Superfund Research Program
Molecular Signals of Epigenetic Toxicity of Superfund Chemicals
Project Leader: Burra V. Madhukar
Grant Number: P42ES004911
Funding Period: 1995 - 2000
Project Summary (1995-2000)
The goal of this project is to test the hypothesis that the non-genotoxic carcinogenic activity of environmental contaminants, particularly PCBs, involves alterations in signal transduction pathways central to cell growth and proliferation. To test this hypothesis, effects on the components of cell signaling pathways known to be perturbed during carcinogenesis have been studied in a number of cell culture systems exposed to PCBs.