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Person Details

Superfund Research Program

Karl T. Kelsey

Brown University
70 Ship St
Box G E5
Providence, RI 02912
Phone: 401-863-6420
Email: Karl_Kelsey@brown.edu

Projects

Publications

2015

  • Andrew AS, Gui J, Hu T, Wyszynski A, Marsit CJ, Kelsey KT, Schned AR, Tanyos SA, Pendleton EM, Ekstrom RM, Li Z, Zens MS, Borsuk M, Moore JH, Karagas MR. 2015. Genetic polymorphisms modify bladder cancer recurrence and survival in a USA population-based prognostic study. BJU Int 115(2):238-247. doi:10.1111/bju.12641 PMID:24666523
  • Andrew AS, Marsit CJ, Schned AR, Seigne JD, Kelsey KT, Moore JH, Perreard L, Karagas MR, Sempere LF. 2015. Expression of tumor suppressive microRNA-34a is associated with a reduced risk of bladder cancer recurrence. Int J Cancer137(5):1157-1166. doi:10.1002/ijc.29413 PMID:25556547 PMCID:PMC4485975

2014

  • Sverrisson EF, Zens MS, Fei DL, Andrews A, Schned AR, Robbins DJ, Kelsey KT, Li H, DiRenzo J, Karagas MR, Seigne JD. 2014. Clinicopathological correlates of Gli1 expression in a population-based cohort of patients with newly diagnosed bladder cancer. Urologic Oncology-Seminars and Original Investigations 32(5):539-545. doi:10.1016/j.urolonc.2014.03.006 PMID:24856810 PMCID:PMC4243987

2013

  • Eum K, Wang FT, Schwartz J, Hersh CP, Kelsey KT, Wright RO, Spiro, III A, Sparrow D, Hu H, Weisskopf MG. 2013. Modifying roles of glutathione S-transferase polymorphisms on the association between cumulative lead exposure and cognitive function. Neurotoxicology39C:65-71. doi:10.1016/j.neuro.2013.08.002
  • Wyszynski A, Tanyos SA, Rees JR, Marsit CJ, Kelsey KT, Schned AR, Pendleton EM, Zens MS, Karagas MR, Andrew AS. 2013. Body mass and smoking are modifiable risk factors for recurrent bladder cancer. Cancerdoi:10.1002/cncr.28394

2012

  • Andrew AS, Hu T, Gu J, Gui J, Ye Y, Marsit CJ, Kelsey KT, Schned AR, Tanyos SA, Pendleton EM, Mason RA, Morlock EV, Zens MS, Li Z, Moore JH, Wu X, Karagas MR. 2012. HSD3B and gene-gene interactions in a pathway-based analysis of genetic susceptibility to bladder cancer. PLoS One7(12):e51301. doi:10.1371/journal.pone.0051301
  • Karagas MR, Andrew AS, Nelson HH, Li Z, Punshon T, Schned AR, Marsit CJ, Morris J, Moore JH, Tyler AL, Gilbert-Diamond D, Guerinot ML, Kelsey KT. 2012. SLC39A2 and FSIP1 polymorphisms as potential modifiers of arsenic-related bladder cancer. Hum Genet131:453-461. doi:10.1007/s00439-011-1090-x
  • Nielsen SS, Checkoway H, Butler RA, Nelson HH, Farin FM, Longstreth WT, Franklin GM, Swanson PD, Kelsey KT. 2012. LINE-1 DNA Methylation, Smoking and Risk of Parkinson's Disease. J Parkinsons Dis2(4):303-308. doi:10.3233/JPD-012129

