Superfund Research Program

Genetics and Metabolomics Core

Project Leader: Pamela L. Mellon
Co-Investigators: Mohit Jain, Christopher W. Benner
Grant Number: P42ES010337
Funding Period: 2017-2023

Project-Specific Links

Publications

2023

• Cassin J, Stamou MI, Keefe KW, Sung K, Bojo C, Tonsfeldt KJ, Rojas RA, Lopes VF, Plummer L, Salnikov KB, Keefe DL, Ozata M, Genel M, Georgopoulos NA, Hall JE, Crowley WF, Seminara SB, Mellon PL, Balasubramanian R. 2023. Heterozygous mutations in SOX2 may cause idiopathic hypogonadotropic hypogonadism via dominant-negative mechanisms. JCI Insight e164324. doi:10.1172/jci.insight.164324 PMID:36602867 PMCID:PMC9977424
• Van Loh B, Yaw AM, Breuer JA, Jackson B, Nguyen D, Jang K, Ramos F, Ho EV, Cui L, Gillette D, Sempere LF, Gorman MR, Tonsfeldt KJ, Mellon PL, Hoffmann HM. 2023. The transcription factor VAX1 in VIP neurons of the suprachiasmatic nucleus impacts circadian rhythm generation, depressive-like behavior, and the reproductive axis in a sex-specific manner in mice. Front. Endocrinol 14:doi:10.3389/fendo.2023.1269672 PMID:38205198 PMCID:10777845
• Yang X, Weber AA, Mennillo E, Paszek M, Wong S, Le S, Teo JY, Chang M, Benner CW, Tukey RH, Chen S. 2023. Oral arsenic administration to humanizedUDP-glucuronosyltransferase1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR. J Biol Chem 299(3):102955. doi:10.1016/j.jbc.2023.102955 PMID:36720308 PMCID:PMC9996368
• Yang X, Weber AA, Mennillo E, Secrest P, Chang M, Wong S, Le S, Liu J, Benner CW, Karin M, Gordts P, Tukey RH, Chen S. 2023. Effects of early life oral arsenic exposure on intestinal tract development and lipid homeostasis in neonatal mice: Implications for NAFLD development. Environ Health Perspect 131(9):doi:10.1289/ehp12381 PMID:37668303 PMCID:10478510

2022

• Lavalle SN, Chou T, Hernandez J, Naing NP, He MY, Tonsfeldt KJ, Mellon PL. 2022. Deletion of the homeodomain gene Six3 from kisspeptin neurons causes subfertility in female mice. Mol Cell Endocrinol 546:111577. doi:10.1016/j.mce.2022.111577 PMID:35121076 PMCID:PMC8934285
• Liu Y, Meric G, Havulinna AS, Teo SM, Aberg F, Ruuskanen MO, Sanders JG, Zhu Q, Tripathi A, Verspoor K, Cheng S, Jain M, Jousilahti P, Vazquez-Baeza Y, Loomba R, Lahti L, Niiranen TJ, Salomaa VV, Knight R, Inouye M. 2022. Early prediction of incident liver disease using conventional risk factors and gut-microbiome-augmented gradient boosting. Cell Metab 34(5):719-730. doi:10.1016/j.cmet.2022.03.002 PMID:35354069 PMCID:PMC9097589
• Meadows JD, Breuer JA, Lavalle SN, Hirschenberger MR, Patel MM, Nguyen D, Kim A, Cassin J, Gorman MR, Welsh DK, Mellon PL, Hoffmann HM. 2022. Deletion of Six3 in post-proliferative neurons produces weakened SCN circadian output, improved metabolic function, and dwarfism in male mice. Mol Metab 57:doi:10.1016/j.molmet.2021.101431 PMID:34974160 PMCID:PMC8810556
• Qin Y, Havulinna AS, Liu Y, Jousilahti P, Ritchie SC, Tokolyi A, Sanders JG, Valsta LM, Brozynska M, Zhu Q, Tripathi A, Vazquez-Baeza Y, Loomba R, Cheng S, Jain M, Niiranen TJ, Lahti L, Knight R, Salomaa VV, Inouye M, Meric G. 2022. Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort. Nat Genet 54:PMID:35115689
• Tonsfeldt KJ, Cui L, Lee J, Walbeek TJ, Brusman LE, Jin Y, Mieda M, Gorman MR, Mellon PL. 2022. Female fertility does not require Bmal1 in suprachiasmatic nucleus neurons expressing arginine vasopressin, vasoactive intestinal peptide, or neuromedin-S. Front. Endocrinol 13:doi:10.3389/fendo.2022.956169 PMID:35992114 PMCID:PMC9389073
• Tonsfeldt KJ, Mellon PL, Hoffmann HM. 2022. Circadian rhythms in the neuronal network timing the luteinizing hormone surge. Endocrinology 163(2):doi:10.1210/endocr/bqab268 PMID:34967900 PMCID:PMC8782605
• Weber AA, Yang X, Mennillo E, Ding J, Watrous JD, Jain M, Chen S, Karin M, Tukey RH. 2022. Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice. Nat Commun 13(1):4346. doi:10.1038/s41467-022-31947-4 PMID:35896521 PMCID:PMC9329322

