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Your Environment. Your Health.

Person Details: Harvey Checkoway

Superfund Research Program

Harvey Checkoway

University of California-San Diego
Department of Family & Preventive Medicine
9500 Gilman Drive, MC 0725
La Jolla, California 92093-0725
Phone: 858-822-0159
Email: hcheckoway@ucsd.edu

Projects

Research Briefs

Publications

2018

2017

  • Racette BA, Searles Nielsen S, Criswell SR, Sheppard L, Seixas N, Warden MN, Checkoway H. 2017. Dose-dependent progression of parkinsonism in manganese-exposed welders. Neurology 88(4):344-351. doi:10.1212/WNL.0000000000003533 PMID:28031394 PMCID:PMC5272970
  • Searles Nielsen S, Al-Lozi A, Hershey T, Birke A, Checkoway H, Criswell SR, Racette BA. 2017. Cognitive control dysfunction in workers exposed to manganese-containing welding fume. Am J Ind Med 60(2):181-188. doi:10.1002/ajim.22675 PMID:27862095

2015

2014

  • Ahmed I, Lee P, Lill CM, Nielsen SS, Artaud F, Gallagher LG, Loriot M, Mulot C, Nacfer M, Liu T, Biernacka JM, Armasu S, Anderson K, Farin FM, Lassen CF, Hansen J, Olsen JH, Bertram L, Maraganore DM, Checkoway H, Ritz B, Elbaz A. 2014. Lack of replication of the GRIN2A-by-coffee interaction in Parkinson disease. PLoS Genet 10(11):e1004788. doi:10.1371/journal.pgen.1004788 PMID:25412286 PMCID:PMC4238979
  • Checkoway H, Searles Nielsen S, Racette BA. 2014. Epidemiological Studies of Parkinsonism in Welders. Chapter 20 in: Manganese in Health and Disease. Royal Society of Chemistry, Cambridge, United Kingdom.
  • Gonzalez-Cuyar LF, Nelson G, Criswell SR, Ho P, Lonzanida JA, Checkoway H, Seixas N, Gelman BB, Evanoff BA, Murray J, Zhang J, Racette BA. 2014. Quantitative neuropathology associated with chronic manganese exposure in South African mine workers. Neurotoxicology 45:260-266. doi:10.1016/j.neuro.2013.12.008 PMID:24374477 PMCID:PMC4072755
  • Lundin JI, Checkoway H, Criswell SR, Hobson AJ, Harris RC, Swisher LM, Evanoff BA, Racette BA. 2014. Screening for early detection of parkinsonism using a self-administered questionnaire: a cross-sectional epidemiologic study. Neurotoxicology 45:232-237. doi:10.1016/j.neuro.2013.08.010 PMID:24035927 PMCID:PMC3954448
  • Lundin JI, Ton TG, LaCroix AZ, Longstreth WT, Swanson PD, Smith-Weller T, Racette BA, Checkoway H. 2014. Formulations of hormone therapy and risk of Parkinson's disease. Movement Disorders 29:1631-1636. doi:10.1002/mds.26037 PMID:25255692 PMCID:PMC4216612

2013

2012

  • Criswell SR, Perlmutter JS, Huang J, Golchin N, Flores HP, Hobson AJ, Aschner M, Erikson KM, Checkoway H, Racette BA. 2012. Basal ganglia intensity indices and diffusion weighted imaging in manganese-exposed welders. Occup Environ Med 69(6):437-443. doi:10.1136/oemed-2011-100119 PMID:22447645 PMCID:PMC3651997
  • Lin X, Cook TJ, Zabetian CP, Leverenz JB, Peskind ER, Hu S, Cain KC, Pan C, Edgar JS, Goodlett DR, Racette BA, Checkoway H, Montine TJ, Shi M, Zhang J. 2012. DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease. Sci Rep 2:doi:10.1038/srep00954 PMID:23233873 PMCID:PMC3518819
  • Mata IF, Checkoway H, Hutter CM, Samii A, Roberts JW, Kim H, Alvarez V, Ribacoba R, Pastor P, Lorenzo-Betancor O, Infante J, Sierra M, Gomez-Garre P, Mir P, Ritz B, Rhodes SL, Colcher A, Van Deerlin V, Chung KA, Quinn JF, Yearout D, Martizez E, Farin FM, Wan JY, Edwards KL, Zabetian CP. 2012. Common variation in the LRRK2 gene is a risk factor for Parkinson's disease. Movement Disorders 27(14):1823-1826. doi:10.1002/mds.25226 PMID:23115130 PMCID:PMC3536918
  • Nielsen SS, Checkoway H, Butler RA, Nelson HH, Farin FM, Longstreth WT, Franklin GM, Swanson PD, Kelsey KT. 2012. LINE-1 DNA methylation, smoking and risk of Parkinson's disease. J Parkinsons Dis 2(4):303-308. doi:10.3233/JPD-012129 PMID:23938260 PMCID:PMC3962286
  • Nielsen SS, Gallagher LG, Lundin JI, Longstreth WT, Smith-Weller T, Franklin GM, Swanson PD, Checkoway H. 2012. Environmental tobacco smoke and Parkinson's disease. Movement Disorders 27(2):293-297. doi:10.1002/mds.24012 PMID:22095755 PMCID:PMC3289937
  • Racette BA, Criswell SR, Lundin JI, Hobson AJ, Seixas N, Kotzbauer PT, Evanoff BA, Perlmutter JS, Zhang J, Sheppard L, Checkoway H. 2012. Increased risk of Parkinsonism associated with welding exposure. Neurotoxicology 33(5):1356-1361. doi:10.1016/j.neuro.2012.08.011 PMID:22975422 PMCID:PMC3651999

