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Person Details

Superfund Research Program

Carmen J. Marsit

Brown University
Laboratories of Molecular Medicine
70 Ship St., Room 537
Providence, RI 02912
Phone: 401-863-6508




  • Koestler DC, Li J, Baron JA, Tsongalis GJ, Butterly LF, Goodrich M, Lesseur C, Karagas MR, Marsit CJ, Moore JH, Andrew AS, Srivastava A. 2014. Distinct patterns of DNA methylation in conventional adenomas involving the right and left colon. Modern Pathology 27:145-155. doi:10.1038/modpathol.2013.104 PMID:23868178 PMCID:PMC3880603
  • Langevin SM, Houseman EA, Accomando WP, Koestler DC, Christensen BC, Nelson HH, Karagas MR, Marsit CJ, Wiencke JK, Kelsey KT. 2014. Leukocyte-adjusted epigenome-wide association studies of blood from solid tumor patients. Epigenetics 9(6):884-895. doi:10.4161/epi.28575 PMID:24671036 PMCID:PMC4065186



  • Avissar-Whiting M, Koestler DC, Houseman EA, Christensen BC, Kelsey KT, Marsit CJ. 2011. Polycomb group genes are targets of aberrant DNA methylation in renal cell carcinoma. Epigenetics 6:703-709. doi:10.4161/epi.6.6.16158 (Completed with ARRA Funds)
  • Banister CE, Koestler DC, Maccani MA, Houseman EA, Padbury JF, Marsit CJ. 2011. Infant growth restriction is associated with distinct patterns of DNA methylation in human placentas. Epigenetics 6:920-927. doi:10.4161/epi.6.7.16079 (Completed with ARRA Funds)
  • Filiberto AC, Maccani MA, Koestler DC, Wilhelm-Benartzi C, Gagne LA, Marsit CJ. 2011. Birthweight is associated with DNA promoter methylation of the glucocorticoid receptor in human placenta. Epigenetics 6(5):566-572. doi:10.4161/epi.6.5.15236
  • Gui J, Moore JH, Kelsey KT, Marsit CJ, Karagas MR, Andrew AS. 2011. A novel survival multifactor dimensionality reduction method for detecting gene-gene interactions with application to bladder cancer prognosis. Hum Genet 129(1):101-110. doi:10.1007/s00439-010-0905-5 PMID:20981448 PMCID:PMC3255326 (Completed with ARRA Funds)
  • Langevin SM, Houseman EA, Christensen BC, Wiencke JK, Nelson HH, Karagas MR, Marsit CJ, Kelsey KT. 2011. The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood. Epigenetics 6:908-919. doi:10.4161/epi.6.7.16431 PMID:21617368 PMCID:PMC3154431 (Completed with ARRA Funds)
  • Maccani MA, Padbury JF, Marsit CJ. 2011. miR-16 and miR-21 Expression in the Placenta Is Associated with Fetal Growth. PLoS One 6:doi:10.1371/journal.pone.0021210 PMID:21698265 PMCID:PMC3115987 (Completed with ARRA Funds)
  • Marsit CJ, Koestler DC, Christensen BC, Karagas MR, Houseman EA, Kelsey KT. 2011. DNA Methylation Array Analysis Identifies Profiles of Blood-Derived DNA Methylation Associated With Bladder Cancer. Journal of Clinical Oncology 29(9):1133-1139. doi:10.1200/JCO.2010.31.3577 PMID:21343564 PMCID:PMC3083868 (Completed with ARRA Funds)
  • Pacheco SE, Christensen BC, Marsit CJ, Kelsey KT, Sigman M, Boekelheide K. 2011. Integrative DNA Methylation and Gene Expression Analyses Identify DNA Packaging and Epigenetic Regulatory Genes Associated with Low Motility Sperm. PLoS One 6:doi:10.1371/journal.pone.0020280 PMID:21674046 PMCID:PMC3107223 (Completed with ARRA Funds)
  • Robins J, Marsit CJ, Padbury J, Sharma S. 2011. Endocrine disruptors, environmental oxygen, epigenetics and pregnancy. Frontiers in Bioscience 3:690-700. (Completed with ARRA Funds)
  • Wilhelm-Benartzi C, Christensen BC, Koestler DC, Houseman EA, Schned AR, Karagas MR, Kelsey KT, Marsit CJ. 2011. Association of secondhand smoke exposures with DNA methylation in bladder cancer cases. Cancer Causes & Control 22(8):1205-1213. doi:10.1007/s10552-011-9788-6 PMID:21660454 PMCID:PMC3140591 (Completed with ARRA Funds)


