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Superfund Research Program

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Toxicological Sciences : An Official Journal of the Society of Toxicology (397 articles)

2024

Aryal A, Harmon AC, Varner K, Noël A, Cormier SA, Nde D, Mottram P, Maxie J, Dugas TR. 2024. Inhalation of particulate matter containing environmentally persistent free radicals induces endothelial dysfunction mediated via AhR activation at the air-blood interface. Toxicol Sci doi:10.1093/toxsci/kfae007 PMID:38310335
Hawkey AB, Shekey N, Dean C, Asrat H, Koburov R, Holloway Z, Kullman SW, Levin ED. 2024. Developmental exposure to pesticides that disrupt retinoic acid signaling causes persistent retinoid and behavioral dysfunction in zebrafish. Toxicol Sci doi:10.1093/toxsci/kfae001 PMID:38237923

2023

Carberry C, Bangma J, Koval L, Keshava D, Hartwell HJ, Sokolsky M, Fry RC, Rager JE. 2023. Extracellular vesicles altered by a per- and polyfluoroalkyl substance mixture: in vitro dose-dependent release, chemical content, and MicroRNA signatures involved in liver health. Toxicol Sci doi:10.1093/toxsci/kfad108 PMID:37851381
Cuomo D, Nitcher M, Barba E, Feinberg AP, Rusyn I, Chiu WA, Threadgill DW. 2023. Refining risk estimates for lead in drinking water based on the impact of genetics and diet on blood lead levels using the Collaborative Cross mouse population. Toxicol Sci doi:10.1093/toxsci/kfad054 PMID:37243727 PMCID:PMC10375319
Dasgupta S, Du JL, Garcia GR, Li S, Tomono-Duval K, Rericha Y, Huang L, Tanguay RL. 2023. A CRISPR-Cas9 mutation in sox9b long intergenic noncoding RNA (slincR) affects zebrafish development, behavior, and regeneration. Toxicol Sci doi:10.1093/toxsci/kfad050 PMID:37220911 PMCID:PMC10375313
Filipovic D, Qi W, Kana O, Marri D, LeCluyse EL, Andersen ME, Cuddapah S, Bhattacharya S. 2023. Interpretable predictive models of genome-wide aryl hydrocarbon receptor-DNA binding reveal tissue-specific binding determinants. Toxicol Sci 196(2):170-186. doi:10.1093/toxsci/kfad094 PMID:37707797 PMCID:PMC10682972
Ge Y, Bruno M, Nash MS, Coates NH, Chorley BN, Cave MC, Beier JI. 2023. Vinyl chloride enhances high-fat diet-induced proteome alterations in the mouse pancreas related to metabolic dysfunction. Toxicol Sci 193(1):103-114. doi:10.1093/toxsci/kfad024 PMID:36892438 PMCID:PMC10176240
Hayek EE, Castillo EF, In JG, Garcia M, Cerrato JM, Brearley AJ, Gonzalez-Estrella J, Herbert G, Bleske B, Benavidez A, Hsiao H, Yin L, Campen M, Yu X. 2023. Photoaging of polystyrene microspheres causes oxidative alterations to surface physicochemistry and enhances airway epithelial toxicity. Toxicol Sci doi:10.1093/toxsci/kfad023 PMID:36881996 PMCID:PMC10176241
Rericha Y, Simonich MT, Truong L, Tanguay RL. 2023. Review of the zebrafish as a model to investigate per- and polyfluoroalkyl substances toxicity. Toxicol Sci doi:10.1093/toxsci/kfad051 PMID:37220906 PMCID:PMC10375317
Rusyn I, Wright FA. 2023. Ten years of using key characteristics of human carcinogens to organize and evaluate mechanistic evidence in IARC Monographs on the identification of carcinogenic hazards to humans: Patterns and associations. Toxicol Sci doi:10.1093/toxsci/kfad134 PMID:38141214
Sakolish C, Moyer HL, Tsai H, Ford L, Dickey AN, Wright FA, Han G, Bajaj P, Baltazar MT, Carmichael PL, Stanko JP, Ferguson SS, Rusyn I. 2023. Analysis of reproducibility and robustness of a renal proximal tubule microphysiological system OrganoPlate 3-lane 40 for in vitro studies of drug transport and toxicity. Toxicol Sci doi:10.1093/toxsci/kfad080 PMID:37555834
Taylor KD, Woodlief TL, Ahmed A, Hu Q, Duncker PC. 2023. Quantifying the impact of PFOA exposure on B cell development and antibody production. Toxicol Sci doi:10.1093/toxsci/kfad043 PMID:37162486 PMCID:PMC10306397
Tsai H, House JS, Wright FA, Chiu WA, Rusyn I. 2023. A tiered testing strategy based on in vitro phenotypic and transcriptomic data for selecting representative petroleum UVCBs for toxicity evaluation in vivo. Toxicol Sci doi:10.1093/toxsci/kfad041 PMID:37079747 PMCID:PMC10230285

2022

Johnson KJ, Auerbach SS, Stevens T, Barton-Maclaren TS, Costa E, Currie RA, Wilk DD, Haq S, Rager JE, Reardon AJ, Wehmas L, Williams A, O'Brien J, Yauk C, LaRocca JL, Pettit S. 2022. A transformative vision for an omics-based regulatory chemical testing paradigm. Toxicol Sci 190(2):127-132. doi:10.1093/toxsci/kfac097 PMID:36165699 PMCID:PMC9702989
Nault R, Saha S, Bhattacharya S, Sinha S, Maiti T, Zacharewski TR. 2022. Single cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice. Toxicol Sci doi:10.1093/toxsci/kfac109 PMID:36222588
Rusyn I, Chiu WA. 2022. Decision-Making with New Approach Methodologies: Time to Replace Default Uncertainty Factors with Data. Toxicol Sci doi:10.1093/toxsci/kfac033 PMID:35404442
Sakolish C, Georgescu A, Huh DD, Rusyn I. 2022. A model of human small airway on a chip for studies of subacute effects of inhalation toxicants. Toxicol Sci 187(2):267-278. doi:10.1093/toxsci/kfac036 PMID:35357501
Scieszka D, Hunter R, Begay J, Bitsui M, Lin Y, Galewsky J, Morishita M, Klaver Z, Wagner JG, Harkema JR, Herbert G, Lucas S, McVeigh C, Bolt AM, Bleske B, Canal CG, Mostovenko E, Ottens AK, Gu H, Campen M, Noor S. 2022. Neuroinflammatory and neurometabolomic consequences from inhaled wildfire smoke-derived particulate matter in the western United States. Toxicol Sci 186(1):doi:10.1093/toxsci/kfab147 PMID:34865172 PMCID:PMC8883349
Shankar P, Garcia GR, La Du JK, Sullivan CM, Dunham CL, Goodale BC, Waters KM, Stanisheuski S, Maier C, Thunga P, Reif DM, Tanguay RL. 2022. The Ahr2-Dependent wfikkn1 gene influences zebrafish transcriptome, proteome, and behavior. Toxicol Sci doi:10.1093/toxsci/kfac037 PMID:35377459
Tackett A, Rebuli ME. 2022. Alternative Flavored Inhalable Products-A New Respiratory Hazard?. Toxicol Sci 187(1):1-2. doi:10.1093/toxsci/kfac021 PMID:35472170 PMCID:PMC9041544
Wahlang B, Gripshover T, Gao H, Krivokhizhina T, Keith RJ, Sithu ID, Rai SN, Bhatnagar A, McClain CJ, Srivastava S, Cave MC. 2022. Associations between residential exposure to volatile organic compounds and liver injury markers. Toxicol Sci 185(1):doi:10.1093/toxsci/kfab119 PMID:34668566 PMCID:PMC8714366

2021

Buchholz BA, Ahn K, Huang H, Gee SJ, Stewart BJ, Ognibene T, Hammock BD. 2021. Pharmacokinetics, metabolite measurement, and biomarker identification of dermal exposure to permethrin using accelerator mass spectrometry. Toxicol Sci 183:49-59. doi:10.1093/toxsci/kfab082 PMID:34460930 PMCID:PMC8404990
Charkoftaki G, Golla JP, Santos-Neto A, Orlicky DJ, Garcia-Milian R, Chen Y, Rattray NJ, Cai Y, Wang Y, Shearn CT, Mironova V, Wang Y, Johnson CH, Thompson DC, Vasiliou V. 2021. Identification of dose-dependent DNA damage and repair responses from subchronic exposure to 1,4-dioxane in mice using a systems analysis approach. Toxicol Sci 183(2):338-351. doi:10.1093/toxsci/kfab030 PMID:33693819 PMCID:PMC8921626
Chen Z, Lloyd D, Zhou Y, Chiu WA, Wright FA, Rusyn I. 2021. Risk characterization of environmental samples using in vitro bioactivity and polycyclic aromatic hydrocarbon (PAH) concentrations data. Toxicol Sci 179(1):108-120. doi:10.1093/toxsci/kfaa166 PMID:33165562 PMCID:PMC7797768
Clark J, Avula V, Ring C, Eaves LA, Howard T, Santos HP, Smeester L, Bangma J, O'Shea TM, Fry RC, Rager JE. 2021. Comparing the predictivity of human placental gene, microRNA, and CpG methylation signatures in relation to perinatal outcomes. Toxicol Sci 183(2):269-284. doi:10.1093/toxsci/kfab089 PMID:34255065 PMCID:PMC8478332
Criswell SR, Searles Nielsen S, Dlamini WW, Warden MN, Perlmutter JS, Sheppard L, Moerlein SM, Lenox-Krug J, Checkoway H, Racette BA. 2021. Principal component analysis of striatal and extrastriatal D2 dopamine receptor positron emission tomography in manganese-exposed workers. Toxicol Sci 182:doi:10.1093/toxsci/kfab045 PMID:33881537 PMCID:PMC8285020
Dalaijamts C, Cichocki JA, Luo Y, Rusyn I, Chiu WA. 2021. Quantitative characterization of population-wide tissue- and metabolite-specific variability in perchloroethylene toxicokinetics in male mice. Toxicol Sci 182(2):doi:10.1093/toxsci/kfab057 PMID:33988684 (ahead of print)
Lin L, Denison MS, Rice RH. 2021. Woodsmoke extracts cross-link proteins and induce cornified envelope formation without stimulating keratinocyte terminal differentiation. Toxicol Sci 183(1):PMID:34086961
Pfohl M, Marques E, Auclair A, Barlock BJ, Jamwal R, Goedken M, Akhlaghi F, Slitt AL. 2021. An 'omics approach to unraveling the paradoxical effect of diet on perfluorooctanesulfonic acid (PFOS) and perfluorononanoic acid (PFNA)-induced hepatic steatosis. Toxicol Sci 180:277-294. doi:10.1093/toxsci/kfaa172 PMID:33483757 PMCID:PMC8041463
Salter DM, Wei W, Nahar PP, Marques E, Slitt AL. 2021. Perfluorooctanesulfonic acid (PFOS) thwarts the beneficial effects of calorie restriction and Metformin. Toxicol Sci 182(1):doi:10.1093/toxsci/kfab043 PMID:33844015 (ahead of print)
Slotkin TA, Levin ED, Seidler FJ. 2021. Paternal cannabis exposure prior to mating, but not 9-tetrahydrocannabinol, elicits deficits in dopaminergic synaptic activity in the offspring. Toxicol Sci 184(2):doi:10.1093/toxsci/kfab117 PMID:34590702
Speer RM, Toyoda JH, Croom-Perez TJ, Liu K, Wise Sr. JP. 2021. Particulate hexavalent chromium inhibits E2F1 leading to reduced RAD51 nuclear foci formation in human lung cells. Toxicol Sci 181(1):35-46. doi:10.1093/toxsci/kfab019 PMID:33677506 PMCID:PMC8081024
Valdiviezo A, Luo Y, Chen Z, Chiu WA, Rusyn I. 2021. Quantitative in vitro-to-in vivo extrapolation for mixtures: A case study of Superfund priority list pesticides. Toxicol Sci 183(1):doi:10.1093/toxsci/kfab076 PMID:34142158 (ahead of print)
Zelko I, Dassanayaka S, Malovichko MV, Howard CM, Garrett LF, Uchida S, Brittian KR, Conklin DJ, Jones SP, Srivastava S. 2021. Chronic benzene exposure aggravates pressure overload-induced cardiac dysfunction. Toxicol Sci 185(1):64-76. doi:10.1093/toxsci/kfab125 PMID:34718823 PMCID:PMC8714365

2020

Blanchette A, Burnett SD, Grimm FA, Rusyn I, Chiu WA. 2020. A Bayesian method for population-wide cardiotoxicity hazard and risk characterization using an in vitro human model. Toxicol Sci 178(2):391-403. doi:10.1093/toxsci/kfaa151 PMID:33078833 PMCID:PMC7751158
Garland MA, Geier MC, Bugel SM, Shankar P, Dunham CL, Brown JM, Tilton SC, Tanguay RL. 2020. Aryl hydrocarbon receptor mediates larval zebrafish fin duplication following exposure to benzofluoranthenes. Toxicol Sci 176:46-64. doi:10.1093/toxsci/kfaa063 PMID:32384158 PMCID:PMC7357178
Gastelum G, Jiang W, Wang L, Zhou G, Borkar R, Putluri N, Moorthy B. 2020. Polycyclic aromatic hydrocarbon-induced pulmonary carcinogenesis in cytochrome P450 (CYP)1A1-and 1A2-null mice: roles of CYP1A1 and CYP1A2. Toxicol Sci 177:347-361. doi:10.1093/toxsci/kfaa107 PMID:32726451
Hsu KS, Goodale BC, Ely KH, Hampton TH, Stanton BA, Enelow RI. 2020. Single-cell RNA-seq analysis reveals that prenatal arsenic exposure results in long-term, adverse effects on immune gene expression in response to Influenza A infection. Toxicol Sci 176:312-328. doi:10.1093/toxsci/kfaa080 PMID:32514536 PMCID:PMC7416320
Lim JJ, Li X, Lehmler H, Wang D, Gu H, Cui JY. 2020. Gut microbiome critically impacts PCB-induced changes in metabolic fingerprints and the hepatic transcriptome in mice. Toxicol Sci 177:168-187. doi:10.1093/toxsci/kfaa090 PMID:32544245 PMCID:PMC7553702
Luo Y, Ferguson K, Rusyn I, Chiu WA. 2020. In Vitro Bioavailability of the Hydrocarbon Fractions of Dimethyl Sulfoxide Extracts of Petroleum Substances. Toxicol Sci doi:10.1093/toxsci/kfaa007 PMID:32040194
Pfohl M, Ingram L, Marques E, Auclair A, Barlock BJ, Jamwal R, Anderson D, Cummings BS, Slitt AL. 2020. Perfluorooctanesulfonic acid and perfluorohexanesulfonic acid alter the blood lipidome and the hepatic proteome in a murine model of diet-induced obesity. Toxicol Sci 178:311-324. doi:10.1093/toxsci/kfaa148 PMID:32991729 PMCID:PMC7751193
Rusyn I, Chiu WA, Wright FA. 2020. Questioning existing cancer hazard evaluation standards in the name of statistics. Toxicol Sci 177:521-522. doi:10.1093/toxsci/kfaa077 PMID:32462183
Shankar P, Dasgupta S, Hahn ME, Tanguay RL. 2020. A review of the functional roles of the zebrafish aryl hydrocarbon receptors. Toxicol Sci 178:215-238. doi:10.1093/toxsci/kfaa143 PMID:32976604 PMCID:PMC7706399
Truong KM, Feng W, Pessah IN. 2020. Ryanodine Receptor Type 2: A Molecular Target for Dichlorodiphenyltrichloroethane- and Dichlorodiphenyldichloroethylene-Mediated Cardiotoxicity. Toxicol Sci 178:159-172. doi:10.1093/toxsci/kfaa139 PMID:32894766
Wang H, Matsushita MT, Zhang L, Abel GM, Mommer BC, Huddy T, Storm D, Xia Z. 2020. Inducible and conditional stimulation of adult hippocampal neurogenesis rescues Cadmium-induced impairments of adult hippocampal neurogenesis and hippocampus-dependent memory in mice. Toxicol Sci 177:263-280. doi:10.1093/toxsci/kfaa104 PMID:32617577 PMCID:PMC7553705
Williams AE, Watt J, Robertson LW, Gadupudi GS, Osborn ML, Soares M, Iqbal K, Pedersen KB, Shankar K, Littleton S, Maimone C, Eti N, Suva LJ, Ronis M. 2020. Skeletal toxicity of coplanar polychlorinated biphenyl congener 126 in the rat is aryl hydrocarbon receptor dependent. Toxicol Sci 175:113-125. doi:10.1093/toxsci/kfaa030 PMID:32119087 PMCID:PMC7197949