2021

• Bohaczuk SC, Cassin J, Slaiwa TI, Thackray VG, Mellon PL. 2021. Distal Enhancer Potentiates Activin- and GnRH-Induced Transcription of FSHB. Endocrinology 162:doi:10.1210/endocr/bqab069 PMID:33824966 PMCID:PMC8157479
• Bohaczuk SC, Thackray VG, Shen J, Skowronska-Krawczyk D, Mellon PL. 2021. FSHB transcription is regulated by a novel 5' distal enhancer with a fertility-associated single nucleotide polymorphism. Endocrinology 162:doi:10.1210/endocr/bqaa181 PMID:33009549 PMCID:PMC7846141
• Ho EV, Shi C, Cassin J, He MY, Nguyen RD, Ryan GE, Tonsfeldt KJ, Mellon PL. 2021. Reproductive deficits induced by prenatal Antimullerian hormone exposure require androgen receptor in kisspeptin cells. Endocrinology 162:doi:10.1210/endocr/bqab197 PMID:34529765 PMCID:PMC8507963
• Hoffmann HM, Meadows JD, Breuer JA, Yaw AM, Nguyen D, Tonsfeldt KJ, Chin AY, Devries BM, Trang C, Oosterhouse HJ, Lee JS, Doser JW, Gorman MR, Welsh DK, Mellon PL. 2021. The transcription factors SIX3 and VAX1 are required for suprachiasmatic nucleus circadian output and fertility in female mice. J Neurosci Res PMID:34212416
• Koponen KK, Salosensaari A, Ruuskanen MO, Havulinna AS, Mannisto S, Jousilahti P, Palmu J, Salido R, Sanders K, Brennan C, Humphrey G, Sanders JG, Meric G, Cheng S, Inouye M, Jain M, Niiranen TJ, Valsta LM, Knight R, Salomaa VV. 2021. Associations of healthy food choices with gut microbiota profiles. Am J Clin Nutr 114(2):605-616. doi:10.1093/ajcn/nqab077 PMID:34020448 PMCID:PMC8326043
• Lavalle SN, Chou T, Hernandez J, Naing NP, Tonsfeldt KJ, Hoffmann HM, Mellon PL. 2021. Kiss1 is differentially regulated in male and female mice by the homeodomain transcription factor VAX1. Mol Cell Endocrinol 534:111358. doi:10.1016/j.mce.2021.111358 PMID:34098016 (ahead of print)
• Moshensky A, Du M, Shin J, Advani I, Gunge D, Mathew D, Alkolla R, Du A, Javier C, Ma L, Tran A, Nguyen N, Olay J, Nilaad S, Ding J, Najhawan M, Watrous JD, Bojanowksi CM, Jain M, Christiani DC, Alexander LE. 2021. Vaping-induced metabolomic signatures in the circulation of mice are driven by device type, e-liquid, exposure duration and sex. ERJ Open Res 7:doi:10.1183/23120541.00229-2021 PMID:34262972 PMCID:PMC8273396
• Ruuskanen MO, Aberg F, Mannisto V, Havulinna AS, Meric G, Liu Y, Loomba R, Vazquez-Baeza Y, Tripathi A, Valsta LM, Inouye M, Jousilahti P, Salomaa VV, Jain M, Knight R, Lahti L, Niiranen TJ. 2021. Links between gut microbiome composition and fatty liver disease in a large population sample. Gut Microbes 13:1-22. doi:10.1080/19490976.2021.1888673 PMID:33651661 PMCID:PMC7928040
• Ryan GE, Bohaczuk SC, Cassin J, Witham EA, Shojaei S, Ho EV, Thackray VG, Mellon PL. 2021. Androgen receptor positively regulates gonadotropin-releasing hormone receptor in pituitary gonadotropes. Mol Cell Endocrinol 530:doi:10.1016/j.mce.2021.111286 PMID:33872733 PMCID:PMC8177864
• Schoeller EL, Tonsfeldt KJ, Sinkovich M, Shi R, Mellon PL. 2021. Growth hormone pulses and liver gene expression are differentially regulated by the circadian clock gene Bmal1. Endocrinology 162(4):doi:10.1210/endocr/bqab023 PMID:33539533 PMCID:PMC7901660
• Ward C, Nallamshetty S, Watrous JD, Acres E, Long T, Mathews IT, Sharma S, Cheng S, Imam F, Jain M. 2021. Nontargeted mass spectrometry of dried blood spots for interrogation of the human circulating metabolome. J Mass Spectrom 56(8):e4772. doi:10.1002/jms.4772 PMID:34240506 (ahead of print)
• Weber AA, Mennillo E, Yang X, van der Schoor LW, Jonker JW, Chen S, Tukey RH. 2021. Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation. Drug Metab Dispos 49:12-19. doi:10.1124/dmd.120.000240 PMID:33154041 PMCID:PMC7745083
• Yoshihara E, O'Connor C, Gasser E, Wei Z, Oh TG, Tseng TW, Wang D, Cayabyab F, Dai Y, Yu RT, Liddle C, Atkins AR, Downes M, Evans RM. 2021. Immune-evasive human islet-like organoids ameliorate diabetes. Nature 590:doi:10.1038/s41586-020-03109-3 PMID:33469222