2010

  • Furlong CE, Suzuki SM, Stevens RC, Marsillach J, Richter RJ, Jarvik GP, Checkoway H, Samii A, Costa LG, Griffith A, Roberts JW, Yearout D, Zabetian CP. 2010. Human PON1, a biomarker of risk of disease and exposure. Chem Biol Interact 187(1-3):355-361. doi:10.1016/j.cbi.2010.03.033 PMID:20338154 PMCID:PMC3035622
  • Hofmann JN, Checkoway H, Borges O, Servin F, Fenske RA, Keifer M. 2010. Development of a computer-based survey instrument for organophosphate and N-methyl-carbamate exposure assessment among agricultural pesticide handlers. Ann Occup Hyg 54:640-650. doi:10.1093/annhyg/meq038 PMID:20413416 PMCID:PMC2918489
  • Hofmann JN, Keifer M, Checkoway H, De Roos AJ, Farin FM, Fenske RA, Richter RJ, van Belle G, Furlong CE. 2010. Biomarkers of sensitivity and exposure in Washington state pesticide handlers. Advances in Experimental Medicine and Biology 660:19-27. doi:10.1007/978-1-60761-350-3_3 PMID:20221867 PMCID:PMC3041670
  • Hofmann JN, Keifer M, De Roos AJ, Fenske RA, Furlong CE, van Belle G, Checkoway H. 2010. Occupational determinants of serum cholinesterase inhibition among organophosphate-exposed agricultural pesticide handlers in Washington State. Occup Environ Med 67(6):375-386. doi:10.1136/oem.2009.046391 PMID:19819864 PMCID:PMC2908529

2009

  • Hobson AJ, Sterling DA, Emo B, Evanoff BA, Sterling CS, Good L, Seixas N, Checkoway H, Racette BA. 2009. Validity and reliability of an occupational exposure questionnaire for parkinsonism in welders. J Occup Environ Hyg 6(6):324-331. doi:10.1080/15459620902836856 PMID:19288335 PMCID:PMC2879629
  • Hofmann JN, Keifer M, Furlong CE, De Roos AJ, Farin FM, Fenske RA, van Belle G, Checkoway H. 2009. Serum cholinesterase inhibition in relation to paraoxonase-1 (PON1) status among organophosphate-exposed agricultural pesticide handlers. Environ Health Perspect 117:1402-1408. PMID:19750105

2008

  • Costa-Mallen P, Checkoway H, Zabetian CP. 2008. The functional polymorphism of the hemoglobin-binding protein haptoglobin influences susceptibility to idiopathic Parkinson's disease. Am J Med Genet B Neuropsychiatr Genet 147B(2):216-222. doi:10.1002/ajmg.b.30593 PMID:17918239

2007

  • Ton TG, Heckbert SR, Longstreth WT, Rossing MA, KuKull WA, Franklin GM, Swanson PD, Smith-Weller T, Checkoway H. 2007. Calcium channel blockers and beta-blockers in relation to Parkinson's disease. Parkinsonism Relat Disord 13(3):165-9. PMID:17055323

