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Your Environment. Your Health.

Person Details

Superfund Research Program

Rita Loch-Caruso

University of Michigan
M6108 SPH II
1415 Washington Heights
Ann Arbor, MI 48109-2029
Phone: 734-936-1256
Fax: 734-763-8095


Research Briefs



  • Elkin ER, Harris SM, Loch-Caruso R. 2018. Trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine induces lipid peroxidation-associated apoptosis via the intrinsic and extrinsic apoptosis pathways in a first-trimester placental cell line. Toxicol Appl Pharmacol 338:30-42. doi:10.1016/j.taap.2017.11.006 PMID:29129777 PMCID:PMC5741094


  • Cordero JF, Meeker JD, Loch-Caruso R, Giese RW, Padilla I, Vesper D, Kaeli D, Sheahan TC, Brown P, Velez-Vega C, Alshawabkeh AN. 2017. Team science applied to environmental health research: Karst hydrogeology and preterm birth in Puerto Rico. In: . Springer Publishing,
  • Park H, Harris SM, Boldenow E, McEachin RC, Sartor MA, Chames MC, Loch-Caruso R. 2017. Group B streptococcus activates transcriptomic pathways related to premature birth in human extraplacental membranes in vitro. Biol Reprod 98(3):396–407. doi:10.1093/biolre/iox147 PMID:29155939


  • Hassan I, Kumar AM, Park H, Lash LH, Loch-Caruso R. 2016. Reactive oxygen stimulation of interleukin-6 release in the human trophoblast cell line HTR-8/SVneo by the trichlorethylene metabolite S-(1,2-Dichloro)-l-Cysteine. Biol Reprod 95(3):66. doi:10.1095/biolreprod.116.139261 PMID:27488030



  • Ferguson KK, Cantonwine DE, Rivera-Gonzalez LO, Loch-Caruso R, Mukherjee B, Anzalota del Toro LV, Jimenez B, Calafat AM, Ye X, Alshawabkeh AN, Cordero JF, Meeker JD. 2014. Urinary phthalate metabolite associations with biomarkers of inflammation and oxidative stress across pregnancy in Puerto Rico. Environ Sci Technol 48(12):7018-7025. doi:10.1021/es502076j PMID:24845688 PMCID:PMC4066910
  • Korir ML, Knupp D, LeMerise K, Boldenow E, Loch-Caruso R, Aronoff DM, Manning SD. 2014. Association and virulence gene expression vary among serotype III group B streptococcus isolates following exposure to decidual and lung epithelial cells. Infect Immun 82(11):4587-4595. doi:10.1128/IAI.02181-14 PMID:25135682 PMCID:PMC4249324
  • Park H, Kamau PW, Loch-Caruso R. 2014. Involvement of reactive oxygen species in brominated diphenyl ether-47-induced inflammatory cytokine release from human extravillous trophoblasts in vitro. Toxicol Appl Pharmacol 274(2):283-292. doi:10.1016/j.taap.2013.11.015 PMID:24296301 PMCID:PMC3931445
  • Park H, Loch-Caruso R. 2014. Protective effect of nuclear factor E2-related factor 2 on inflammatory cytokine response to brominated diphenyl ether-47 in the HTR-8/SVneo human first trimester extravillous trophoblast cell line. Toxicol Appl Pharmacol 281(1):67-77. doi:10.1016/j.taap.2014.09.015 PMID:25305463 PMCID:PMC4393751
  • Park HR, Kamau PW, Korte CS, Loch-Caruso R. 2014. Tetrabromobisphenol A activates inflammatory pathways in human first trimester extravillous trophoblasts in vitro. Reprod Toxicol 50:154-162. doi:10.1016/j.reprotox.2014.10.005 PMID:25461914 PMCID:PMC4260776



