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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Person Details: Patricia A. Buffler

Superfund Research Program

Patricia A. Buffler

University of California-Berkeley
50 University Hall #7360
University of California-Berkeley
Berkeley, California 94720-7360
Phone: 510-643-8083
Fax: 510-642-6669
Email: pab@berkeley.edu

Projects

Research Briefs

Publications

2014

  • de Smith AJ, Walsh KM, Ladner MB, Zhang S, Xiao C, Cohen F, Moore TB, Chokkalingam AP, Metayer C, Buffler PA, Trachtenberg EA, Wiemels JL. 2014. The role of KIR genes and their cognate HLA class I ligands in childhood acute lymphoblastic leukemia. Blood 123:2497-2503. doi:10.1182/blood-2013-11-540625 PMID:24518758 PMCID:PMC3990912
  • Deziel NC, Rull RP, Colt JS, Reynolds P, Whitehead TP, Gunier RB, Month SR, Taggart DR, Buffler PA, Ward MH, Metayer C. 2014. Polycyclic aromatic hydrocarbons in residential dust and risk of childhood acute lymphoblastic leukemia. Environ Res 133:388-395. doi:10.1016/j.envres.2014.04.033 PMID:24948546 PMCID:PMC4119528
  • Slusky DA, Does MB, Metayer C, Mezei G, Selvin S, Buffler PA. 2014. Potential role of selection bias in the association between childhood leukemia and residential magnetic fields exposure: a population-based assessment. Cancer Epidemiol 38(3):307-313. doi:10.1016/j.canep.2014.02.010 PMID:24679435 PMCID:PMC4140526
  • Ward MH, Colt JS, Deziel NC, Whitehead TP, Reynolds P, Gunier RB, Nishioka M, Dahl GV, Rappaport SM, Buffler PA, Metayer C. 2014. Residential levels of polybrominated diphenyl ethers and risk of childhood acute lymphoblastic leukemia in California. Environ Health Perspect 122(10):1110-1116. doi:10.1289/ehp.1307602 PMID:24911217 PMCID:PMC4181922
  • Whitehead T, Brown F, Metayer C, Park J, Does MB, Dhaliwal J, Petreas MX, Buffler PA, Rappaport SM. 2014. Polychlorinated biphenyls in residential dust: sources of variability. Environ Sci Technol 48:157-164. doi:10.1021/es403863m PMID:24313682 PMCID:PMC3941978
  • Xiao J, Lee S, Xiao Y, Ma X, Houseman EA, Hsu L, Roy R, Wrensch MR, de Smith AJ, Chokkalingam AP, Buffler PA, Wiencke JK, Wiemels JL. 2014. PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia. Int J Cancer 135(5):1101-1109. doi:10.1002/ijc.28759 PMID:24496747 PMCID:PMC4776754

2013

  • Metayer C, Colt JS, Buffler PA, Reed HD, Selvin S, Crouse V, Ward MH. 2013. Exposure to herbicides in house dust and risk of childhood acute lymphoblastic leukemia. J Expo Sci Environ Epidemiol 23:363-370. doi:10.1038/jes.2012.115 PMID:23321862
  • Metayer C, Zhang L, Wiemels JL, Bartley K, Schiffman J, Ma X, Aldrich MC, Chang JS, Selvin S, Fu CH, Ducore J, Smith MT, Buffler PA. 2013. Tobacco smoke exposure and the risk of childhood acute lymphoblastic and Myeloid Leukemias by cytogenetic subtype. Cancer Epidemiol Biomarkers Prev 22(9):1600. doi:10.1158/1055-9965.epi-13-0350 PMID:23853208 PMCID:PMC3769478
  • Milne E, Greenop KR, Metayer C, Schuz J, Petridou E, Pombo-de-Oliveira MS, Infante-Rivard C, Roman E, Dockerty JD, Spector LG, Koifman S, Orsi L, Rudant J, Dessypris N, Simpson J, Lightfoot TJ, Kaatsch P, Baka M, Faro A, Armstrong BK, Clavel J, Buffler PA. 2013. Fetal growth and childhood acute lymphoblastic leukemia: findings from the childhood leukemia international consortium. Int J Cancer 133:2968-2979. doi:10.1002/ijc.28314 PMID:23754574 PMCID:PMC3797193