2020

• Ajmera VH, Liu A, Singh S, Yachoa G, Ramey M, Bhargava M, Zamani A, Lopez S, Mangla N, Bettencourt R, Rizo E, Valasek MA, Behling C, Richards L, Sirlin C, Loomba R. 2020. Clinical utility of an increase in magnetic resonance elastography in predicting fibrosis progression in nonalcoholic fatty liver disease. Hepatology 71(3):849-860. doi:10.1002/hep.30974 PMID:31556124 PMCID:PMC7828573
• Balakrishnan M, Loomba R. 2020. The role of noninvasive tests for differentiating NASH from NAFL and diagnosing advanced fibrosis among patients with NAFLD. J Clin Gastroenterol 54(2):107-113. doi:10.1097/MCG.0000000000001284 PMID:31789757 PMCID:PMC7945957
• Cifarelli V, Beeman SC, Smith GI, Yoshino J, Morozov D, Beals JW, Kayser BD, Watrous JD, Jain M, Patterson BW, Klein S. 2020. Decreased adipose tissue oxygenation associates with insulin resistance in individuals with obesity. J Clin Invest 130(12):6688-6699. doi:10.1172/JCI141828 PMID:33164985 PMCID:PMC7685757
• Core N, Erni A, Hoffmann HM, Mellon PL, Saurin AJ, Beclin C, Cremer H. 2020. Stem cell regionalization during olfactory bulb neurogenesis depends on regulatory interactions between Vax1 and Pax6. Elife 9:doi:10.7554/eLife.58215 PMID:32762844 PMCID:PMC7440913
• Gou L, Lim D, Ma W, Aubol BE, Hao Y, Wang X, Zhao J, Liang Z, Shao C, Zhang X, Meng F, Li H, Zhang X, Xu R, Li D, Rosenfeld MG, Mellon PL, Adams JA, Liu M, Fu X. 2020. Initiation of parental genome reprogramming in fertilized oocyte by splicing kinase SRPK1 catalyzed protamine phosphorylation. Cell 180:doi:10.1016/j.cell.2020.02.020 PMID:32169215
• Han A, O'Brien WD, Erdman JW, Byra M, Heba E, Andre MP, Loomba R, Sirlin C. 2020. Noninvasive diagnosis of nonalcoholic fatty liver disease and quantification of liver fat with radiofrequency ultrasound data using one-dimensional convolutional neural networks. Radiology 295:342-350. doi:10.1148/radiol.2020191160 PMID:32096706 PMCID:PMC7193902
• Han A, Zhang YN, Boehringer AS, Montes V, Andre MP, Erdman JW, Loomba R, Valasek MA, Sirlin C, O'Brien WD. 2020. Assessment of hepatic steatosis in nonalcoholic fatty liver disease by using quantitative US. Radiology 295:106-113. doi:10.1148/radiol.2020191152 PMID:32013792 PMCID:PMC7104700
• Hansmann E, Mennillo E, Yoda E, Verreault M, Barbier O, Chen S, Tukey RH. 2020. Differential role of LXRa and LXRy in the regulation of UDP-glucuronosyltransferase 1A1 in humanized UGT1 mice. Drug Metab Dispos 48:255-263. doi:10.1124/dmd.119.090068 PMID:31980500 PMCID:PMC7065491
• He F, Antonucci L, Yamachika S, Zhang Z, Taniguchi K, Umemura A, Hatzivassiliou G, Roose-Girma M, Reina-Campos M, Molina AD, Diaz-Meco MT, Moscat J, Sun B, Karin M. 2020. NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly. J Hepatol 72:1182-1195. doi:10.1016/j.jhep.2020.01.023 PMID:32105670
• Hydes TJ, Ravi S, Loomba R, Gray ME. 2020. Evidence-based clinical advice for nutrition and dietary weight loss strategies for the management of NAFLD and NASH. Clin Mol Hepatol 26:doi:10.3350/cmh.2020.0067 PMID:32674529 PMCID:PMC7641567