  • Cordero JF, Meeker JD, Sheahan TC, Padilla I, Giese RW, Silevitch M, Loch-Caruso R, Kaeli D, Alshawabkeh AN. 2012. Case study - Puerto Rico test site for exploring contamination threats. Proceedings of Geo-Congress 3553-3562. doi:10.1061/9780784412121.364
  • Ferguson KK, Loch-Caruso R, Meeker JD. 2012. Exploration of oxidative stress and inflammatory markers in relation to urinary phthalate metabolites: NHANES 1999-2006. Environ Sci Technol 46(1):477-485. doi:10.1021/es202340b PMID:22085025 PMCID:PMC3258337
  • Korte C, Loch-Caruso R. 2012. Oxidative insult activates parturition-associated pathways in a human placental cell line. The Toxicologist - Supplement to Toxicol. Sci., Abstract #2383, 2012.
  • Loch-Caruso R, Kimani PW, Park HR. 2012. Brominated diphenyl ether-47 enhanced mRNA expression of pro-inflammatory cytokines and prostaglandin-endoperoxide synthase 2 in human placental cells. The Toxicologist - Supplement to Toxicol. Sci., Abstract #2386, 2012.
  • Mao X, Ciblak A, Baek K, Amiri M, Loch-Caruso R, Alshawabkeh AN. 2012. Optimization of electrochemical dechlorination of trichloroethylene in reducing electrolytes. Water Res 46(6):1847–1857. doi:10.1016/j.watres.2012.01.002 PMID:22264798 PMCID:PMC3288245
  • Mao X, Yuan S, Fallahpour N, Ciblak A, Howard J, Padilla I, Loch-Caruso R, Alshawabkeh AN. 2012. Electrochemically induced dual reactive barriers for transformation of TCE and mixture of contaminants in groundwater. Environ Sci Technol 46(21):12003-12011. doi:10.1021/es301711a PMID:23067023 PMCID:PMC3493133
  • Tetz LM, Loch-Caruso R, Giese RW, Wang P. 2012. Mono-2-ethylhexyl phthalate induced oxidative stress in human placental cells. The Toxicologist - Supplement to Toxicol. Sci., Abstract #2383, 2012.



  • Silevitch M, Giese RW, Kaeli D, Sheahan TC, Nobrega MC, Alshawabkeh AN, Cordero JF, Padilla I, Loch-Caruso R, Meeker JD. 2010. Interdisciplinary Three-Level Approach to Study Impact of Contamination on Public Health in Puerto Rico. In: Proceedings of Sixth International Congress on Environmental Geotechnics. New Delhi,
  • Thiex NW, Chames MC, Loch-Caruso R. 2010. Tissue-specific induction of COX-2 and prostaglandins in lipopolysaccharide-stimulated extraplacental human gestational membranes in a 2-chamber transwell culture system. Reprod Sci 17(12):1120-1129. doi:10.1177/1933719110378344 PMID:20861394 PMCID:PMC3096444


  • Meeker JD, Hu H, Cantonwine DE, Lamadrid-Figueroa H, Calafat AM, Ettinger AS, Hernandez-Avila M, Loch-Caruso R, Tellez-Rojo MM. 2009. Urinary phthalate metabolites in relation to preterm birth in Mexico City. Environ Health Perspect 117(10):1587-92. PMID:20019910



  • Brant KA, Loch-Caruso R. 2006. PCB 50 stimulates release of arachidonic acid and prostaglandins from late gestation rat amnion fibroblast cells. Reprod Toxicol 22(4):591-8. PMID:16713698


  • Loch-Caruso R, Upham BL, Harris C, Trosko JE. 2005. Divergent roles for glutathione in lindane-induced acute and delayed-onset inhibition of rat myometrial gap junctions. Toxicol Sci 85(1):694-702. PMID:15716478


  • Brant KA, Loch-Caruso R. 2004. Gestational increases and activation of rat uterine phospholipase A2 enzyme expression mediates PCB 50 - induced stimulation of uterine function. In: Proceedings of the 43rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.
  • Chung D, Loch-Caruso R. 2004. Role of gap junctions in the modification on rat uterine contraction by 2,2'-dichlorobiphenyl. In: Proceedings of the 43rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.
  • Loch-Caruso R, Galvez MM, Brant KA, Chung D. 2004. Cell and toxicant specific phosphorylation of conexin43: effects of lindane and TPA on rat myometrial and WB-F344 liver cell gap junctions. Cell Biol Toxicol 20(3):147-169. doi:10.1023/B:CBTO.0000029465.74815.62 PMID:15250540
  • Loch-Caruso R, Tsuneta T, Hanna M, Grindatti C, Quensen JF. 2004. Stimulatory effects of a microbially dechlorinated polychlorinated biphenyl (PCB) mixture on rat uterine contraction in vitro. In: Proceedings of the 43rd Annual Meeting of the Society of Toxicology (SOT), March 21-25, 2004. Baltimore, MD.