2019

Abplanalp WT, Wickramasinghe NS, Sithu S, Conklin DJ, Xie Z, Bhatnagar A, Srivastava S, O'Toole TE. 2019. Benzene exposure induces insulin resistance in mice. Toxicol Sci 167(2):426-437. doi:10.1093/toxsci/kfy252 PMID:30346588 PMCID:PMC6358255
Alves VM, Borba J, Capuzzi SJ, Muratov EN, Andrade CH, Rusyn I, Tropsha A. 2019. Oy vey! A comment on machine learning of toxicological big data enables read-across structure activity relationships outperforming animal test reproducibility. Toxicol Sci 167:3-4. doi:10.1093/toxsci/kfy286 PMID:30500930 PMCID:PMC6317419
Ash P, Dhawan U, Boudeau S, Lei S, Carlomagno Y, Knobel M, Al Mohanna L, Boomhower S, Newland MC, Sherr DH, Wolozin B. 2019. Heavy metal neurotoxicants induce ALS-linked TDP-43 pathology. Toxicol Sci 167(1):105-115. doi:10.1093/toxsci/kfy267 PMID:30371865 PMCID:PMC6317426
Hagstrom D, Truong L, Zhang S, Tanguay RL, Collins ES. 2019. Comparative analysis of zebrafish and planarian model systems for developmental neurotoxicity screens using an 87-compound library. Toxicol Sci 167(1):15-25. doi:10.1093/toxsci/kfy180 PMID:30011007 PMCID:PMC6317421
Pessah IN, Truong KM. 2019. Additional safety assessments needed for diamide insecticides. Toxicol Sci 171(2):282. doi:10.1093/toxsci/kfz062 PMID:30830166 PMCID:PMC6760268
Salanga MC, Brun NR, Francolini RD, Stegeman JJ, Goldstone JV. 2019. CRISPR-Cas9 mutated pregnane x receptor (pxr) retains pregnenolone-induced expression of cyp3a65 in zebrafish. Toxicol Sci 174:51-62. doi:10.1093/toxsci/kfz246 PMID:31868891 PMCID:PMC7043230
Slotkin TA, Skavicus S, Ko A, Levin ED, Seidler FJ. 2019. The developmental neurotoxicity of tobacco smoke can be mimicked by a combination of nicotine and benzo[a]pyrene: effects on cholinergic and serotonergic systems. Toxicol Sci 168:280. doi:10.1093/toxsci/kfy304 PMID:30247698 PMCID:PMC6681680
Sobh A, Loguinov AV, Stornetta A, Balbo S, Tagmount A, Zhang L, Vulpe CD. 2019. Genome-wide CRISPR screening identifies the tumor suppressor candidate OVCA2 as a determinant of tolerance to acetaldehyde. Toxicol Sci 169:235-245. doi:10.1093/toxsci/kfz037 PMID:31059574 PMCID:PMC6484886
Sobh A, Loguinov AV, Yazici GN, Zeidan RS, Tagmount A, Hejazi NS, Hubbard AE, Zhang L, Vulpe CD. 2019. Functional profiling identifies determinants of arsenic trioxide cellular toxicity. Toxicol Sci 169:108-121. doi:10.1093/toxsci/kfz024 PMID:30815697 PMCID:PMC6484884
Spade DJ, Dere E, Hall SJ, Schorl C, Freiman RN, Boekelheide K. 2019. All-Trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. I: Altered Seminiferous Cord Maturation and Testicular Cell Fate. Toxicol Sci 167:546-558. doi:10.1093/toxsci/kfy260 PMID:30329139 PMCID:PMC6358251
Spade DJ, Hall SJ, Wortzel J, Reyes G, Boekelheide K. 2019. All-trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. II: Modulation of Mono-(2-ethylhexyl) Phthalate Toxicity. Toxicol Sci 168(1):149-159. doi:10.1093/toxsci/kfy283 PMID:30476341 PMCID:PMC6390659
Stermer A, Reyes G, Hall SJ, Boekelheide K. 2019. Small RNAs in rat sperm are a predictive and sensitive biomarker of exposure to the testicular toxicant ethylene glycol monomethyl ether. Toxicol Sci 169(2):399-408. doi:10.1093/toxsci/kfz041 PMID:30768127 PMCID:PMC6934889
Truong KM, Cherednichenko G, Pessah IN. 2019. Interactions of Dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) with skeletal muscle ryanodine receptor type 1. Toxicol Sci 170(2):50-524. doi:10.1093/toxsci/kfz120 PMID:31127943 PMCID:PMC6657572
Truong KM, Pessah IN. 2019. Comparison of chlorantraniliprole and flubendiamide activity toward wild-type and malignant hyperthermia-susceptible ryanodine receptors and heat stress intolerance. Toxicol Sci 167(2):509-523. doi:10.1093/toxsci/kfy256 PMID:30329129 PMCID:PMC6358238
Wahlang B, Hardesty JE, Head KZ, Jin J, Falkner K, Prough RA, Cave MC, Beier JI. 2019. Hepatic injury caused by the environmental toxicant vinyl chloride is sex-dependent in mice. Toxicol Sci 174(1):79-91. doi:10.1093/toxsci/kfz236 PMID:31774537 PMCID:PMC7043220
Wang H, Abel GM, Storm D, Xia Z. 2019. Cadmium exposure impairs adult hippocampal neurogenesis. Toxicol Sci 171:501-514. doi:10.1093/toxsci/kfz152 PMID:31271426
Watson AT, Nordberg RC, Loboa EG, Kullman SW. 2019. Evidence for aryl hydrocarbon receptor-mediated inhibition of osteoblast differentiation in human mesenchymal stem cells. Toxicol Sci 167(1):145-156. doi:10.1093/toxsci/kfy225 PMID:30203000 PMCID:PMC6317429
Zhang L, Wang H, Abel GM, Storm D, Xia Z. 2019. The effects of gene-environment interactions between cadmium exposure and apolipoprotein E4 on memory in a mouse model of alzheimer's disease. Toxicol Sci 173(1):189-201. doi:10.1093/toxsci/kfz218 PMID:31626305

2018

Caito SW, Jackson BP, Punshon T, Scrimale T, Grier A, Gill SR, Love TM, Watson GE, van Wijngaarden E, Rand MD. 2018. Variation in methylmercury metabolism and elimination status in humans following fish consumption. Toxicol Sci 161:443-453. doi:10.1093/toxsci/kfx226 PMID:29145616 PMCID:PMC5837402
Cheng SL, Li X, Lehmler H, Phillips B, Shen D, Cui JY. 2018. Gut microbiota modulates interactions between polychlorinated biphenyls and bile acid homeostasis. Toxicol Sci 166:269-287. doi:10.1093/toxsci/kfy208 PMID:30496569 PMCID:PMC6260149
Cichocki JA, Luo Y, Furuya S, Venkatratnam A, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. 2018. Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice. Toxicol Sci 167(1):126-137. doi:10.1093/toxsci/kfy223 PMID:30202895 PMCID:PMC6317418
Clair HB, Pinkston CM, Rai SN, Pavuk M, Dutton ND, Brock GN, Prough RA, Falkner KC, McClain CJ, Cave MC. 2018. Liver disease in a residential cohort with elevated polychlorinated biphenyl exposures. Toxicol Sci 164:39-49. doi:10.1093/toxsci/kfy076 PMID:29684222 PMCID:PMC6016643
Costa LG. 2018. Organophosphorus compounds at 80: some old and new issues. Toxicol Sci 162:24-35. doi:10.1093/toxsci/kfx266 PMID:29228398
Gadupudi GS, Elser BA, Sandgruber FA, Li X, Gibson-Corley KN, Robertson LW. 2018. PCB126 inhibits the activation of AMPK-CREB signal transduction required for energy sensing in liver. Toxicol Sci 163:440-453. doi:10.1093/toxsci/kfy041 PMID:29474705 PMCID:PMC5974782
Glazer L, Hawkey AB, Wells C, Drastal M, Odamah K, Behl M, Levin ED. 2018. Developmental exposure to low concentrations of organophosphate flame retardants causes life-long behavioral alterations in zebrafish. Toxicol Sci 165(2):487-498. doi:10.1093/toxsci/kfy173 PMID:29982741 PMCID:PMC6154272
Hardesty JE, Al-Eryani L, Wahlang B, Falkner KC, Shi H, Jin J, Vivace BJ, Ceresa BP, Prough RA, Cave MC. 2018. Epidermal growth factor receptor signaling disruption by endocrine and metabolic disrupting chemicals. Toxicol Sci 162:622-634. doi:10.1093/toxsci/kfy004 PMID:29329451 PMCID:PMC5888991
Kassotis CD, Kollitz EM, Ferguson PL, Stapleton HM. 2018. Nonionic ethoxylated surfactants induce adipogenesis in 3T3-L1 cells. Toxicol Sci 162(1):124-136. doi:10.1093/toxsci/kfx234 PMID:29106673 PMCID:PMC625695
Kollitz EM, De Carbonnel L, Stapleton HM, Ferguson PL. 2018. The affinity of brominated phenolic compounds for human and zebrafish thyroid receptor beta: Influence of chemical structure. Toxicol Sci doi:10.1093/toxsci/kfy028 PMID:29409039
Lille-Langoy R, Karlsen OA, Myklebust LM, Goldstone JV, Mork-Jansson A, Male R, Blumberg B, Stegeman JJ, Goksoyr A. 2018. Sequence variations in pxr (nr1i2) from zebrafish (Danio rerio) strains affect nuclear receptor function. Toxicol Sci 168:28-39. doi:10.1093/toxsci/kfy269 PMID:30371853 PMCID:PMC6390661
Luo Y, Furuya S, Soldatov VY, Kosyk O, Yoo HS, Fukushima H, Lewis L, Iwata Y, Rusyn I. 2018. Metabolism and toxicity of trichloroethylene and tetrachloroethylene in cytochrome P450 2E1 knockout and humanized transgenic mice. Toxicol Sci doi:10.1093/toxsci/kfy099 PMID:29897530
Meyer JN, Hartman JH, Mello DF. 2018. Mitochondrial toxicity. Toxicol Sci 162(1):15-23. doi:10.1093/toxsci/kfy008 PMID:29340618 PMCID:PMC5837373 (in press)
Petriello MC, Brandon JA, Hoffman JB, Wang C, Tripathi H, Abdel-Latif A, Ye X, Li X, Yang L, Lee EY, Soman S, Barney J, Wahlang B, Hennig B, Morris AJ. 2018. Dioxin-like PCB 126 increases systemic inflammation and accelerates atherosclerosis in lean LDL receptor-deficient mice. Toxicol Sci 162(2):548-558. doi:10.1093/toxsci/kfx275 PMID:29216392 PMCID:PMC5888982
Rusyn I, Greene N. 2018. The impact of novel assessment methodologies in toxicology on green chemistry and chemical alternatives. Toxicol Sci 161:276-284. doi:10.1093/toxsci/kfx196 PMID:29378069
Ulin A, Henderson J, Pham MT, Meyo J, Chen Y, Karchner SI, Goldstone JV, Hahn ME, Williams LM. 2018. Developmental regulation of nuclear factor erythroid-2 related factors (nrfs) by AHR1b in zebrafish (Danio rerio). Toxicol Sci 167(2):536-545. doi:10.1093/toxsci/kfy257 PMID:30321412 PMCID:PMC6358246
Wang H, Zhang L, Abel GM, Storm D, Xia Z. 2018. Cadmium exposure impairs cognition and olfactory memory in male C57BL/6 mice. Toxicol Sci 161:87-102. doi:10.1093/toxsci/kfx202 PMID:29029324 PMCID:PMC5837361
Zhou J, Henriquez J, Crawford RB, Kaminski NE. 2018. Suppression of the IgM response by aryl hydrocarbon receptor activation in human primary B cells involves impairment of immunoglobulin secretory processes. Toxicol Sci 163(1):doi:10.1093/toxsci/kfy036 PMID:29462421 (ahead of print)
Zhou J, Zhang Q, Henriquez J, Crawford RB, Kaminski NE. 2018. Lymphocyte-specific protein tyrosine kinase (LCK) is involved in the aryl hydrocarbon receptor-mediated impairment of immunoglobulin secretion in human primary B cells. Toxicol Sci 165(2):322-334. doi:10.1093/toxsci/kfy133 PMID:29860352
Zychowski KE, Kodali V, Harmon M, Tyler CR, Sanchez B, Suarez YO, Herbert G, Wheeler A, Avasarala S, Cerrato JM, Kunda NK, Muttil P, Shuey CL, Brearley AJ, Ali AS, Lin Y, Shoeb M, Erdely A, Campen M. 2018. Respirable Uranyl-Vanadate-Containing Particulate Matter Derived From a Legacy Uranium Mine Site Exhibits Potentiated Cardiopulmonary Toxicity. Toxicol Sci 164:101-114. doi:10.1093/toxsci/kfy064 PMID:29660078 PMCID:PMC6016706

