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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Final Progress Reports: Duke University: Transgenic Fish Facility

Superfund Research Program

Transgenic Fish Facility

Project Leader: Elwood A. Linney (Duke University Medical Center)
Grant Number: P42ES010356
Funding Period: 2000 - 2005

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Final Progress Reports

Year:   2004 

The research core has provided support for a series of collaborative efforts between the Levin and Linney laboratories that have resulted in the identification of early environmental exposures of chlorpyrifos, which result in adult fish with learning deficiencies. This has become an important research effort for both laboratories.   Embryos, reagents, and access to all of the research core’s equipment has been provided to the DiGuilio laboratory so that they could molecularly explore phenomena in zebrafish that they have been studying in Fundulus. This has turned out to be one of the more valuable and efficient uses of the research core.  As this first cycle of funding for this superfund center gets close to its end and the anticipation of there not being a zebrafish core in the renewal, this aspect of making available zebrafish technology without there being a formal core appears to be an efficient mechanism for interaction amongst superfund members.

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