulus heteroclitus) inhabiting a polluted estuary. Ecol Appl 13(2):490-503.
  • Meyer JN, Smith JD, Winston GW, Di Giulio RT. 2003. Antioxidant defenses in killifish (Fundulus heteroclitus) exposed to contaminated sediments and model prooxidants: short-term and heritable responses. Aquat Toxicol 65(4):377-395. doi:10.1016/j.aquatox.2003.06.001 PMID:14568353
  • Meyer JN, Wassenberg DM, Karchner SI, Hahn ME, Di Giulio RT. 2003. Expression and inducibility of aryl hydrocarbon receptor pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure histories. Environ Toxicol Chem 22(10):2337-2343. PMID:14551997

2002

  • Maurer LL, Luz AL, Meyer JN. 2002. Detection of mitochondrial toxicity of environmental pollutants using Caenorhabditis elegans. In: Wiley Encyclopedia of Molecular Medicine. Medicine John Wiley & Sons Inc., New York, NY.
  • Meyer JN, Di Giulio RT. 2002. Patterns of heritability of decreased EROD activity and resistance to PCB 126-induced teratogenesis in laboratory-reared offspring of killifish (Fundulus heteroclitus) from a creosote-contaminated site in the Elizabeth River, VA, USA. Mar Environ Res 54(3-5):621-626. PMID:12408627
  • Meyer JN, Nacci DE, Di Giulio RT. 2002. Cytochrome P4501A (CYP1A) in killifish (Fundulus heteroclitus): heritability of altered expression and relationship to survival in contaminated sediments. Toxicol Sci 68(1):69-81. PMID:12075112
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