2017

Chen H, Streifel KM, Singh V, Yang DR, Mangini L, Wulff H, Lein PJ. 2017. BDE-47 and BDE-49 inhibit axonal growth in primary hippocampal neuron-glia co-cultures via ryanodine receptor-dependent mechanisms. Toxicol Sci 156:375-386. doi:10.1093/toxsci/kfw259 PMID:28003438
Chlebowski A, Garcia GR, La Du JK, Bisson WH, Simonich SL, Tanguay RL. 2017. Mechanistic investigations into the developmental toxicity of nitrated and heterocyclic PAHs. Toxicol Sci 157(1):246-259. doi:10.1093/toxsci/kfx035 PMID:28186253 PMCID:PMC5414855
De La Rosa VY, Asfaha J, Fasullo M, Loguinov AV, Li P, Moore LE, Rothman N, Nakamura J, Swenberg JA, Scelo G, Zhang L, Smith MT, Vulpe CD. 2017. Editor's highlight: High-throughput functional genomics identifies modulators of TCE metabolite genotoxicity and candidate susceptibility genes. Toxicol Sci 160:111-120. doi:10.1093/toxsci/kfx159 PMID:28973557 PMCID:PMC5837773
Holland EB, Feng W, Zheng J, Dong Y, Li X, Lehmler H, Pessah IN. 2017. An extended structure-activity relationship of nondioxin-like PCBs evaluates and supports modeling predictions and identifies picomolar potency of PCB 202 towards ryanodine receptors. Toxicol Sci 155(1):170-181. doi:10.1093/toxsci/kfw189 PMID:27655348 PMCID:PMC5216651
Kania-Korwel I, Lukasiewicz T, Barnhart CD, Stamou M, Chung H, Kelly KM, Bandiera SM, Lein PJ, Lehmler H. 2017. Congener-specific disposition of chiral polychlorinated biphenyls in lactating mice and their offspring: Implications for PCB developmental neurotoxicity. Toxicol Sci 158(1):101-115. doi:10.1093/toxsci/kfx071 PMID:28431184 PMCID:PMC6070089
Sethi S, Keil KP, Chen H, Hayakawa K, Li X, Lin Y, Lehmler H, Puschner B, Lein PJ. 2017. Detection of 3,3 '-dichlorobiphenyl in human maternal plasma and its effects on axonal and dendritic growth in primary rat neurons. Toxicol Sci 158(2):401-411. doi:10.1093/toxsci/kfx100 PMID:28510766 PMCID:PMC5837364
Venkatratnam A, Furuya S, Kosyk O, Gold A, Bodnar WM, Konganti K, Threadgill DW, Gillespie DA, Aylor DL, Wright FA, Chiu WA, Rusyn I. 2017. Editor's Highlight: Collaborative Cross mouse population enables refinements to characterization of the variability in toxicokinetics of trichloroethylene and provides genetic evidence for the role of PPAR pathway in its oxidative metabolism. Toxicol Sci 158(1):48-62. doi:10.1093/toxsci/kfx065 PMID:28369613
Wahlang B, Barney J, Thompson B, Wang C, Hamad OM, Hoffman JB, Petriello MC, Morris AJ, Hennig B. 2017. Editors highlight: PCB126 exposure increases risk for peripheral vascular diseases in a liver injury mouse model. Toxicol Sci 160:256-267. doi:10.1093/toxsci/kfx180 PMID:28973532 PMCID:PMC5837513
Wittwehr C, Aladjov H, Ankley GT, Byrne H, de Knecht J, Heinzle E, Klambauer G, Landesmann b, Luijten M, MacKay C, Maxwell G, Meek MB, Paini A, Perkins EJ, Sobanski T, Villeneuve DL, Waters KM, Whelan M. 2017. How adverse outcome pathways can aid the development and use of computational prediction models for regulatory toxicology. Toxicol Sci 155(2):326-336. doi:10.1093/toxsci/kfw207 PMID:27994170 PMCID:PMC5340205
Zhou Y, Cichocki JA, Soldatow VY, Scholl EH, Gallins P, Jima DD, Yoo HS, Chiu WA, Wright FA, Rusyn I. 2017. Editor's highlight: comparative dose-response analysis of liver and kidney transcriptomic effects of trichloroethylene and tetrachloroethylene in B6C3F1 mouse. Toxicol Sci 160(1):95-110. doi:10.1093/toxsci/kfx165 PMID:28973375 PMCID:PMC5837274

2016

Bolt AM, Grant MP, Flores Molina M, Plourde D, Kelly AD, Negro Silva LF, Lemaire M, Schlezinger JJ, Mwale F, Mann K. 2016. Tungsten promotes sex-specific adipogenesis in the bone by altering differentiation of bone marrow-resident mesenchymal stromal cells. Toxicol Sci 150(2):333-346. doi:10.1093/toxsci/kfw008 PMID:26865663 PMCID:PMC4900133
Dere E, Wilson SK, Anderson LM, Boekelheide K. 2016. From the cover: sperm molecular biomarkers are sensitive indicators of testicular injury following subchronic model toxicant exposure. Toxicol Sci 153(2):327-340. doi:10.1093/toxsci/kfw137 PMID:27466211 PMCID:PMC5036622
Dornbos P, Crawford RB, Kaminski NE, Hession SL, LaPres JJ. 2016. The influence of human interindividual variability on the low-dose region of dose-response curve induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in primary B cells. Toxicol Sci 153(2):352-360. doi:10.1093/toxsci/kfw128 PMID:27473338 PMCID:PMC5036619
Gadupudi GS, Klaren WD, Olivier AK, Klingelhutz AJ, Robertson LW. 2016. PCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats. Toxicol Sci 149(1):98-110. doi:10.1093/toxsci/kfv215 PMID:26396156 PMCID:PMC4731404
Luz AL, Godebo TR, Bhatt DP, Ilkayeva OR, Maurer LL, Hirschey MD, Meyer JN. 2016. From the cover: arsenite uncouples mitochondrial respiration and induces a Warburg-like effect in Caenorhabditis elegans. Toxicol Sci 152(2):349-362. doi:10.1093/toxsci/kfw093 PMID:27208080 PMCID:PMC4960910
Nault R, Fader KA, Ammendolia DA, Dornbos P, Potter D, Sharratt B, Kumagai K, Harkema JR, Lunt SY, Matthews J, Zacharewski TR. 2016. Dose-dependent metabolic reprogramming and differential gene expression in TCDD-elicited hepatic fibrosis. Toxicol Sci 154(2):253-266. doi:10.1093/toxsci/kfw163 PMID:27562557 PMCID:PMC5139066
Nault R, Fader KA, Kirby MP, Ahmed S, Matthews J, Jones AD, Lunt SY, Zacharewski TR. 2016. Pyruvate kinase isoform switching and hepatic metabolic reprogramming by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 149(2):358-371. doi:10.1093/toxsci/kfv245 PMID:26582802 PMCID:PMC4900217
Nault R, Fader KA, Kopec AK, Harkema JR, Zacharewski TR, Luyendyk J. 2016. From the cover: coagulation-driven hepatic fibrosis requires protease activated receptor-1 (PAR-1) in a mouse model of TCDD-elicited steatohepatitis. Toxicol Sci 154(2):381-391. doi:10.1093/toxsci/kfw175 PMID:27613713 PMCID:PMC5139072
Rand MD, Vorojeikina D, van Wijngaarden E, Jackson BP, Scrimale T, Zareba G, Love TM, Myers GJ, Watson GE. 2016. Methods for individualized determination of methylmercury elimination rate and de-methylation status in humans following fish consumption. Toxicol Sci 149(2):385-395. doi:10.1093/toxsci/kfv241 PMID:26572661 PMCID:PMC4757939
Shen H, McHale CM, Haider SI, Jung C, Zhang S, Smith MT, Zhang L. 2016. Identification of genes that modulate susceptibility to formaldehyde and imatinib by functional genomic screening in human haploid KBM7 cells. Toxicol Sci 151(1):10-22. doi:10.1093/toxsci/kfw032 PMID:27008852 PMCID:PMC4914802
Wang B, Klaren WD, Wels B, Simmons DL, Olivier AK, Wang K, Robertson LW, Ludewig G. 2016. Dietary manganese modulates PCB126 toxicity, metal status, and MnSOD in the rat. Toxicol Sci 150(1):15-26. doi:10.1093/toxsci/kfv312 PMID:26660635 PMCID:PMC5009614
Wang L, Espinoza HM, MacDonald JW, Bammler TK, Williams CR, Yeh A, Louie KW, Marcinek DJ, Gallagher EP. 2016. Olfactory transcriptional analysis of salmon exposed to mixtures of chlorpyrifos and malathion reveal novel molecular pathways of neurobehavioral injury. Toxicol Sci 149(1):145-157. doi:10.1093/toxsci/kfv223 PMID:26494550 PMCID:PMC4731405
Watt J, Webster TF, Schlezinger JJ. 2016. Generalized concentration addition modeling predicts mixture effects of environmental PPARγ agonists. Toxicol Sci 153(1):18-27. doi:10.1093/toxsci/kfw100 PMID:27255385 PMCID:PMC5013877
Williams CR, MacDonald JW, Bammler TK, Simpson C, Paulsen M, Gallagher EP. 2016. From the cover: cadmium exposure differentially alters odorant-driven behaviors and expression of olfactory receptors in juvenile Coho salmon (Oncorhynchus kisutch). Toxicol Sci 154(2):267-277. doi:10.1093/toxsci/kfw172 PMID:27621283 PMCID:PMC5139070
Wu X, Yang J, Morisseau C, Robertson LW, Hammock BD, Lehmler H. 2016. 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) decreases hepatic and systemic ratios of epoxide to diol metabolites of unsaturated fatty acids in male rats. Toxicol Sci 152(2):309-322. doi:10.1093/toxsci/kfw084 PMID:27208083 PMCID:PMC4960907
Xu X, Drobna Z, Voruganti VS, Barron K, Gonzalez-Horta C, Sanchez-Ramirez B, Ballinas-Casarrubias L, Ceron RH, Morales DV, Baeza Terrazas FA, Ishida MC, Gutierrez-Torres DS, Saunders RJ, Crandell J, Fry RC, Loomis D, Garcia-Vargas G, Del Razo LM, Styblo M, Mendez MA. 2016. Association between variants in arsenic (+3 oxidation state) methyltranserase (AS3MT) and urinary metabolites of inorganic arsenic: role of exposure level. Toxicol Sci 153(1):112-123. doi:10.1093/toxsci/kfw112 PMID:27370415 PMCID:PMC5808745

2015

Anderson DS, Patchin ES, Silva RM, Uyeminami DL, Sharmah A, Guo T, Das GK, Brown JM, Shannahan JH, Gordon T, Chen L, Pinkerton KE, Van Winkle LS. 2015. Influence of particle size on persistence and clearance of aerosolized silver nanoparticles in the rat lung. Toxicol Sci 144(2):366-381. doi:10.1093/toxsci/kfv005 PMID:25577195 PMCID:PMC4372666
Fader KA, Nault R, Ammendolia DA, Harkema JR, Williams KJ, Crawford RB, Kaminski NE, Potter D, Sharratt B, Zacharewski TR. 2015. 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters lipid metabolism and depletes immune cell populations in the jejunum of C57BL/6 mice. Toxicol Sci 148(2):567-580. doi:10.1093/toxsci/kfv206 PMID:26377647 PMCID:PMC5009443
Goodale BC, La Du JK, Tilton SC, Sullivan CM, Bisson WH, Waters KM, Tanguay RL. 2015. Ligand-specific transcriptional mechanisms underlie aryl hydrocarbon receptor-mediated developmental toxicity of oxygenated PAHs. Toxicol Sci 147(2):397-411. doi:10.1093/toxsci/kfv139 PMID:26141390 PMCID:PMC4612346
Huang T, Ditzel EJ, Perrera AB, Broka D, Camenisch TD. 2015. Arsenite disrupts zinc-dependent TGFβ2-SMAD activity during murine cardiac progenitor cell differentiation. Toxicol Sci 148(2):409-420. doi:10.1093/toxsci/kfv191 PMID:26354774 PMCID:PMC5009438
Jayasundara N, Garner LV, Meyer JN, Erwin K, Di Giulio RT. 2015. AHR2-Mediated transcriptomic responses underlying the synergistic cardiac developmental toxicity of PAHs. Toxicol Sci 143(2):469-481. doi:10.1093/toxsci/kfu245 PMID:25412620 PMCID:PMC4306723
Kubota A, Goldstone JV, Lemaire B, Takata M, Woodin BR, Stegeman JJ. 2015. Role of pregnane X receptor and aryl hydrocarbon receptor in transcriptional regulation of pxr, CYP2, and CYP3 genes in developing zebrafish. Toxicol Sci 143(2):398-407. doi:10.1093/toxsci/kfu240 PMID:25424564 PMCID:PMC4306721
Martin EA, Gonzalez-Horta C, Rager JE, Bailey KA, Sanchez-Ramirez B, Ballinas-Casarrubias L, Ishida MC, Gutierrez-Torres DS, Ceron RH, Morales DV, Baeza Terrazas FA, Saunders RJ, Drobna Z, Mendez MA, Buse JB, Loomis D, Jia W, Garcia-Vargas GG, Del Razo LM, Styblo M, Fry RC. 2015. Metabolomic characteristics of arsenic-associated diabetes in a prospective cohort in Chihuahua, Mexico. Toxicol Sci 144(2):338-346. doi:10.1093/toxsci/kfu318 PMID:25577196 PMCID:PMC4372663
Moorthy B, Chu C, Carlin DJ. 2015. Polycyclic aromatic hydrocarbons: from metabolism to lung cancer. Toxicol Sci 145(1):5-15. doi:10.1093/toxsci/kfv040 PMID:25911656 PMCID:PMC4408964
Noyes PD, Haggard DE, Gonnerman GD, Tanguay RL. 2015. Advanced morphological - behavioral test platform reveals neurodevelopmental defects in embryonic zebrafish exposed to comprehensive suite of halogenated and organophosphate flame retardants. Toxicol Sci 145(1):177-195. doi:10.1093/toxsci/kfv044 PMID:25711236 PMCID:PMC4408965
Phadnis AS, Crawford RB, Kaminski NE. 2015. Suppression of human B cell activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin involves altered regulation of B cell lymphoma-6. Toxicol Sci 144(1):39-50. doi:10.1093/toxsci/kfu257 PMID:25543051 PMCID:PMC4349138
Rojas D, Rager JE, Smeester L, Bailey KA, Drobna Z, Rubio-Andrade M, Styblo M, Garcia-Vargas GG, Fry RC. 2015. Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci 143(1):97-106. doi:10.1093/toxsci/kfu210 PMID:25304211 PMCID:PMC4274382
Tilton SC, Siddens LK, Krueger SK, Larkin A, Lohr CV, Williams DE, Baird WM, Waters KM. 2015. Mechanism-based classification of PAH mixtures to predict carcinogenic potential. Toxicol Sci 146(1):135-145. doi:10.1093/toxsci/kfv080 PMID:25908611 PMCID:PMC4476464
Van Winkle LS, Bein KJ, Anderson DS, Pinkerton KE, Tablin F, Wilson D, Wexler AS. 2015. Biological dose response to PM25: effect of particle extraction method on platelet and lung responses. Toxicol Sci 143(2):349-359. doi:10.1093/toxsci/kfu230 PMID:25389146 PMCID:PMC4306718
Yoo HS, Cichocki JA, Kim S, Venkatratnam A, Iwata Y, Kosyk O, Bodnar WM, Sweet S, Knap A, Wade TL, Campbell J, Clewell H, Melnyk SB, Chiu WA, Rusyn I. 2015. The contribution of peroxisome proliferator-activated receptor alpha to the relationship between toxicokinetics and toxicodynamics of trichloroethylene. Toxicol Sci 147(2):339-349. doi:10.1093/toxsci/kfv134 PMID:26136231 PMCID:PMC4598794
Yu R, Lai Y, Hartwell HJ, Moeller BC, Doyle-Eisele M, Bodnar WM, Starr TB, Swenberg JA. 2015. Formation, accumulation, and hydrolysis of endogenous and exogenous formaldehyde-induced DNA damage. Toxicol Sci 146(1):170-182. doi:10.1093/toxsci/kfv079 PMID:25904104 PMCID:PMC4476463
Zhang Q, Bhattacharya S, Clewell RA, Carmichael PL, Andersen ME. 2015. Adaptive posttranslational control in cellular stress response pathways and its relationship to toxicity testing and safety assessment. Toxicol Sci 147(2):302-316. doi:10.1093/toxsci/kfv130 PMID:26408567 PMCID:PMC4707198

