Project Summary (1995-2000)

The long term objective of this project is to characterize the dog as a model for monitoring the impact of polychlorinated biphenyls (PCBs) and other environmental contaminants on the immune system. A panel of tests have been developed based on laboratory exposure of dogs to levels of PCB (Aroclor 1248) commonly found around Superfund sites. Through these studies researchers hope to have a greater understanding of the basic mechanisms involved in PCB toxicity. The dog model is providing immunologic and endocrine targets for PCB activity. Scientists are determining the lowest concentration of PCB which can pose a toxic risk to dogs (and humans) and validate the panel of biomarkers in dogs by cross-comparison to humans and wildlife which share the contaminated environment with dogs.