Superfund Research Program

Molecular Signals of Epigenetic Toxicity of Superfund Chemicals

Project Leader: Burra V. Madhukar
Grant Number: P42ES004911
Funding Period: 1995 - 2000

Project-Specific Links

Publications

2000

• Madhukar BV, Zeng XY, Hernandez O. 2000. Activation of extracellular signal regulated kinases (ERKs) by polychlorinated biphenyls in MCF-7 human breast cancer cells. In: Proceedings of the 1^st PCB Workshop: Recent Advances in the Environmental Toxicology and Health Effects of PCBs (polychlorinated biphenyls), 2000. Lexington, KY. pp.no.30.
• Madhukar BV, Zeng XY, Hernandez O. 2000. Activation of extracellular signal-regulated kinases (ERKs) by 2,2',4,4'-tetrachlorobiphenyl in rat liver cells: Role of calcium. Environ Health Perspect 54:210.

1999

• Fischer L, Wagner MA, Madhukar BV. 1999. Potential involvement of calcium, CaM kinase II and MAP kinases in PCB-stimulated insulin release from RINm5F cells. Toxicol Appl Pharmacol 159:194-203. PMID:10486306

1998

• Fischer L, Madhukar BV, Zeng XY, Wagner MA. 1998. Activation of MAP kinases by polychlorinated biphenyls in rat insulinoma cells: correlation with insulin release. Environ Health Perspect 42:133.
• Madhukar BV. 1998. Modulation of protein kinases by xenobiotics. In: Toxicant-Receptor Interactions and Modulation of Gene Expression. Lippincott-Raven Publishers, Philadelphia, PA.
• Madhukar BV, Zeng XY, Fischer L. 1998. Polychlorinated biphenyls, transforming growth factor-alpha activate mitogen activated protein kinases in rat liver epithelial cells. Environ Health Perspect 42:133.
• Mousa MA, Ganey PE, Quensen JF, Madhukar BV, Chou K, Giesy JP, Fischer L, Boyd SA. 1998. Altered biological activity of commercial PCB mixtures due to microbial reductive dechlorination. In: Proceedings of the 17^th International Symposium on Chlorinated Dioxins and Related Compounds. pp.1-5.

1997

• Madhukar BV, Trosko JE. 1997. The causes of cancer: implications for prevention and treatment. Indian Journal of Pediatrics 64:131-141. PMID:10771828

1996

• Beavens JS, Little RA, Madhukar BV. 1996. Altered subcellular distribution of protein kinase C (PKC) isozymes in C3H 10T1/2 mouse embryo cells exposed to halogenated aromatic hydrocarbons (HAH). In: Proceedings of the 35^thAnnual Meeting of the Society of Toxicology Meeting, March 10-14, 1996. Anaheim, CA.
• Madhukar BV, Little RA, Beavens JS. 1996. Non-coplanar polychlorinated biphenyls (PCBs) induce AP-1 transcription factor-mediated expression of Luciferase activity. In: Proceedings of the 35^thAnnual Meeting of the Society of Toxicology Meeting, March 10-14, 1996. Anaheim, CA.
• Madhukar BV, Quensen JF, Mousa MA, Fischer L, Boyd SA. 1996. Induction of AP-1 transcription factor activity by polychlorinated biphenyls (PCBs) and their microbial metabolites. In: Proceedings of the Forum on Environmental Remediation & Environmental Toxicology. Lansing, MI. pp.351-352.
• Madhukar BV, Zeng XY. 1996. Induction of AP-1 transcription factor-mediated gene expression by polychlorinated biphenyls (PCBs) in a rat pituitary cell line GH3. In: Proceedings of the 35^thAnnual Meeting of the Society of Toxicology Meeting, March 10-14, 1996. Anaheim, CA.
• Trosko JE, Chang C, Madhukar BV, Dupont E. 1996. Intercellular communication: A paradigm for the interpretation of the initiation/promotion/ progression model of carcinogenesis. In: Chemical Induction of Cancer: Modulation and Combination Effects. Birkhauser Publisher, Boston, MA. pp.3.17-3.29.

1995

• Madhukar BV. 1995. Implication of growth factor and growth factor receptor modulation in dioxin toxicity. Organohalogen Compounds 25:377-380.