2014

Bailey KA, Laine JE, Rager JE, Sebastian E, Olshan A, Smeester L, Drobna Z, Styblo M, Rubio-Andrade M, Garcia-Vargas GG, Fry RC. 2014. Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci 139(2):328-337. doi:10.1093/toxsci/kfu053 PMID:24675094 PMCID:PMC4031624
Cole TB, Li WF, Co AL, Hay AM, MacDonald JW, Bammler TK, Farin FM, Costa LG, Furlong CE. 2014. Repeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1) modulated effects in maternal and fetal tissues. Toxicol Sci 141(2):409-422. doi:10.1093/toxsci/kfu144 PMID:25070982 PMCID:PMC4271046
DeGroot DE, Denison MS. 2014. Nucleotide specificity of DNA binding of the aryl hydrocarbon receptor: ARNT complex is unaffected by Ligand structure. Toxicol Sci 137(1):102-113. doi:10.1093/toxsci/kft234 PMID:24136190 PMCID:PMC3924043
Dominguez GA, Bisesi JH, Kroll KJ, Denslow ND, Sabo-Attwood TL. 2014. Control of transcriptional repression of the vitellogenin receptor gene in largemouth bass (Micropterus salmoides) by select estrogen receptors isotypes. Toxicol Sci 141(2):423-431. doi:10.1093/toxsci/kfu145 PMID:25061109 PMCID:PMC4271047
Huang T, Barnett JV, Camenisch TD. 2014. Cardiac epithelial-mesenchymal transition is blocked by monomethylarsonous acid (III). Toxicol Sci 142(1):225-238. doi:10.1093/toxsci/kfu170 PMID:25145660 PMCID:PMC4334812
Peluso M, Munnia A, Bollati V, Srivatanakul P, Jedpiyawongse A, Sangrajrang S, Ceppi M, Giese RW, Boffetta P, Baccarelli A. 2014. Aberrant methylation of hypermethylated-in-cancer-1 and exocyclic DNA adducts in tobacco smokers. Toxicol Sci 137(1):47-54. doi:10.1093/toxsci/kft241 PMID:24154486 PMCID:PMC3871933
Rager JE, Moeller BC, Miller SK, Kracko D, Doyle-Eisele M, Swenberg JA, Fry RC. 2014. Formaldehyde-associated changes in microRNAs: tissue and temporal specificity in the rat nose, white blood cells, and bone marrow. Toxicol Sci 138(1):36-46. doi:10.1093/toxsci/kft267 PMID:24304932 PMCID:PMC3930361
Rider CV, Boekelheide K, Catlin NR, Gordon CJ, Morata T, Selgrade MK, Sexton K, Simmons JE. 2014. Cumulative risk: toxicity and interactions of physical and chemical stressors. Toxicol Sci 137(1):3-11. doi:10.1093/toxsci/kft228 PMID:24154487 PMCID:PMC3871930
Sueyoshi T, Li L, Wang H, Moore R, Kodavanti PS, Lehmler H, Negishi M, Birnbaum LS. 2014. Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes. Toxicol Sci 137(2):292-302. doi:10.1093/toxsci/kft243 PMID:24218150 PMCID:PMC3908718
Truong L, Reif DM, St Mary L, Geier MC, Truong HD, Tanguay RL. 2014. Multidimensional in vivo hazard assessment using zebrafish. Toxicol Sci 137(1):212-233. doi:10.1093/toxsci/kft235 PMID:24136191 PMCID:PMC3871932
Yang DR, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler H, Lein PJ. 2014. PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms. Toxicol Sci 138(2):379-392. doi:10.1093/toxsci/kft334 PMID:24385416 PMCID:PMC4007107

2013

Angrish MM, Dominici CY, Zacharewski TR. 2013. TCDD-elicited effects on liver, serum, and adipose lipid composition in C57BL/6 mice. Toxicol Sci 131(1):108-115. doi:10.1093/toxsci/kfs277 PMID:22977169 PMCID:PMC3537129
Crowell SR, Sharma AK, Amin S, Soelberg JJ, Sadler NC, Wright AT, Baird WM, Williams DE, Corley RA. 2013. Impact of pregnancy on the pharmacokinetics of dibenzo[def,p]chrysene in mice. Toxicol Sci 135(1):48-62. doi:10.1093/toxsci/kft124 PMID:23744095 PMCID:PMC3748759
Dere E, Anderson LM, Coulson M, McIntyre BS, Boekelheide K, Chapin RE. 2013. SOT symposium highlight: translatable indicators of testicular toxicity: inhibin B, microRNAs, and sperm signatures. Toxicol Sci 136(2):265-273. doi:10.1093/toxsci/kft207 PMID:24052563 PMCID:PMC3858194
Forgacs AL, Dere E, Angrish MM, Zacharewski TR. 2013. Comparative analysis of temporal and dose-dependent TCDD-elicited gene expression in human, mouse, and rat primary hepatocytes. Toxicol Sci 133(1):54-66. doi:10.1093/toxsci/kft028 PMID:23418086 PMCID:PMC3627554
Gaytan BD, Loguinov AV, Lantz SR, Lerot J, Denslow ND, Vulpe CD. 2013. Functional profiling discovers the dieldrin organochlorinated pesticide affects leucine availability in yeast. Toxicol Sci 132(2):347-358. doi:10.1093/toxsci/kft018 PMID:23358190 PMCID:PMC3595527
Green SE, Luczak MW, Morse JL, DeLoughery Z, Zhitkovich A. 2013. Uptake, p53 pathway activation, and cytotoxic responses for Co(II) and Ni(II) in human lung cells: implications for carcinogenicity. Toxicol Sci 136:467-477. doi:10.1093/toxsci/kft214 PMID:24068677 PMCID:PMC3858198
Kopec AK, Boverhof DR, Nault R, Harkema JR, Tashiro C, Potter D, Sharratt B, Chittim B, Zacharewski TR. 2013. Toxicogenomic evaluation of long-term hepatic effects of TCDD in immature, ovariectomized C57BL/6 mice. Toxicol Sci 135(2):465-475. doi:10.1093/toxsci/kft156 PMID:23864506 PMCID:PMC3807621
Meyer JN, Leung MC, Rooney JP, Sendoel A, Hengartner MO, Kisby GE, Bess AS. 2013. Mitochondria as a target of environmental toxicants. Toxicol Sci 134:1-17. doi:10.1093/toxsci/kft102 PMID:23629515 PMCID:PMC3693132
Moeller BC, Recio L, Green A, Sun W, Wright FA, Bodnar WM, Swenberg JA. 2013. Biomarkers of exposure and effect in human lymphoblastoid TK6 cells following [¹³C₂]-acetaldehyde exposure. Toxicol Sci 133(1):1-12. doi:10.1093/toxsci/kft029 PMID:23425604 PMCID:PMC3627555
Niknam Y, Feng W, Cherednichenko G, Dong Y, Joshi SN, Vyas SM, Lehmler H, Pessah IN. 2013. Structure-activity relationship of selected meta- and para-hydroxylated non-dioxin like polychlorinated biphenyls: from single RyR1 channels to muscle dysfunction. Toxicol Sci 136(2):500-513. doi:10.1093/toxsci/kft202 PMID:24014653 PMCID:PMC3858193
Rignall B, Grote K, Gavrilov A, Weimer M, Kopp-Schneider A, Krause E, Appel KE, Buchmann A, Robertson LW, Lehmler H, Kania-Korwel I, Chahoud I, Schwarz M. 2013. Biological and tumor-promoting effects of dioxin-like and non-dioxin-like polychlorinated biphenyls in mouse liver after single or combined treatment. Toxicol Sci 133(1):29-41. doi:10.1093/toxsci/kft034 PMID:23457121 PMCID:PMC3627557
Sherwood CL, Lantz RC, Boitano S. 2013. Chronic arsenic exposure in nanomolar concentrations compromises wound response and intercellular signaling in airway epithelial cells. Toxicol Sci 132:222-234. doi:10.1093/toxsci/kfs331 PMID:23204110 PMCID:PMC3576008
Uehara T, Ainslie GR, Kutanzi K, Pogribny IP, Muskhelishvili L, Izawa T, Yamate J, Kosyk O, Shymoniak S, Bradford BU, Boorman GA, Bataller R, Rusyn I. 2013. Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis. Toxicol Sci 132(1):53-63. doi:10.1093/toxsci/kfs342 PMID:23288052 PMCID:PMC3576012
Yang J, Solaimani P, Dong H, Hammock BD, Hankinson O. 2013. Treatment of mice with 2,3,7,8-Tetrachlorodibenzo-p-dioxin markedly increases the levels of a number of cytochrome P450 metabolites of omega-3 polyunsaturated fatty acids in the liver and lung. Toxicol Sci 38(6):833-836. PMID:24213002 PMCID:PMC4068614
Zhu Y, Mapuskar KA, Marek RF, Xu W, Lehmler H, Robertson LW, Hornbuckle KC, Spitz DR, Aykin-Burns N. 2013. A new player in environmentally induced oxidative stress: polychlorinated biphenyl congener, 3,3'-dichlorobiphenyl (PCB11). Toxicol Sci 136(1):39-50. doi:10.1093/toxsci/kft186 PMID:23997111 PMCID:PMC3829572

2012

Benninghoff AD, Orner GA, Buchner CH, Hendricks JD, Duffy AM, Williams DE. 2012. Promotion of hepatocarcinogenesis by perfluoroalkyl acids in rainbow trout. Toxicol Sci 125(1):69-78. doi:10.1093/toxsci/kfr267 PMID:21984479 PMCID:PMC3243748
Cao Z, Hammock BD, McCoy MR, Rogawski MA, Lein PJ, Pessah IN. 2012. Tetramethylenedisulfotetramine alters Ca2+ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation. Toxicol Sci 130(2):362-372. doi:10.1093/toxsci/kfs244 PMID:22889812 PMCID:PMC3529644
Guo L, Ghassemian M, Komives EA, Russell P. 2012. Cadmium-induced proteome remodeling regulated by Spc I/Sty I and Zip I in fission yeast. Toxicol Sci 129(1):200-212. doi:10.1093/toxsci/kfs179 PMID:22610605 PMCID:PMC3713068
Jung D, MacIver B, Jackson BP, Barnaby R, Sato J, Zeidel ML, Shaw JR, Stanton BA. 2012. A novel Aquaporin 3 in Killifish (Fundulus heteroclitus) is not an arsenic channel. Toxicol Sci 127(1):101-109. doi:10.1093/toxsci/kfs078 PMID:22323512 PMCID:PMC3327866
Lock EF, Abdo N, Huang R, Xia M, Kosyk O, O'Shea SH, Zhou Y, Sedykh A, Tropsha A, Austin CP, Tice RR, Wright FA, Rusyn I. 2012. Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Toxicol Sci 126(2):578-588. doi:10.1093/toxsci/kfs023 PMID:22268004 PMCID:PMC3307611
Lu K, Gul H, Upton PB, Moeller BC, Swenberg JA. 2012. Formation of hydroxymethyl DNA adducts in rats orally exposed to stable isotope labeled methanol. Toxicol Sci 126(1):28-38. doi:10.1093/toxsci/kfr328 PMID:22157354 PMCID:PMC3289495
Sipos E, Chen L, Andras IE, Wrobel JK, Zhang B, Pu H, Park M, Eum SY, Toborek M. 2012. Proinflammatory adhesion molecules facilitate polychlorinated biphenyl–mediated enhancement of brain metastasis formation. Toxicol Sci 126(2):362-371. doi:10.1093/toxsci/kfr349 PMID:22240979 PMCID:PMC3307603
Stansfield KH, Pilsner JR, Lu Q, Wright RO, Guilarte TR. 2012. Dysregulation of BDNF-TrkB signaling in developing hippocampal neurons by Pb(2+): Implications for an environmental basis of neurodevelopmental disorders. Toxicol Sci 127:277-295. doi:10.1093/toxsci/kfs090 PMID:22345308 PMCID:PMC3327871

2011

Adami H, Berry CL, Breckenridge CB, Smith LL, Swenberg JA, Trichopoulos D, Weiss NS, Pastoor TP. 2011. Toxicology and epidemiology: improving the science with a framework for combining toxicological and epidemiological evidence to establish causal inference. Toxicol Sci 122(2):223-234. doi:10.1093/toxsci/kfr113 PMID:21561883 PMCID:PMC3155086
Angrish MM, Jones AD, Harkema JR, Zacharewski TR. 2011. Aryl hydrocarbon receptor-mediated induction of stearoyl-CoA desaturase 1 alters hepatic fatty acid composition in TCDD-elicited steatosis. Toxicol Sci 124(2):299-310. doi:10.1093/toxsci/kfr226 PMID:21890736 PMCID:PMC3216411
Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T, Harbourt D, DeSimone MC, Threadgill DW, Tryndyak VP, Pogribny IP, Bleyle L, Koop DR, Rusyn I. 2011. Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice. Toxicol Sci 120(1):206-217. doi:10.1093/toxsci/kfq362 PMID:21135412 PMCID:PMC3044200
Chan JK, Fanucchi MV, Anderson DS, Abid AD, Wallis C, Dickinson DA, Kumfer BM, Kennedy IM, Wexler AS, Van Winkle LS. 2011. Susceptibility to inhaled flame-generated ultrafine soot in neonatal and adult rat lungs. Toxicol Sci 124(2):472-486. doi:10.1093/toxsci/kfr233 PMID:21914721 PMCID:PMC3216412
Cole TB, Beyer RP, Bammler TK, Park SS, Farin FM, Costa LG, Furlong CE. 2011. Repeated developmental exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects on cerebellar gene expression. Toxicol Sci 123:155-169. doi:10.1093/toxsci/kfr157 PMID:21673326 PMCID:PMC3164442
Denison MS, Soshilov AA, He G, DeGroot DE, Zhao B. 2011. Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. Toxicol Sci 124:1-22. doi:10.1093/toxsci/kfr218 PMID:21908767 PMCID:PMC3196658
He G, Tsutsumi T, Baston DS, Zhao B, Zhao J, Heath-Pagliuso S, Denison MS. 2011. Third-generation Ah receptor-responsive luciferase reporter plasmids: amplification of dioxin-responsive elements dramatically increases CALUX bioassay sensitivity and responsiveness. Toxicol Sci 123:511-522. doi:10.1093/toxsci/kfr189 PMID:21775728 PMCID:PMC3179681
Lai IK, Chai Y, Simmons DL, Watson WH, Tan R, Haschek-Hock WM, Wang K, Wang B, Ludewig G, Robertson LW. 2011. Dietary selenium as a modulator of PCB 126-induced hepatotoxicity in male Sprague-Dawley rats. Toxicol Sci 124:202-214. doi:10.1093/toxsci/kfr215 PMID:21865291 PMCID:PMC3196656
McClure EA, North CM, Kaminski NE, Goodman JI. 2011. Changes in DNA methylation and gene expression during 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced suppression of the lipopolysaccharide-stimulated IgM response in splenocytes. Toxicol Sci 120(2):339-348. doi:10.1093/toxsci/kfq396 PMID:21212295 PMCID:PMC3061478
Olivero-Verbal J, Roth RA, Ganey PE. 2011. Dioxin alters inflammatory responses to lipopolysaccharide. Toxicol Sci 93:1180-1194. doi:10.1080/02772248.2011.577554
Pietruska JR, Liu X, Smith A, McNeil K, Weston P, Zhitkovich A, Hurt RH, Kane AB. 2011. Bioavailability, intracellular mobilization of nickel, and HIF-1α activation in human lung epithelial cells exposed to metallic nickel and nickel oxide nanoparticles. Toxicol Sci 124(1):138-148. doi:10.1093/toxsci/kfr206 PMID:21828359 PMCID:PMC3196652 (Completed with ARRA Funds)
Sherwood CL, Lantz RC, Burgess JL, Boitano S. 2011. Arsenic alters ATP-dependent Ca2+ signaling in human airway epithelial cell wound response. Toxicol Sci 121:191-206. doi:10.1093/toxsci/kfr044 PMID:21357385 PMCID:PMC3080191
Sulentic CE, Kaminski NE. 2011. The long winding road toward understanding the molecular mechanisms for B cell suppression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Toxicol Sci 120(suppl1):S171-S191. doi:10.1093/toxsci/kfq324 PMID:20952503 PMCID:PMC3043085
Swenberg JA, Lu K, Moeller BC, Gao L, Upton PB, Nakamura J, Starr TB. 2011. Endogenous versus exogenous DNA adducts: their role in carcinogenesis, epidemiology, and risk assessment. Toxicol Sci 120(suppl1):S130-S145. doi:10.1093/toxsci/kfq371 PMID:21163908 PMCID:PMC3043087

