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Study Information
Study Attribute Value
CEBS Accession Number: 002-01485-0004-0000-4
Chemical Name: 4-Biphenylamine
CASRN: 92-67-1
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: 121112
Vehicle Control: Dimethyl Sulfoxide
Study Result: Positive

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose No Activation
(Negative) 		10% RLI
(Positive) 		10% RLI
(Positive) 		10% HLI
(Positive) 		10% HLI
(Positive)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 112 7.1 82 5.2 88 4.7 82 7.2 101 9.3 
2         
 100 4.7 182 2.9 254 11.9 211 20.7 228 16.5 
7         
 94 9.9 573 32.7 569 7.8 511 31.1 492 33.9 
21         
 105 11.2 1239 54.1 1603 46.7 1165 59.9 1301 31 
67         
 104 2.6 1845 87 3033 68.3 2299 47.6 2028 61.5 
200         
 t 2179 210 2941 66.1 2116 357.4 2291 61.8
Positive Control 1972 47.7 2760 56.6 1862 63.3 3063 100.5 2777 117.3

Strain: TA1535
Dose No Activation
(Negative) 		10% RLI
(Positive) 		10% RLI
(Weakly Positive) 		10% HLI
(Equivocal) 		10% HLI
(Positive)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 15 1.5 10 4.2 4 1.2 7 1.2 7 .6 
2         
 13 1.7 11 3.7 3 .6 6 2 6 1.5 
7         
 16 1.7 11 2.9 5 1.2 9 1.2 10 1.2 
21         
 13 2.6 24 .3 11 .6 12 1.2 19 2.3 
67         
 16 1.5 35 1.7 17 5.2 17 1.5 24 2 
200         
 9 s .6 34 2.8 19 6.7 15 2.4 24 4.8
Positive Control 1268 52.3 179 10.4 149 7.5 199 6.9 228 21.5

Strain: TA1537
Dose No Activation
(Negative) 		10% RLI
(Positive) 		10% RLI
(Positive) 		10% HLI
(Positive) 		10% HLI
(Weakly Positive)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 5 .7 8 3 5 1.8 10 0 10 1.2 
2         
 6 1.2 14 2 7 2 8 1.2 8 2 
7         
 7 .7 17 3 16 0 17 4 11 2 
21         
 7 1.2 27 2.2 33 3.5 30 1.7 23 1.9 
67         
 5 .3 32 3.2 64 3.5 40 1.5 25 2.3 
200         
 t 35 .9 52 1.5 35 4.6 27 3.5
Positive Control 332 47.4 139 13.7 139 10.2 208 25.3 81 4.4

Strain: TA98
Dose No Activation
(Negative) 		10% RLI
(Positive) 		10% RLI
(Positive) 		10% HLI
(Positive) 		10% HLI
(Positive)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 19 2.6 30 1.5 13 .6 14 2.3 25 1.5 
2         
 23 1.3 68 5.6 56 17.9 51 3.1 57 4.5 
7         
 18 2.7 151 12.4 180 15 178 1.5 186 11.5 
21         
 20 3.5 453 9.6 323 75.4 381 5.7 369 31.3 
67         
 18 3.4 986 90.9 586 96.4 881 28.9 931 19.1 
200         
 t 1224 55.1 838 197.6 1421 95.9 1271 11
Positive Control 1984 78.6 2597 76.7 1618 62.3 3170 27 2423 74.8

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;