Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Person Details: Andrew J. Wyrobek

Superfund Research Program

Andrew J. Wyrobek

Lawrence Livermore National Laboratory
Health Effects Genetics Division, L-448
Biology and Biotechnology Research Program
Berkeley, California 94551
Phone: 925-422-6296
Fax: 925-424-3130


Research Briefs





  • Marchetti F, Eskenazi B, Weldon RH, Li G, Zhang L, Rappaport SM, Schmid TE, Xing C, Kurtovich E, Wyrobek AJ. 2012. Occupational exposure to benzene and chromosomal structural aberrations in the sperm of Chinese men. Environ Health Perspect 120(2):229-234. doi:10.1289/ehp.1103921 PMID:22086566 PMCID:PMC3279447
  • Schmid TE, Eskenazi B, Marchetti F, Young SS, Weldon RH, Baumgartner A, Anderson D, Wyrobek AJ. 2012. Micronutrients intake is associated with improved sperm DNA quality in older men. Fertil Steril 98:1130-1137. doi:10.1016/j.fertnstert.2012.07.1126 PMID:22935557


  • Xing C, Marchetti F, Li G, Weldon RH, Kurtovich E, Young SS, Schmid TE, Zhang L, Rappaport SM, Waidyanatha S, Wyrobek AJ, Eskenazi B. 2010. Benzene exposure near the US permissible limit is associated with sperm aneuploidy. Environ Health Perspect 118:833-839. doi:10.1289/ehp.0901531 PMID:20418200 PMCID:PMC2898861


  • Young SS, Eskenazi B, Marchetti F, Block G, Wyrobek AJ. 2008. The association of folate, zinc and antioxidant intake with sperm aneuploidy in healthy non-smoking men. Hum Reprod 23(5):1014-1022. doi:10.1093/humrep/den036 PMID:18353905


  • Eskenazi B, Kidd SA, Marks AR, Sloter E, Block G, Wyrobek AJ. 2005. Antioxidant intake is associated with semen quality in healthy men. Hum Reprod 20(4):1006-1012. PMID:15665024
  • Wyrobek AJ, Schmid TE, Marchetti F. 2005. Cross-species sperm-FISH assays for chemical testing and assessing paternal risk for chromosomally abnormal pregnancies. Environ Mol Mutagen 45(2-3):271-283. PMID:15754381
  • Wyrobek AJ, Schmid TE, Marchetti F. 2005. Relative susceptibilities of male germ cells to genetic defects induced by cancer chemotherapies. J Natl Cancer Inst (34):31-35. doi:10.1093/jncimonographs/lgi001 PMID:15784819


  • Sloter E, Nath J, Eskenazi B, Wyrobek AJ. 2004. Effects of male age on the frequencies of germinal and heritable chromosomal abnormalities in humans and rodents. Fertil Steril 81(4):925-943. PMID:15066442


  • Eskenazi B, Wyrobek AJ, Sloter E, Kidd SA, Young SS, Moore DH. 2003. The association of age and semen quality in healthy men. Hum Reprod 18(2):447-454. PMID:12571189
  • Glaser RL, Broman KW, Schulman RL, Eskenazi B, Wyrobek AJ, Jabs EW. 2003. The paternal-age effect in Apert syndrome is due, in part, to the increased frequency of mutations in sperm. Am J Hum Genet 73(4):939-947. PMID:12900791


  • Eskenazi B, Wyrobek AJ, Kidd SA, Lowe X, Moore DH, Weisiger K, Aylstock M. 2002. Sperm aneuploidy in fathers of children with paternally and maternally inherited Klinefelter syndrome. Hum Reprod 17(3):576-583. PMID:11870106
  • Eskenazi B, Wyrobek AJ, Sloter E, Kidd SA, Moore LE, Young SS, Moore DH, Nath J. 2002. Semen quality and chromosomal integrity of sperm decreases with age among healthy men. Environ Mol Mutagen 39(Supp33):59.
  • Rubes J, Vozdova M, Robbins WA, Rezacova O, Perreault SD, Wyrobek AJ. 2002. Stable variants of sperm aneuploidy among healthy men show associations between germinal and somatic aneuploidy. Am J Hum Genet 70(6):1507-1519. PMID:11992257
  • Tiemann-Boege I, Navidi W, Grewal R, Cohn D, Eskenazi B, Wyrobek AJ, Arnheim N. 2002. The observed human sperm mutation frequency cannot explain the achondroplasia paternal age effect. Proc Natl Acad Sci U S A 99(23):14952-14957. PMID:12397172
  • Velazquez-Wong AC, Sloter E, Tomascik-Cheeseman LM, Araujo-Solis MA, Wyrobek AJ, Salamanca-Gomez F. 2002. Structural and numerical chromosomal abnormalities in sperm following accidental occupational exposure to 192Iridium. Environ Mol Mutagen 39(Supp33):65.