  • Avissar-Whiting M, Veiga KR, Uhl KM, Maccani MA, Gagne LA, Moen EL, Marsit CJ. 2010. Bisphenol A exposure leads to specific microRNA alterations in placental cells. Reproductive Toxicology 29(4):401-406. doi:10.1016/j.reprotox.2010.04.004
  • Christensen BC, Smith A, Zheng S, Koestler DC, Houseman E, Marsit CJ, Wiemels JL, Nelson HH, Karagas MR, Wrensch MR, Kelsey KT, Wiencke JK. 2010. DNA Methylation, Isocitrate Dehydrogenase Mutation, and Survival in Glioma. J Natl Cancer Inst 103:143-153.
  • Gee GV, Koestler DC, Christensen BC, Sugarbaker DJ, Ugolini DJ, Ivaldi GP, Resnick MB, Houseman E, Kelsey KT, Marsit CJ. 2010. Downregulated MicroRNAs in the differential diagnosis of malignant pleural mesothelioma. Int J Cancer 127(12):2859–2869. doi:10.1002/ijc.25285 PMID:21351265 PMCID:PMC2911512
  • Koestler DC, Marsit CJ, Christensen BC, Karagas MR, Bueno R, Sugarbaker DJ, Kelsey KT, Houseman EA. 2010. Semi-supervised recursively partitioned mixture models for identifying cancer subtypes. Bioinformatics 26(20):2578-2585. doi:10.1093/bioinformatics/btq470 (Completed with ARRA Funds)
  • Kwong RC, Karagas MR, Kelsey KT, Mason RA, Tanyos SA, Schned AR, Marsit CJ, Andrew AS. 2010. Arsenic exposure predicts bladder cancer survival in a US population. World J Urol 28:487-92. doi:10.1007/s00345-009-0477-y PMID:19834714 PMCID:PMC3296964 (Completed with ARRA Funds)
  • Maccani MA, Avissar-Whiting M, Banister CE, McGonnigal B, Padbury J, Marsit CJ. 2010. Maternal cigarette smoking during pregnancy is associated with downregulation of miR-16, miR-21, and miR-146a in the placenta. Epigenetics 5(7):583-589. doi:10.4161/epi.5.7.12762
  • Marsit CJ, Houseman EA, Christensen BC, Gagne LA, Wrensch MR, Nelson HH, Wiemels JL, Zheng S, Wiencke JK, Andrew AS, Schned AR, Karagas MR, Kelsey KT. 2010. Identification of Methylated Genes Associated with Aggressive Bladder Cancer. PLoS One 5:e12334. doi:10.1371/journal.pone.0012334 PMID:20808801 PMCID:PMC2925945
  • Wilhelm CS, Kelsey KT, Butler RA, Plaza S, Gagne LA, Zens MS, Andrew AS, Morris S, Nelson HH, Schned AR, Karagas MR, Marsit CJ. 2010. Implications of LINE1 methylation for bladder cancer risk in women. Clinical Cancer Research 16:1682-1689. doi:10.1158/1078-0432.ccr-09-2983
  • Wilhelm-Benartzi C, Koestler DC, Houseman E, Christensen BC, Wiencke JK, Schned AR, Karagas MR, Kelsey KT, Marsit CJ. 2010. DNA methylation profiles delineate etiologic heterogeneity and clinically important subgroups of bladder cancer. Carcinogenesis 31(11):1972-1976. doi:10.1093/carcin/bgq178 PMID:20802236 PMCID:PMC2966555 (Completed with ARRA Funds)



