Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Internet Explorer is no longer a supported browser.

This website may not display properly with Internet Explorer. For the best experience, please use a more recent browser such as the latest versions of Google Chrome, Microsoft Edge, and/or Mozilla Firefox. Thank you.

Your Environment. Your Health.

Texas A&M University

Superfund Research Program

Genotoxic Effects

Project Leader: Kirby C. Donnelly
Grant Number: P42ES004917
Funding Period: 2000-2008

Project Summary (2000-2005)

This project is designed to improve understanding of the genotoxic effects of complex mixtures of polycyclic aromatic hydrocarbons (PAHs), such as coal tar or petroleum waste, and mixtures of PAHs and halogenated aromatic hydrocarbons (HAHs), such as wood preserving waste. Microbial genotoxicity assays characterize the potential of a sample to induce point mutations, and gap junctional intercellular communication measures the epigenetic potential of a sample. Researchers are measuring the formation of DNA adducts in vivo as well as gene expression (primarily metabolic enzymes) as affected by exposure to complex mixtures. In addition, studies are measuring expression of p53, p2l, or Gadd45 proteins following exposure to mixtures or model chemicals. These studies are identifying factors governing the metabolism of mixtures, as well as tie initiation, promotion and progression of malignant cells.

Back
to Top