2010

Bhattacharya S, Conolly RB, Kaminski NE, Thomas RS, Andersen ME, Zhang Q. 2010. A bistable switch underlying B-cell differentiation and its disruption by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 115(1):51-65. doi:10.1093/toxsci/kfq035 PMID:20123757 PMCID:PMC2855357
Bissonnette SL, Haas A, Mann KK, Schlezinger JJ. 2010. The role of CaMKII in calcium-activated death pathways in bone marrow B cells. Toxicol Sci 118(1):108-118. doi:10.1093/toxsci/kfq256 PMID:20810541 PMCID:PMC2955217
Boekelheide K, Campion SN. 2010. Toxicity testing in the 21st century: using the new toxicity testing paradigm to create a taxonomy of adverse effects. Toxicol Sci 114(1):20-24. doi:10.1093/toxsci/kfp307 PMID:20026472 PMCID:PMC2902917
Campion SN, Sandrof MA, Hensley J, Sui Y, Gaido KW, Boekelheide K. 2010. Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. II. Gene array analysis reveals adaptive changes in cell cycle and cell death pathways. Toxicol Sci 117(2):457-465. doi:10.1093/toxsci/kfq204 PMID:20616210 PMCID:PMC2940405
Campion SN, Sandrof MA, Yamasaki H, Boekelheide K. 2010. Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. III. Candidate gene analysis identifies a role for fas in the attenuation of X-ray-induced apoptosis. Toxicol Sci 117(2):466-474. doi:10.1093/toxsci/kfq205 PMID:20616204 PMCID:PMC2940406
Crawford RB, Kaminski NE, Lu H, North CM. 2010. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated suppression of toll-like receptor stimulated B-lymphocyte activation and initiation of plasmacytic differentiation. Toxicol Sci 116:99-112. doi:10.1093/toxsci/kfq095 PMID:20348231 PMCID:PMC2886857
De Abrew KN, Kaminski NE, Thomas RS. 2010. An integrated genomic analysis of aryl hydrocarbon receptor-mediated inhibition of B-cell differentiation. Toxicol Sci 118(2):454-469. doi:10.1093/toxsci/kfq265 PMID:20819909 PMCID:PMC3003543
Kopec AK, Burgoon LD, Ibrahim-Aibo D, Burg AR, Lee AW, Tashiro C, Sharratt B, Harkema JR, Rowlands C, Budinsky R, Zacharewski TR. 2010. Automated dose-response analysis and comparative toxicogenomic evaluation of the hepatic effects elicited by TCDD, TCDF, and PCB126 in C57BL/6 mice. Toxicol Sci 118(1):286-297. doi:10.1093/toxsci/kfq236 PMID:20702594 PMCID:PMC2955213
Leung MC, Goldstone JV, Boyd W, Freedman JH, Meyer JN. 2010. Caenorhabditis elegans generates biologically relevant levels of genotoxic metabolites from aflatoxin B-1 but not benzo a pyrene in vivo. Toxicol Sci 118:444-453. doi:10.1093/toxsci/kfq295 PMID:20864627 PMCID:PMC2984530
Lu H, Crawford RB, Suarez-Martinez J, Kaplan BL, Kaminski NE. 2010. Induction of the aryl hydrocarbon receptor-responsive genes and modulation of the immunoglobulin M response by 2,3,7,8-tetrachlorodibenzo-p-dioxin in primary human B cells. Toxicol Sci 118(1):86-97. doi:10.1093/toxsci/kfq234 PMID:20702590 PMCID:PMC2955211
Lu K, Collins LB, Ru H, Bermudez E, Swenberg JA. 2010. Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not Leukemia. Toxicol Sci 116(2):441-451. doi:10.1093/toxsci/kfq061 PMID:20176625 PMCID:PMC2905397
Martyniuk CJ, Kroll KJ, Doperalski NJ, Barber DS, Denslow ND. 2010. Genomic and proteomic responses to environmentally relevant exposures to dieldrin: Indicators of neurodegeneration?. Toxicol Sci 117(1):190-199. doi:10.1093/toxsci/kfq192 PMID:20584760 PMCID:PMC2923291 (Completed with ARRA Funds)
Saini Y, Greenwood K, Merrill C, Kim KY, Patial S, Parameswaran N, Harkema JR, LaPres JJ. 2010. Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1 alpha in modulating inflammation. Toxicol Sci 116:673-681. doi:10.1093/toxsci/kfq155 PMID:20511350 PMCID:PMC2905409
Wnek SM, Jensen TJ, Severson PL, Futscher BW, Gandolfi A. 2010. Monomethylarsonous acid produces irreversible events resulting in malignant transformation of a human bladder cell line following 12 weeks of low-level exposure. Toxicol Sci 116(1):44-57. doi:10.1093/toxsci/kfq106 PMID:20375083 PMCID:PMC2886861
Yamasaki H, Sandrof MA, Boekelheide K. 2010. Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. I. Histopathological analysis reveals stage dependence of attenuated apoptosis. Toxicol Sci 117(2):449-456. doi:10.1093/toxsci/kfq203 PMID:20616207 PMCID:PMC2940404
Zhao B, DeGroot DE, Hayashi A, He G, Denison MS. 2010. CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor. Toxicol Sci 117(2):393-403. doi:10.1093/toxsci/kfq217 PMID:20634293 PMCID:PMC2940411

2009

Crawford RB, North CM, Kaplan BL, Kaminski NE, Lu H. 2009. Establishment of an immunoglobulin m antibody-forming cell response model for characterizing immunotoxicity in primary human B cells. Toxicol Sci 112(2):363-373. doi:10.1093/toxsci/kfp224 PMID:19767444 PMCID:PMC2777081
Jo WJ, Loguinov AV, Wintz H, Chang M, Smith AH, Vulpe CD, Kalman DA, Zhang L, Smith MT. 2009. Comparative functional genomic analysis identifies distinct and overlapping sets of genes required for resistance to monomethylarsonous acid (MMAIII) and arsenite (AsIII) in yeast. Toxicol Sci 111(2):424-436. doi:10.1093/toxsci/kfp162 PMID:19635755 PMCID:PMC2742584
Lefebvre KA, Tilton SC, Bammler TK, Beyer RP, Srinouanprachanh SL, Stapleton PL, Farin FM, Gallagher EP. 2009. Gene expression profiles in zebrafish brain after acute exposure to domoic acid at symptomatic and asymptomatic doses. Toxicol Sci 107(1):65-77. doi:10.1093/toxsci/kfn207 PMID:18936300 PMCID:PMC2735419
North CM, Crawford RB, Kaminski NE, Lu H. 2009. Simultaneous in vivo time course and dose response evaluation for TCDD-induced impairment of the LPS-stimulated primary IgM response. Toxicol Sci 112(1):123-132. doi:10.1093/toxsci/kfp187 PMID:19675145 PMCID:PMC2769062
North CM, Kim B, Snyder N, Crawford RB, Holsapple MP, Kaminski NE. 2009. TCDD-mediated suppression of the in vitro anti-sheep erythrocyte IgM antibody forming cell response is reversed by interferon-gamma. Toxicol Sci 107(1):85-92. doi:10.1093/toxsci/kfn223 PMID:18948302 PMCID:PMC2638643
Nyagode BA, James MO, Kleinow KM. 2009. Influence of dietary Coexposure to benzo(a)pyrene on the biotransformation and distribution of 14C-methoxychlor in the channel catfish (Ictalurus punctatus). Toxicol Sci 108(2):320-329. doi:10.1093/toxsci/kfp018 PMID:19181613 PMCID:PMC2664691
Ren X, Lim S, Smith MT, Zhang L. 2009. Werner syndrome protein, WRN, protects cells from DNA damage induced by the benzene metabolite hydroquinone. Toxicol Sci 107(2):367-375. doi:10.1093/toxsci/kfn254 PMID:19064679 PMCID:PMC2639759
Schneider D, Yoo B, Kaminski NE. 2009. Involvement of Blimp-1 and AP-1 dysregulation in the 2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated suppression of the IgM response by B cells. Toxicol Sci 108(2):377-388. doi:10.1093/toxsci/kfp028 PMID:19237549 PMCID:PMC2664693
Timme-Laragy AR, Van Tiem LA, Linney EA, Di Giulio RT. 2009. Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish. Toxicol Sci 109(2):217-227. doi:10.1093/toxsci/kfp038 PMID:19233942 PMCID:PMC2721659

2008

Berman RF, Pessah IN, Mouton PR, Mav D, Harry J. 2008. Low-level neonatal thimerosal exposure: further evaluation of altered neurotoxic potential in SJL mice. Toxicol Sci 101(2):294-309. PMID:17977901
Billiard SM, Meyer JN, Wassenberg DM, Hodson PV, Di Giulio RT. 2008. Nonadditive effects of PAHs on early vertebrate development: mechanisms and implications for risk assessment. Toxicol Sci 105(1):5-23. doi:10.1093/toxsci/kfm303 PMID:18156145 PMCID:PMC2734299
Caldwell P, Thome PA, Johnson PD, Boitano S, Runyan RB, Selmin O. 2008. Trichloroethylene disrupts cardiac gene expression and calcium homeostasis in rat myocytes. Toxicol Sci 104(1):135-143. doi:10.1093/toxsci/kfn078 PMID:18411232 PMCID:PMC4001797
Hegedus CM, Skibola CF, Warner M, Skibola DR, Zhang L, Steinmaus CM, Smith AH, Smith MT, Moore LE, Alexander D, Lim S, Dangleben NL, Clark M, Pfeiffer RM. 2008. Decreased urinary beta-defensin-1 expression as a biomarker of response to arsenic. Toxicol Sci 106(1):74-82. doi:10.1093/toxsci/kfn104 PMID:18511430 PMCID:PMC2563143
Holder A, Lucas D, Goth-Goldstein R, Koshland CP. 2008. Cellular response to diesel exhaust particles strongly depends on the exposure method. Toxicol Sci 103(1):108-115. doi:10.1093/toxsci/kfn014 PMID:18227103
Kennedy PJ, Vashisht AA, Hoe K, Kim D, Park H, Hayles J, Russell P. 2008. A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe. Toxicol Sci 106(1):124-139. doi:10.1093/toxsci/kfn153 PMID:18684775 PMCID:PMC2563147
Kopec AK, Boverhof DR, Burgoon LD, Ibrahim-Aibo D, Harkema JR, Tashiro C, Chittim B, Zacharewski TR. 2008. Comparative toxicogenomic examination of the hepatic effects of PCB126 and TCDD in immature, ovariectomized C57BL/6 mice. Toxicol Sci 102(1):61-75. doi:10.1093/toxsci/kfm289 PMID:18042819
Meza MM, Kopplin MJ, Burgess JL, Gandolfi A. 2008. Urinary arsenic methylation profile in children exposed to low arsenic levels through drinking water. Toxicol Sci 90:957-970. doi:10.1080/02772240701782140
Zhou GD, Donnelly KC, Tian Y, Naspinski C, Gu X, Mertens-Talcott SU. 2008. Pregnane X receptor protects HepG2 cells from BaP-induced DNA damage. Toxicol Sci 104(1):67-73. doi:10.1093/toxsci/kfn058 PMID:18381355

2007

Andrew AS, Bernardo V, Warnke L, Davey JC, Hampton TH, Mason RA, Thorpe JE, Ihnat MA, Hamilton JW. 2007. Exposure to arsenic at levels found inUS drinking water modifies expression in the mouse lung. Toxicol Sci 100(1):75-87. doi:10.1093/toxsci/kfm200 PMID:17682005
Beyer RP, Lasarev MR, Meira LB, Palmer VS, Ross PK, Bammler TK, Bradford BU, Cunningham ML, Higgins G, Hurban P, Kayton RJ, Kosyk O, Vliet PA, Wolfinger R, Woods CG, Freedman JH, Linney EA, Kaufmann WK, Kavanagh TJ, Rusyn I, Samson LD, Spencer PS, Suk WA, Zarbl HF. 2007. Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. Toxicol Sci 99(1):326-337. PMID:17562736
Bodwell J, Gosse JA, Hamilton JW, Davey JC. 2007. Arsenic as an endocrine disruptor: effects of arsenic on estrogen receptor-mediated gene expression in vivo and in cell culture. Toxicol Sci 98(1):75-86. doi:10.1093/toxsci/kfm013 PMID:17283378
Boekelheide K. 2007. Mixed messages. Toxicol Sci 99(1):1-2. doi:10.1093/toxsci/kfm117
Eblin KE, Bredfeldt TG, Buffington SE, Gandolfi A. 2007. Mitogenic signal transduction caused by monomethylarsonous acid in human bladder cells: role in arsenic-induced carcinogenesis. Toxicol Sci 95(2):321-330. PMID:17093206
Jonsson ME, Jenny MJ, Woodin BR, Hahn ME, Stegeman JJ. 2007. Role of AHR2 in the expression of novel cytochrome P450 1 family genes, cell cycle genes, and morphological defects in developing zebra fish exposed to 3,3',4,4',5-pentachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 100(1):180-93. PMID:17686920
Miller DS, Shaw JR, Stanton CR, Barnaby R, Karlson KH, Hamilton JW, Stanton BA. 2007. MRP2 and acquired tolerance to inorganic arsenic in the kidney of killifish (Fundulus heteroclitus). Toxicol Sci 97(1):103-110. doi:10.1093/toxsci/kfm030 PMID:17324950
Operana T, Nguyen N, Chen S, Beaton D, Tukey RH. 2007. Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure. Toxicol Sci 95(1):98-107. doi:10.1093/toxsci/kfl144 PMID:17065433
Schlezinger JJ, Emberley JK, Sherr DH, Bissonnette SL. 2007. An L-tyrosine derivative and PPARγ agonist, GW7845, activates a multi-faceted capase cascade in bone marrow B cells. Toxicol Sci 98(1):125-36. PMID:17400580
Wilson JY, Wells R, Aguilar AA, Borrell A, Tornero V, Reijnders P, Moore M, Stegeman JJ. 2007. Correlates of cytochrome P450 1A1 expression in bottlenose dolphin (Tursiops truncatus) integument biopsies. Toxicol Sci 97(1):111-9. PMID:17324949
Zettner M, Flor S, Ludewig G, Wagner J, Robertson LW, Lehmann L. 2007. Quinoid metabolites of 4-monochlorobiphenyl (PCB3) induce gene mutations in cultured Chinese hamster V79 Cells. Toxicol Sci 100:88-98. PMID:17686921