• Lenkiewicz E, Malasi S, Hogenson TL, Flores LF, Barham W, Phillips WJ, Roesler AS, Chambers KR, Rajbhandari N, Hayashi A, Antal CE, Downes M, Grandgenett PM, Hollingsworth MA, Cridebring D, Xiong Y, Lee J, Ye Z, Yan H, Hernandez MC, Leiting JL, Evans RM, Ordog T, Truty MJ, Borad MJ, Reya T, Von Hoff DD, Fernandez-Zapico ME, Barrett MT. 2020. Genomic and epigenomic landscaping defines new therapeutic targets for adenosquamous carcinoma of the pancreas. Cancer Res 80:4324-4334. doi:10.1158/0008-5472.CAN-20-0078 PMID:32928922
• Lowey B, Whiteley AT, Keszei AF, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee AS, Kranzusch PJ. 2020. CBASS immunity uses CARF-related effectors to sense 3'-5'- and 2'-5'-linked cyclic oligonucleotide signals and protect bacteria from phage infection. Cell 182:38. doi:10.1016/j.cell.2020.05.019 PMID:32544385 PMCID:PMC7728545
• Ma H, Yamamoto G, Xu J, Liu X, Karin D, Kim J, Alexandrov LB, Koyama Y, Nishio T, Benner CW, Heinz S, Rosenthal S, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop I, Quehenberger O, Dennis EA, Saltiel AR, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. 2020. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol 72:946-959. doi:10.1016/j.jhep.2019.12.016 PMID:31899206 PMCID:PMC7167339
• Mangla N, Ajmera VH, Caussy C, Sirlin C, Brouha SS, Bajwa-Dulai S, Madamba E, Bettencourt R, Richards L, Loomba R. 2020. Liver stiffness severity is associated with increased cardiovascular risk in patients with type 2 diabetes. Clin Gastroenterol Hepatol 18(3):744-746. doi:10.1016/j.cgh.2019.05.003 PMID:31100460 PMCID:PMC6984972
• Mennillo E, Yang X, Paszek M, Auwerx J, Benner CW, Chen S. 2020. NCoR1 protects mice from dextran sodium sulfate-induced colitis by guarding colonic crypt cells from luminal insult. Cell Mol Gastroenterol Hepatol 10:133-147. doi:10.1016/j.jcmgh.2020.01.014 PMID:32044398 PMCID:PMC7229481
• Nicholas DA, Knight VS, Tonsfeldt KJ, Terasaka T, Molinar-Inglis O, Stephens SB, Trejo J, Kauffman AS, Mellon PL, Lawson MA. 2020. GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes. Sci Rep 10:13063. doi:10.1038/s41598-020-69913-z PMID:32747664 PMCID:PMC7400764
• Noel P, Hussein S, Ng S, Antal CE, Lin W, Rodela E, Delgado P, Naveed S, Downes M, Lin Y, Evans RM, Von Hoff DD, Han H. 2020. Triptolide targets super-enhancer networks in pancreatic cancer cells and cancer-associated fibroblasts. Oncogenesis 9(100):doi:10.1038/s41389-020-00285-9 PMID:33168807 PMCID:PMC7653036
• Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba E, Bettencourt R, Richards L, Raffatellu M, Dorrestein PC, Yu RT, Atkins AR, Huan T, Brenner DA, Sirlin C, Knight R, Downes M, Evans RM, Loomba R. 2020. A universal gut-microbiome-derived signature predicts cirrhosis. Cell Metab 32:doi:10.1016/j.cmet.2020.10.015 PMID:33147487 PMCID:PMC7891106 (accepted for publication)
• Paszek M, Tukey RH. 2020. NRF2-Independent regulation of intestinal constitutive androstane receptor by the pro-oxidants cadmium and isothiocyanate in hUGT1 mice. Drug Metab Dispos 48:25-30. doi:10.1124/dmd.119.089508 PMID:31704714 PMCID:PMC6904881
