Superfund Research Program
Detection, Prioritization and Detoxification of Developmental Toxicants Associated with Chemical Wastes
Project Leader: Timothy D. Phillips
Grant Number: P42ES004917
Funding Period: 1995 - 2000
Project Summary (1995-2000)
In this project, Superfund chemicals and mixtures are being ranked according to teratogenic potency using rapid developmental bioassays, and dehalogenation of polychlorinated biphenyls (PCBs) on clay is being studied as a detoxification method. Prioritized toxicants and potential antagonists are investigated in vivo utilizing the pregnant Sprague Dawley rat and C57BL/6 mouse as whole animal models. The cellular effects and molecular mechanisms of selected target chemicals are being assessed using in vitro fluorescence bioassays. Clay minerals are being developed to facilitate the adsorption and degradation of diverse toxins, with emphasis on elucidating the mechanisms of dehalogenation of chlorophenols and PCBs by modified smectite. Diverse bioassays established in Projects 1-4 are used to confirm detoxification.