Superfund Research Program
Inflammation and Metabolic Changes in Children Developmentally Exposed to PFASs
Project Leader: Philippe Grandjean
Grant Number: P42ES027706
Funding Period: 2017-2022
Project-Specific Links
- Project Summary
Publications
2022
- Lochhead P, Khalili H, Ananthakrishnan AN, Burke KE, Richter JM, Sun Q, Grandjean P, Chan AT. 2022. Plasma concentrations of perfluoroalkyl substances and risk of inflammatory bowel diseases in women: a nested case control analysis in the Nurses' Health Study cohorts. Environ Res 207:112222. doi:10.1016/j.envres.2021.112222 PMID:34662575
2021
- Birukov A, Andersen LB, Andersen M, Nielsen JH, Nielsen F, Kyhl HB, Jorgensen JS, Grandjean P, Dechend R, Jensen TK. 2021. Exposure to perfluoroalkyl substances and blood pressure in pregnancy among 1436 women from the Odense Child Cohort. Environ Int 151:106442. doi:10.1016/j.envint.2021.106442 PMID:33610053
- Blomberg AJ, Shih Y, Messerlian C, Jorgensen LH, Weihe P, Grandjean P. 2021. Early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort. Environ Res 200:111400. doi:10.1016/j.envres.2021.111400 PMID:34081971 PMCID:PMC8403652
- Dalsager L, Christensen N, Halekoh U, Timmermann CA, Nielsen F, Kyhl HB, Husby S, Grandjean P, Jensen TK, Andersen HR. 2021. Exposure to perfluoroalkyl substances during fetal life and hospitalization for infectious disease in childhood: A study among 1,503 children from the Odense Child Cohort. Environ Int 149:106395. doi:10.1016/j.envint.2021.106395 PMID:33508532
- Dalsager L, Jensen TK, Nielsen F, Grandjean P, Bilenberg N, Andersen HR. 2021. No association between maternal and child PFAS concentrations and repeated measures of ADHD symptoms at age 21/2 and 5 years in children from the Odense Child Cohort. Neurotoxicol Teratol 88:PMID:34563660
- Etzel RA, Grandjean P, Ozonoff DM. 2021. Environmental epidemiology in a crossfire. Environmental Health 20(1):91. doi:10.1186/s12940-021-00776-1 PMID:34412648 PMCID:PMC8375458
- Gardener H, Sun Q, Grandjean P. 2021. PFAS concentration during pregnancy in relation to cardiometabolic health and birth outcomes. Environ Res 192:110287. doi:10.1016/j.envres.2020.110287 PMID:33038367 PMCID:PMC7736328
- Shih Y, Blomberg AJ, Bind M, Holm D, Nielsen F, Heilmann C, Weihe P, Grandjean P. 2021. Serum vaccine antibody concentrations in adults exposed to per- and polyfluoroalkyl substances: A birth cohort in the Faroe Islands. J Immunotoxicol 18(1):85-92. PMID:34143710 (ahead of print)
- Shih Y, Blomberg AJ, Jorgensen LH, Weihe P, Grandjean P. 2021. Early-life exposure to perfluoroalkyl substances in relation to serum adipokines in a longitudinal birth cohort. Environ Res 204(7):111905. doi:10.1016/j.envres.2021.111905 PMID:34419464
- Valvi D, Hojlund K, Coull BA, Nielsen F, Weihe P, Grandjean P. 2021. Life-course exposure to perfluoroalkyl substances in relation to markers of glucose homeostasis in early adulthood. J Clin Endocrinol Metab 106(8):2495-2504. doi:10.1210/clinem/dgab267 PMID:33890111 PMCID:PMC8277200
- Wu Q, Coumoul X, Grandjean P, Barouki R, Audouze K. 2021. Endocrine disrupting chemicals and COVID-19 relationships: A computational systems biology approach. Environ Int 157:doi:10.1016/j.envint.2020.106232 PMID:33223326 PMCID:PMC7831776
2020
- Grandjean P, Timmermann CA, Kruse M, Nielsen F, Vinholt PJ, Boding L, Heilmann C, Molbak K. 2020. Severity of COVID-19 at elevated exposure to perfluorinated alkylates. PLoS One 15:doi:10.1371/journal.pone.0244815 PMID:33382826
- Jensen RC, Andersen M, Larsen PV, Glintborg D, Dalgard C, Timmermann CA, Nielsen F, Sandberg MB, Andersen HR, Christesen HT, Grandjean P, Jensen TK. 2020. Prenatal exposures to perfluoroalkyl acids and associations with markers of adiposity and plasma lipids in infancy: An Odense Child Cohort study. Environ Health Perspect 128(7):77001. doi:10.1289/EHP5184 PMID:32628516 PMCID:PMC7338787
