Research Briefs: University of California-Davis

Superfund Research Program

Development and Application of Integrated In Vitro and Cell-Based Bioassays

Project Leader: Michael S. Denison
Co-Investigator: Isaac N. Pessah
Grant Number: P42ES004699
Funding Period: 1995-2015

Project-Specific Links

Research Briefs

• 225 - Commercial Paper and Rubber Products Contain Activators of the Aryl Hydrocarbon Receptor -- Denison, Di Giulio
  Release Date: 09/04/2013

  Common commercial and consumer products, including newspapers and rubber bands, contain chemicals that are recognized by the body as toxins, according to a collaborative study by researchers at the Duke University and University of California, Davis Superfund Research Program (SRP) Centers.

• 216 - New Highly Sensitive On-Chip Nanoparticle Immunoassay -- Kennedy
  Release Date: 12/05/2012

  A breakthrough in bioassay technology allows detection of attomolar concentrations of biomolecules on a microchip. This new nanotechnology approach to detecting proteins and other compounds increases sensitivity more than 1,000-fold over conventional assays, and yet is affordable and easy to use.

• 213 - Widely Used Antibacterial Agents May Lead to Significant Health Concerns -- Pessah, Hammock
  Release Date: 09/05/2012

  Researchers at UC Davis show that triclosan, a chemical widely used in antibacterial products, impairs heart and skeletal muscle activity in animal models. Other studies link another antibacterial agent, triclocarban, to changes in regulatory pathways in mice and in human cells.

• 204 - CALUX Generation 3 - Enhanced Sensitivity for Low Volume/Low Concentration Samples -- Denison
  Release Date: 12/07/2011

  Firefly genes make the CALUX contaminant detection tool literally light up in the presence of dioxin and related chemicals. New advances make the tool 10- to 100 times more sensitive.

• 150 - A New USEPA SW-846 Method 4435 for HAH Analysis -- Clark, Denison
  Release Date: 06/06/2007
  
  
• 1 - Bioassay Developed for Detection of Dioxin-Like Chemicals -- Denison
  Release Date: 08/07/1997