Project Publications: Baylor College of Medicine: Research Support Core

Superfund Research Program

Project Leader: Dean Edwards
Co-Investigators: Shixia Huang, Sung Yun Jung, Daniel Kraushaar, Nagireddy Putluri
Grant Number: P42ES027725
Funding Period: 2020-2025

Ahn S, Park J, Grimm SL, Piyarathna DW, Samanta T, Putluri V, Mezquita D, Fuqua SA, Putluri N, Coarfa C, Kaipparettu B. 2024. Metabolomic rewiring promotes endocrine therapy resistance in breast cancer. Cancer Res 84(2):291-304. doi:10.1158/0008-5472.Can-23-0184 PMID:37906431 PMCID:10842725
Amara C, Kami Reddy K, Yuntao Y, Chan Y, Piyarathna DW, Dobrolecki L, Shih D, Shi Z, Xu J, Huang S, Ellis M, Apolo A, Ballester L, Gao J, Hansel D, Lotan Y, Hodges H, Lerner S, Creighton C, Sreekumar A, Zheng W, Msaouel P, Kavuri S, Putluri N. 2024. The IL6/JAK/STAT3 signaling axis is a therapeutic vulnerability in SMARCB1-deficient bladder cancer. Nat Commun 15(1):1373. doi:10.1038/s41467-024-45132-2 PMID:38355560 PMCID:10867091

Purushothaman A, Olivia-Ramirez J, Treekitkarnmongkol W, Sankaran D, Hurd MW, Putluri N, Maitra A, Haymaker C, Sen S. 2023. Differential effects of pancreatic cancer-derived extracellular vesicles driving a suppressive environment. Int J Mol Sci 24(19):14652. doi:10.3390/ijms241914652 PMID:37834100 PMCID:PMC10572854
Thaiparambil J, Amara CS, Sen S, Putluri N, El-Zein R. 2023. Cigarette smoke condensate induces centrosome clustering in normal lung epithelial cells. Cancer Med doi:10.1002/cam4.5599 PMID:36621828 PMCID:PMC10134322
Yu W, Chen Y, Putluri N, Osman A, Coarfa C, Putluri V, Kamal AH, Asmussen JK, Katsonis P, Meyers JN, Lai SY, Lu W, Stephan C, Powell R, Johnson FM, Skinner HD, Kazi J, Ahmed KM, Hu L, Threet A, Meyer MD, Bankson JA, Wang T, Davis J, Parker KR, Harris MA, Baek ML, Echeverria GV, Qi X, Wang J, Frederick AI, Walsh AJ, Lichtarge O, Frederick MJ, Sandulache VC. 2023. Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state. Br J Cancer 128(11):2013-2024. doi:10.1038/s41416-023-02253-7 PMID:37012319 PMCID:PMC10205814

Reddy KR, Piyarathna DW, Kamal AH, Putluri V, Ravi SS, Bollag RJ, Terris MK, Lotan Y, Putluri N. 2022. Lipidomic profiling identifies a novel lipid signature associated with ethnicity-specific disparity of bladder cancer. Metabolites 12(6):doi:10.3390/metabo12060544 PMID:35736477 PMCID:PMC9230655
Saie AE, Fu C, Grimm SL, Robertson M, Hoffman K, Putluri V, Ambati CS, Putluri N, Shivanna B, Coarfa C, Pammi M. 2022. Metabolome and microbiome multi-omics integration from a murine lung inflammation model of bronchopulmonary dysplasia. Pediatric Research 10:doi:10.1038/s41390-022-02002-1 PMID:35338351
Thaiparambil J, Dong J, Grimm SL, Perera D, Ambati CS, Putluri V, Robertson M, Patel TD, Mistretta B, Gunaratne PH, Kim MP, Yustein JT, Putluri N, Coarfa C, El-Zein R. 2022. Integrative metabolomics and transcriptomics analysis reveals novel therapeutic vulnerabilities in lung cancer. Cancer Med doi:10.1002/cam4.4933 PMID:35676822

Coarfa C, Grimm SL, Rajapakshe K, Perera D, Lu H, Wang X, Christensen KR, Mo Q, Edwards D, Huang S. 2021. Reverse-phase protein array: technology, application, data processing, and integration. J Biomol Tech doi:10.7171/jbt.2021-3202-001 PMID:33584151 PMCID:PMC7861052 (ahead of print)
Kaochar S, Rusin A, Foley C, Rajapakshe K, Robertson M, Skapura D, Mason C, Ruiz CB, Tyryshkin AM, Deng J, Shin JN, Fiskus W, Dong J, Huang S, Navone NM, Davis CM, Ehli EA, Coarfa C, Mitsiades N. 2021. Inhibition of GATA2 in prostate cancer by a clinically available small molecule. Endocr Relat Cancer 29(1):15-31. doi:10.1530/ERC-21-0085 PMID:34636746 PMCID:PMC8634153