  • Houseman EA, Christensen BC, Yeh R, Marsit CJ, Karagas MR, Wrensch MR, Nelson HH, Wiemels JL, Zheng S, Wiencke JK, Kelsey KT. 2008. Model-based clustering of DNA methylation array data: A recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions. BMC Biochem 9:365. doi:10.1186/1471-2105-9-365 PMID:18782434 PMCID:PMC2553421
  • Schned AR, Andrew AS, Marsit CJ, Kelsey KT, Zens MS, Karagas MR. 2008. Histological classification and stage of newly diagnosed bladder cancer in a population-based study from the Northeastern United States. Scand J Urol Nephrol 42(3):237-42.
  • Wiemels JL, Hofmann J, Kang M, Selzer R, Green R, Zhou M, Zhong S, Zhang L, Smith MT, Marsit CJ, Loh ML, Buffler PA, Yeh R. 2008. Chromosome 12p Deletions in TEL-AML1 Childhood Acute Lymphoblastic Leukemia Are Associated with Retrotransposon Elements and Occur Postnatally. Cancer Res 68:9935-9944. doi:10.1158/0008-5472.CAN-08-2139 PMID:19047175 PMCID:PMC2597307


  • Hsiung DT, Marsit CJ, Houseman EA, Eddy K, Furniss CS, McClean MD, Kelsey KT. 2007. Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma. Cancer Epidemiology Biomarkers & Prevention 16(1):108-14.


  • Marsit CJ, Eddy K, Kelsey KT. 2006. MicroRNA responses to cellular stress. Cancer Res 66(22):10843-10848.
  • Marsit CJ, Houseman EA, Eddy K, Bueno R, Sugarbaker DJ, Nelson HH, Karagas MR, Kelsey KT, Christensen BC. 2006. Examination of a CpG island methylator phenotype and implications of methylation profiles in solid tumors. Cancer Res 66(21):10621-9.
  • Marsit CJ, Karagas MR, Danaee H, Liu M, Andrew AS, Schned AR, Nelson HH, Kelsey KT. 2006. Carcinogen exposure and gene promoter hypermethylation in bladder cancer. Carcinogenesis 27(1):112-116.
  • Marsit CJ, Karagas MR, Schned AR, Kelsey KT. 2006. Carcinogen exposure and epigenetic silencing in bladder cancer. Ann N Y Acad Sci 1076:810-21.


  • Hirao S, Hirao T, Hirao Y, Marsit CJ, Schned AR, Devi-Ashok T, Nelson HH, Andrew AS, Karagas MR, Kelsey KT. 2005. Loss of heterozygosity on chromosome 9q and p53 alterations in human bladder cancer. Cancer 104(9):1918-1923.
  • Marsit CJ, Karagas MR, Andrew AS, Liu M, Danaee H, Schned AR, Nelson HH, Kelsey KT. 2005. Epigenetic Inactivation of SFRP Genes and TP53 Alteration Act Jointly as Markers of Invasive Bladder Cancer. Cancer Res 65(16):7081-7085.


  • Wiencke JK, Zheng S, Smith MT, Zhang L, Ma X, Wiemels JL, Marsit CJ, Kelsey KT, Buffler PA. 2003. Methylation of transcribed PTEN pseudogene in pediatric leukemia is associated with subtypes of common ALL containing t(12;21) translocation. In: Proceedings of the Ninety Fourth Annual Meeting of the (AACR) American Association for Cancer Research, July 11-14, 2003, San Francisco. San Franciso, CA.

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