2006

Billiard SM, Timme-Laragy AR, Wassenberg DM, Cockman C, Di Giulio RT. 2006. The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish. Toxicol Sci 92:526-536. PMID:16687390
Burgoon LD, Boutros PC, Dere E, Zacharewski TR. 2006. dbZach: A MIAME-compliant toxicogenomic supportive relational database. Toxicol Sci 90(2):558-68. PMID:16403854
Johns DO, Daniell WE, Shen D, Kalman DA, Dills RL, Morgan MS. 2006. Ethanol-induced increase in the metabolic clearance of 1,1,1-trichloroethane in human volunteers. Toxicol Sci 92(1):61-70. PMID:16638923
Kim D, Andersen ME, Nylander-French LA. 2006. A dermatotoxicokinetic model of human exposures to jet fuel. Toxicol Sci 93(1):22-33. doi:10.1093/toxsci/kfl048 PMID:16801332
Kubota A, Iwata H, Handley-Goldstone HM, Kim EY, Stegeman JJ, Tanabe S. 2006. Cytochrome P450 1A4 and 1A5 in common cormorant (Phalacrocorax carbo): evolutionary relationships and functional implications associated with dioxin and related compounds. Toxicol Sci 92(2):394-408. doi:10.1093/toxsci/kfl001 PMID:16679348
Peters AK, Nijmeijer S, Gradin K, Backlund M, Bergman A, Poellinger L, Denison MS, van den Berg M. 2006. Interactions of polybrominated diphenyl ethers with the aryl hydrocarbon receptor pathway. Toxicol Sci 92(1):133-142. PMID:16601081
Rha GB, Eum SY, Hennig B, Toborek M. 2006. c-Src is the primary signaling mediator of polychlorinated biphenyl-induced interleukin-8 expression in a human microvascular endothelial cell line. Toxicol Sci 92(1):311-20. PMID:16611624
Schlezinger JJ, Emberley JK, Sherr DH. 2006. Activation of multiple mitogen-activated protein kinases in pro/pre-B cells by GW7845, a peroxisome proliferator-activated receptor gamma agonist, and their contribution to GW7845-induced apoptosis. Toxicol Sci 92(2):433-44. PMID:16672323
Strathmann J, Schwarz M, Tharappel JC, Glauert HP, Spear BT, Robertson LW, Appel KE, Buchmann A. 2006. PCB 153, a non-dioxin-like tumor promoter, selects for beta-catenin (Catnb)-mutated mouse liver tumors. Toxicol Sci 93(1):34-40. doi:10.1093/toxsci/kfl041 PMID:16782779

2005

Balshaw DM, Philbert M, Suk WA. 2005. Research strategies for safety evaluation of nanomaterials, Part III: nanoscale technologies for assessing risk and improving public health. Toxicol Sci 88(2):298-306. PMID:16162851
Bezdecny SA, Roth RA, Ganey PE. 2005. Effects of 2,2',4,4'-tetrachlorobiphenyl on granulocytic HL-60 cell function and expression of cyclooxygenase-2. Toxicol Sci 84(2):328-334. doi:10.1093/toxsci/kfi093 PMID:15673847
Handley-Goldstone HM, Grow MW, Stegeman JJ. 2005. Cardiovascular gene expression profiles of dioxin exposure in zebrafish embryos. Toxicol Sci 85(1):683-693. PMID:15716485
Hurst CH, Waxman DJ. 2005. Interactions of endocrine-active environmental chemicals with the nuclear receptor PXR. Toxicol Sci 87:299-311.
Kamat CD, Green DE, Curilla S, Warnke L, Hamilton JW, Sturup S, Clark C, Ihnat MA. 2005. Role of HIF signaling on tumorigenesis in response to chronic low-dose arsenic administration. Toxicol Sci 86(2):248-257. doi:10.1093/toxsci/kfi190 PMID:15888669
Kann S, Estes C, Reichard JF, Huang M, Sartor MA, Schwemberger S, Chen Y, Dalton TP, Shertzer HG, Xia Y, Puga A. 2005. Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status. Toxicol Sci 87(2):365-384. PMID:16014739
Loch-Caruso R, Upham BL, Harris C, Trosko JE. 2005. Divergent roles for glutathione in lindane-induced acute and delayed-onset inhibition of rat myometrial gap junctions. Toxicol Sci 85(1):694-702. PMID:15716478
Machemer DE, Tukey RH. 2005. The role of protein kinase C in regulation of TCDD-mediated CYP1A1 gene expression. Toxicol Sci 87(1):27-37. PMID:15947024
Song MO, Freedman JH. 2005. Activation of mitogen activated protein kinases by PCB126 (3,3',4,4',5-pentachlorobiphenyl) in HepG2 cells. Toxicol Sci 84(2):308-318. doi:10.1093/toxsci/kfi084 PMID:15647597
Xu S, D'Angelo E, Ghosh D, Feliciano JS, Deo SK, Daunert S. 2005. Detection of polychlorinated biphenyls employing chemical dechlorination followed by biphenyl whole cell sensing system. Toxicol Sci 87(3):287-298. doi:10.1080/02772240400029769

2004

Bielmeier SR, Best DS, Narotsky MG. 2004. Serum hormone characterization and exogeneous hormone rescue of bromodichloromethane-induced pregnancy loss in the F344 rat. Toxicol Sci 77(1):101-108. PMID:14657523
Chen J, Thirkill TL, Lohstroh PN, Bielmeier SR, Narotsky MG, Best DS, Harrison RA, Natarajan K, Pegram RA, Overstreet JW, Lasley BL, Douglas GC. 2004. Bromodichloromethane inhibits human placental trophoblast differentiation. Toxicol Sci 78(1):166-174. PMID:14691210
Davila JC, Cezar GG, Thiede M, Strom S, Miki T, Trosko JE. 2004. Use and application of stem cells in toxicology. Toxicol Sci 79(2):214-223. PMID:15014205
Dieguez-Acuna FJ, Polk WF, Ellis ME, Simmonds PL, Kushleika JV, Woods JS. 2004. Nuclear factor kappa B activity determines the sensitivity of kidney epithelial cells to apoptosis: Implications for mercury-induced renal failure. Toxicol Sci 82(1):114-123. PMID:15282405
Dong W, Teraoka H, Tsujimoto Y, Stegeman JJ, Hiraga T. 2004. Role of aryl hydrocarbon receptor in mesencephalic circulation failure and apoptosis in zebrafish embryos exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 77(1):109-116. PMID:14657521
DuTeaux SB, Newman JW, Morisseau C, Fairbairn EA, Jelks K, Hammock BD, Miller MG. 2004. Epoxide hydrolases in the rat epididymis: possible roles in xenobiotic and endogenous fatty acid metabolism. Toxicol Sci 78(2):187-195. PMID:14737000
Espandiari P, Glauert HP, Lehmler H, Lee EY, Srinivasan C, Robertson LW. 2004. Initiating activity of 4-chlorobiphenyl metabolites in the resistant hepatocyte model. Toxicol Sci 79(1):41-46. PMID:14976334
Gafni J, Wong PW, Pessah IN. 2004. Non-coplanar 2,2 ',3,5 ',6-pentachlorobiphenyl (PCB 95) amplifies ionotropic glutamate receptor signaling in embryonic cerebellar granule neurons by a mechanism involving ryanodine receptors. Toxicol Sci 77(1):72-82. PMID:14600284
Henson KL, Gallagher EP. 2004. Glutathione S-transferase expression in pollution-associated hepatic lesions of brown bullheads (Ameiurus nebulosus) from the Cuyahoga River, Cleveland, Ohio. Toxicol Sci 80(1):26-33. PMID:15071171
Heyer NJ, Echeverria D, Bittner AC, Farin FM, Garabedian CC, Woods JS. 2004. Chronic low-level mercury exposure, BDNF polymorphism, and associations with self-reported symptoms and mood. Toxicol Sci 81(2):354-363. PMID:15254338
Jiang J, Dean D, Burghardt RC, Parrish AR. 2004. Disruption of cadherin/catenin expression, localization, and interactions during HgCl2-induced nephrotoxicity. Toxicol Sci 80(1):170-182. PMID:15084754
Lu Z, Lee EY, Robertson LW, Glauert HP, Spear BT. 2004. Effect of 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB-153) on Hepatocyte Proliferation and Apoptosis in Mice Deficient in the p50 Subunit of the Transcription Factor NF-B. Toxicol Sci 81(1):35-42.
Phimister AJ, Lee MG, Morin D, Buckpitt AR, Plopper CG. 2004. Glutathione depletion is a major determinant of inhaled naphthalene respiratory toxicity and naphthalene metabolism in mice. Toxicol Sci 82(1):268-278. PMID:15319489
Tan Z, Huang M, Puga A, Xia Y. 2004. A critical role for MAP kinases in the control of Ah receptor complex activity. Toxicol Sci 82(1):80-87. doi:10.1093/toxsci/kfh228 PMID:15272135

2003

Allan LL, Mann KK, Matulka RA, Ryu H, Schlezinger JJ, Sherr DH. 2003. Bone marrow stromal-B cell interactions in polycyclic aromatic hydrocarbon-induced pro/pre-B cell apoptosis. Toxicol Sci 76(2):357-365. PMID:14514961
Andersen ME, Ou YC, Yang RH, Conolly RB, Thomas RS, Gustafson DL, Long ME, Dobrev ID, Chubb LS, Xu Y, Lapidot SA. 2003. Stochastic simulation of hepatic preneoplastic foci development for four chlorobenzene congeners in a medium-term bioassay. Toxicol Sci 73(2):301-314. PMID:12700395
Andrew AS, Karagas MR, Klei L, Hamilton JW. 2003. Drinking water arsenic exposure is associated with decreased DNA repair gene expression. Toxicol Sci 72(S1):184.
Bae D, Handa RJ, Yang RH, Campain JA. 2003. Gene expression patterns as potential molecular biomarkers for malignant transformation in human keratinocytes treated with MNNG, arsenic, or a metal mixture. Toxicol Sci 74(1):32-42. PMID:12773770
Bekris LM, Shephard C, Zarghami M, Griffith WC, Kavanagh TJ, Lernmark A. 2003. Glutamate cysteine ligase catalytic subunit trinucleotide repeat polymorphism and type I diabetes. Toxicol Sci 72(1):480Suppl.S. PMID:17479437
Bezdecny SA, Roth RA, Ganey PE. 2003. Expression of cyclooxygenase-2 in HL-60 cells exposed to polychlorinated biphenyls. Toxicol Sci 72(1):1571Suppl.S..
Carnell AN, Goodman JI, Abriola LM. 2003. The long (LINEs) and the short (SINEs) of it: altered methylation as a precursor to toxicity. Toxicol Sci 65:229-235. PMID:12773759
Chen J, Douglas GC, Thirkill TL, Lohstroh PN, Bielmeier SR, Narotsky MG, Best DS, Harrison RA, Natarajan K, Pegram RA, Overstreet JW, Lasley BL. 2003. Effect of bromodichloromethane on chorionic gonadotrophin secretion by human placental trophoblast cultures. Toxicol Sci 76(1):75-82. PMID:12970577
Choi W, Eum SY, Lee YW, Hennig B, Robertson LW, Toborek M. 2003. PCB 104-induced proinflammatory reactions in human vascular endothelial cells: relationship to cancer metastasis and atherogenesis. Toxicol Sci 75(1):47-56. doi:10.1093/toxsci/kfg149 PMID:12805654
Chung D, Loch-Caruso R. 2003. Role of oxidative stress in the modification on rat uterine contraction by 2,2 '-dichlorobiphenyl. Toxicol Sci 72(1):376.
Espandiari P, Lehmler H, Stemm DN, Glauert HP, Robertson LW. 2003. PCB metabolites as initiating agents in hepatocarcinogenesis. Toxicol Sci 72(S-1):1145.
Fadhel ZA, Bunaciu RP, Glauert HP, Robertson LW, Ludewig G. 2003. Lipid peroxidation and antioxidant enzymes in testes of rats treated with 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and effects of corn oil, medium-chain triglyceride (MCT) oil and olive oil. Toxicol Sci 72(1):1771Suppl.S.
Garry MR, Sidhu JS, Kavanagh TJ, Faustman EM. 2003. Differential modulation of stress and ubiquitination signaling pathways by cadmium, H202, and serum withdrawal in cultured mouse fibroblasts. Society of Toxicology 42nd annual Meeting in Salt Lake City, Utah, March 2003. Toxicol Sci 72(1):311Suppl.S.
Hamilton JW. 2003. Mechanism of hexavalent chromium (Cr(VI)) toxicity and carcinogenicity. Toxicol Sci 72(1):58.
Hamilton JW, Bodwell J, Kingsley LA, Barnet CS, Davey JC. 2003. Arsenic alters hormone-mediated positive, but not negative, regulatory effects of steroid receptors. Toxicol Sci 72(S1):16.
Hurst CH, Waxman DJ. 2003. Activation of PPARalpha and PPARgamma by environmental phthalate monoesters. Toxicol Sci 74(2):297-308. doi:10.1093/toxsci/kfg145 PMID:12805656
Kavanagh TJ, Shi S, Botta D, White CC, Dabrowski MJ, Shephard C, Quigley SD, Farin FM, Beyer RP, Pierce RH, Franklin CC, Zarbl HF, Bammler TK. 2003. Using toxicogenomic analysis to assess the protective effects of enhanced glutathione synthesis in glutamate cysteine ligase transgenic mice. Toxicol Sci 72(1):805Suppl.S.
Machala M, Blaha L, Vondracek J, Trosko JE, Scott J, Upham BL. 2003. Inhibition of gap junctional intercellular communication by noncoplanar polychlorinated biphenyls: Inhibitory potencies and screening for potential mode(s) of action. Toxicol Sci 76(1):102-111. PMID:12915713
Madhukar BV, Hernandez-Maldonado O. 2003. A diorthochlorinated PCB congener 2,2 ',4,4 '-tetrachlorobiphenyl (TCB) activates extracellular signal regulated kinases (ERKs) independent of protein kinase C (PKC) in JB6 mouse epidermal cells. Toxicol Sci 72(1):1574Suppl.S.
Prasch AL, Teraoka H, Carney SA, Dong W, Hiraga T, Stegeman JJ, Heideman W, Peterson RE. 2003. Aryl hydrocarbon receptor 2 mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin developmental toxicity in zebrafish. Toxicol Sci 76(1):138-150. PMID:12883077
Ramadass P, Meerarani P, Toborek M, Robertson LW, Hennig B. 2003. Dietary flavonoids modulate PCB-induced oxidative stress, CYP1A1 induction, and AhR-DNA binding activity in vascular endothelial cells. Toxicol Sci 76(1):212-219. PMID:12970578
Shao J, McKone EF, Keener CL, Shephard C, Farin FM, Aitken ML, Kavanagh TJ. 2003. The modification of cystic fibrosis lung disease by a polymorphism in a glutamate cysteine ligase gene. Toxicol Sci 72(1):487Suppl.S.
Shi S, Hendsch MB, Ogburn CE, Rabinovitch PS, Martin GM, Kavanagh TJ. 2003. Female mice transgenic for mitochondrial directed catalase have altered glutathione redox cycle enzyme activities coincident with tissue specific catalase expression. Toxicol Sci 72(1):394Suppl.S.
Shiverick KT, Medrano TA. 2003. Maternal-fetal programming in utero: adult metabolic disease and diabetes. Toxicol Sci 72(1):273Suppl.S.
Soucy NV, Ihnat MA, Kamat CD, Hess L, Post MJ, Klei L, Clark C, Barchowsky A. 2003. Arsenic stimulates angiogenesis and tumorigenesis in vivo. Toxicol Sci 76(2):271-279. doi:10.1093/toxsci/kfg231 PMID:12970581
Tharappel JC, Glauert HP, Spear BT. 2003. The effect of phenobarbital on cell proliferation in mice deficient in the p50 subunit of NF-kappa B. Toxicol Sci 72(S-1):1160.
Tsai CH, Lin P, Troester MA, Rappaport SM. 2003. Formation and removal of pentachlorophenol-derived protein adducts in rodent liver under acute, multiple, and chronic dosing regimens. Toxicol Sci 73(1):26-35. PMID:12700421
West JA, Van Winkle LS, Morin D, Fleschner CA, Forman HJ, Plopper CG. 2003. Repeated inhalation exposures to the bioactivated cytotoxicant naphthalene (NA) produce airway-specific Clara cell tolerance in mice. Toxicol Sci 75:161-168. PMID:12805647
Wu J, Eckard J, Rossman TG, Yang C, Frenkel K. 2003. p53 Signaling pathway involved in arsenite-induced HOS cell transformation and its prevention by caffeic acid phenethyl ester (CAPE). Toxicol Sci 72(1):1307Suppl.S.
Yang C, Frenkel K. 2003. Caffeic acid phenethyl ester (CAPE) inhibits arsenite-induced human cell transformation and induces G2/M phase arrest of arsenite-transformed human cells. Toxicol Sci 72(1):1029Suppl.S.

