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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Project Publications: Boston University: Activation Of Orphan Receptors By Chlorinated Hydrocarbons

Superfund Research Program

Activation Of Orphan Receptors By Chlorinated Hydrocarbons

Project Leader: David J. Waxman
Grant Number: P42ES007381
Funding Period: 1995 - 2000

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Publications

1999

  • Maloney EK, Waxman DJ. 1999. trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals. Toxicol Appl Pharmacol 161(2):209-218. PMID:10581215
  • Schlezinger JJ, White RD, Stegeman JJ. 1999. Oxidative inactivation of cytochrome P450 1A stimulated by 3,3',4,4'-tetrachlorobiphenyl: production of reactive oxygen by vertebrate CYP1As. Mol Pharmacol 56(3):588-597. PMID:10462547
  • Waxman DJ. 1999. P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR and PPAR. Arch Biochem Biophys 369(1):11-23. PMID:10462436
  • Zhou Y, Waxman DJ. 1999. Inhibitory cross-talk between JAK2/STAT5b and PPARa. In: Proceedings of the 81st Annual Endocrine Society Meeting. pp.108.
  • Zhou Y, Waxman DJ. 1999. STAT5b down-regulates peroxisome proliferator-activated receptor alpha transcription by inhibition of ligand-independent activation function region-1 trans-activation domain. J Biol Chem 274(42):29874-29882. PMID:10514468

1998

  • Zhou Y. 1998. JAK-STAT interaction with PPARα. In: Proceedings of the 80th Annual Endocrine Society Meeting.
  • Zhou Y, Waxman DJ. 1998. Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids. Environ Health Perspect 106Suppl.4:983-988. PMID:9703482
  • Zhou Y, Waxman DJ. 1998. Cross-talk between JAK-STAT and PPARα signaling pathways: Growth hormone (GH) inhibition of PPARα activity mediated by STAT5b. In: Proceedings of the 12th International Symposium on Microsomes and Drug Oxidations. pp.123.

1997

  • Chang TK. 1997. Catalytic assays for human cytochrome P450. Chapter 9 in: Methods in Molecular Biology series: Cytochrome P450 Protocols. Humana Press, Inc., pp.95-102.
  • Chang TK. 1997. Enzymatic Analysis of cDNA-expressed human CYP1A1,CYP1A2 and CYP1B1 with 7-ethoxyresorufin as substrate. Chapter 10 in: Methods in Molecular Biology series: Cytochrome P450 Protocols. Humana Press, Inc., pp.103-110.
  • Chang TK, Crespi CL, Waxman DJ. 1997. Spectrophotometric Analysis of Human CY P2El -Catalyzed pNitrophenol Hydroxylation. Chapter 17 in: Methods in Molecular Biology series: Cytochrome P450 Protocols. Humana Press, Inc., pp.147-152.
  • Crespi CL, Chang TK, Waxman DJ. 1997. CYP2D6-dependent bufuralol 1'-hydroxylation assayed by reversed-phase ion-pair high performance liquid chromatography with fluorescence detection. Chapter 16 in: Methods in Molecular Biology series: Cytochrome P450 Protocols. Humana Press, Inc., pp.141-146.
  • Waxman DJ, Chang TK. 1997. Use of 7-Ethoxycoumarin to Monitor Multiple Enzymes in the Human CYPI, CYP2, and CYP3 Families. Chapter 21 in: Methods in Molecular Biology series: Cytochrome P450 Protocols. Humana Press, Inc., pp.175-180.
  • Zhou Y, Waxman DJ. 1997. Cross-talk between PPAR and JAK-STAT signaling pathways regulating liver P450 expression. In: Proceedings of the 15th New England Membrane Enzyme Conference.

1996

  • Peters JM, Zhou Y, Ram PA, Lee SS, Gonzalez FJ, Waxman DJ. 1996. Peroxisome proliferator-activated receptor a required for gene induction by dehydroepiandrosterone 3b-sulfate. Mol Pharmacol 50(1):67-74.
  • Waxman DJ. 1996. Role of metabolism in the activation of dehydroepiandrosterone as a peroxisome proliferator. Journal of Endocrinology 150:S129-S147. PMID:8943797
  • Zhou Y, Peters JM, Ram PA, Lee SS, Gonzalez FJ, Waxman DJ. 1996. Peroxisome proliferator-activated receptor a (PPARa) mediates gene induction by dehydroepiandrosterone 3b-sulfate (DHEA-S). In: Proceedings of the 11th International Symposium on Microsomes and Drug Oxidations. pp.209.

1995

  • Waxman DJ. 1995. Metabolism of DHEA and related steroids: interaction with liver cytochromes P450 (CYPs). In: Proceedings of the International Symposium on DHEA (Dehydroepiandrosterone) Transformation. pp.29.
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