Superfund Research Program
Hepatotoxicant-Induced Immune Suppression through TGF-beta Release
Project Leader: Norbert E. Kaminski
Grant Number: P42ES004911
Funding Period: 1995 - 2000
Project-Specific Links
- Project Summary
Publications
2000
- McKarns SC, Kaminski NE. 2000. TGF-beta(1) differentially regulates IL-2 expression and [H-3]-thymidine incorporation in CD3 epsilon mAb- and CD28 mAb-activated splenocytes and thymocytes. Immunopharmocology 48(2):101-115. PMID:10936508
1998
- Han SH, Yea SS, Jeon YJ, Yang K, Kaminski NE. 1998. Transforming growth factor-beta 1 (TGF-beta1) promotes IL-2 mRNA expression through the up-regulation of NF-kappaB, AP-1 and NF-AT in EL4 cells. J Pharmacol Exp Ther 287(3):1105-1112. PMID:9864299
1997
- Jeon YJ, Han SH, Yang K, Kaminski NE. 1997. Induction of transforming growth factor β1 transcription by carbon tetrachloride leads to the inhibition of T helper 2 cell associated lymphokines. Toxicol Appl Pharmacol 144:27-35.
1996
- Delaney B, Kaminski NE. 1996. Liver-Immune interactions induced by hepatic regeneration: Similarities between partial hepatectomy and chemically-mediated hepatotoxicity. In: Experimental Immunotoxicology. CRC Press Inc, Boca Raton, FL. pp.157-167.
- Han SH, Jeon YJ, Yang K, Kaminski NE. 1996. Induction of interleukin 2 gene expression by tranforming growth factor β1 in the murine T-cell line, EL4.IL-2. In: Proceedings of the 11th Annual Symposium on Mechanisms of Immunotoxicology. Virginia Beach, VA.