2002

Ablordeppy EA, Medrano TA, Shiverick KT. 2002. Effects of polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin on proliferation and cell regulation in human placental trophoblastic JEG-3 cells. Toxicol Sci Suppl66(1-S):349.
Andreasen EA, Spitsbergen JM, Tanguay RL, Stegeman JJ, Heideman W, Peterson RE. 2002. Tissue-specific expression of AHR2, ARNT2, and CYP1A in zebrafish embryos and larvae: effects of developmental stage and 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. Toxicol Sci 68(2):403-419. PMID:12151636
Andrew AS, Warren AJ, Temple KA, Hamilton JW. 2002. Differential effects of arsenic, chromium, cadmium, nickel and mitomycin C on gene expression as measured by DNA microarray. Toxicol Sci 66(S1):116.
Barhoumi R, Mouneimne Y, Awooda I, Safe SH, Donnelly KC, Burghardt RC. 2002. Characterization of calcium oscillations in normal and benzo[a]pyrene-treated clone 9 cells. Toxicol Sci 68(2):444-450. PMID:12151640
Blaha L, Kapplova P, Vondracek J, Upham BL, Machala M. 2002. Inhibition of gap-junctional intercellular communication by environmentally occurring polycyclic aromatic hydrocarbons. Toxicol Sci 65:43-51. PMID:11752684
Dean, Jr. CE, Benjamin SA, Chubb LS, Tessari JD, Keefe TJ. 2002. Nonadditive hepatic tumor promoting effects by a mixture of two structurally different polychlorinated biphenyls in female rat livers. Toxicol Sci 66(1):54-61. PMID:11861972
Espandiari P, Glauert HP, Robertson LW. 2002. Replacement of partial hepatectomy with fasting/refeeding or the use of neonatal animals in the resistant hepatocyte model. Toxicol Sci 66:310.
Fadhel ZA, Stafine N, Glauert HP, Robertson LW, Ludewig G. 2002. The effects of purified vs. unrefined diets on lipid peroxidation and antioxidant enzymes in tests of PCB-153 treated rats. Toxicol Sci 66:349.
Hamilton JW, Bodwell J, Kaltreider RC, Davis AM, Davey JC, Kingsley LA, Lariviere JP. 2002. Arsenic is an endocrine disruptor, blocking hormone-mediated gene regulation by the estrogen and glucocorticoid receptors in vivo. Toxicol Sci 66(S1):85.
Hansen LG, Machala M, Fischer L, James MO, Hennig B, Glauert HP, Narbonne J, van Bree L, Schultz T, Grevett P, Suk WA, Holoubek I, Robertson LW. 2002. Research needs identified at the second PCB Workshop in Brno, Czech Republic. Toxicol Sci 87(3):261-265. doi:10.1080/02772240500079011
Hu W, Jones PD, Upham BL, Trosko JE, Lau C, Giesy JP. 2002. Inhibition of gap junctional intercellular communication by perfluorinated compounds in rat liver and dolphin kidney epithelial cell lines in vitro and Sprague-Dawley rats in vivo. Toxicol Sci 68(2):429-436. PMID:12151638
Kleinow KM, Uppu P, Holmes E, Zhang Y. 2002. Alteration of p-glycoprotein expression in catfish by select environmental toxicants. Toxicol Sci 66:327.
Krig SR, Chandraratna RA, Chang MM, Wu R, Rice RH. 2002. Gene-specific TCDD suppression of RAR- and RXR-mediated induction of tissue transglutaminase. Toxicol Sci 68(1):102-108. PMID:12075115
Medrano TA, Schwanke JL, Ablordeppy EA, Shiverick KT. 2002. Identification of differential effects of benzo(a)pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin on gene expression in human placental JEG-3 cells using cell cycle and DNA microarray analysis. Toxicol Sci Suppl66(1-S):298.
Meyer JN, Nacci DE, Di Giulio RT. 2002. Cytochrome P4501A (CYP1A) in killifish (Fundulus heteroclitus): heritability of altered expression and relationship to survival in contaminated sediments. Toxicol Sci 68(1):69-81. PMID:12075112
Nagy SR, Sanborn JR, Hammock BD, Denison MS. 2002. Development of a green fluorescent protein based cell bioassay for the rapid and inexpensive detection and characterization of AhR agonists. Toxicol Sci 65(2):200-210. PMID:11812924
Soucy NV, Barchowsky A, Klei L, Hamilton JW, Ihnat MA. 2002. Potential cellular mechanisms for arsenite-induced vascular diseases. Toxicol Sci 66(S1):86.
Thrall K, Weitz KK, Woodstock AD. 2002. Use of real-time breath analysis and physiologically based pharmacokinetic modeling to evaluate dermal absorption of aqueous toluene in human volunteers. Toxicol Sci 68(2):280-287. PMID:12151623
Troester MA, Lindstrom AB, Waidyanatha S, Kupper LL, Rappaport SM. 2002. Stability of hemoglobin and albumin adducts of naphthalene oxide, 1,2-naphthoquinone, and 1,4-naphthoquinone. Toxicol Sci 68(2):314-321. PMID:12151627
Upham BL, Davis JM, Trosko JE, Schwartz KA. 2002. Polycyclic aromatic hydrocarbons with bay-like structures inhibited gap junctional intercellular communication in neonatal rat cardiomyocytes and caused asynchronous beating. Toxicol Sci 00:1410.
Wolf KK, Davis XM, Kaltreider RC, Davey JC, Lariviere JP, Hamilton JW. 2002. Chromium(III) and chromium(VI) stimulate cAMP-mediated cell signaling in cell culture and in vivo. Toxicol Sci 66(S1):32.

2001

Bae D, Gennings C, Carter, Jr. WH, Yang RH, Campain JA. 2001. Toxicological interactions among arsenic, cadmium, chromium, and lead in human keratinocytes. Toxicol Sci 63(1):132-142. PMID:11509753
Bello SM, Franks DG, Stegeman JJ, Hahn ME. 2001. Acquired resistance to Ah receptor agonists in a population of Atlantic killifish (Fundulus heteroclitus) inhabiting a marine superfund site: in vivo and in vitro studies on the inducibility of xenobiotic metabolizing enzymes. Toxicol Sci 60(1):77-91. PMID:11222875
Bielmeier SR, Best DS, Guidici DL, Narotsky MG. 2001. Pregnancy loss in the rat caused by bromodichloromethane. Toxicol Sci 59(2):309-315. PMID:11158724
Bunn TL, Parsons PJ, Kao E, Dietert RR. 2001. Exposure to lead during critical windows of embryonic development: differential immunotoxic outcome based on stage of exposure and gender. Toxicol Sci 64:57-66. PMID:11606801
Hamilton JW, Davis AM, Kaltreider RC. 2001. Chromium(VI) alters glucocorticoid receptor (GR)-dependent and cAMP-dependent gene expression through a chromium(III)-sensitive, cAMP-mediated pathway. Toxicol Sci 60(S1):316.
Hamm JT, Wilson BW, Hinton DE. 2001. Increasing uptake and bioactivation with development positively modulate diazinon toxicity in early life stage medaka (Oryzias latipes). Toxicol Sci 61(2):304-313. PMID:11353139
Handley H, Grow MW, Fishman MC, Stegeman JJ. 2001. Broad-scale characterization of gene expression patterns associated with embryonic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 60(1):1604S.
Henson KL, Stauffer G, Gallagher EP. 2001. Induction of glutathione S-transferase activity and protein expression in brown bullhead (Ameriurus nebulosus) liver by ethoxyquin. Toxicol Sci 62(1):54-60. PMID:11399793
Li P, Rossman TG. 2001. Genes upregulated in lead-resistant glioma cells reveal possible targets for lead-induced developmental neurotoxicity. Toxicol Sci 64:90-99. PMID:11606805
Lu Z, Lee EY, Robertson LW, Spear BT, Glauert HP. 2001. Effect of dietary vitamin E on the promotion of altered hepatic foci by 3,3',4,4'-tetrachlorobiphenyl (PCB-77) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) in rats initiated with diethylnitrosamine. Toxicol Sci 60:161.
Nichols BG, Woods JS, Luchtel DL, Corral J, Koenig JQ. 2001. Effects of ozone exposure on nuclear factor-kappa B activation and tumor necrosis factor-alpha expression in human nasal epithelial cells. Toxicol Sci 60(2):356-362. PMID:11248148
Pingree SD, Simmonds PL, Woods JS. 2001. Effects of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on tissue and urine mercury levels following prolonged methylmercury exposure in rats. Toxicol Sci 61(2):224-233. PMID:11353131
Slim RM, Hammock BD, Toborek M, Robertson LW. 2001. The role of methyl linoleic acid epoxide and diol metabolites in the synergistic toxicity of linoleic acid and PCBs to vascular endothelial cells. Toxicol Sci 60:13.
Srinivasan A, Lehmler H, Robertson LW, Ludewig G. 2001. Production of DNA strand breaks in vitro and Reactive Oxygen Species in vitro and in HL-60 cells by PCB Metabolites. Toxicol Sci 60(1):92-102. PMID:11222876
Trosko JE, Kwan K, Upham BL, Halgren R, Zacharewski TR, Chang C. 2001. Stem cell biology in toxicology. Toxicol Sci 60:150.
Upham BL, Rummel AM, Carbone JM, Trosko JE, Ouyang Y, Kaminski NE. 2001. Cannabinoids inhibited gap junctional intercellular communication and activated extracellular receptor kinase in a rat liver epithelial cell line. Toxicol Sci 60:750.
Upham BL, Trosko JE, Hirose I, Hasegawa R, Kanno J, Inoue T, Sai K. 2001. Structure-activity relationships of perfluorinated fatty acids on gap junctional intercellular communication and MAPK using in vivo and in vitro model systems. Toxicol Sci 60:746.
Upham BL, Wagner JG. 2001. Toxicological Highlight: Toxicant-induced oxidative stress in cancer. Toxicol Sci 64:1-3.
Waters KM, Safe SH, Gaido KW. 2001. Differential gene expression in response to methoxychlor and estradiol through ERalpha, ERbeta, and AR in reproductive tissues of female mice. Toxicol Sci 63:47-56. PMID:11509743
Wijeweera JB, Gandolfi A, Parrish AR, Lantz RC. 2001. Sodium arsenite enhances AP-1 and NFKB DNA binding and induces stress protein expression in precision-cut rat lung slices. Toxicol Sci 61(2):283-294. PMID:11353137

