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Progress Reports: Duke University: Cholinergic and Monoaminergic Mechanisms of Persistent Neurobehavioral Toxicity

Superfund Research Program

Cholinergic and Monoaminergic Mechanisms of Persistent Neurobehavioral Toxicity

Project Leader: Edward D. Levin
Co-Investigators: Theodore A. Slotkin (Duke University Medical Center), Frederic J. Seidler
Grant Number: P42ES010356
Funding Period: 2017-2022
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Progress Reports

Year:   2020  2019  2018  2017 

The Cholinergic and Monoaminergic Mechanisms of Persistent Neurobehavioral Toxicity Project has provided important new information concerning the long-term behavioral effects of gestational exposure to the common combustion product benzo[a]pyrene (BaP) and the widely used organophosphate insecticide diazinon. The team has found that gestational exposure to low chronic BaP or diazinon in rats caused sex-selective behavioral and neurochemical dysfunction which persisted into adulthood. Zebrafish are being used to provide a more economic model for determining the neurobehavioral toxic risks of developmental toxicant exposure. The team has found that early developmental exposure to BaP and diazinon as well as flame retardants cause short and long term behavioral impairments in zebrafish. This project provides important information for protecting children against risks of neurobehavioral impairment from exposure to environmental toxicants.

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