2012

  • Slusky DA, Metayer C, Aldrich MC, Ward MH, Lea CS, Selvin S, Buffler PA. 2012. Reliability of maternal-reports regarding the use of household pesticides: Experience from a case-control study of childhood leukemia. Cancer Epidemiol 36(4):375-380. doi:10.1016/j.canep.2011.12.009 PMID:22277328 PMCID:PMC4140525

2011

  • Metayer C, Scelo G, Chokkalingam AP, Barcellos L, Aldrich MC, Chang JS, Guha N, Urayama KY, Hansen HM, Block G, Kiley VA, Wiencke JK, Wiemels JL, Buffler PA. 2011. Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia. Cancer Causes Control 22:1243-1258. doi:10.1007/s10552-011-9795-7 PMID:21748308 PMCID:PMC3744066
  • Slusky DA, Mezei G, Metayer C, Selvin S, Von Behren J, Buffler PA. 2011. Comparison of racial differences in childhood cancer risk in case-control studies and population-based cancer registries. Cancer Epidemiol 36:36-44. doi:10.1016/j.canep.2011.05.005 PMID:22018954
  • Whitehead T, Metayer C, Gunier RB, Ward MH, Nishioka M, Buffler PA, Rappaport SM. 2011. Determinants of polycyclic aromatic hydrocarbon levels in house dust. J Expo Sci Environ Epidemiol 21(2):123-132. doi:10.1038/jes.2009.68 PMID:20040932 PMCID:PMC2891419

2010

2009

  • Chang JS, Buffler PA, Metayer C, Chokkalingam AP, Patoka J, Kronish D, Wiemels JL. 2009. Maternal immunoglobulin E and childhood leukemia. Cancer Epidemiol Biomarkers Prev 18(8):2221-2227. doi:10.1158/1055-9965.EPI-09-0212 PMID:19622720
  • Scelo G, Metayer C, Zhang L, Wiemels JL, Aldrich MC, Selvin S, Month S, Smith MT, Buffler PA. 2009. Household exposure to paint and petroleum solvents, chromosomal translocations, and the risk of childhood leukemia. Environ Health Perspect 117(1):133-139. PMID:19165400
  • Urayama KY, Von Behren J, Reynolds P, Hertz A, Does MB, Buffler PA. 2009. Factors associated with residential mobility in children with leukemia: implications for assigning exposures. Ann Epidemiol 19(11):834-840. doi:10.1016/j.annepidem.2009.03.001 PMID:19364662 PMCID:PMC2761989
  • Ward MH, Colt JS, Metayer C, Gunier RB, Lubin JH, Crouse V, Nishioka M, Reynolds P, Buffler PA. 2009. Residential exposure to polychlorinated biphenyls and organochlorine pesticides and risk of childhood leukemia. Environ Health Perspect 117(6):1007-13. doi:10.1289/ehp.0900583 PMID:19590698 PMCID:PMC2702395
  • Whitehead T, Metayer C, Ward MH, Nishioka M, Gunier RB, Colt JS, Reynolds P, Selvin S, Buffler PA, Rappaport SM. 2009. Is house-dust nicotine a good surrogate for household smoking?. Am J Epidemiol 169(9):1113-1123. doi:10.1093/aje/kwp021 PMID:19299402 PMCID:PMC2727236

2008

  • Colt JS, Gunier RB, Metayer C, Nishioka M, Bell EM, Reynolds P, Buffler PA, Ward MH. 2008. Household vacuum cleaners vs the high-volume surface sampler for collection of carpet dust samples in epidemiologic studies of children. Environ Health 7:6. doi:10.1186/1476-069X-7-6 PMID:18291036 PMCID:PMC2265689
  • Guha N, Chang JS, Chokkalingam AP, Wiemels JL, Smith MT, Buffler PA. 2008. NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis. Am J Epidemiol 168(11):1221-1232. doi:10.1093/aje/kwn246 PMID:18945694 PMCID:PMC2727266
  • Metayer C, Buffler PA. 2008. Residential pesticides and childhood leukemia. Radiat Prot Dosimetry 132:212-9. PMID:18940823
  • Schiffenbauer J, Buffler PA, Wiemels JL, Vasconcelos GM, Kang M, Pombo-de-Oliveira MS, Lorey F. 2008. Adenovirus detection in Guthrie cards from paediatric leukaemia cases and controls. Br J Cancer 99(10):1668-1672. doi:10.1038/sj.bjc.6604714 PMID:19002185 PMCID:PMC2584954
  • Wiemels JL, Hofmann J, Kang M, Selzer R, Green R, Zhou M, Zhong S, Zhang L, Smith MT, Marsit CJ, Loh ML, Buffler PA, Yeh R. 2008. Chromosome 12p deletions in TEL-AML1 childhood acute lymphoblastic leukemia are associated with retrotransposon elements and occur postnatally. Cancer Res 68(23):9935-9944. doi:10.1158/0008-5472.CAN-08-2139 PMID:19047175 PMCID:PMC2597307

