Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Internet Explorer is no longer a supported browser.

This website may not display properly with Internet Explorer. For the best experience, please use a more recent browser such as the latest versions of Google Chrome, Microsoft Edge, and/or Mozilla Firefox. Thank you.

Your Environment. Your Health.

Progress Reports: University of California-Berkeley: Exposomics of Endocrine Disruption

Superfund Research Program

Exposomics of Endocrine Disruption

Project Leader: Martyn T. Smith
Co-Investigator: Jen-Chywan Wang
Grant Number: P42ES004705
Funding Period: 2017-2022
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

Learn More About the Grantee

Visit the grantee's eNewsletter page Visit the grantee's Twitter page Visit the grantee's Facebook page

Progress Reports

Year:   2019  2018  2017 

The global prevalence of type 2 diabetes (T2D) has doubled since 1980. Human epidemiological studies support arsenic exposure as a risk factor for T2D, although the precise mechanism is unclear. This project surveyed the literature and published a state-of-the science review in Environmental Health Perspectives(Castriota et al. 2020, PMID:31898917 DOI:10.1289/EHP4517, Epub Jan 3, PMC In Progress), which identified the current knowledge gaps in the understanding of arsenite on diabetes development. From this review, the researchers hypothesized that chronic arsenic ingestion may alter glucose homeostasis by impairing adaptive thermogenesis, i.e., body heat production in cold environments. The researchers found that male C57BL/6J mice exposed to sodium arsenite in drinking water experienced significantly decreased metabolic heat production when acclimated to chronic cold tolerance testing despite no change in physical activity. The researchers went on to show that chronic arsenic exposure impacts the mitochondria of thermogenic tissues involved in energy expenditure and glucose regulation, providing a novel mechanism by which arsenic exposure may contribute to T2D development.

Back
to Top