2006

  • Checkoway H. 2006. Methodological challenges in identifying occupational risk factors for neurodegenerative diseases. In: Regional North American Annual Meeting of the World. Federation of Neurology - Research Group on Neuroepidemiology; April 7. San Diego, CA.
  • Kelada SN, Checkoway H, Kardia SL, Carlson CS, Costa-Mallen P, Eaton DL, Firestone JA, Powers KM, Swanson PD, Franklin GM, Longstreth WT, Smith-Weller T, Afsharinejad Z, Costa LG. 2006. 5' and 3' region variability in the dopamine transporter gene (SLC6A3), pesticide exposure and Parkinson's disease risk: a hypothesis-generating study. Hum Mol Genet 15(20):3055-3062. doi:10.1093/hmg/ddl247 PMID:16963468
  • Kelada SN, Costa-Mallen P, Costa LG, Checkoway H. 2006. 5' and 3' region variation in the dopamine trasporter gene (SLC6A3) and Parkinson's disease risk. In: Regional North American Annual Meeting of the World. Federation of Neurology - Research Group on Neuroepidemiology; April 7. San Diego, CA.
  • Maraganore DM, de Andrade M, Elbaz A, Farrer MJ, Ioannidis JP, Kruger R, Rocca WA, Schneider NK, Lesnick TG, Lincoln SJ, Hulihan MM, Aasly JO, Ashizawa T, Chartier-Harlin M, Checkoway H, Ferrarese C, Hadjigeorgiou G, Hattori N, Kawakami H, Lambert J, Lynch T, Mellick GD, Papapetropoulos S, Parsian A, Quattrone A, Riess O, Tan E, Van Broeckhoven C. 2006. Collaborative analysis of {alpha}-synuclein gene promoter variability and parkinson disease. JAMA - Journal of the American Medical Association 296(6):661-670. PMID:16896109
  • Powers KM, Smith-Weller T, Franklin GM, Longstreth WT, Swanson PD, Checkoway H. 2006. Diabetes, smoking, and other medical conditions in relation to Parkinson's disease risk. Parkinsonism Relat Disord 12(3):185-189. PMID:16364673
  • Ritz B, Ascherio A, Checkoway H, Marder KS, Nelson LM, Rocca WA, Ross GW, Strickland D, Van Den Eeden SK, Gorell J. 2006. Pooled anaylis of tobacco use and Parkinson's disease. Arch Neurol 64(7):990-997. PMID:17620489
  • Ton TG, Heckbert SR, Longstreth WT, Rossing MA, KuKull WA, Franklin GM, Swanson PD, Smith-Weller T, Checkoway H. 2006. Nonsteroidal anti-inflammatory drugs and risk of Parkinson's disease. Movement Disorders 21(7):964-969. PMID:16550541

2005

  • Firestone JA, Smith-Weller T, Franklin GM, Swanson PD, Longstreth WT, Checkoway H. 2005. Pesticides and risk of Parkinson disease a population-based case-control study. Arch Neurol 62(1):91-95. PMID:15642854
  • Kelada SN, Costa-Mallen P, Checkoway H, Carlson CS, Smith-Weller T, Swanson PD, Franklin GM, Longstreth WT, Afsharinejad Z, Costa LG. 2005. Dopamine transporter (SLC6A3) 5' region haplotypes significantly affect transcriptional activity in vitro but are not associated with Parkinson's disease. Pharmacogenet Genomics 15(9):659-668. PMID:16041244
  • Okada S, Farin FM, Stapleton PL, Viernes HA, Quigley SD, Powers KM, Smith-Weller T, Franklin GM, Longstreth WT, Swanson PD, Checkoway H. 2005. No associations between Parkinson's disease and polymorphisms of the quinone oxidoreductase (NQO1, NQO2) genes. Neurosci Lett 375(3):178-180. PMID:15694256

2004

  • Costa LG, Kelada SN, Costa-Mallen P, Farin FM, Viernes HA, Smith-Weller T, Franklin GM, Longstreth WT, Swanson PD, Checkoway H, Furlong CE. 2004. Paraoxonase 2 (PON2) polymorphisms and Parkinson's disease. Neurosci Res Commun 34(3):130-135.
  • Costa-Mallen P, Afsharinejad Z, Kelada SN, Costa LG, Franklin GM, Swanson PD, Longstreth WT, Viernes HA, Farin FM, Smith-Weller T, Checkoway H. 2004. DNA sequence analysis of monoamine oxidase B gene coding and promoter regions in Parkinson's disease cases and unrelated controls. Movement Disorders 19(1):76-83. PMID:14743364