  • Brant KA, Loch-Caruso R. 2003. iPLA2 contributes to the gestation day sensitivity to 2,2',4,6 tetrachlorobiphenyl-induced stimulation of contraction frequency in rat uterus. Biol Reprod 68:382Suppl.1.
  • Chung D, Loch-Caruso R. 2003. Role of oxidative stress in the modification on rat uterine contraction by 2,2 '-dichlorobiphenyl. Toxicol Sci 72(1):376.
  • Nasser F, Chung D, Loch-Caruso R. 2003. Roles of endocannabinoids in rat uterine contractions. Biol Reprod 68:390Suppl.1.


  • Loch-Caruso R. 2002. Uterine muscle as a potential target of polychlorinated biphenyls during pregnancy. Int J Hyg Environ Health 205:121-130. PMID:12018005


  • Bae J, Mousa MA, Quensen JF, Boyd SA, Loch-Caruso R. 2001. Stimulation of contraction of pregnant rat uterus in vitro by non-dechlorinated and microbially dechlorinated mixtures of polychlorinated biphenyls. Environ Health Perspect 109(3):275-282. PMID:11333189


  • Bae J, Peters-Golden M, Loch-Caruso R. 1999. Stimulation of pregnant rat uterine contraction by the polychlorinated biphenyl (PCB) mixture Aroclor 1242 may be mediated by arachidonic acid release through activation of phospholipase A2 enzymes. J Pharmacol Exp Ther 289:1112-1120. PMID:10215694
  • Bae J, Stuenkel E, Loch-Caruso R. 1999. Stimulation of oscillatory uterine contraction by the PCB mixture Aroclor 1242 may involve increased [Ca2+]i through voltage-operated calcium channels. Toxicol Appl Pharmacol 155(3):261-272. PMID:10079212


  • Tsai M, Webb RC, Loch-Caruso R. 1997. The increase of oxytocin-induced oscillatory contractions by 4-hydroxy-2',4',6'-trichlorobiphenyl is estrogen receptor-mediated. Biol Reprod 56(2):341-347. PMID:9116132


  • Bae J, Loch-Caruso R. 1996. Stimulation of rat uterine oscillatory contraction by a polychlorinated biphenyl mixture, Aroclor 1242, and its sustained effect after removal of the compound. Biol Reprod 54(supp.):182.
  • Loch-Caruso R, Tsai M. 1996. Possible involvement of gap junctions in the development of spontaneous oscillatory contractions in uteri. Biol Reprod 54(supp.):118.
  • Tsai M, Webb RC, Loch-Caruso R. 1996. Congener-specific effects of PCBs on contractions of pregnant rat uteri. Reprod Toxicol 10(1):21-28. PMID:8998381


  • Criswell KA, Loch-Caruso R. 1995. Lindane-induced elimination of gap junctional communication in rat uterine myocytes is mediated by an arachidonic acid-sensitive cAMP-independent mechanism. Toxicol Appl Pharmacol 135(1):127-138. PMID:7482532
  • Criswell KA, Loch-Caruso R, Stuenkel E. 1995. Lindane inhibition of gap junctional communication in myometrial myocytes is partially dependent on phosphoinositide-generated second messenger. Toxicol Appl Pharmacol 130:280-293. PMID:7532876
  • Tsai M, Webb RC, Loch-Caruso R. 1995. Acute inhibition of uterine contraction by 4-hydroxy-2',4',6'-trichlorobiphenyl (4OHTCB) may result from disruption of gap junctional communication. Environ Health Perspect 15:275.
  • Tsai M, Webb RC, Loch-Caruso R. 1995. Inhibition of spontaneous oscillatory uterine contractions by 17β-estradiol is associated with disruption of gap junctional communication. Biol Reprod 52(supp.1):115.