Project Summary (1995-2000)

The epidemiology core has 5 subprojects for this funding period. These are: (1) linkage of occupational epidemiology methodology with the Project #2 work on markers of vinyl chloride exposure (hprt mutations in T-lymphocytes, mutant p21 oncoproteins, etc.): (2) a field study of a community with potential exposure to PCP (from a former wood treatment plant) incorporating self-administered instruments developed in Project #3 for measurement of PCP exposures; (3) a field study of a community with potential exposure to benzene (from leaking petroleum storage tanks), incorporating self-administered breath sampling instruments developed in Project #3; (4) a small-scale study of benzene exposed workers which is determining workplace practices that influence personal exposures and provide dose data that can be used for calculating dose-response relations with protein adduct levels;(5) a Geographic Information System component to assist with development of models of exposure based on soil, hydrography, and other factors.