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Your Environment. Your Health.

Person Details

Superfund Research Program

Christopher D. Vulpe

University of California-Berkeley
Nutritional Sciences & Toxicology
119 Morgan Hall #3104
Berkeley, CA 94720-3104
Phone: (510) 642-1834
Fax: (510) 642-0535




  • Gaytan BD, Vulpe CD. 2014. Functional toxicology: tools to advance the future of toxicity testing. Frontiers in Genetics 5:110. doi:10.3389/fgene.2014.00110 PMID:24847352 PMCID:PMC4017141
  • Mehinto AC, Prucha MS, Colli-Dula RC, Kroll KJ, Lavelle CM, Barber DS, Vulpe CD, Denslow ND. 2014. Gene networks and toxicity pathways induced by acute cadmium exposure in adult largemouth bass (Micropterus salmoides). Aquatic Toxicology152:186-194. doi:10.1016/j.aquatox.2014.04.004
  • North M, Shuga J, Fromowitz M, Loguinov AV, Shannon K, Zhang L, Smith MT, Vulpe CD. 2014. Modulation of Ras signaling alters the toxicity of hydroquinone, a benzene metabolite and component of cigarette smoke. BMC Cancer 14:6. doi:10.1186/1471-2407-14-6


  • Gaytan BD, Loguinov AV, De La Rosa VY, Lerot J, Vulpe CD. 2013. Functional genomics indicates yeast requires Golgi/ER transport, chromatin remodeling, and DNA repair for low dose DMSO tolerance. Frontiers in Genetics 4(154):doi:10.3389/fgene.2013.00154
  • Gaytan BD, Loguinov AV, Lantz SR, Lerot J, Denslow ND, Vulpe CD. 2013. Functional profiling discovers the Dieldrin organochlorinated pesticide affects leucine availability in yeast. Toxicological Sciences132(2):347-358. doi:10.1093/toxsci/kft018
  • Gaytan BD, Loguinov AV, Penate X, Lerot J, Chavez S, Denslow ND, Vulpe CD. 2013. A genome-wide screen identifies yeast genes required for tolerance to technical toxaphene, an organochlorinated pesticide mixture. PLoS One8(11):e81253. doi:10.1371/journal.pone.0081253


  • Fromowitz M, Shuga J, Wlassowsky AY, Ji Z, North M, Vulpe CD, Smith MT, Zhang L. 2012. Bone Marrow Genotoxicity of 2,5-dimethylfuran, a green biofuel candidate. Environ Mol Mutagen53:488-491. doi:10.1002/em.21707
  • North M, Steffen J, Loguinov AV, Zimmerman GR, Vulpe CD, Eide DJ. 2012. Genome-wide functional profiling identifies genes and processes important for zinc-limited growth of Saccharomyces Cerevisiae. PLoS Genet8(6):e1002699. doi:10.1371/journal.pgen.1002699
  • O'Connor SF, Lan J, North M, Loguinov AV, Zhang L, Smith MT, Gu AZ, Vulpe CD. 2012. Genome-wide functional and stress response profiling reveals toxic mechanism and genes required for tolerence to benzo[a]pyrene in S. cerevisiae. Frontiers in Genetics 3:316. doi:10.3389/fgene.2012.00316


  • Ela WP, Sedlak DL, Barlaz MA, Henry HF, Muir DG, Swackhamer DL, Weber EJ, Arnold RG, Ferguson PL, Field JA, Furlong ET, Giesy JP, Halden RU, Henry T, Hites RA, Hornbuckle KC, Howard PH, Luthy RG, Meyer AK, Saez AE, vom Saal FS, Vulpe CD, Wiesner MR. 2011. Toward identifying the next generation of superfund and hazardous waste site contaminants. Environ Health Perspect 119(1):6-10. doi:10.1289/ehp.1002497 PMID:21205582 PMCID:PMC301850
  • Ela WP, Sedlak DL, Barlaz MA, Henry HF, Muir DG, Swackhamer DL, Weber EJ, Arnold RG, Ferguson PL, Field JA, Furlong ET, Giesy JP, Halden RU, Henry T, Hites RA, Hornbuckle KC, Howard PH, Luthy RG, Meyer AK, Saez AE, vom Saal FS, Vulpe CD, Wiesner MR. 2011. Workshop Summary: Toward Identifying the Next Generation of Superfund and Hazardous Waste Site Contaminants.
  • North M, Tandon VJ, Thomas R, Loguinov AV, Gerlovina I, Hubbard AE, Zhang L, Smith MT, Vulpe CD. 2011. Genome-wide functional profiling reveals genes required for tolerance to benzene metabolites in yeast. PLoS One6(8):e24205. doi:10.1371/journal.pone.0024205
  • Ren X, Aleshin M, Jo WJ, Kalman DA, Vulpe CD, Smith MT, Zhang L. 2011. Involvement of N-6 Adenine-Specific DNA Methyltransferase 1 (N6AMT1) in Arsenic Biomethylation and Its Role in Arsenic-Induced Toxicity. Environ Health Perspect 119:771-777. doi:10.1289/ehp.1002733



  • Jo WJ, Kim JH, Oh E, Jaramillo D, Holman P, Loguinov AV, Arkin AP, Nislow C, Giaever G, Vulpe CD. 2009. Novel Insights Into iron metabolism by integrating deletome and transcriptome analysis in an iron deficiency model ofthe yeast Saccharomyces cerevisiae. Genomics 10(130):doi:10.1186/1471-2164-10-130
  • Jo WJ, Loguinov AV, Wintz H, Chang M, Smith AH, Vulpe CD, Kalman DA, Zhang L, Smith MT. 2009. Comparative functional genomic analysis identifies distinct and overlapping sets of genes required for resistance to monomethylarsonous acid (MMAIll) and arsenite (Aslll) in yeast. Toxicological Sciences111(2):424-436. doi:10.1093/toxsci/kfp162
  • Jo WJ, Ren X, Chu F, Aleshin M, Wintz H, Burlingame AL, Smith MT, Vulpe CD, Zhang L. 2009. Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposure. Toxicol Appl Pharmacol241(3):294-302. doi:10.1016/j.taap.2009.08.027
  • Lan Q, Zhang L, Shen M, Jo WJ, Vermeulen R, Li G, Vulpe CD, Lim S, Ren X, Rappaport SM, Berndt SI, Yeager M, Yuenger J, Hayes RB, Linet MS, Yin S, Chanock SJ, Smith MT, Rothman N. 2009. Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity. Carcinogenesis30(1):50-58. doi:10.1093/carcin/bgn249
  • Zhang L, McHale CM, Rothman N, Li G, Ji Z, Vermeulen R, Hubbard AE, Ren X, Shen M, Rappaport SM, North M, Skibola CF, Yin S, Vulpe CD, Chanock SJ, Smith MT, Lan Q. 2009. Systems biology of human benzene exposure. Chem Biol Interact184(1-2):86-93. doi:10.1016/j.cbi.2009.12.011

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