2011

  • Avissar-Whiting M, Koestler DC, Houseman EA, Christensen BC, Kelsey KT, Marsit CJ. 2011. Polycomb group genes are targets of aberrant DNA methylation in renal cell carcinoma. Epigenetics6:703-709. doi:10.4161/epi.6.6.16158 (Completed with ARRA Funds)
  • Gui J, Andrew AS, Andrews PC, Nelson HH, Kelsey KT, Karagas MR, Moore JH. 2011. A robust multifactor dimensionality reduction method for detecting gene-gene interactions with application to the genetic analysis of bladder cancer susceptibility. Ann Hum Genet75(1):20-28. doi:10.1111/j.1469-1809.2010.00624.x (Completed with ARRA Funds)
  • Gui J, Moore JH, Kelsey KT, Marsit CJ, Karagas MR, Andrew AS. 2011. A novel survival multifactor dimensionality reduction method for detecting gene-gene interactions with application to bladder cancer prognosis. Hum Genet129(1):101-110. doi:10.1007/s00439-010-0905-5 (Completed with ARRA Funds)
  • Langevin SM, Houseman EA, Christensen BC, Wiencke JK, Nelson HH, Karagas MR, Marsit CJ, Kelsey KT. 2011. The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood. Epigenetics6:908-919. doi:10.4161/epi.6.7.16431 (Completed with ARRA Funds)
  • Marsit CJ, Koestler DC, Christensen BC, Karagas MR, Houseman EA, Kelsey KT. 2011. DNA Methylation Array Analysis Identifies Profiles of Blood-Derived DNA Methylation Associated With Bladder Cancer. Journal of Clinical Oncology29(9):1133-1139. doi:10.1200/JCO.2010.31.3577 (Completed with ARRA Funds)
  • Pacheco SE, Christensen BC, Marsit CJ, Kelsey KT, Sigman M, Boekelheide K. 2011. Integrative DNA Methylation and Gene Expression Analyses Identify DNA Packaging and Epigenetic Regulatory Genes Associated with Low Motility Sperm. PLoS One6:doi:10.1371/journal.pone.0020280 (Completed with ARRA Funds)
  • Wilhelm-Benartzi C, Christensen BC, Koestler DC, Houseman EA, Schned AR, Karagas MR, Kelsey KT, Marsit CJ. 2011. Association of secondhand smoke exposures with DNA methylation in bladder cancer cases. Cancer Causes & Control 22(8):1205-1213. doi:10.1007/s10552-011-9788-6 (Completed with ARRA Funds)

2010

  • Christensen BC, Smith A, Zheng S, Koestler DC, Houseman E, Marsit CJ, Wiemels JL, Nelson HH, Karagas MR, Wrensch MR, Kelsey KT, Wiencke JK. 2010. DNA Methylation, Isocitrate Dehydrogenase Mutation, and Survival in Glioma. J Natl Cancer Inst103:143-153.
  • Gee GV, Koestler DC, Christensen BC, Sugarbaker DJ, Ugolini DJ, Ivaldi GP, Resnick MB, Houseman E, Kelsey KT, Marsit CJ. 2010. Downregulated MicroRNAs in the differential diagnosis of malignant pleural mesothelioma. Int J Cancer127(12):2859–2869. doi:10.1002/ijc.25285 PMID:21351265 PMCID:PMC2911512
  • Greene CS, Himmelstein DS, Nelson HH, Kelsey KT, Williams SM, Andrew AS, Karagas MR, Moore JH. 2010. Enabling personal genomics with an explicit test of epistasis. Pacific Symposium on Biocomputing 327-36. doi:10.1142/9789814295291_0035
  • Gui J, Andrew AS, Andrews PC, Nelson HA, Kelsey KT, Karagas MR, Moore JH. 2010. A simple and computationally efficient sampling approach to covariate adjustment for multifactor dimensionality reduction analysis of epistasis. Hum Hered 70:219-225. doi:10.1159/000319175
  • Koestler DC, Marsit CJ, Christensen BC, Karagas MR, Bueno R, Sugarbaker DJ, Kelsey KT, Houseman EA. 2010. Semi-supervised recursively partitioned mixture models for identifying cancer subtypes. Bioinformatics26(20):2578-2585. doi:10.1093/bioinformatics/btq470 (Completed with ARRA Funds)
  • Kwong RC, Karagas MR, Kelsey KT, Mason RA, Tanyos SA, Schned AR, Marsit CJ, Andrew AS. 2010. Arsenic exposure predicts bladder cancer survival in a US population. World J Urol28:487-92. doi:10.1007/s00345-009-0477-y (Completed with ARRA Funds)
  • Marsit CJ, Houseman EA, Christensen BC, Gagne LA, Wrensch MR, Nelson HH, Wiemels JL, Zheng S, Wiencke JK, Andrew AS, Schned AR, Karagas MR, Kelsey KT. 2010. Identification of Methylated Genes Associated with Aggressive Bladder Cancer. PLoS One5:e12334. doi:10.1371/journal.pone.0012334
  • Wilhelm CS, Kelsey KT, Butler RA, Plaza S, Gagne LA, Zens MS, Andrew AS, Morris S, Nelson HH, Schned AR, Karagas MR, Marsit CJ. 2010. Implications of LINE1 methylation for bladder cancer risk in women. Clinical Cancer Research16:1682-1689. doi:10.1158/1078-0432.ccr-09-2983
  • Wilhelm-Benartzi C, Koestler DC, Houseman E, Christensen BC, Wiencke JK, Schned AR, Karagas MR, Kelsey KT, Marsit CJ. 2010. DNA methylation profiles delineate etiologic heterogeneity and clinically important subgroups of bladder cancer. Carcinogenesis31(11):1972-1976. doi:10.1093/carcin/bgq178 PMID:20802236 PMCID:PMC2966555 (Completed with ARRA Funds)