2003

  • Kelada SN, Costa-Mallen P, Checkoway H, Costa LG. 2003. Exploration of alternative splicing of monoamine oxidase B transcripts by the intron 13 polymorphism. In: Proceedings of the 42nd Annual Meeting of the Society of Toxicology (SOT), March 9-13, 2003. Salt Lake City, UT.
  • Kelada SN, Costa-Mallen P, Checkoway H, Viernes HA, Farin FM, Costa LG, Longstreth WT, Furlong CE, Jarvik GP, Swanson PD. 2003. Paraoxonase 1 promoter and coding region polymorphisms in Parkinson's disease. Journal of Neurology, Neurosurgery & Psychiatry 74(4):546-547. PMID:12640090
  • Kelada SN, Stapleton PL, Farin FM, Bammler TK, Eaton DL, Smith-Weller T, Franklin GM, Swanson PD, Longstreth WT, Checkoway H. 2003. Glutathione S-transferase M1, T1, and P1 polymorphisms and Parkinson's disease. Neurosci Lett 337(1):5-8. PMID:12524158
  • Powers KM, Smith-Weller T, Franklin GM, Longstreth WT, Swanson PD, Checkoway H. 2003. Parkinson's disease risks associated with dietary iron, manganese, and other nutrient intakes. Neurology 60(11):1761-1766. PMID:12796527

2002

  • Checkoway H, Powers KM, Smith-Weller T, Franklin GM, Longstreth WT, Swanson PD. 2002. Parkinson's disease risks associated with cigarette smoking, alcohol use, and caffeine intake. Am J Epidemiol 155:732-738. PMID:11943691
  • Costa-Mallen P, Kelada SN, Viernes HA, Srinouanprachanh SL, Farin FM, Costa LG, Checkoway H. 2002. DNA sequencing analysis of the monoamine oxidase B gene coding region in Parkinson's disease cases and controls. In: Proceedings of the Tenth International Aamine Oxidases Workshop, August. Istanbul, Turkey.
  • Firestone JA, Franklin GM, Longstreth WT, Smith-Weller T, Swanson PD, Checkoway H. 2002. Occupational exposures to pesticides and risk of Parkinson's disease. In: Proceedings of the World Federation of Neurology Annual Meeting, June. Denver, CO.
  • Firestone JA, Franklin GM, Longstreth WT, Smith-Weller T, Swanson PD, Checkoway H. 2002. Residential pesticide exposures and risk of Parkinson's disease. Presented at the 14th Conference of the International Society for Environmental Epidemiology, Vancouver, BC, August 2002. Epidemiology 13:222Suppl.S.
  • Hernan MA, Checkoway H, O'Brien R, Costa-Mallen P, De Vivo I, Colditz GA, Hunter DJ, Kelsey KT, Ascherio A. 2002. MAOB intron 13 and COMT codon 158 polymorphisms, cigarette smoking, and the risk of PD. Neurology 58(9):1381-1387. PMID:12011284
  • Kelada SN, Costa-Mallen P, Costa LG, Smith-Weller T, Franklin GM, Swanson PD, Longstreth WT, Checkoway H. 2002. Gender difference in the interaction of smoking and monoamine oxidase B intron 13 genotype in Parkinson's disease. Neurotoxicology 23(4-5):515-519. PMID:12428723

2001

  • Farin FM, Hitosis Y, Hallagan SE, Kushleika JV, Woods JS, Janssen P, Smith-Weller T, Franklin GM, Swanson PD, Checkoway H. 2001. Genetic polymorphisms of superoxide dismutase in Parkinson's disease. Movement Disorders 16(4):705-707. PMID:11481695
  • Farin FM, Janssen P, Quigley SD, Abbott D, Hassett C, Smith-Weller T, Franklin GM, Swanson PD, Longstreth WT, Omiecinski CJ, Checkoway H. 2001. Genetic polymorphisms of microsomal and soluble epoxide hydrolase and the risk of Parkinson's disease. Pharmacogenet Genomics 11(8):703-708. PMID:11692079

