Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Internet Explorer is no longer a supported browser.

This website may not display properly with Internet Explorer. For the best experience, please use a more recent browser such as the latest versions of Google Chrome, Microsoft Edge, and/or Mozilla Firefox. Thank you.

COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC. Get the latest research information from NIH.

Your Environment. Your Health.

Person Details: John F. Gierthy

Superfund Research Program

John F. Gierthy

Wadsworth Center, New York State Department of Health
Empire State Plaza
Wadsworth Center
Albany, New York 12201
Phone: 518-474-8195
Email: gierthy@wadsworth.org

Projects

Research Briefs

Publications

2000

  • Arcaro KF, Yang Y, Vakharia D, Gierthy JF. 2000. Toxaphene is antiestrogenic in a human breast-cancer cell assay. J Toxicol Environ Health A 59:197-210. PMID:10667634
  • Spink DC, Spink BC, Zhuo X, Hussain MM, Gierthy JF, Ding X. 2000. NADPH- and hydroperoxide-supported 17beta-estradiol hydroxylation catalyzed by a variant form (432L, 453S) of human cytochrome P450 1B1. J Steroid Biochem Mol Biol 74(1-2):11-18. doi:10.1016/s0960-0760(00)00083-2 PMID:11074351
  • Vakharia D, Gierthy JF. 2000. Use of a combined human liver microsome-estrogen receptor assay to assess potential estrogen modulating activity of PCB metabolites. Toxicol Lett 114(1-3):55-65. PMID:10713469

1999

  • Arcaro KF, O'Keefe PW, Yang Y, Clayton W, Gierthy JF. 1999. Antiestrogenicity of environmental polycyclic aromatic hydrocarbons in human breast cancer cells. Toxicology 133(2-3):115-127. doi:10.1016/S0300-483X(99)00018-9 PMID:10378478
  • Arcaro KF, Yi L, Seegal R, Vakharia D, Yang Y, Spink DC, Brosch KO, Gierthy JF. 1999. 2,2',6,6'-tetrachlorobiphenyl is estrogenic in vitro and in vivo. J Cell Biochem 72(1):94-102. PMID:10025670
  • Vakharia D, Gierthy JF. 1999. Rapid assay for estrogen receptor binding to PCB metabolites. Toxicol In Vitro 13(2):275-282. PMID:20654485
  • Vakharia D, Gierthy JF. 1999. Rapid screen for ER-binding of human liver microsome-generated PCB-metabolites. Environ Health Perspect 42(1-S):221.

1998

  • Arcaro KF, O'Keefe PW, Yang Y, Gierthy JF. 1998. Antiestrogenic activity of polycyclic aromatic hydrocarbons. Environ Health Perspect 42(1-S):240.
  • Arcaro KF, Vakharia D, Yang Y, Gierthy JF. 1998. Lack of synergy by mixtures of weakly estrogenic hydroxylated polychlorinated biphenyls and pesticides. Environ Health Perspect 106:1041-1046. PMID:9703490
  • Seegal R, Gierthy JF, Arcaro KF, Brosch KO. 1998. Neurochemical and neuroendocrine effects of non-coplanar and coplanar PCBs. Fundam Appl Toxicol 41:49-61.
  • Spink BC, Fasco MJ, Gierthy JF, Spink DC. 1998. 12-O-Tetradecanolyl-phorbol-13-acetate differentially alters CYP1A1 and CYP1B1 expression in MCF-7 breast cancer cells. J Cell Biochem 70(3):289-296.

1997

  • Arcaro KF, Gierthy JF. 1997. Estrogenic responses of human breast cancer cells to combinations of hydroxylated PCBs, pesticides and 17 beta-estradiol. Environ Health Perspect 36(1):295.
  • Arcaro KF, Gierthy JF, Yang Y, Robertson LW, Oakley GG, Vakharia D. 1997. Position of hydroxyl group influences PCB estrogenicity and antiestrogenicity. Organohalogen Compounds 34:386-390.
  • Gierthy JF, Arcaro KF, Floyd M. 1997. Assessment of PCB estrogenicity in a human breast cancer cell line. Chemosphere 34(5-7):1495-1505. PMID:9134682
  • Gierthy JF, Yang Y, Robertson LW, Oakley GG, Arcaro KF, Vakharia D. 1997. Position of hydroxyl group influences PCB estrogenicity and antiestrogenicity. Environ Health Perspect 36(1):159.
  • Spink DC, Cao JQ, Gierthy JF, Hayes CL, Li Y, Sutter TR. 1997. Induction of cytochrome P450 1B1 and catechol estrogen metabolism in ACHN renal adenocarcinoma cells. Psychiatr Pol 62:223-232. PMID:9393958

1996

  • Gierthy JF, Seegal R, Floyd M, Arcaro KF, Spink DC. 1996. Estrogenic activity of 2,2',6,6'-tetrachlorobiphenyl in MCF-7 human breast cancer cells. Environ Health Perspect 30:225-226.
  • Gierthy JF, Spink BC, Figge HL, Pentecost BT, Spink DC. 1996. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate and 17-estradiol on estrogen receptor regulation in MCF-7 human breast cancer cells. J Cell Biochem 60:173-184. PMID:8655628
  • Seegal R, Chishti MA, Gierthy JF. 1996. Uterotropic and neurochemical effects of 2,2',6,6'-tetrachlorobiphenyl in the prepubertal rat. Environ Health Perspect 30:227.
  • Spink DC, Spink BC, Hayes CL, Cao JQ, Gierthy JF, Sutter TR. 1996. TCDD induces catechol estrogen metabolism and CYP1B1 in ACHN human renal adenocarcinoma cells. Environ Health Perspect 30:180.

1995

  • Gierthy JF, Arcaro KF, Floyd M. 1995. Assessment and implications of PCB estrogenicity. In: Proceedings of the 15th International Symposium on Chlorinated Dioxins and Related Compounds. pp.419-423.
  • Seegal R, Gierthy JF. 1995. Developmental exposure to individual PCB congeners - multiple mechanisms of action. Neurotoxicology 16:753.
Back
to Top