Superfund Research Program
Elucidating Mechanisms of Heavy Metal-Induced Toxicity and Disease
Project Leader: Rebecca C. Fry
Grant Number: P42ES005948
Funding Period: 2011-2018
- Project Summary
- 268 - Prenatal Arsenic Exposure Alters Newborn Metabolite Profiles -- Fry
Release Date: 04/05/2017
Researchers at the University of North Carolina at Chapel Hill Superfund Research Program (UNC SRP) Center have identified metabolites in umbilical cord blood that are associated with exposure to arsenic in the womb. The findings also show that differences in a mother's metabolism of arsenic may influence the metabolite profile of her baby. Assessing changes in the newborn's metabolite profile by looking at the full range of metabolites, or metabolome, may provide insight into how prenatal arsenic exposure could affect important pathways responsible for maintaining normal cell processes in the body.
- 233 - Investigating the Newborn Proteome: Prenatal Arsenic Exposure and Altered Protein Expression -- Fry
Release Date: 05/07/2014
Scientists have identified changes in biological pathways that are associated with prenatal arsenic exposure. This research, led by Rebecca Fry, Ph.D., at the University of North Carolina Superfund Research Program (UNC SRP), is the largest protein-based study of an arsenic pregnancy cohort to date. The NIEHS-funded work provides mechanistic insights into the links between early life exposure to arsenic and disease susceptibility and also identifies proteins and pathways that may later be used to identify markers of arsenic exposure and disease risk in humans.
- 221 - Novel Method Identifies Potential Key Pathway in Arsenic-Induced Birth Defects -- Fry
Release Date: 05/01/2013
Blocking the glucocorticoid receptor (GR) pathway in a chick embryo model prevents structural birth defects induced by arsenic, according to a 2013 NIEHS-funded study at the University of North Carolina at Chapel Hill Superfund Research Program (UNC SRP). The laboratory study was performed after computationally predicting the association between the GR pathway and metal-induced birth defects with a novel approach to identify targeted biological pathways.