2000

  • Costa-Mallen P, Checkoway H, Fishel M, Cohen AW, Smith-Weller T, Franklin GM, Swanson PD, Costa LG. 2000. The EcoRV genetic polymorphism of human monoamine oxidase type A is not associated with Parkinson's disease and does not modify the effect of smoking on Parkinson's disease. Neurosci Lett 278(1-2):33-36. PMID:10643794
  • Costa-Mallen P, Costa LG, Smith-Weller T, Franklin GM, Swanson PD, Checkoway H. 2000. Genetic polymorphism of dopamine D2 receptors in Parkinson's disease and interactions with cigarette smoking and MAO-B intron 13 polymorphism. Journal of Neurology, Neurosurgery & Psychiatry 69(4):535-7. PMID:10990520
  • Kirchner SC, Hallagan SE, Farin FM, Dilley J, Costa-Mallen P, Smith-Weller T, Franklin GM, Swanson PD, Checkoway H. 2000. Mitochondrial Complex I (ND1 subunit) sequence analysis and association of the T4216C mutation with Parkinson's disease. Neurotoxicology 21:441-446. PMID:11022854

1999

  • Anderson C, Checkoway H, Franklin GM, Beresford S, Smith-Weller T, Swanson PD. 1999. Dietary factors in Parkinson's disease: the role of food groups and specific foods. Movement Disorders 14(1):21-27. PMID:9918340
  • Checkoway H, Nelson LM. 1999. Epidemiologic approaches to the study of Parkinson's disease etiology. Epidemiology 10(3):327-336. PMID:10230846

1998

  • Alexander BH, Checkoway H, Costa-Mallen P, Faustman EM, Woods JS, Kelsey KT, Van Netten C, Costa LG. 1998. Interaction of blood lead and delta-aminolevulinic acid dehydratase genotype on markers of heme synthesis and sperm production in lead smelter workers. Environ Health Perspect 106(4):213-216. PMID:9495797 PMCID:PMC1532970
  • Checkoway H, Farin FM, Costa-Mallen P, Kirchner SC, Costa LG. 1998. Genetic polymorphisms in Parkinson's disease. Neurotoxicology 19:635-643. PMID:9745923
  • Checkoway H, Franklin GM, Costa-Mallen P, Smith-Weller T, Dilley J, Swanson PD, Costa LG. 1998. A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease. Neurology 50(5):1458-1461. PMID:9596006

1997

  • Costa-Mallen P, Checkoway H, Levy D, Smith-Weller T, Franklin GM, Swanson PD, Costa LG. 1997. Association of a polymorphism in intron 13 of the monoamine oxidase B gene with Parkinson's Disease. Am J Med Genet 74:154-156. PMID:9129714

1996

  • Alexander BH, Checkoway H, Van Netten C, Muller CH, Ewers TG, Kaufman JD, Mueller BA, Vaughan TL, Faustman EM. 1996. Semen quality of men employed at a lead smelter. J Occup Environ Med 53(6):411-416. PMID:8758037
  • Alexander BH, Checkoway H, Van Netten C, Muller CH, Kaufman JD, Vaughan TL, Mueller BA, Faustman EM. 1996. Paternal occupational lead exposure and pregnancy outcome. Int J Occup Environ Health 2(4):280-285. PMID:9933882
  • Kushleika JV, Checkoway H, Woods JS. 1996. Selegiline and lymphocyte superoxide dismutase activities in Parkinson's disease. Ann Neurol 39:278-281. PMID:8602757
  • Kushleika JV, Checkoway H, Woods JS, Moon J, Smith-Weller T, Franklin GM, Swanson PD. 1996. Selegiline (L-Deprenyl) mediates increased lymphocyte cytosolic and mitochondrial superoxide dismutase activities in Parkinson's Disease. Ann Neurol 39(3):378-381.

1995

  • Brodkin CA, Daniell WE, Checkoway H, Echeverria D, Johnson J, Wang K, Sohaey R, Green D, Redlich CA, Gretch D. 1995. Hepatic ultrasonic changes in workers exposed to perchlorethylene. Occup Environ Med 52(10):667-685. PMID:7489059
  • Heyer NJ, Echeverria D, Checkoway H, Toutonghi G, Ronhovde N. 1995. Behavioral effects from exposure to styrene among reinforced plastic laminators. Occup Environ Med
  • Muller CH, Checkoway H, Alexander BH, Van Netten C, Ewers TG, Faustman EM. 1995. Relationship Between metal exposure and sperm acrosomal function tests among workers at a lead smelter. In: Proceedings of the American Society of Andrology. Raliegh, NC.
  • Muller CH, Checkoway H, Alexander BH, Van Netten C, Ewers TG, Faustman EM. 1995. Sperm function and motility tests among workers at a lead smelter. In: Proceedings of the International Congress of Toxicology - VII. Seattle, WA.
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