Superfund Research Program
Neurobehavioral Toxicity Core
Project Leader: Edward D. Levin
Grant Number: P42ES010356
Funding Period: 2011-2022
The Neurobehavioral Toxicity Core has worked with the Cholinergic and Monoaminergic Mechanisms of Persistent Neurobehavioral Toxicity and Persistent Mitochondrial and Epigenetic Effects of Early Life Toxicant Exposure Projects to determine the effects in zebrafish of neurotoxic effects on larval motility. This provides a rapid feedback of the functional effects of embryonic neurotoxicity. The Neurobehavioral Toxicity Core provided assistance to the Cholinergic and Monoaminergic Mechanisms project to determine persisting effects of embryonic benzo[a]pyrene (BaP) (rats and zebrafish), diazinon and triphenyl phosphate (rats) and a variety of brominated and organophosphate flame retardant exposure (zebrafish). Effects on motor function, emotional regulation and cognition were assessed. The core also has been working with the Persistent Mitochondrial and Epigenetic Effects of Early Life Toxicant Exposure Project to develop computerized behavioral assessment methods for determining neurobehavioral toxicity in C. elegans.