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Your Environment. Your Health.

Person Details: Evelyn Tiffany-Castiglioni

Superfund Research Program

Evelyn Tiffany-Castiglioni

Texas A&M University
Veterinary Anatomy and Public Health
College of Veterinary Medicine
Mail Stop 4458
College Station, Texas 77843-4458
Phone: 979-845-2828
Fax: 979-847-8981


Research Briefs



  • Barhoumi R, Catania JM, Parrish AR, Awooda I, Tiffany-Castiglioni E, Safe SH, Burghardt RC. 2009. Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in breast epithelial cell lines. J Toxicol Sci 34(1):13-25. doi:10.2131/jts.34.13 PMID:19182432 PMCID:PMC2739812


  • Yang W, Tiffany-Castiglioni E. 2008. Paraquat-induced apoptosis in human neuroblastoma SH-SY5Y cells: involvement of p53 and mitochondria. J Toxicol Environ Health A 71(4):289-99. PMID:18253895


  • Qian Y, Venkatraj J, Barhoumi R, Pal R, Datta A, Wild JR, Tiffany-Castiglioni E. 2007. Comparative non-cholinergic neurotoxic effects of paraoxon and diisopropyl fluorophosphate (DFP) on human neuroblastoma and astrocytoma cell lines. Toxicol Appl Pharmacol 219(2-3):162-171. PMID:17223147
  • White LD, Cory-Slechta DA, Gilbert ME, Tiffany-Castiglioni E, Zawia NH, Virgolini M, Rossi-George A, Lasley SM, Qian Y, Basha M. 2007. New and evolving concepts in the neurotoxicology of lead. Toxicol Appl Pharmacol 225(1):1-27. doi:10.1016/j.taap.2007.08.001 PMID:17904601


  • Cho T, Wild JR, Donnelly KC, Tiffany-Castiglioni E. 2006. Degradation of organophosphorus neurotoxicity in SY5Y neuroblastoma cells by organophosphorus hydrolase (OPH). J Toxicol Environ Health A 69(15):1413-1429. PMID:16766477
  • Tiffany-Castiglioni E, Hong SJ, Qian Y, Tang Y, Donnelly KC. 2006. In vitro models for assessing neurotoxicity of mixtures. Neurotoxicology 27(5):835-839. PMID:16843529


  • Qian Y, Zheng Y, Abraham L, Ramos KS, Tiffany-Castiglioni E. 2005. Differential profiles of copper-induced ROS generation in human neuroblastoma and astrocytoma cells. Brain Res 134(2):323-332. doi:10.1016/j.molbrainres.2004.11.004 PMID:15836927
  • Qian Y, Zheng Y, Ramos KS, Tiffany-Castiglioni E. 2005. GRP78 compartmentalized redistribution in Pb-treated glia: role of GRP78 in lead-induced oxidative stress. Neurotoxicology 26(2):267-275. doi:10.1016/j.neuro.2004.09.002 PMID:15713347
  • Qian Y, Zheng Y, Ramos KS, Tiffany-Castiglioni E. 2005. The involvement of copper transporter in lead-induced oxidative stress in astroglia. Neurochem Res 30(4):429-438. PMID:16076012


  • Donnelly KC, Lingenfelter R, Cizmas LH, Falahatpisheh MH, Qian Y, Tang Y, Garcia SS, Ramos KS, Tiffany-Castiglioni E, Mumtaz MM. 2004. Toxicity assessment of complex mixtures remains a goal. Environ Toxicol Pharmacol 18(2):135-141. doi:10.1016/j.etap.2004.03.013 PMID:21782742


  • Hong MS, Hong SJ, Barhoumi R, Burghardt RC, Donnelly KC, Wild JR, Venkatraj V, Tiffany-Castiglioni E. 2003. Neurotoxicity induced in differentiated SK-N-SH-SY5Y human neuroblastoma cells by organophosphorus compounds. Toxicol Appl Pharmacol 186(2):110-118. PMID:12639502
  • Qian Y, Tiffany-Castiglioni E. 2003. Lead-induced endoplasmic reticulum (ER) stress responses in the nervous system. Neurochem Res 28:153-162. PMID:12587673
  • Tang Y, Donnelly KC, Tiffany-Castiglioni E, Mumtaz MM. 2003. Neurotoxicity of polycyclic aromatic hydrocarbons and simple chemical mixtures. J Toxicol Environ Health A 66(10):919-940. PMID:12825237
  • Tiffany-Castiglioni E. 2003. In Vitro Neurotoxicology. In: Methods in Pharmacology and Toxicology: In Vitro Neurotoxicology: Principles and Challenges. Humana Press Inc., pp.1-28.
  • Tiffany-Castiglioni E, Qian Y. 2003. Cell-Type Specific Responses of the Nervous System to Lead. In: Methods in Pharmacology and Toxicology: In Vitro Neurotoxicology: Principles and Challenges. Humana Press Inc., pp.151-186.


  • Legare ME, Hanneman WH, Barhoumi R, Burghardt RC, Tiffany-Castiglioni E. 2000. 2,3,7,8-tetrachlorodibenzo-p-dioxin alters hippocampal astroglia-neuronal gap junctional communication. Neurotoxicology 21(6):1109-1116. PMID:11233757


  • Legare ME, Barhoumi R, Hebert E, Bratton GR, Burghardt RC, Tiffany-Castiglioni E. 1998. Analysis of Pb2+ entry into cultured astroglia. Toxicol Sci 46(1):90-100. doi:10.1006/toxs.1998.2492 PMID:9928672


  • Legare ME, Hanneman WH, Barhoumi R, Tiffany-Castiglioni E. 1997. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure in primary astroglia: identification of biochemical and cellular targets. Neurotoxicology 18:515-524. PMID:9291499


  • Hanneman WH, Legare ME, Barhoumi R, Burghardt RC, Safe SH, Tiffany-Castiglioni E. 1996. Stimulation of calcium uptake in cultured rat hippocampal neurons by 2,3,7,8-tetrachlorodibenxo-p-dioxin (TCDD). Toxicology 112:19-28. PMID:8792845
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