2007

  • Chang JS, Metayer C, Fear NT, Reinier K, Yin X, Urayama KY, Russo C, Buffler PA. 2007. Parental social contact in the work place and the risk of childhood acute lymphoblastic leukaemia. Br J Cancer 97(9):1315-1321. doi:10.1038/sj.bjc.6604024 PMID:17923868 PMCID:PMC2360459
  • Urayama KY, Wiencke JK, Buffler PA, Selvin S, Wiemels JL. 2007. MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia. Cancer Epidemiol Biomarkers Prev 16(6):1172-1177. doi:10.1158/1055-9965.EPI-07-0007 PMID:17548681

2006

  • Aldrich MC, Zhang L, Wiemels JL, Ma X, Loh ML, Metayer C, Selvin S, Feusner J, Smith MT, Buffler PA. 2006. Cytogenetics of hispanic and white children with acute lymphoblastic leukemia in california. Cancer Epidemiol Biomarkers Prev 15(3):578-581. PMID:16537719
  • Chang JS, Selvin S, Metayer C, Crouse V, Golembesky A, Buffler PA. 2006. Parental smoking and the risk of childhood leukemia. Am J Epidemiol 163(12):1091-1100. doi:10.1093/aje/kwj143 PMID:16597704
  • Kwan ML, Metayer C, Crouse V, Buffler PA. 2006. Maternal illness and drug/medication use during the period surrounding pregnancy and risk of childhood leukemia among offspring. Am J Epidemiol 165(1):27-35. PMID:17035343
  • Paynter RA, Skibola DR, Skibola CF, Buffler PA, Wiemels JL, Smith MT. 2006. Accuracy of multiplexed Illumina platform-based single-nucleotide polymorphism genotyping compared between genomic and whole genome amplified DNA collected from multiple sources. Cancer Epidemiol Biomarkers Prev 15(12):2533-2536. doi:10.1158/1055-9965.EPI-06-0219 PMID:17164381

2005

  • Smith MT, McHale CM, Wiemels JL, Zhang L, Wiencke JK, Zheng S, Gunn L, Skibola CF, Ma X, Buffler PA. 2005. Molecular biomarkers for the study of childhood leukemia. Toxicol Appl Pharmacol 206(2):237-245. PMID:15967214
  • Wiemels JL, Zhang Y, Chang J, Zheng S, Metayer C, Zhang L, Smith MT, Ma X, Selvin S, Buffler PA, Wiencke JK. 2005. RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia. Leukemia 19(3):415-419. PMID:15674422

