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Study Information
Study Attribute Value
CEBS Accession Number: 002-02133-0004-0000-5
Chemical Name: Ethoxyquin
CASRN: 91-53-2
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: 620987
Vehicle Control: Dimethyl Sulfoxide
Study Result: Negative

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose No Activation
(Negative) 		No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 87 3.8 99 .3 167 9 130 7.2 92 3.3 181 1.9 159 5 
 0.3       
 102 11.1 147 5 
1         
 121 13.5 132 10.7 
3         
 73 2.1 102 5 133 22.5 
10         
 87 5.6 100 4 144 3.4 187 1.2 175 3.5 
33         
 85 3.8 114 8.8 121 11.8 103 2.8 115 9.6 190 9.1 160 11.6 
100         
 43 14.1 135 6.2 100 9 178 12.2 174 2.2 
166         
 26 s 3.3 
333         
 116 5.6 109 .3 168 11.6 131 9.2 
666         
 136 s 14.8 
1000         
 114 2 127 s 13.8 145 s 10.3 
1666         
 86 s 3.6 137 s 13.3
Positive Control 519 9.9 1005 3.5 563 14.4 337 24.3 674 156.3 447 14.7 821 30.3

Strain: TA104
Dose No Activation
(Equivocal) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 352 5 341 7.5 428 18.7 396 1 437 11.4 411 11.8 
 0.3       
 371 32.8 337 9 
1         
 399 8.6 330 9.9 
3         
 396 8.2 344 14.7 
10         
 401 14.4 360 5 426 3.3 418 14.9 421 8.4 389 17.1 
33         
 447 4.6 356 7.8 451 11.3 424 13.2 430 15.3 418 19.6 
100         
 467 17.1 460 16 424 13.5 387 25.9 
333         
 447 7 442 12.4 395 7 376 8.4 
666         
 387 16.3 390 s 9.7 
1000         
 350 8.5 319 s 20.2
Positive Control 553 20.1 953 26.9 789 27.1 944 37.9 947 30.8 1068 29.4

Strain: TA1535
Dose No Activation
(Negative) 		No Activation
(Negative) 		No Activation
(Weakly Positive) 		30% RLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 8 .9 6 2 8 2.4 12 .9 10 .3 8 1 9 2 
 0.3       
 7 1.2 5 .7 10 2.1 
1         
 6 2 6 1.9 17 2.4 
3         
 8 1.2 6 .3 24 4.1 
10         
 6 .9 8 1.2 25 .3 12 1.2 11 .9 11 2.5 6 2.6 
33         
 6 .6 4 1.2 20 1.8 9 .6 7 1 8 1.5 10 2 
100         
 12 .3 9 2.3 9 1.2 7 .9 
333         
 20 5.2 6 .7 5 .7 4 1.3 
666         
 5 1.2 2 s 1 
1000         
 17 .7 3 s 1
Positive Control 1186 56.2 480 28 826 29.9 51 5.6 279 10.5 54 3.5 65 5.9

Strain: TA97
Dose No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 149 3.8 169 5.3 207 10.5 151 6.1 198 17.9 164 8.1 
 0.3       
 150 5.2 166 2.6 
1         
 163 1.7 170 6.1 
3         
 143 7.9 166 6.6 
10         
 149 2.5 153 12.7 140 8.3 155 9.2 187 2.5 176 5.5 
33         
 151 6.1 141 8.8 156 5.5 131 3.6 187 8.3 180 2 
100         
 149 4.6 167 5.1 175 6.5 183 4 
333         
 169 18 163 7.9 202 3.3 166 3.2 
666         
 176 7.2 157 5.1 
1000         
 146 9.6 158 4.7
Positive Control 350 12.8 374 21.5 357 17.9 383 11.5 306 13.3 464 29.6

Strain: TA98
Dose No Activation
(Negative) 		No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 12 2.7 14 1.5 20 2.1 30 5.8 20 1.8 33 5.7 26 1.2 
 0.3       
 21 1.2 22 2.5 
1         
 17 1.7 17 2 
3         
 12 2.6 21 .6 21 .9 
10         
 13 2.3 14 1.5 16 3.1 33 3.4 26 3.5 
33         
 12 1.7 14 1.9 20 1.2 20 .6 15 4.7 27 5.2 28 4.4 
100         
 6 .9 18 .6 19 1.5 28 .3 26 3.3 
166         
 6 3 
333         
 12 0 18 1.8 18 1.2 11 s 1.3 
666         
 9 s .3 
1000         
 13 1.2 10 s 1.8 10 s 1.9 
1666         
 11 s 1.5 7 s 1.9
Positive Control 499 10.2 681 11.4 554 24.2 87 8.8 480 27 260 .9 608 33.6

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;