  • Kidd SA, Eskenazi B, Wyrobek AJ. 2001. Effects of male age on semen quality and fertility: a review of the literature. Fertil Steril 75(2):237-248. PMID:11172821
  • Lowe X, Eskenazi B, Nelson DO, Kidd SA, Alme A, Wyrobek AJ. 2001. Frequency of XY sperm increases with age in fathers of boys with Klinefelter syndrome. Am J Hum Genet 69(5):1046-1054. PMID:11582569
  • Marchetti F, Sloter E, Wyrobek AJ. 2001. Advances in understanding paternally transmitted chromosomal abnormalities. In: Impact of air pollution on human health. Academia Press, Prague, Czech Republic. pp.193-205.
  • Sloter E, Eskenazi B, Kidd SA, Moore DH, Hill F, Nath J, Wyrobek AJ. 2001. Effects of age on structural chromosomal abnormalities in sperm from healthy men. Environ Mol Mutagen 37(32):70.


  • Sloter E, Nath J, Wyrobek AJ. 2000. Associations between chromosomal abnormalities and semen quality in healthy men. Environ Mol Mutagen 35(31):57.


  • Holland NT, Ahlborn T, Turteltaub KW, Markee C, Moore DH, Wyrobek AJ, Smith MT. 1999. Acrylamide causes preimplantation abnormalities in embryos and induces chromatin-adducts in male germ cells of mice. Reprod Toxicol 13(3):167-178. PMID:10378466
  • Sloter E, Nath J, Wyrobek AJ. 1999. Correlation between numerical and structural chromosome damage in sperm from 13 healthy men using multicolor FISH. Am J Hum Genet 65(4):A357.


  • Eskenazi B, Chuu Y, Kidd SA, Lowe X, Aylstock M, Weisiger K, Moore DH, Wyrobek AJ. 1998. Elevated frequencies of aneuploid sperm (x-y and 21-21) in fathers of boys with klinefelter syndrome (47, x-x-y), when the extra x-chromosome was of paternal origin. Am J Epidemiol 147(11):S11.
  • Lowe X, Eskenazi B, Kidd SA, Alme A, Weisiger K, Aylstock M, Nelson DE, Wyrobek AJ. 1998. Sperm disomy 21 is associated with sex chromosomal aneuploidies but does not preferentially segregate with the Y chromosome: a study of 38 healthy fertile men. Am J Hum Genet 63(4):A143.
  • Sloter E, Lowe X, Nath J, Wyrobek AJ. 1998. A novel multi-color FISH method for human sperm demonstrates that post-meiotic chromosome breaks occur more frequently than duplications and deletions. Am J Hum Genet 63(4):A150.
  • Sloter E, Lowe X, Nath J, Wyrobek AJ. 1998. Detection of chromosome breaks and aneuploidies in human sperm by multicolor fluorescence in situ hybridization. Environ Mol Mutagen 31(29):61.
  • Titenko-Holland N, Ahlborn T, Lowe X, Shang N, Smith MT, Wyrobek AJ. 1998. Micronucleal and developmental abnormalities in 4-day mouse embryos after paternal treatment with acrylamide. Environ Mol Mutagen 31(3):206-217. PMID:9585259
  • Wyrobek AJ, Eskenazi B, Chuu Y, Kidd SA, Lowe X, Weisiger K, Aylstock M, Sloter E, Moore DH, Katz D. 1998. Genetic Biomarkers in Human Sperm: Applications in Reproductive Epidemiology. In: Proceedings of the Superfund Basic Research Program: A Decade of Improving Health through Multi-Disciplinary Research. Chapel Hill, NC.


  • Chuu Y, Lowe X, Kidd SA, Weisiger K, Eskenazi B, Wyrobek AJ. 1997. Elevated Frequencies Of Hyperhaploid Sperm Were Detected In A Man With A History Of Multiple Aneuploid Pregnancies. In: Proceedings of Environmental Mutagen Society Meeting, 1997. Minneapolis, MN.
  • Robbins WA, Meistrich ML, Moore DH, Hagemeister FB, Weier H, Cassel MJ, Wilson G, Eskenazi B, Wyrobek AJ. 1997. Chemotherapy induces transient sex chromosomal and autosomal aneuploidy in human sperm. Nat Genet 16:74-78. PMID:9140398
  • Wyrobek AJ, Eskenazi B, Chuu Y, Kidd SA, Lowe X, Weisiger K, Aylstock M, Sloter E, Moore DH, Katz D. 1997. Genetic biomarkers in human sperm: Applications in reproductive epidemiology. In: Proceedings of the Superfund Basic Research Program: A decade of improving health through multi-disciplinary research, Chapel Hill, NC, February 23-26, 1997. Chapel Hill, NC.


  • Titenko-Holland N, Turteltaub KW, Wyrobek AJ, Smith MT. 1995. Acrylamide induces DNA adducts in male germ cells and causes preimplantation abnormalities and dominant lethal mutations in mice. Environ Health Perspect 15(1):167.
to Top