• Quinn RA, Melnik A, Vrbanac AF, Fu T, Patras K, Christy M, Bodai Z, Belda-Ferre P, Tripathi A, Chung L, Downes M, Welch R, Quinn M, Humphrey G, Panitchpakdi M, Weldon K, Aksenov AA, da Silva R, Avila-Pacheco J, Clish C, Bae S, Mallick H, Franzosa E, Lloyd-Price J, Bussell R, Thron T, Nelson AT, Wang M, Leszczynski E, Vargas F, Gauglitz J, Meehan M, Gentry E, Arthur T, Komor A, Poulsen O, Boland BS, Chang JT, Sandborn W, Lim M, Garg N, Lumeng J, Xavier R, Kazmierczak B, Jain R, Egan M, Rhee K, Ferguson D, Raffatellu M, Vlamakis H, Haddad G, Siegel D, Huttenhower C, Mazmanian S, Evans RM, Nizet V, Knight R, Dorrestein PC. 2020. Global chemical effects of the microbiome include new bile-acid conjugations. Nature 579:123-129. doi:10.1038/s41586-020-2047-9 PMID:32103176
• Sun X, Seidman J, Zhao P, Troutman T, Spann N, Que X, Zhou F, Liao Z, Pasillas M, Yang X, Magida J, Kisseleva T, Brenner DA, Downes M, Evans RM, Saltiel AR, Tsimikas S, Glass CK, Witztum JL. 2020. Neutralization of oxidized phospholipids ameliorates non-alcoholic steatohepatitis. Cell Metab 31(1):189-206. doi:10.1016/j.cmet.2019.10.014 PMID:31761566 PMCID:PMC7028360
• Takahashi Y, Zhang J, Hsu P, Ceciliato PH, Dubeaux G, Munemasa S, Ge C, Zhao Y, Hauser F, Schroeder JI. 2020. MAP3Kinase-dependent SnRK2-kinase activation is required for abscisic acid signal transduction and rapid osmotic stress response. Nat Commun 11(1):12. doi:10.1038/s41467-019-13875-y PMID:31896774 PMCID:PMC6940395
• Todoric J, Di Caro G, Reibe S, Henstridge DC, Green CR, Vrbanac AF, Ceteci F, Conche C, McNulty R, Shalapour S, Taniguchi K, Meikle PJ, Watrous JD, Moranchel R, Najhawan M, Jain M, Liu X, Kisseleva T, Diaz-Meco MT, Moscat J, Knight R, Greten FR, Lau LF, Metallo CM, Febbraio MA, Karin M. 2020. Fructose stimulated de novo lipogenesis is promoted by inflammation. Nat Metab 2:1034-1045. doi:10.1038/s42255-020-0261-2 PMID:32839596 PMCID:PMC8018782
• Xu J, Ma H, Liu X, Rosenthal SB, Baglieri J, Mccubbin R, Sun M, Koyama Y, Geoffroy C, Saijo K, Shang L, Nishio T, Maricic I, Kriefeldt M, Kusumanchi P, Roberts a, Zheng B, Kumar V, Zengler K, Pizzo D, Hosseini M, Contet C, Glass CK, Liangpunsakul S, Tsukamoto H, Gao B, Karin M, Brenner DA, Koob G, Kisseleva T. 2020. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. JCI Insight doi:10.1172/jci.insight.131277 PMID:32051339 PMCID:PMC7098802
• Yoshino M, Kayser BD, Yoshino J, Stein RI, Reeds D, Eagon JC, Eckhouse SR, Watrous JD, Jain M, Knight R, Schechtman K, Patterson BW, Klein S. 2020. Effects of diet versus gastric bypass on metabolic function in diabetes. N Engl J Med 383:721-732. doi:10.1056/NEJMoa2003697 PMID:32813948 PMCID:PMC7456610
• Yueh MF, He F, Chen C, Vu C, Tripathi A, Knight R, Karin M, Chen S, Tukey RH. 2020. Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A 117:31259-31266. doi:10.1073/pnas.2017129117 PMID:33229553 PMCID:PMC7733785
• Zhao P, Sun X, Chaggan C, Liao Z, Wong KI, He F, Singh S, Loomba R, Karin M, Witztum JL, Saltiel AR. 2020. An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. Science 367:doi:10.1126/science.aay0542 PMID:32029622 PMCID:PMC8012106 (accepted for publication)