2004

  • Block G, Buffler PA, Ma X, Selvin S. 2004. Maternal intake of vegetables, protein sources and glutathione are associated with reduced risk of childhood leukemia. In: The American Public Health Association 131st Annual Meeting, November. San Francisco, CA.
  • Jensen CD, Block G, Buffler PA, Ma X, Selvin S, Month S. 2004. Maternal dietary risk factors in childhood acute lymphoblastic leukemia (United States). Cancer Causes Control 15(6):559-570. PMID:15280635
  • Kwan ML, Block G, Selvin S, Buffler PA. 2004. Early childhood nutrition and risk of childhood acute leukemia: Results from a case-control study. Am J Epidemiol 157(11):43Suppl.S.
  • Kwan ML, Block G, Selvin S, Buffler PA. 2004. Early childhood nutrition and risk of childhood acute leukemia: Results from a case-control study. In: The 36th Annual Meeting of the Society for Epidemiologic Research, June. Alanta, GA.
  • Kwan ML, Block G, Selvin S, Month S, Buffler PA. 2004. Food consumption by children and the risk of childhood acute leukemia. Am J Epidemiol 160(11):1098-1107. PMID:15561989
  • Kwan ML, Buffler PA, Abrams B, Kiley VA. 2004. Breastfeeding and the risk of childhood leukemia: a meta-analysis. Public Health Rep 119(6):521-535. PMID:15504444
  • Ma X, Buffler PA, Layefsky M, Does MB, Reynolds P. 2004. Control selection strategies in case-control studies of childhood diseases. Am J Epidemiol 159(10):915-921. PMID:15128601
  • Metayer C, Aldrich MC, Guha N, Does MB, Buffler PA. 2004. Childhood Leukemia and Environmental Exposures: the Northern and Central California Childhood Leukemia Study (NCCLS). In: The American Public Health Association 131st Annual Meeting, November. San Francisco, CA.
  • Reinier K, Hammond SK, Buffler PA, Gunier RB, Lea CS, Quinlan P, Kirsch J. 2004. Development and evaluation of parental occupational exposure questionnaires for a childhood leukemia study. Scand J Work Environ Health 30(6):450-458. PMID:15633596
  • Selvin S, Ragland KE, Chien EY, Buffler PA. 2004. Spatial analysis of childhood leukemia in a case/control study. Int J Hyg Environ Health 207(6):555-562. PMID:15729836
  • Zheng S, Ma X, Zhang L, Gunn L, Smith MT, Wiemels JL, Leung K, Buffler PA, Wiencke JK. 2004. Hypermethylation of the 5 ' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia. Cancer Res 64(6):2000-2006. PMID:15026336

2003

  • Golembesky A, Ma X, Buffler PA. 2003. Paternal smoking and childhood leukemia: Preliminary results from the Northern California Childhood Leukemia Study and a meta-analysis. In: Proceedings of the 94th annual conference of the American Association for Cancer Research, July 11-14, 2003. Washington, DC.
  • Guha N, Reynolds P, Buffler PA. 2003. Home pesticide exposure assessment in the Northern California Childhood Leukemia Study. In: Proceedings of the NIEHS (National Institute of Environmental Health Sciences) Superfund Region 9 Conference, October 2003. Berkley, CA.
  • McHale CM, Wiemels JL, Zhang L, Ma X, Buffler PA, Feusner J, Matthay KK, Dahl GV, Smith MT. 2003. Prenatal origin of childhood acute myeloid leukemias harboring chromosomal rearrangements t(15;17) and inv(16). Blood 101(11):4640-4641. PMID:12756163
  • McHale CM, Wiemels JL, Zhang L, Ma X, Buffler PA, Guo W, Loh ML, Smith MT. 2003. Prenatal origin of TEL-AML1-positive acute lymphoblastic leukemia in children born in California. Genes, Chromosomes and Cancer 37(1):36-43. PMID:12661004
  • Smith MT, Wiencke JK, Wiemels JL, Zhang L, Ma X, McHale CM, Buffler PA. 2003. Molecular epidemiology of childhood leukemia. Environ Mol Mutagen 41(3):206.
  • Wiencke JK, Zheng S, Smith MT, Zhang L, Ma X, Wiemels JL, Marsit CJ, Kelsey KT, Buffler PA. 2003. Methylation of transcribed PTEN pseudogene in pediatric leukemia is associated with subtypes of common ALL containing t(12;21) translocation. In: Proceedings of the Ninety Fourth Annual Meeting of the (AACR) American Association for Cancer Research, July 11-14, 2003, San Francisco. San Franciso, CA.
  • Zhang L, Zheng S, Ma X, Wiemels JL, Buffler PA, Smith MT, Wiencke JK. 2003. Molecular cytogenetic characterization of childhood acute lymphoblastic leukemia and its relation to FHIT gene methylation. Environ Mol Mutagen 41(3):215.
  • Zheng S, Ma X, Wiemels JL, Zhang L, Gunn L, Smith MT, Buffler PA, Wiencke JK. 2003. Hypermethylation of the 5'CpG island of the FHIT gene is associated with hyperdiploid and translocation negative subtypes of pediatric leukemia. In: Proceedings of the Ninety Fourth Annual Meeting of the (AACR) American Association for Cancer Research, July 11-14, 2003, San Francisco. San Franciso, CA.