- Landrigan PJ, Stegeman JJ, Fleming LE, Allemand D, Anderson DM, Backer L, Brucker-Davis F, Chevalier N, Corra L, Czerucka D, Bottein MD, Demeneix B, Depledge MH, Deheyn DD, Dorman CJ, Fenichel P, Fisher S, Gaill F, Galgani F, Gaze WH, Giuliano L, Grandjean P, Hahn ME, Hamdoun A, Hess P, Judson B, Laborde A, McGlade J, Mu J, Mustapha A, Neira M, Noble RT, Pedrotti ML, Reddy C, Rocklov J, Scharler UM, Shanmugam H, Taghian G, van de Water JA, Vezzulli L, Weihe P, Zeka A, Raps H, Rampal P. 2020. Human health and ocean pollution. Ann Glob Health 86:64. doi:10.5334/aogh.2831 PMID:33354517 PMCID:PMC7731724
- Liu G, Zhang B, Hu Y, Rood J, Liang L, Qi L, Bray GA, DeJonge L, Coull BA, Grandjean P, Furtado JD, Sun Q. 2020. Associations of perfluoroalkyl substances with blood lipids and apolipoproteins in lipoprotein subspecies: The POUNDS-lost study. Environmental Health 19:doi:10.1186/s12940-020-0561-8 PMID:31931806 PMCID:PMC6958662
- Timmermann CA, Jensen KJ, Nielsen F, Budtz-Jorgensen E, van der Klis F, Benn CS, Grandjean P, Fisker AB. 2020. Serum Perfluoroalkyl Substances, Vaccine Responses, and Morbidity in a Cohort of Guinea-Bissau Children. Environ Health Perspect 128:doi:10.1289/ehp6517 PMID:32772733 PMCID:PMC7416537
- Waterfield G, Rogers M, Grandjean P, Auffhammer M, Sunding D. 2020. Reducing exposure to high levels of perfluorinated compounds in drinking water improves reproductive outcomes: Evidence from an intervention in Minnesota. Environ Health 19(1):42. doi:10.1186/s12940-020-00591-0 PMID:32321520 PMCID:PMC7178962
2019
- Ammitzboll C, Bornsen L, Petersen ER, Oturai AB, Sondergaard HB, Grandjean P, Sellebjerg F. 2019. Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation. J Neuroimmunol 330:90-95. doi:10.1016/j.jneuroim.2019.03.002 PMID:30852181 PMCID:PMC6461219
- Eryasa B, Grandjean P, Nielsen F, Valvi D, Zmirou-Navier D, Sunderland EM, Weihe P, Oulhote Y. 2019. Physico-chemical properties and gestational diabetes predict transplacental transfer and partitioning of perfluoroalkyl substances. Environ Int 130:doi:10.1016/j.envint.2019.05.068 PMID:31200157 PMCID:PMC7029428
- Grandjean P. 2019. Developmental fluoride neurotoxicity: An updated review. Environmental Health 18:doi:10.1186/s12940-019-0551-x PMID:31856837 PMCID:PMC6923889
- Grandjean P, Abdennebi-Najar L, Barouki R, Cranor CF, Etzel RA, Gee D, Heindel J, Hougaard KS, Hunt P, Nawrot T, Prins GS, Ritz B, Soffritti M, Sunyer J, Weihe P. 2019. Timescales of developmental toxicity impacting on research and needs for intervention. Basic Clin Pharmacol Toxicol 125:70-80. doi:10.1111/bcpt.13162 PMID:30387920 PMCID:PMC6497561
- Hu XC, Tokranov AK, Liddie J, Zhang X, Grandjean P, Hart JE, Laden F, Sun Q, Yeung LW, Sunderland EM. 2019. Tap water contributions to plasma concentrations of poly- and perfluoroalkyl substances (PFAS) in a nationwide prospective cohort of U.S. women. Environ Health Perspect doi:10.1289/EHP4093 PMID:31170009 PMCID:PMC6792361
- Lim X. 2019. Tainted water: the scientists tracing thousands of fluorinated chemicals in our environment. Nature 566:26-29. doi:10.1038/d41586-019-00441-1 PMID:30728524
- Shaffer RM, Sellers SP, Baker MG, de Buen Kalman R, Frostad J, Suter MK, Anenberg SC, Balbus J, Basu N, Bellinger DC, Birnbaum LS, Brauer M, Cohen A, Ebi KL, Fuller R, Grandjean P, Hess JJ, Kogevinas M, Kumar P, Landrigan PJ, Lanphear BP, London SJ, Rooney AA, Stanaway JD, Trasande L, Walker K, Hu H. 2019. Improving and expanding estimates of the global burden of disease due to environmental health risk factors. Environ Health Perspect 127:doi:10.1289/EHP5496 PMID:31626566 PMCID:PMC6867191