2019

• Cai D, Wang J, Gao B, Li J, Wu F, Zou JX, Xu J, Jiang Y, Zou H, Huang Z, Borowsky AD, Bold RJ, Lara PN, Li JJ, Chen X, Lam KS, To K, Kung H, Fiehn O, Zhao R, Evans RM, Chen H. 2019. RORgamma is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. Nat Commun 10(1):4621. doi:10.1038/s41467-019-12529-3 PMID:31604910 PMCID:PMC6789042
• Castera L, Friedrich-Rust M, Loomba R. 2019. Noninvasive Assessment of Liver Disease in Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology 156(5):1264-1281. doi:10.1053/j.gastro.2018.12.036 PMID:30660725 PMCID:PMC7505052
• Caussy C, Bhargava M, Villesen I, Gudmann N, Leeming D, Karsdal M, Faulkner C, Bao D, Liu A, Lo M, Bettencourt R, Bassirian S, Richards L, Brenner DA, Chen C, Sirlin C, Loomba R. 2019. Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. Hepatology 70(1):127-141. doi:10.1002/hep.30610 PMID:30859582 PMCID:PMC6984974
• Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R, Rizo E, Richards L, Xu Z, Downes M, Evans RM, Brenner DA, Sirlin CB, Knight R, Loomba R. 2019. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Nat Commun 10:1406. doi:10.1038/s41467-019-09455-9 PMID:30926798 PMCID:PMC6440960
• Chang C, Loo C, Zhao X, Solt LA, Liang Y, Bapat SP, Cho H, Kamenecka TM, Leblanc M, Atkins AR, Yu RT, Downes M, Burris TP, Evans RM, Zheng Y. 2019. The nuclear receptor REV-ERB alpha modulates Th17 cell-mediated autoimmune disease. Proc Natl Acad Sci U S A 116:18528-18536. doi:10.1073/pnas.1907563116 PMID:31455731 PMCID:PMC6744854
• Fu T, Coulter S, Yoshihara E, Oh TG, Fang S, Cayabyab F, Zhu Q, Zhang T, Leblanc M, Liu S, He M, Waizenegger W, Gasser E, Schnabl B, Atkins AR, Yu RT, Knight R, Liddle C, Downes M, Evans RM. 2019. FXR regulates intestinal cancer stem cell proliferation. Cell 176:1098-1112. doi:10.1016/j.cell.2019.01.036 PMID:30794774 PMCID:PMC6701863
• Hoffman HM, Larder R, Lee JS, Hu RJ, Trang C, Devries BM, Clark DD, Mellon PL. 2019. Differential CRE expression in Lhrh-cre and GnRH-cre alleles and the impact on fertility in Otx2-Flox mice. Neuroendocrinology 108:328-342. doi:10.1159/000497791 PMID:30739114 PMCID:PMC6753941
• Hoffmann HM, Pandolfi EC, Larder R, Mellon PL. 2019. Haploinsufficiency of homeodomain proteins Six3, Vax1, and Otx2 causes subfertility in mice via distinct mechanisms. Neuroendocrinology 109:200-207. doi:10.1159/000494086 PMID:30261489 PMCID:PMC6437011
• Liang S, Ma H, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA. 2019. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Gastroenterology 156(4):1156-1172. doi:10.1053/j.gastro.2018.11.019 PMID:30445007 PMCID:PMC6409207
• Loomba R, Adams L. 2019. The 20 Rule of NASH Progression: The Natural History of Advanced Fibrosis and Cirrhosis Caused by NASH. Hepatology 70(6):1885-1888. doi:10.1002/hep.30946 PMID:31520407 PMCID:PMC7504908