2000

Barhoumi R, Mouneimne Y, Ramos KS, Safe SH, Phillips TD, Centonze VE, Ainley C, Gupta MS, Burghardt RC. 2000. Analysis of Benzo[a]pyrene partitioning and cellular homeostasis in a rat liver cell line. Toxicol Sci 53:264-270. PMID:10696774
Bordelon NR, Donnelly KC, King LC, Wolf DC, Reeves WR, George S. 2000. Bioavailability of genotoxic compounds in coal tar contaminated soils in Fisher 344 rats. Toxicol Sci 56(1):37-48. doi:10.1093/toxsci/56.1.37 PMID:10869452
Bowman CJ, Kroll KJ, Folmar LC, Heurne MJ, Denslow ND. 2000. Vitellogenin transcriptional activation in sheepshead minnow following acute estrogen exposure in vivo. Toxicol Sci 54:326.
Boyer AS, Finch WT, Runyan RB. 2000. Trichloroethylene inhibits development of embryonic heart valve precursors in vitro. Toxicol Sci 53(1):109-117. PMID:10653528
Bunn TL, Ladics GS, Holsapple MP, Dietert RR. 2000. Developmental immunotoxicology assessment in the rat: age, gender, and strain comparisons. Toxicol Sci 54:10.
Calfee-Mason K, Spear BT, Glauert HP. 2000. Effect of dietary vitamin E on other cellular antioxidant defense systems in phenobarbital-treated rats. Toxicol Sci 54(1):946.
Chen S, Golemboski KA, Dietert RR. 2000. Embryonic exposure to lead modulates Th1/Th2 associated immune functions and is influenced by developmental status. Toxicol Sci 49(1-S):5.
Doi AM, Lou Z, Holmes E, Li CL, Venugopal CS, James MO, Kleinow KM. 2000. Effect of micelle fatty acid composition and 3,4,3',4'-tetrachlorobiphenyl (TCB) exposure on intestinal [14C]-TCB bioavailability and biotransformation in channel catfish in situ preparations. Toxicol Sci 55(1):85-96. PMID:10788563
Fadhel ZA, Lu Z, Robertson LW, Glauert HP. 2000. Role of cytochrome P-450 induction and lipid peroxidation in 3,3',4,4'-tetrachlorobiphenyl (PCB-77)- and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153)-induced toxicity in liver of male rats. Toxicol Sci 54:78.
Ganey PE, Olivero-Verbal J, Madhukar BV. 2000. Mechanism of inhibition of stimulated neutrophil degranulation by 2,2',4,4'-tetrachlorobiphenyl. Toxicol Sci 54:77.
Greene JF, Zheng J, Grant DF, Hammock BD. 2000. Cytotoxicity of 1,2-epoxynaphthalene is correlated with protein binding and in situ glutathione depletion in cytochrome P4501A1 expressing Sf-21 cells. Toxicol Sci 53(2):352-360. PMID:10696783
Gustafson DL, Long ME, Thomas RS, Benjamin SA, Yang RH. 2000. Comparative hepatocarcinogenicity of hexachlorobenzene, pentachlorobenzene, 1,2,4,5-tetrachlorobenzene, and 1,4-dichlorobenzene: application of a medium-term liver focus bioassay and molecular and cellular indices. Toxicol Sci 53(2):245-252. PMID:10696772
Krig SR, Rice RH. 2000. TCDD suppression of tissue transglutaminase stimulation by retinoids in malignant human keratinocytes. Toxicol Sci 56(2):357-364. PMID:10910994
Krovat BC, Tracy JH, Omiecinski CJ. 2000. Fingerprinting of cytochrome P450 and microsomal epoxide hydrolase gene expression in human blood cells. Toxicol Sci 55(2):352-360. PMID:10828267
Lee J, Naqui SA, Dietert RR. 2000. Embryonic windows of increased vulnerability to Pb-induced immunotoxicity during avian development. Toxicol Sci 54(1):9.
Lou Z, Celander MC, James MO. 2000. Expression and steroid hydroxylation activity of a CYP3A-like protein in channel catfish proximal and distal intestine. Toxicol Sci 54:97-98.
Lu Z, Spear BT, Robertson LW, Glauert HP. 2000. Activation of hepatic hepatic NF-kB by polychlorinated biphenyls (PCBs) in vivo and in cultured rat hepatocytes. Toxicol Sci 54:254.
Ludewig G, Lehmler H, Boivin R, Srinivasan A, Robertson LW. 2000. Reactivity of halogenated and non-halogenated dihydroxy-biphenyls in vitro and in cells in culture. Toxicol Sci 54(1):76.
McGarry MA, Bubb M, Campbell-Thompson M, Medrano TA, Shiverick KT. 2000. Differential effects of benzo(a)pyrene and 2,3,7,8-tetrachlorodibenzo(a)pyrene on cell adherens junction and actin cytoskeletal proteins in human uterine RL95-2 cells. Toxicol Sci 54:348.
Olivero-Verbal J, Ganey PE. 2000. A common elecrotopological motif among organochlorine compounds that activate neutrophils. Toxicol Sci 54:77.
Pereg D, Tampal N, Robertson LW. 2000. Covalent binding of benzo[a]pyrene, 4-chlorobiphenyl and 3,3',4,4'-tetrachlorobiphenyl to nuclear macromolecules in female mice. Toxicol Sci 54(1):366.
Powell WH, Bright R, Bello SM, Hahn ME. 2000. Developmental and tissue-specific expression of AHR1, AHR2, and ARNT2 in dioxin-sensitive and -resistant populations of the marine fish, Fundulus heteroclitus. Toxicol Sci 57(2):229-239. PMID:11006353
Rael LT, Ayala-Fierro F, Carter DE. 2000. The effects of sulfur-, thiol-, and thiol inhibitor compounds on arsine-induced toxicity in the human erythrocyte membrane. Toxicol Sci 55(2):468-477. PMID:10828280
Rice T, Clarke RW, Hauser R, Antonini JM, Godleski J, Paulauskis JD. 2000. Differential ability of transition metals to induce pulmonary inflammation. Toxicol Sci 54(1):36. PMID:11708899
Sabo-Attwood TL, Bowman CJ, Denslow ND. 2000. Molecular cloning of estrogen receptor isotypes in largemouth bass, Micropterus salmoides. Toxicol Sci 54:263.
Safe SH. 2000. Bisphenol A and related endocrine disrupters. Toxicol Sci 56(2):251-252. PMID:10910979
Seidel SD, Li V, Winters GM, Rogers WJ, Martinez EI, Denison MS. 2000. Ah receptor-based chemical screening bioassays: application and limitations for the detection of Ah receptor agonists. Toxicol Sci 55(1):107-115. PMID:10788565
Srinivasan A, Robertson LW, Ludewig G. 2000. PCB metabolites: cytotoxicity, glutathione depletion and inhibition of topoisomerase II. Toxicol Sci 54(1):78.
Tampal N, Myers S, Pereg D, Robertson LW. 2000. Hemoglobin adducts of polychlorinated biphenyls as potential biomarkers of exposure. Toxicol Sci 54(1):365.
Tharappel JC, Robertson LW, Lee EY, Spear BT, Glauert HP. 2000. Effect of 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and 3,3',4,4'-tetrachlorobiphenyl (PCB-77) on NF-kB and AP-1 activation, altered hepatic foci formation, cell proliferation, and apoptosis in rats. Toxicol Sci 54:271.
Thompson SA, White CC, Krejsa CM, Eaton DL, Kavanagh TJ. 2000. Modulation of glutathione and glutamate-L-cysteine ligase by methylmercury during mouse development. Toxicol Sci 57:141-6. PMID:10966520
Tithof PK, Olivero J, Ruehle K, Ganey PE. 2000. Activation of neutrophil calcium-dependent and -independent phospholipases A2 by organochlorine compounds. Toxicol Sci 53(1):40-47. PMID:10653519
Troester MA, Lindstrom AB, Waidyanatha S, Kupper LL, Rappaport SM. 2000. Stability of hemoglobin and albumin adducts of benzene oxide and 1,4-benzoquinone after administration of benzene to F344 rats. Toxicol Sci 54:88-94. PMID:10746935
Zheng XH, Wilson CL, Parrish AR, Gandolfi A. 2000. Differential gene expression in rabbit renal cortical slices exposed to arsenic compounds. Toxicol Sci 54:
Ziccardi MH, Gardner IA, Denison MS. 2000. Development and modification of a recombinant cell bioassay to directly detect halogenated and polycyclic aromatic hydrocarbons in serum. Toxicol Sci 54(1):183-193. PMID:10746945

1999

Ayala-Fierro F, Barber DS, Rael LT, Carter DE. 1999. In vitro tissue specificity for arsine and arsenite toxicity in the rat. Toxicol Sci 52(1):122-129. PMID:10568705
Bunn TL, Marsh JA, Golemboski KA, Dietert RR. 1999. Gender-based differential humoral responses to a foreign versus self antigen after in ovo lead exposure. Toxicol Sci 48(1-S):5.
Clarke RW, Al-Mutairi E, Love JA, Rice T, Antonini JM, Paulauskis JD, Godleski J. 1999. Residual oil ashes with differing composition elicit pro-inflammatory chemokines in the lung and heart. Toxicol Sci 48(15):259.
Draper AJ, Hammock BD. 1999. Inhibition of soluble and microsomal epoxide hydrolase by zinc and other metals. Toxicol Sci 52:26-32. PMID:10568695
Draper AJ, Hammock BD. 1999. Soluble epoxide hydrolase in rat inflammatory cells is indistinguishable from soluble epoxide hydrolase in rat liver. Toxicol Sci 50:30-35. PMID:10445750
Driscoll LL, Wu JJ, Zurich KJ, Strupp BJ. 1999. Chronic lead exposure alters explicit memory function. Toxicol Sci 48(1-S):360.
Garcia-Arenas G, Claudio L, Perez-Severiano F, Rios C. 1999. Low-level lead acetate exposure inhibits nitric oxide synthase activity in capillary and synaptosomal fractions of mouse brain. Toxicol Sci 50:244-258.
Korytko PJ, Casey AC, Bush B, Quimby FW. 1999. Induction of hepatic cytochrome P450 in dogs exposed to a chronic low dose of polychlorinated biphenyls. Toxicol Sci 47(1):52-61. PMID:10048153
Lin P, Waidyanatha S, Pollack GM, Swenberg JA, Rappaport SM. 1999. Dose-specific production of chlorinated quinone and semiquinone adducts in rodent livers following administration of pentachlorophenol. Toxicol Sci 47(1):126-133. PMID:10048161
Mann KK, Hahn ME, Trombino AF, Lawrence BP, Kerkvliet NI, Sherr DH. 1999. The role of DMBA metabolites in preB cell apoptosis. Toxicol Sci 48(1-S):
Morisseau C, Derbel M, Lane TR, Stoutamire DW, Hammock BD. 1999. Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats. Toxicol Sci 52(2):148-153. PMID:10630566
Parrish AR, Zheng XH, Turney KD, Younis HS, Gandolfi A. 1999. Enhanced transcription factor DNA binding and gene expression induced by arsenite or arsenate in renal slices. Toxicol Sci 50:98-105. PMID:10445758
Paulauskis JD, Danaee H, Antonini JM, Al-Mutairi E, Rice T, Godleski J, Clarke RW. 1999. Instilled soluble vanadium evokes pulmonary inflammation but does not elicit pro-inflammatory chemokine mRNA in the heart. Toxicol Sci 48(15):52.
Phillips TD. 1999. Dietary clay in the chemoprevention of aflatoxin-induced disease. Toxicol Sci 52:118-126. PMID:10630600
Rummel AM, Trosko JE, Wilson MR, Upham BL. 1999. Polycyclic aromatic hydrocarbons with bay-like regions inhibited gap junctional intercellular communication and stimulated MAPK activity. Toxicol Sci 49:232-240. PMID:10416268
Strupp BJ, Morgan RE, Garavan H. 1999. Enduring effects of early lead exposure: Assessment of sustained attention, inhibitory control, and information processing speed. Toxicol Sci 48(1-S):360.
Turney KD, Parrish AR, Gandolfi A. 1999. Selective activation in the MAPK pathway by Hg(II). Toxicol Sci 48:331.
Twaroski TP, Espandiari P, Robertson LW. 1999. Effects of selected PCB congeners on drug- and glutathione-metabolizing enzymes in the rat. Toxicol Sci 48(1-S):
Zheng XH, Parrish AR, Turney KD, Younis HS, Gandolfi A. 1999. Arsenite [AS(III)] and arsenate [AS(V)] enhance DNA binding of the AP-1 and elk-1 transcription factors and c-jun and c-fos gene expression in precision-cut renal slices. Toxicol Sci 48:351.

1998

Besselink HT, Denison MS, Hahn ME, Karchner SI, Vethaak AD, Koeman JH, Brouwer A. 1998. Low inducibility of CYP1A activity by polychlorinated biphenyls (PCBs) in flounder (Platichthys flesus): characterization of the Ah receptor and the role of CYP1A inhibition. Toxicol Sci 43(2):161-171. doi:10.1006/toxs.1998.2455 PMID:9710958
Bunn TL, Golemboski KA, Dietert RR. 1998. In utero exposure to lead modulates Th1/Th2 associated functions and is influenced by gender. Toxicol Sci 42(1-S):206.
Cremin JD, Olsen HE, Seaton C, Woolard D, Littles S, Strupp BJ, Smith DR. 1998. Effects of neo-natal Pb exposure on protein kinase C (PKC) in rat brain regions. Toxicol Sci 42:27.
Doi AM, Kleinow KM, James MO, Venugopalan CS, Holmes E. 1998. Bioavailability and biotransformation of 3,4,3',4'-tetrachlorobiphenyl (TCB) in in situ intestinal preparations of uninduced and TCB-induced channel catfish. Toxicol Sci 42:337.
Fischer L, Seegal R, Ganey PE, Pessah IN, Kodavanti PR. 1998. Symposium overview: toxicity of non-coplanar PCBs. Toxicol Sci 41(1):49-61. doi:10.1006/toxs.1997.2386 PMID:9520341
Gadagbui BK, James MO, Faux LR, Sikazwe DN. 1998. Distribution of glutathione S-transferase (GST) activity and anti GST-p cross-reactive protein in intestine of the channel catfish. Toxicol Sci 42:274.
Kodavanti UP, Hauser R, Christiani DC, Meng ZH, McGee J, Ledbetter AD, Richards J, Costa DL. 1998. Pulmonary responses to oil fly ash particles in the rat differ by virtue of their specific soluble metals. Toxicol Sci 43:204-212. PMID:9710962
Koistinen J, Soimasuo R, Tukia K, Blankenship AL, Giesy JP. 1998. Induction of EROD activity in hepa-1 mouse hepatoma cells and estrogenicity in MCF-7 human breast cancer cells by extracts of pulp mill effluents, biosludge, and sediment exposed effluents. Toxicol Sci 17(8):1499-1507.
Legare ME, Barhoumi R, Hebert E, Bratton GR, Burghardt RC, Tiffany-Castiglioni E. 1998. Analysis of Pb2+ entry into cultured astroglia. Toxicol Sci 46(1):90-100. doi:10.1006/toxs.1998.2492 PMID:9928672
Mayura K, Abdel-Wahhab MA, McKenzie KS, Sarr AB, Edwards JF, Naguib K, Phillips TD. 1998. Prevention of maternal and developmental toxicity in rats via dietary inclusion of common aflatoxin sorbents: Potential for hidden risks. Toxicol Sci 41:175-182. PMID:9520353
Miller TE, Golemboski KA, Ha R, Bunn TL, Sanders FS, Dietert RR. 1998. Developmental exposure to lead causes persistent immunotoxicity in Fischer 344 rats. Toxicol Sci 42(2):129-135. PMID:9579025
Oakley GG, Roe AL, Blouin RA, Ganguly TC, Vore M, Robertson LW. 1998. Activation of AP-1 and STAT transcription factors by non-coplanar Polychlorinated Biphenyls (PCBs). Toxicol Sci 42:133.
Strupp BJ, Patton L, Smith DR. 1998. Evaluation of succimer chelation for reducing brain-Pb levels in a rodent model. Toxicol Sci 42:27.
Twaroski TP, Robertson LW. 1998. PCB-induced oxidative stress and effects on glutathione, glutathione peroxidase and catalase. Toxicol Sci 42:153.
Wetmur JG, Rosenfeld A, Desnick RJ. 1998. Genetic influences on lead poisoning. Toxicol Sci 42:2335.
Zheng XH, Younis HS, Turney KD, Parrish AR, Gandolfi A. 1998. Molecular alterations in renal cortical slices following exposure to sub-toxic levels of arsenic. Toxicol Sci 42:323.

1996

Starodub ME, Miller PA, Ferguson GM, Giesy JP, Willes RF. 1996. The use of risk assessment techniques to develop a protocol for determining acceptable concentrations of bioaccumulative chlorinated organic chemicals in sediments for the protection of piscivorous wildlife. Toxicol Sci 54:243-259. doi:10.1080/02772249609358316

1995

Johnson KA, Naddy RB, Weisskopf CP. 1995. Passive sampling devices for rapid determination of soil contaminant distributions. Toxicol Sci 51:31-44.
Safe SH, Rodriguez LV, Goldstein L. 1995. Toxic equivalency factor approach for risk assessment of combustion by-products. Toxicol Sci 49:181-191.
Yu C, Conklin MH. 1995. Effect of trichloroethene on the aqueous solubility of chlorobenzenes. Toxicol Sci 49:73-84.

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