- Shelly C, Grandjean P, Oulhote Y, Plomgaard P, Frikke-Schmidt R, Nielsen F, Zmirou-Navier D, Weihe P, Valvi D. 2019. Early life exposures to perfluoroalkyl substances in relation to adipokine hormone levels at birth and during childhood. J Clin Endocrinol Metab 104(11):5338-48. doi:10.1210/jc.2019-00385 PMID:31216000 PMCID:PMC6773461 (ahead of print)
- Ugai T, Ito H, Oze I, Saito E, Rahman S, Boffetta P, Gupta PC, Sawada N, Tamakoshi A, Shu X, Koh W, Gao Y, Sadakane A, Tsuji I, Park SK, Nagata C, You S, Pednekar MS, Tsugane S, Cai H, Yuan J, Xiang Y, Ozasa K, Tomata Y, Kanemura S, Sugawara Y, Wada K, Chen C, Yoo K, Chia K, Ahsan H, Zheng W, Inoue M, Kang D, Potter JD, Matsuo K. 2019. Association of BMI, Smoking, and Alcohol with Multiple Myeloma Mortality in Asians: A Pooled Analysis of More than 800,000 Participants in the Asia Cohort Consortium. Cancer Epidemiol Biomarkers Prev 28:1861-1867. doi:10.1158/1055-9965.Epi-19-0389 PMID:31399476
- Xiao C, Grandjean P, Valvi D, Nielson F, Jensen TK, Weihe P, Oulhote Y. 2019. Associations of Exposure to Perfluoroalkyl Substances With Thyroid Hormone Concentrations and Birth Size. J Clin Endocrinol Metab 105:doi:10.1210/clinem/dgz147
2018
- Barouki R, Melen E, Herceg Z, Beckers J, Chen J, Karagas MR, Puga A, Xia Y, Chadwick LH, Yan W, Audouze K, Slama R, Heindel J, Grandjean P, Kawamoto T, Nohara K. 2018. Epigenetics as a mechanism linking developmental exposures to long-term toxicity. Environ Int 114:77-86. doi:10.1016/j.envint.2018.02.014 PMID:29499450 PMCID:PMC5899930
- Budtz-Jorgensen E, Grandjean P. 2018. Application of benchmark analysis for mixed contaminant exposures: Mutual adjustment of perfluoroalkylate substances associated with immunotoxicity. PLoS One 13:14. doi:10.1371/journal.pone.0205388 PMID:30339706 PMCID:PMC6195268
- Dassuncao C, Hu XC, Nielsen F, Weihe P, Grandjean P, Sunderland EM. 2018. Shifting global exposures to poly- and perfluoroalkyl substances (PFASs) evident in longitudinal birth cohorts from a seafood-consuming population. Environ Sci Technol 52:3738-3747. doi:10.1021/acs.est.7b06044 PMID:29516726 PMCID:PMC6438388
- Grandjean P. 2018. Delayed discovery, dissemination, and decisions on intervention in environmental health: A case study on immunotoxicity of perfluorinated alkylate substances. Environ Health 17:62. doi:10.1186/s12940-018-0405-y PMID:30060739 PMCID:PMC6066926
- Grandjean P. 2018. Health status of workers exposed to perfluorinated alkylate substances. Occup Environ Med 60:E562. doi:10.1097/JOM.0000000000001411 PMID:30289834 PMCID:PMC6195218
- Hu XC, Dassuncao C, Zhang X, Grandjean P, Weihe P, Webster GM, Nielsen F, Sunderland EM. 2018. Can profiles of poly- and Perfluoroalkyl substances (PFASs) in human serum provide information on major exposure sources?. Environ Health 17:11. doi:10.1186/s12940-018-0355-4 PMID:29391068 PMCID:PMC5796515
- Jensen RC, Glintborg D, Timmermann CA, Nielsen F, Kyhl HB, Andersen HR, Grandjean P, Jensen TK, Andersen M. 2018. Perfluoroalkyl substances and glycemic status in pregnant Danish women: The Odense Child Cohort. Environ Int 116:101-107. doi:10.1016/j.envint.2018.04.010 PMID:29660612
- Mie A, Ruden C, Grandjean P. 2018. Safety of safety evaluation of pesticides: developmental neurotoxicity of chlorpyrifos and chlorpyrifos-methyl. Environ Health 17:77. doi:10.1186/s12940-018-0421-y PMID:30442131 PMCID:PMC6238321
- Sun Q, Zong G, Valvi D, Nielsen F, Coull BA, Grandjean P. 2018. Plasma concentrations of perfluoroalkyl substances and risk of type 2 diabetes: A prospective investigation among U.S. women. Environ Health Perspect 126:037001. doi:10.1289/ehp2619 PMID:29498927 PMCID:PMC6071816