2002

  • Ma X, Buffler PA, Gunier RB, Dahl GV, Smith MT, Reinier K, Reynolds P. 2002. Critical windows of exposure to household pesticides and risk of childhood leukemia. Environ Health Perspect 110(9):955-960. PMID:12204832
  • Ma X, Buffler PA, Selvin S, Matthay KK, Wiencke JK, Wiemels JL, Reynolds P. 2002. Daycare attendance and the risk of childhood acute lymphoblastic leukemia. Br J Cancer 86(9):1419-1424.
  • McHale CM, Wiemels JL, Zhang L, Ma X, Buffler PA, Smith MT. 2002. Prenatal origin of TEL-AML positive acute lymphoblastic leukemia in children born in California. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.4566.
  • Urayama KY, Wiencke JK, Buffler PA, Wiemels JL. 2002. #21-S the role of MDR-1 gene polymorphisms in the genetic susceptibility to childhood leukemia. Ann Epidemiol 12(7):497.
  • Urayama KY, Wiencke JK, Buffler PA, Wiemels JL. 2002. The role of MDR-1 gene polymorphisms in the genetic susceptibility to childhood leukemia. In: The proceedings of the American College of Epidemiology Annual Scientific Session, September 22-24. Albuquerque, NM.
  • Wiemels JL, Leonard BC, Wang Y, Segal MR, Hunger SP, Smith MT, Crouse V, Ma X, Buffler PA, Pine SR. 2002. Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia. Proc Natl Acad Sci U S A 99(23):15101-15106. PMID:12415113
  • Wiemels JL, Xiao Z, Buffler PA, Maia AT, Ma X, Dicks BM, Smith MT, Zhang L, Feusner J, Wiencke JK, Pritchard-Jones K, Kempski H, Greaves MF. 2002. In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia. In: Proceedings of the Ninety Third (AACR) American Association for Cancer Research, April 6-10, 2002, San Francisco. San Franciso, CA. pp.4567.
  • Wiemels JL, Xiao Z, Buffler PA, Maia AT, Ma X, Dicks BM, Smith MT, Zhang L, Feusner J, Wiencke JK, Pritchard-Jones K, Kempski H, Greaves MF. 2002. In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia. Blood 99(10):3801-3805. PMID:11986239

2001

  • Ma X, Buffler PA, Gunier RB, Reinier K, Reynolds P. 2001. Household pesticide exposure and childhood leukemia: results from a case-control study. Epidemiology 12(4):S42.
  • Reinier K, Buffler PA. 2001. The anatomy of participation rates in case-control studies. Am J Epidemiol 153(11):S258.
  • Reinier K, Does MB, Ragland D, Layefsky M, Buffler PA. 2001. Population-based controls in the Northern California Childhood Leukemia Study: an evaluation of possible selection bias. Epidemiology 12(4):S85.
  • Xiao Z, Greaves MF, Buffler PA, Smith MT, Segal MR, Dicks BM, Wiencke JK, Wiemels JL. 2001. Molecular characterization of genomic AML1-ETO fusions in childhood leukemia. Leukemia 15:1906-1913. PMID:11753612
  • Zheng S, Ma X, Buffler PA, Smith MT, Wiencke JK. 2001. Whole genome amplification increases the efficiency and validity of buccal cell genotyping in pediatric populations. Cancer Epidemiol Biomarkers Prev 10:697-700. PMID:11401921

1998

  • Wood S, Buffler PA, Burau K, Krivanek N. 1998. Mortality and morbidity experience of workers exposed to acrylonitrile in fiber production. Scand J Work Environ Health 24(2):54-62.

1997

  • Croen LA, Shaw GM, Sanbonmatsu L, Selvin S, Buffler PA. 1997. Maternal residential proximity to hazardous waste sites and risk for selected congenital malformations. Epidemiology 8(4):347-354. PMID:9209846

1996

  • Buffler PA, Reynolds P, Smith MT, Lea CS, Wood S. 1996. The molecular epidemiology of childhood leukemia with emphasis on chemical exposures. In: Proceedings of the Pacific Basin Conference on Hazardous Waste, November 4-8, 1996, Kuala Lumpur, Malaysia. East-West Center, Kuala Lumpur, Malaysia.

1995

  • Smith MT, Lea CS, Buffler PA. 1995. Human population changes caused by hazardous waste. Eur J Public Health 2(3):77-79. PMID:7655408
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