• Mills P, Caussy C, Loomba R. 2019. Glyphosate Excretion is Associated with Steatohepatitis and Advanced Liver Fibrosis in Patients with Fatty Liver Disease. Clin Gastroenterol Hepatol 18(3):741-743. doi:10.1016/j.cgh.2019.03.045 PMID:30954713 PMCID:PMC6776714
• Pai R, Kleiner D, Hart J, Adeyi O, Clouston A, Behling C, Jain D, Kakar S, Brahmania M, Burgart L, Batts K, Valasek MA, Torbenson M, Guindi M, Wang H, Ajmera VH, Adams L, Parker CE, Feagan B, Loomba R, Jairath V. 2019. Standardising the interpretation of liver biopsies in non-alcoholic fatty liver disease clinical trials. Aliment Pharmacol Ther 50(10):1100-1111. doi:10.1111/apt.15503 PMID:31583739 PMCID:PMC6817398
• Pandolfi EC, Breuer JA, Huu VN, Talluri T, Nguyen D, Lee JS, Hu R, Bharti K, Skowronska-Krawczyk D, Gorman MR, Mellon PL, Hoffmann HM. 2019. The homeodomain transcription factors vax1 and six6 are required for scn development and function. Mol Neurobiol 1-16. doi:10.1007/s12035-019-01781-9 PMID:31705443 PMCID:PMC7035166
• Pandolfi EC, Tonsfeldt KJ, Hoffmann HM, Mellon PL. 2019. Deletion of the homeodomain protein Six6 from GnRH neurons decreases GnRH gene expression, resulting in infertility. Endocrinology 160:2151-2164. doi:10.1210/en.2019-00113 PMID:31211355 PMCID:PMC6821215
• Park J, Kim T, Takahashi Y, Schwab R, Dressano K, Stephan AB, Ceciliato PH, Ramirez E, Garin V, Huffaker A, Schroeder JI. 2019. Chemical genetic identification of a lectin receptor kinase that transduces immune responses and interferes with abscisic acid signaling. The Plant Journal doi:10.1111/tpj.14232 PMID:30659683 PMCID:PMC6488365
• Ruf-Zamojski F, Ge Y, Pincas H, Shan J, Song Y, Hines N, Kelley K, Montagna C, Nair P, Toufaily C, Bernard DJ, Mellon PL, Nair V, Turgeon JL, Sealfon SC. 2019. Cytogenetic, Genomic, and Functional Characterization of Pituitary Gonadotrope Cell Lines. J Endocr Soc 3. doi:10.1210/js.2019-00064 PMID:31020055 PMCID:PMC6469952 (accepted for publication)
• Sanchez-Lopez E, Zhong Z, Stubelius A, Sweeney SR, Booshehri LM, Antonucci L, Liu-Bryan R, Lodi A, Terkeltaub R, Lacal JC, Murphy AN, Hoffman HM, Tiziani S, Guma M, Karin M. 2019. Choline Uptake and metabolism modulate macrophage IL-1 beta and IL-18 production. Cell Metab 29:1350. doi:10.1016/j.cmet.2019.03.011 PMID:30982734 PMCID:PMC6675591
• Tonsfeldt KJ, Schoeller EL, Brusman LE, Cui L, Lee J, Mellon PL. 2019. The Contribution of the Circadian Gene Bmal1 to Female Fertility and the Generation of the Preovulatory Luteinizing Hormone Surge. J Endocr Soc 3(4):716-733. doi:10.1210/js.2018-00228 PMID:30906911 PMCID:PMC6425515
• Wang L, Mazagova M, Pan C, Yang S, Brandl KL, Liu J, Reilly SM, Wang Y, Miao Z, Loomba R, Lu N, Guo Q, Liu J, Yu RT, Downes M, Evans RM, Brenner DA, Saltiel AR, Beutler B, Schnabl B. 2019. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Proc Natl Acad Sci U S A 116:15184-15193. doi:10.1073/pnas.1904360116 PMID:31289229 PMCID:PMC6660779

