COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01485-0005-0000-5
Chemical Name: 4-Biphenylamine
CASRN: 92-67-1
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: 150557
Vehicle Control: 95% Ethanol
Study Result: Positive

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose No Activation
(Negative) 		10% RLI
(Positive) 		10% RLI
(Positive) 		10% HLI
(Positive) 		10% HLI
(Positive)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 139 7.8 159 4.4 112 7.9 163 8.8 129 6.9 
3         
 298 17 351 13.9 
10         
 113 5.8 701 17.8 757 45.8 591 39.4 734 57.4 
33         
 111 8.1 1044 20.8 1331 45.3 922 31.7 945 50.8 
100         
 0 s 0 1091 14.7 1195 54.2 901 3.2 943 58.9 
333         
 0 s 0 0 s 0 85 s 56 0 s 0 t 
1000         
 0 s 0 0 s 0 0 s 0
Positive Control 434 3.7 735 22.3 551 3.5 1796 23.7 1290 45.3

Strain: TA1535
Dose No Activation
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 27 .9 46 3.8 42 4.5 
10         
 24 1.7 30 .6 27 4.9 
33         
 24 1.5 31 2.4 24 2 
100         
 15 1.8 23 2.7 12 2.9 
333         
 0 s 0 0 s 0 0 s 0 
1000         
 0 s 0 0 s 0 0 s 0
Positive Control 427 7.1 277 7.1 536 12.8

Strain: TA1537
Dose No Activation
(Negative) 		10% RLI
(Positive) 		10% RLI
(Positive) 		10% HLI
(Positive) 		10% HLI
(Positive)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 5 .9 10 1 8 3.2 5 .6 8 2.9 
3         
 13 .6 15 5.2 
10         
 9 1.7 22 5 25 1.9 25 2.3 29 2 
33         
 6 .9 40 6.5 48 2.7 69 3.2 72 4.8 
100         
 3 .6 77 8.3 79 4.4 65 5.6 90 5 
333         
 0 s 0 0 s 0 2 s 0 0 s 0 t 
1000         
 0 s 0 0 s 0 0 s 0
Positive Control 172 4.7 167 14.8 164 4.8 500 5.5 345 15

Strain: TA98
Dose No Activation
(Negative) 		10% RLI
(Positive) 		10% RLI
(Positive) 		10% HLI
(Positive) 		10% HLI
(Positive)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 29 2.2 42 1 37 3.5 37 3.7 37 4.3 
3         
 123 9.9 115 9 
10         
 19 3.5 325 21.9 367 27.8 427 26 302 45.4 
33         
 23 2.5 734 41.5 852 48.1 825 74.8 549 79.8 
100         
 28 4 886 85.7 766 85.5 969 72.3 605 25.7 
333         
 0 s 0 0 s 0 93 s 5 t t 
1000         
 0 s 0 0 s 0 t
Positive Control 724 7.1 563 13.9 382 27 1514 107.5 1027 53.1

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;