2009

  • Andrew AS, Gui J, Sanderson A, Mason RA, Morlock EV, Schned AR, Kelsey KT, Marsit CJ, Moore JH, Karagas MR. 2009. Bladder cancer SNP panel predicts susceptibility and survival. Hum Genet125(5-6):527-539. doi:10.1007/s00439-009-0645-6
  • Andrew AS, Mason RA, Kelsey KT, Schned AR, Marsit CJ, Nelson HH, Karagas MR. 2009. DNA repair genotype interacts with arsenic exposure to increase bladder cancer risk. Toxicol Lett187(1):10-14. doi:10.1016/j.toxlet.2009.01.013
  • Baris D, Karagas MR, Verrill C, Johnson A, Andrew AS, Marsit CJ, Colt JS, Cherala S, Samanic C, Waddell R, Cantor KP, Schned AR, Rothman N, Lubin JH, Fraumeni JF, Hoover RN, Kelsey KT, Silverman DT, Schwenn M. 2009. A case-control study of smoking and bladder cancer risk: Emergent patterns over time. J Natl Cancer Inst101(22):1553-61. doi:10.1093/jnci/djp361
  • Christensen BC, Houseman EA, Marsit CJ, Zheng S, Wrensch MR, Wiemels JL, Nelson HH, Karagas MR, Padbury J, Bueno R, Sugarbaker DJ, Yeh R, Wiencke JK, Kelsey KT. 2009. Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet5(8):e1000602. doi:10.1371/journal.pgen.1000602
  • Dietrich K, Schned AR, Fortuny J, Heaney JA, Marsit CJ, Kelsey KT, Karagas MR. 2009. Glucocorticoid therapy and risk of bladder cancer. Br J Cancer101(8):1316-20. doi:10.1038/sj.bjc.6605314
  • Mason RA, Morlock EV, Karagas MR, Kelsey KT, Marsit CJ, Schned AR, Andrew AS. 2009. EGFR pathway polymorphisms in bladder cancer susceptibility and prognosis. Carcinogenesis30(7):1155-1160. doi:10.1093/carcin/bgp077
  • Stern MC, Lin J, Figueroa JD, Kelsey KT, Kiltie AE, Yuan J, Matullo G, Fletcher T, Benhamou S, Taylor JA, Placidi D, Zhang Z, Steineck G, Rothman N, Kogevinas M, Silverman DT, Malats N, Chanock SJ, Wu X, Karagas MR, Andrew AS, Nelson HH, Bishop DT, Sak S, Choudhury A, Barrett JH, Elliot F, Corral R, Joshi AD, Gago-Dominguez M, Cortessis VK, Gao Y, Xiang Y, Vineis P, Sacerdote C, Guarrera S, Polidoro S, Allione A, Gurzau ES, Koppova K, Kumar R, Rudnai P, Porru S, Carta A, Campagna M, Arici C, Park S, Garcia-Closas M. 2009. Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: Findings from the International Consortium of Bladder Cancer. Cancer Res69(17):6857-64. doi:10.1158/0008-5472.CAN-09-1091

2008

  • Houseman EA, Christensen BC, Yeh R, Marsit CJ, Karagas MR, Wrensch MR, Nelson HH, Wiemels JL, Zheng S, Wiencke JK, Kelsey KT. 2008. Model-based clustering of DNA methylation array data: A recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions. BMC Biochem9:365. doi:10.1186/1471-2105-9-365

2007

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