2018

• Hoffman HM, Gong P, Tamrazian A, Mellon PL. 2018. Transcriptional interaction between cFOS and the homeodomain-binding transcription factor VAX1 on the GnRH promoter controls Gnrh1 expression levels in a GnRH neuron maturation specific manner. Mol Cell Endocrinol 461:143-154. doi:10.1016/j.mce.2017.09.004 PMID:28890143 PMCID:PMC5756504
• Pandolfi EC, Hoffmann HM, Schoeller EL, Gorman MR, Mellon PL. 2018. Haploinsufficiency of SIX3 Abolishes Male Reproductive Behavior Through Disrupted Olfactory Development, and Impairs Female Fertility Through Disrupted GnRH Neuron Migration. Mol Neurobiol 55(11):8709-8727. doi:10.1007/s12035-018-1013-0 PMID:29589282 PMCID:PMC6156938
• Que X, Hung M, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Maatta A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Yla-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. 2018. Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature 558:301. doi:10.1038/s41586-018-0198-8 PMID:29875409 PMCID:PMC6033669
• Ryan GE, Malik S, Mellon PL. 2018. Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS. Endocrinology 159(4):1734-1747. doi:10.1210/en.2017-03218 PMID:29471436 PMCID:PMC6097580

2017

• Fujiwara R, Mitsugi R, Uemura A, Itoh T, Tukey RH. 2017. Severe neonatal hyperbilirubinemia in Crigler-Najjar Syndrome model mice can be reversed with zinc protoporphyrin. Hepatol Commun 1(8):792-802. doi:10.1002/hep4.1082 PMID:29399656 PMCID:PMC567892
• Fujiwara R, Yoda E, Tukey RH. 2017. Species differences in drug glucuronidation: humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans. Drug Metab Pharmacokinet 33(1):9-16. doi:10.1016/j.dmpk.2017.10.002 PMID:29079228 PMCID:PMC5809266
• Goetz A, Wilkinson MF. 2017. Stress and the nonsense-mediated RNA decay pathway. Cellular and Molecular Life Sciences 74(19):3509-3531. doi:10.1007/s00018-017-2537-6 PMID:28503708 PMCID:PMC568394
• Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C, Bettencourt R, Highlander SK, Jones MB, Sirlin CB, Schnabl B, Brinkac L, Schork N, Chen C, Brenner DA, Biggs W, Yooseph S, Venter JC, Nelson KE. 2017. Gut microbiome-based metagenomic signature for non-invasive detection of advanced fibrosis in human nonalcoholic fatty liver disease. Cell Metab 25(5):1054-1062.e5. doi:10.1016/j.cmet.2017.04.001 PMID:28467925 PMCID:PMC550273
• Shalapour S, Lin X, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner CW, Anstee QM, Karin M. 2017. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature 551(7680):340-345. doi:10.1038/nature24302 PMID:29144460 PMCID:PMC5884449
• Xie H, Hoffmann HM, Iyer AK, Brayman MJ, Ngo C, Sunshine M, Mellon PL. 2017. Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines. Reprod Biol Endocrinol 15(1):86. doi:10.1186/s12958-017-0304-z PMID:29065928 PMCID:PMC5655979
• Xu J, Ma H, Liang S, Sun M, Karin G, Koyama Y, Hu R, Quehenberger O, Davidson NO, Dennis EA, Kisseleva T, Brenner DA. 2017. The role of human CYP2E1 in liver inflammation and fibrosis. Hepatol Commun 1:1043-1057. doi:10.1002/hep4.1115 PMID:29404441 PMCID:PMC572140