Superfund Research Program
Serum PCB as a Risk Indicator for Breast Cancer in Women
Project Leader: Philippe Grandjean (Harvard School of Public Health)
Grant Number: P42ES007381
Funding Period: 1995 - 2000
Project Summary (1995-2000)
This project will determine whether breast cancer patients had an increased body burden of organochlorine compounds, as reflected in the serum concentration before the disease developed. The study will utilize the unique opportunity created by the long-term population studies carried out in Denmark. The women belong to three major cohorts examined in 1976 and 1982, and a case group of women who later developed breast cancer will be matched with a control group (two controls for each case). A total of 215 cases are expected. Extensive baseline data on relevant risk factors as well as frozen serum samples will be used from the original examinations, and follow-up will be made through the Danish Cancer Registry and the mortality database extended through 31 December 1992. Organochlorine analyses will be carried out at the Centers for Disease Control in Atlanta. Information on major confounders will be included in the statistical analyses where adjusted odds ratios will be calculated.