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Your Environment. Your Health.

Person Details

Superfund Research Program

Rita Loch-Caruso

University of Michigan
Toxicology Program
Ann Arbor, MI 48109-2029
Phone: 734-936-1256
Fax: 734-647-9770
Email: rlc@umich.edu

Projects

Research Briefs

Publications

2016

  • Hassan I, Kumar AM, Park H, Lash LH, Loch-Caruso R. 2016. Reactive Oxygen Stimulation of Interleukin-6 Release in the Human Trophoblast Cell Line HTR-8/SVneo by the Trichlorethylene Metabolite S-(1,2-Dichloro)-L-Cysteine. Biol Reprod95:66. doi:10.1095/biolreprod.116.139261 PMID:27488030

2015

2014

2013

2012

  • Cordero JF, Meeker JD, Sheahan TC, Padilla I, Giese RW, Silevitch M, Loch-Caruso R, Kaeli D, Alshawabkeh AN. 2012. Case study - Puerto Rico test site for exploring contamination threats. Proceedings of Geo-Congress 3553-3562. doi:10.1061/9780784412121.364
  • Ferguson KK, Loch-Caruso R, Meeker JD. 2012. Exploration of oxidative stress and inflammatory markers in relation to urinary phthalate metabolites: NHANES 1999-2006. Environ Sci Technol46(1):477-485. doi:10.1021/es202340b
  • Korte C, Loch-Caruso R. 2012. Oxidative insult activates parturition-associated pathways in a human placental cell line. The Toxicologist - Supplement to Toxicol. Sci., Abstract #2383, 2012.
  • Loch-Caruso R, Kimani PW, Park HR. 2012. Brominated diphenyl ether-47 enhanced mRNA expression of pro-inflammatory cytokines and prostaglandin-endoperoxide synthase 2 in human placental cells. The Toxicologist - Supplement to Toxicol. Sci., Abstract #2386, 2012.
  • Mao X, Ciblak A, Baek K, Amiri M, Loch-Caruso R, Alshawabkeh AN. 2012. Optimization of electrochemical dechlorination of trichloroethylene in reducing electrolytes. Water Res46(6):1847–1857. doi:10.1016/j.watres.2012.01.002
  • Mao X, Yuan S, Fallahpour N, Ciblak A, Howard J, Padilla I, Loch-Caruso R, Alshawabkeh AN. 2012. Electrochemically induced dual reactive barriers for transformation of TCE and mixture of contaminants in groundwater. Environ Sci Technol46(21):12003-12011. doi:10.1021/es301711a PMID:23067023 PMCID:PMC3493133
  • Tetz LM, Loch-Caruso R, Giese RW, Wang P. 2012. Mono-2-ethylhexyl phthalate induced oxidative stress in human placental cells. The Toxicologist - Supplement to Toxicol. Sci., Abstract #2383, 2012.

2011

  • Ferguson KK, Loch-Caruso R, Meeker JD. 2011. Urinary phthalate metabolites in relation to biomarkers of inflammation and oxidative stress: NHANES 1999-2006. Environ Res111(5):718-726. doi:10.1016/j.envres.2011.02.002

2010

  • Silevitch M, Giese RW, Kaeli D, Sheahan TC, Nobrega MC, Alshawabkeh AN, Cordero JF, Padilla I, Loch-Caruso R, Meeker JD. 2010. Interdisciplinary Three-Level Approach to Study Impact of Contamination on Public Health in Puerto Rico. In: Proceedings of Sixth International Congress on Environmental Geotechnics. New Delhi,
  • Thiex NW, Chames MC, Loch-Caruso R. 2010. Tissue-specific induction of COX-2 and prostaglandins in lipopolysaccharide-stimulated extraplacental human gestational membranes in a 2-chamber transwell culture system. Reproductive Sciences17(12):1120-1129. doi:10.1177/1933719110378344 PMID:20861394 PMCID:PMC3096444

2009

  • Meeker JD, Hu H, Cantonwine DE, Lamadrid-Figueroa H, Calafat AM, Ettinger AS, Hernandez-Avila M, Loch-Caruso R, Tellez-Rojo MM. 2009. Urinary phthalate metabolites in relation to preterm birth in Mexico City. Environ Health Perspect 117(10):1587-92.

2008

2006

  • Brant KA, Loch-Caruso R. 2006. PCB 50 stimulates release of arachidonic acid and prostaglandins from late gestation rat amnion fibroblast cells. Reproductive Toxicology22(4):591-8.

2005

  • Loch-Caruso R, Upham BL, Harris C, Trosko JE. 2005. Divergent roles for glutathione in lindane-induced acute and delayed-onset inhibition of rat myometrial gap junctions. Toxicological Sciences85(1):694-702.

