Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Michigan State University

Superfund Research Program

Hepatotoxicant-Induced Immune Suppression through TGF-beta Release

Project Leader: Norbert E. Kaminski
Grant Number: P42ES004911
Funding Period: 1995 - 2000

Learn More About the Grantee

Visit the grantee's eNewsletter page Visit the grantee's eNewsletter page

Project Summary (1995-2000)

It has been found that liver damage produced by environmental contaminants, such as carbon tetrachloride, leads to suppression of the immune system. The goal of this project is to investigate the mechanism behind this immune suppression, especially the impacts of growth factor molecules on the expression of the IL-2 gene, a gene that codes for a product that is critical to proper immunological function. Improper expression of this gene is associated with a wide range of immunotoxic effects.

Back
to Top