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Your Environment. Your Health.

Person Details: David C. Spink

Superfund Research Program

David C. Spink

University of Albany - SUNY
Empire State Plaza
Wadsworth Center
Albany, New York 12201
Phone: 518-486-2532
Email:

Projects

Research Briefs

Publications

2000

  • Oenga G, Spink DC. 2000. Estrone (E1) hydroxylation catalyzed by human cytochromes P450 1A1 (CYP1A1) and 1B1 (CYP1B1). Environ Health Perspect 54:102.
  • Spink DC, Katz BH, Hussain MM, Kaminsky LS. 2000. Transient induction of CYP1A1/CYP1B1-catalyzed estrogen metabolism is diminished by arsenite. Environ Health Perspect 54:100.
  • Spink DC, Spink BC, Zhuo X, Hussain MM, Gierthy JF, Ding X. 2000. NADPH- and hydroperoxide-supported 17beta-estradiol hydroxylation catalyzed by a variant form (432L, 453S) of human cytochrome P450 1B1. J Steroid Biochem Mol Biol 74(1-2):11-18. doi:10.1016/s0960-0760(00)00083-2 PMID:11074351

1999

  • Arcaro KF, Yi L, Seegal R, Vakharia D, Yang Y, Spink DC, Brosch KO, Gierthy JF. 1999. 2,2',6,6'-tetrachlorobiphenyl is estrogenic in vitro and in vivo. J Cell Biochem 72(1):94-102. PMID:10025670
  • Pang S, Cao JQ, Katz BH, Hayes CL, Sutter TR, Spink DC. 1999. Inductive and inhibitory effects on non-ortho-substituted polychlorinated biphenyls on estrogen metabolism and human cytochromes P450 1A1 and 1B1. Biochem Pharmacol 58(1):29-38. PMID:10403516

1998

  • Spink BC, Fasco MJ, Gierthy JF, Spink DC. 1998. 12-O-Tetradecanolyl-phorbol-13-acetate differentially alters CYP1A1 and CYP1B1 expression in MCF-7 breast cancer cells. J Cell Biochem 70(3):289-296.
  • Spink DC, Spink BC, Cao JQ, DePasquale JA, Pentecost BT, Fasco MJ, Li Y, Sutter TR. 1998. Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells. Carcinogenesis 19(2):291-298. PMID:9498279
  • Spink DC, Zhang F, Roe LL, Katz BH, Bolton JL. 1998. Metabolism of equilenin in human breast cancer cells. Environ Health Perspect 42:93.

1997

  • Arguello J, Kinonen C, Miller C, Palmer J, Dowell C, Cao JQ, Spink DC, Tessari L, Weeramachaneni DN, Cosma G. 1997. Comparative reproductive toxicities of p,p-DDT vs. p,p-DDE following perinatal exposures in male rabbits. Environ Health Perspect 36:136.
  • Pang S, Cao JQ, Hayes CL, Sutter TR, Spink DC. 1997. Coplanar polychlorinated biphenyls as inducers and inhibitors of human cytochromes P450 1A1 and 1B1. Environ Health Perspect 36:158.
  • Spink DC, Cao JQ, Gierthy JF, Hayes CL, Li Y, Sutter TR. 1997. Induction of cytochrome P450 1B1 and catechol estrogen metabolism in ACHN renal adenocarcinoma cells. Psychiatr Pol 62:223-232. PMID:9393958
  • Spink DC, Spink BC, Cao JQ, DePasquale JA, Pentecost BT, Yi L, Sutter TR. 1997. Differential induction of CYP1A1 and CYP1B1 by TCDD in human breast cells and breast epithelial cells. Environ Health Perspect 36:24.

1996

  • Gierthy JF, Seegal R, Floyd M, Arcaro KF, Spink DC. 1996. Estrogenic activity of 2,2',6,6'-tetrachlorobiphenyl in MCF-7 human breast cancer cells. Environ Health Perspect 30:225-226.
  • Gierthy JF, Spink BC, Figge HL, Pentecost BT, Spink DC. 1996. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate and 17-estradiol on estrogen receptor regulation in MCF-7 human breast cancer cells. J Cell Biochem 60:173-184. PMID:8655628
  • Hayes CL, Spink DC, Spink BC, Cao JQ, Sutter TR. 1996. Human cytochrome P450 (CYP) 1B1 is a low Km 17 beta-estradiol (E2) 4-hydroxylase. Environ Health Perspect 30:182.
  • Hayes CL, Spink DC, Spink BC, Cao JQ, Walker NJ, Sutter TR. 1996. 17β-estradiol hydroxylation catalyzed by human cytochrome P450 1B1. Proc Natl Acad Sci U S A 93:9776-9781. PMID:8790407
  • Pang S, Cao JQ, Spink DC. 1996. Effects of polychlorinated biphenyls on estrogen metabolism in human breast cancer cells. Environ Health Perspect 30:290.
  • Spink DC, Spink BC, Hayes CL, Cao JQ, Gierthy JF, Sutter TR. 1996. TCDD induces catechol estrogen metabolism and CYP1B1 in ACHN human renal adenocarcinoma cells. Environ Health Perspect 30:180.
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