2004

  • Brant KA, Loch-Caruso R. 2004. Gestational increases and activation of rat uterine phospholipase A2 enzyme expression mediates PCB 50 - induced stimulation of uterine function. In: Proceedings of the 43rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.
  • Chung D, Loch-Caruso R. 2004. Role of gap junctions in the modification on rat uterine contraction by 2,2'-dichlorobiphenyl. In: Proceedings of the 43rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.
  • Loch-Caruso R, Galvez MM, Brant KA, Chung D. 2004. Cell and toxicant specific phosphorylation of conexin43: effects of lindane and TPA on rat myometrial and WB-F344 liver cell gap junctions. Cell Biol Toxicol 20(3):147-169. doi:10.1023/B:CBTO.0000029465.74815.62
  • Loch-Caruso R, Tsuneta T, Hanna M, Grindatti C, Quensen JF. 2004. Stimulatory effects of a microbially dechlorinated polychlorinated biphenyl (PCB) mixture on rat uterine contraction in vitro. In: Proceedings of the 43rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.

2003

  • Brant KA, Loch-Caruso R. 2003. iPLA2 contributes to the gestation day sensitivity to 2,2',4,6 tetrachlorobiphenyl-induced stimulation of contraction frequency in rat uterus. Biol Reprod68:382Suppl.1.
  • Chung D, Loch-Caruso R. 2003. Role of oxidative stress in the modification on rat uterine contraction by 2,2 '-dichlorobiphenyl. Toxicological Sciences72(1):376.
  • Nasser F, Chung D, Loch-Caruso R. 2003. Roles of endocannabinoids in rat uterine contractions. Biol Reprod68:390Suppl.1.

2002

  • Loch-Caruso R. 2002. Uterine muscle as a potential target of polychlorinated biphenyls during pregnancy. Int J Hyg Environ Health205:121-130.

2001

  • Bae J, Mousa MA, Quensen JF, Boyd SA, Loch-Caruso R. 2001. Stimulation of contraction of pregnant rat uterus in vitro by non-dechlorinated and microbially dechlorinated mixtures of polychlorinated biphenyls. Environ Health Perspect 109(3):275-282.

1999

  • Bae J, Peters-Golden M, Loch-Caruso R. 1999. Stimulation of pregnant rat uterine contraction by the polychlorinated biphenyl (PCB) mixture Aroclor 1242 may be mediated by arachidonic acid release through activation of phospholipase A2 enzymes. Journal of Pharmacology and Experimental Therapeutics289:1112-1120.
  • Bae J, Stuenkel E, Loch-Caruso R. 1999. Stimulation of oscillatory uterine contraction by the PCB mixture Aroclor 1242 may involve increased [Ca2+]i through voltage-operated calcium channels. Toxicol Appl Pharmacol155(3):261-272.

1997

  • Tsai M, Webb RC, Loch-Caruso R. 1997. The increase of oxytocin-induced oscillatory contractions by 4-hydroxy-2',4',6'-trichlorobiphenyl is estrogen receptor-mediated. Biol Reprod56(2):341-347.

1996

  • Bae J, Loch-Caruso R. 1996. Stimulation of rat uterine oscillatory contraction by a polychlorinated biphenyl mixture, Aroclor 1242, and its sustained effect after removal of the compound. Biol Reprod54(supp.):182.
  • Loch-Caruso R, Tsai M. 1996. Possible involvement of gap junctions in the development of spontaneous oscillatory contractions in uteri. Biol Reprod54(supp.):118.
  • Tsai M, Webb RC, Loch-Caruso R. 1996. Congener-specific effects of PCBs on contractions of pregnant rat uteri. Reproductive Toxicology10(1):21-28.

1995

  • Criswell KA, Loch-Caruso R. 1995. Lindane-Induced Elimination of Gap Junctional Communication in Rat Uterine Myocytes Is Mediated by an Arachidonic Acid-Sensitive cAMP-Independent Mechanism. Toxicol Appl Pharmacol135(1):127-138.
  • Criswell KA, Loch-Caruso R, Stuenkel E. 1995. Lindane inhibition of gap junctional communication in myometrial myocytes is partially dependent on phosphoinositide-generated second messenger. Toxicol Appl Pharmacol130:280-293.
  • Tsai M, Webb RC, Loch-Caruso R. 1995. Acute inhibition of uterine contraction by 4-hydroxy-2',4',6'-trichlorobiphenyl (4OHTCB) may result from disruption of gap junctional communication. The Toxicologist15:275.
  • Tsai M, Webb RC, Loch-Caruso R. 1995. Inhibition of spontaneous oscillatory uterine contractions by 17β-estradiol is associated with disruption of gap junctional communication. Biol Reprod52(supp.1):115.

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