Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02262-0001-0000-5
Chemical Name:	Hops extract
CASRN:	8060-28-4
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	A14323
Vehicle Control:	Water
Study Result:	Negative

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	41	3.4	68	2.5	57	1.5	53	2.3
1000	55	4.4	46	3.5	58	4.7	50	6
2500	47	4.7	39	4.8	56	6.7	51	4.7
5000	55	5.9	50	3	60	4	51	5.9
7500	45	3.9	58	2.5	60	2	57	5
10000	55	11.5	62	10	87	15.7	74	8.2
Positive Control	385	4.4	407	9.8	648	20.5	985	38.5

Strain: TA98
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% RLI (Positive)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	12	1.2	17	2.3	21	3.5	29	1.9	13	1.8
1000	27	5.6	18	2.3	21	3.8	20	1.8	33	3.4
2500	12	.9	20	3.7	12	1	22	1.2	24	.9
5000	20	2.6	16	2.3	20	3.5	17	2.3	28	5
7500	26	2.7	21	4	19	1.7	26	4.3	28	2.3
10000	15	2.7	20	1	11	1.7	30	3.1	29	2.1
Positive Control	170	5.5	427	4	473	19.8	826	49.9	500	27.9

Strain: eColi pKM101
Dose	No Activation (Equivocal)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% RLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	166	29	229	13.3	231	12.9	264	9.1	244	9.2
250							256	32.4
500							237	9.7
1000	234	8.6	248	15.2	308	16.5	234	3.2	254	12.8
2500	266	7.1	273	11.4	313	6.8	235	32.7	268	5.9
5000	259	5.9	262	8.7	285	6.2	263	15.1	285	12.5
7500	244	7.8	268	6.1	312	3			278	20.7
10000	233	.7	260	7.7	291	13.5			303	10.9
Positive Control	768	5.4	663	46	713	18.2	848	23.8	752	7.4

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;