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<P>This project is testing the hypothesis that the level of aromatic hydrocarbon receptor (AhR) activity represents a critical and limiting factor in the induction of multiple pathways of hydrocarbon-induced cell activation by manipulating activity in well-defined animal systems and eventually by evaluating AhR activity in humans. Investigators are producing somatic hybrid mice which bear lymphocytes expressing no AhR, high levels of AhR, or a mutant AhR capable of binding PAH but incapable of complexing with DNA recognition elements. The AhR function in and PAH (polynuclear aromatic hydrocarbon)-responsiveness of lymphocytes from these somatic hybrid mice will then be evaluated.</P>